Clinical trials: sponsored by Central Hospital, Nancy, France
Heart Failure
Evaluation of the Effects of Sauna Therapy on Congestion and Loop Diuretic Use in Patients With Heart Failure With Reduced or Moderately Reduced Ejection Fraction
This study aims to evaluate the effect of sauna therapy on congestion levels during cardiac rehabilitation in patients with heart failure who have an impaired or moderately impaired ejection fraction, compared to standard cardiac…
- Trial name
- SAUNA-HF RCT (NCT07468344)
- Testing
- Sauna
- Where
- France
- Volunteers
- 46 people
- Sponsor
- Central Hospital, Nancy, France
Cardiac Amyloidosis
Fast Cardiac Bone SPECT-CZT in Transthyretin Cardiac Amyloidosis
Transthyretin cardiac amyloidosis (ATTR-CA) is traditionally diagnosed using planar bone scintigraphy with a Perugini visual score ≥ 2.
- Trial name
- PeakAmyL (NCT07605741)
- Testing
- bone scintigraphy
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Central Hospital, Nancy, France
Therapy-Associated Cancer
Prognostic Value of 177Lutetium-PSMA Single Photon Emission Tomography and Timing of Response
177Lutetium-PSMA-617 is an established treatment for patients with metastatic castration-resistant prostate cancer (mCRPC). Early response assessment is critical for optimizing patient management.
- Trial name
- RECIP (NCT07643935)
- Where
- France
- Volunteers
- 280 people
- Sponsor
- Central Hospital, Nancy, France
Cervical Disc Herniation, Cervical Foraminal Stenosis
Endoscopic Posterior Cervical Foraminotomy Versus Anterior Cervical Discectomy and Fusion for Cervical Radiculopathy
Cervical radiculopathy caused by cervical disc herniation or foraminal stenosis is a common condition that may result in upper limb pain, sensory disturbances, and motor deficits.
- Conditions
- Cervical Disc Herniation, Cervical Foraminal Stenosis, Cervical Radiculopathy
- Trial name
- ENDOFOR (NCT07894159)
- Testing
- Uniportal Endoscopic Posterior Cervical Foraminotomy, Anterior Cervical Discectomy and Fusion
- Where
- France
- Volunteers
- 46 people
- Sponsor
- Central Hospital, Nancy, France
Renal Function
Urinary Creatinine Excretion Time in the Neonatal Period
Newborn's renal function is difficult to assess and its physiology during the first days of life is still incompletely known. Studies suggest that the newborn almost completely reabsorbs creatinine during the first 48 to 72 hours…
- Trial name
- C-Rex (NCT05813730)
- Testing
- urinary creatinine excretion measurement
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Cardiac Disease
Replacing Spatial Filtering With Deep-learning Noise Reduction
Spatial filtering is routinely required to reduce the statistical noise of gated SPECT myocardial perfusion imaging, but at the expense of image blurring.
- Trial name
- DEEPLAIM (NCT07888218)
- Where
- France
- Volunteers
- 49 people
- Sponsor
- Central Hospital, Nancy, France
Pheochromocytoma, Cardiovascular Complication
Cardiovascular Complications After Adrenalectomy for Pheochromocytoma and Non-secreting Tumors
Pheochromocytoma is an adrenomedullary chromaffin cell tumour that releases catecholamines. Adverse cardiovascular events are considered the main cause of morbidity and mortality in patients with pheochromocytoma.
- Conditions
- Pheochromocytoma, Cardiovascular Complication, Adrenal Incidentaloma
- Trial name
- HEMODYNAMICS (NCT07200245)
- Testing
- adrenalectomy
- Where
- France
- Volunteers
- 522 people
- Sponsor
- Central Hospital, Nancy, France
Endocrine Tumor
Registry of Endocrine Tumors (Thyroid, Parathyroid, Adrenal, Endocrine Pancreas, Endocrine Digestive Tube)
This registry aims to collect informations about patients with endocrine tumors (Thyroid, Parathyroid, Adrenal, Endocrine Pancreas, Endocrine Digestive Tube) who undergo endocrine surgical procedures.
- Trial name
- eurocrine (NCT03410394)
- Where
- France
- Volunteers
- 3,000 people
- Sponsor
- Central Hospital, Nancy, France
Liver Neoplasm
Variability of Microwave Ablation Volume Based on Clinical, Radiological, Biological, and Tissue Factors
Microwave ablation is a minimally invasive technique whose planning relies on manufacturer tables derived from ex vivo models that do not account for patient or tumor-specific factors.
- Trial name
- MICRO-VAR (NCT07413640)
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Central Hospital, Nancy, France
Crohn Disease (CD)
Virtual hIStology of Crohn's Disease Ex-vivo Resected Anatomical Lesions
Crohn's disease is a chronic, incurable inflammatory bowel disease with an unpredictable course, characterized by alternating remission and inflammatory flares.
- Trial name
- VISCERAL (NCT07413653)
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Central Hospital, Nancy, France
Endocrine Procedural Complications, Thyroid
Intraoperative Monitoring to Predict Postoperative Complications After Thyroidectomy
The goal of this study is to evaluate the role of intraoperative continous and intermittent neuromonitoring and intraoperative parathormone (PTH) to predict postoperative nerve morbidity and hypocalcemia.
- Conditions
- Endocrine Procedural Complications, Thyroid, Parathyroid; Deficiency, Laryngeal Injury
- Trial name
- PARACAL (NCT03309384)
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Central Hospital, Nancy, France
FLU
Wastewater Epidemiology to Document the Circulation of Influenza Viruses
Primary objective: To evaluate the wastewater surveillance strategy for anticipating the circulation of influenza virus strains in the general population and among hospitalized patients.
- Trial name
- EPI-FLU-EAU (NCT07880834)
- Volunteers
- 300 people
- Sponsor
- Central Hospital, Nancy, France
Chronic Migraine Headache, Psychologic Adaptation
Psychological Support for Chronic Migraine Patients Treated With Anti-CGRP (Anti-Calcitonin Gene-Related Peptide ) Monoclonal Antibodies
Chronic migraine is a disabling neurological condition that can significantly affect quality of life, emotional well-being, social participation, and daily functioning.
- Trial name
- MIG-PSY-CGRP (NCT07877493)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Central Hospital, Nancy, France
Lyme Borreliosis, Fibromyalgia
Experiences and Care Pathways Shared on Social Media Regarding 5 Conditions Causing Chronic Pain
Chronic pain is a major symptom shared by several medical conditions. This study focuses on five well-defined chronic diseases : Lyme Borreliosis (LB), Post-Acute COVID-19 Syndrome (PACS or "long COVID"), fibromyalgia…
- Conditions
- Lyme Borreliosis, Fibromyalgia, Rheumatoid Arthritis (RA), Post Acute COVID 19 Syndrome
- Trial name
- NCT07871578
- Where
- France
- Volunteers
- 501 people
- Sponsor
- Central Hospital, Nancy, France
Intra-Abdominal Infection, Candida
Rezafungin Peritoneal Diffusion for Intra-abdominal Candidiasis
ntra-abdominal candidiasis is a serious infection common in critically ill patients, often leading to high mortality if not treated quickly.
- Conditions
- Intra-Abdominal Infection, Candida, Abdominal Surgery Patients, Critically Ill Intensive Care Unit Patients
- Trial name
- REAREZ (NCT07093203)
- Where
- France
- Volunteers
- 18 people
- Sponsor
- Central Hospital, Nancy, France
Antibiotic Prophylaxis, Pancreatic Surgey
Perioperative Pharmacokinetic/Pharmacodynamic Target Attainment of Piperacillin During Major Hepatic and Pancreatic Surgery
Hepatic and pancreatic surgeries are associated with a high risk of surgical site infections, particularly in patients with preoperative biliary drainage, which is frequently associated with bacterial colonization of bile.
- Conditions
- Antibiotic Prophylaxis, Pancreatic Surgey, Hepatic Surgery
- Trial name
- PROPHTAZ (NCT07558681)
- Where
- 2 sites in France
- Volunteers
- 60 people
- Sponsor
- Central Hospital, Nancy, France
Acute Dyspnea
Implementation of Mobile Intensive Care Unit Ultrasound Based Management for Acute Dyspnea
This multicentre, cluster-randomised, stepped-wedge clinical trial aims to assess whether an intervention designed to implement an ultrasound-guided pre-hospital care pathway for the management of acute dyspnea would improve the…
- Trial name
- IMICU2-Dyspnea (NCT07852364)
- Testing
- Ultrasound pre-hospital care
- Where
- 11 sites in France
- Volunteers
- 800 people
- Sponsor
- Central Hospital, Nancy, France
Focal Epilepsy With and Without Secondary Generalization, Psychotic Symptoms
Prospective Study of Postictal Psychotic Symptoms Occuring After Video-EEG Monitoring in Focal Epilepsies
Psychotic disorders are up to eight times more prevalent in patients with epilepsy compared to the general population. Among them, postictal psychosis (PIP) is a severe complication of focal epilepsy, characterized by a brief…
- Trial name
- INSPEV (NCT07471334)
- Testing
- Psychiatric assessment
- Volunteers
- 110 people
- Sponsor
- Central Hospital, Nancy, France
Carotid Stenosis
Determination of the Best Therapeutic Strategy, Interventional With Best Medical Management (BMM) Versus BMM Alone, for Patients With Symptomatic Moderate <70% Atherosclerotic Carotid Artery Stenosis: the SIMCA Multicenter Randomized Trial
Stroke is one of the leading causes of death and the main cause of long-term disability worldwide. A frequent cause is the narrowing of the carotid artery due to atherosclerosis, known as carotid artery stenosis.
- Trial name
- SIMCA (NCT07839390)
- Testing
- endarterectomy, stenting, Control group
- Volunteers
- 1,440 people
- Sponsor
- Central Hospital, Nancy, France
Auto Immune Disease
Does Borrelia Burgdorferi Increases the Risk of Auto-immune Disease ?
Lyme borreliosis (LB) is an infectious disease that may be followed by a post-infectious syndrome known as PTLDS: Post-Treatment Lyme Disease Syndrome.
- Trial name
- DOBI (NCT07837232)
- Where
- France
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France