Clinical trials: sponsored by Centre Hospitalier St Anne
Stroke, Upper Extremity Paresis
Sensory Mechanisms of Manual Dexterity Recovery After Stroke: a Prospective Cohort Study of Prediction and Cerebral Correlates
In the proposed research, we will assess motor and sensory functions of the hand using clinical tests and a tool designed to measure manual dexterity combined with vibrotactile stimulation.
- Conditions
- Stroke, Upper Extremity Paresis, Manual Dexterity, Sensory Integration Dysfunction
- Trial name
- HapticS 2 (NCT07340736)
- Testing
- Haptic stimulation device, Brain MRI
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier St Anne
Bipolar Disorder (BD)
Anticipating Depressive and Manic Episodes in Bipolar Disorders Using Vocal Biomarkers
Bipolar disorder (BD) is a chronic, cyclical mental illness affecting over 1% of the global population. It is characterized by alternating episodes of elevated mood and energy (mania or hypomania) and episodes of decreased mood…
- Trial name
- SPEECHBIPO (NCT07298278)
- Testing
- Voice interviews and questionnaires carried out via the CALLYOPE application, Sleep measurements using an under-mattress sensor, Smartwatch for measuring activity, sleep, and skin temperature
- Volunteers
- 170 people
- Sponsor
- Centre Hospitalier St Anne
Neurologic Disorders, Schizophrenia
Characterization of High-Level Cognitive Impairments in Patients With Neuropsychiatric Disorders
Neuropsychiatric disorders are extremely common, severe, and disabling conditions. In the field of psychiatry, they notably include schizophrenia, mood disorders (depressive and bipolar disorders), autism spectrum or…
- Conditions
- Neurologic Disorders, Schizophrenia, Bipolar Disorder (BD), Depressive Disorder
- Trial name
- COGPSY (NCT07295652)
- Testing
- Cognitive assessment, Brain MRI (optional), Electroencephalography (optional)
- Where
- 3 sites in France
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier St Anne
Role of the Noradrenergic System in the Regulation of Learning Dynamics, No Disease or Condition is Being Studied
Role of the Noradrenergic System in the Regulation of Learning Dynamics: Evaluation of the Effect of a Low-dose Selective Noradrenaline Reuptake Inhibitor (NOISYXETINE)
Administration of low-dose selective noradrenaline reuptake inhibitor (sNRI) (e.g. atomoxetine) to healthy subjects is a validated model of increasing cortical noradrenaline levels which, combined with computational modelling of…
- Trial name
- NOISYXETINE (NCT07239791)
- Testing
- Atomoxetine
- Where
- France
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier St Anne
Sleep Disorder
Targeted Intervention on Sleep Disorders During Tobacco or Cannabis Cessation Therapy
During a cessation therapy for tobacco or cannabis, sleep disorders are one of the main risk factors of relapse, and a symptom of substance withdrawing.
- Trial name
- ISAC (NCT07202351)
- Testing
- Screening and management of sleep disorders
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Centre Hospitalier St Anne
Insomnia Related to Another Mental Condition
Association Between the Quality of the Therapeutic Alliance and the Response to ChronoS Therapy
PREDI-CHRONOS is an ancillary study of the CHRONOS project (NCT07180290) The goal of this study is to measure the association between therapeutic alliance and the clinical response to the CHRONOS therapy.
- Trial name
- PREDI-CHRONOS (NCT07202338)
- Testing
- CHRONOS therapy
- Where
- France
- Volunteers
- 48 people
- Sponsor
- Centre Hospitalier St Anne
Bipolar 1 Disorder
Feasibility and Preliminary Results of the Efficacy of Blue-Blocking Glasses on Manic Symptoms in Bipolar Disorder
The goal of this clinical trial is to assess the feasibility of conducting a clinical trial of the use of blue-blocking glasses among patients with a type1 bipolar disorder, experiencing a manic episode.
- Trial name
- B2Bi (NCT07194278)
- Testing
- Blue-blocking glasses
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Centre Hospitalier St Anne
Insomnia Due to Mental Disorder
Evaluation of the ChronoS Therapy on the Severity of Sleep Disturbances Among Patients With Mood Disorders: A Within-subjects Study
A new psychotherapy has been developed within the Psychiatry, Sleep and Chronobiology Reference Center (ChronoS) since January 2022.Results have shown relevant clinical interest on insomnia symptoms, as well on mood, anxiety and…
- Trial name
- CRHONOS (NCT07180290)
- Testing
- Psychotherapy
- Where
- France
- Volunteers
- 67 people
- Sponsor
- Centre Hospitalier St Anne
Drepanocytosis, Chronic Neurological Deficiency
Transfusion Exchanges and Cognition in Sickle Cell Disease
DREPA-COG is an observational study evaluating the effect of exchange transfusions on cognitive function in adults with severe sickle cell disease (SS or Sβ0).
- Trial name
- DREPA-COG (NCT07168447)
- Where
- 6 sites in France
- Volunteers
- 85 people
- Sponsor
- Centre Hospitalier St Anne
Aneurysmal Subarachnoid Hemorrhage
Cilostazol With Nimodipine to Improve Outcome After Aneurysmal Subarachnoid Hemorrhage
The CASH study is a randomized, double-blind, placebo-controlled trial evaluating whether adding cilostazol to standard nimodipine therapy improves neurological outcomes in patients with aneurysmal subarachnoid hemorrhage (aSAH).
- Trial name
- CASH (NCT07144956)
- Testing
- Cilostazol (Pletal®) 100 mg Tablets, Nimodipine group
- Volunteers
- 630 people
- Sponsor
- Centre Hospitalier St Anne
Tobacco Use, Smoking Cessation
Can Cognitive Behavioural Therapy Help Incarcerated Men Quit Smoking? Efficacy and Predictors of Treatment Outcomes
The goal of this clinical trial is to evaluate whether a brief group-based psychological intervention using cognitive-behavioral therapy (CBT) helps people in prison quit smoking.
- Conditions
- Tobacco Use, Smoking Cessation, Cognitive Behavioral Therapy, Prisoners
- Trial name
- PriSanTabac (NCT06873009)
- Testing
- Cognitive-Behavioral Therapy (CBT) for Smoking Cessation, Health Education Session on Tobacco Use
- Where
- France
- Volunteers
- 202 people
- Sponsor
- Centre Hospitalier St Anne
Mental Health
Implications of Myelin in Executive Control in Adolescence and Early Adulthood
The Myelex study is a fundamental research study that aims to better understand how the brain functions and develops. The objective of this study is to better understand the role of myelin, a sheath that surrounds nerve fibers…
- Trial name
- MYELEX (NCT06868966)
- Where
- France
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier St Anne
Sexual Disorder, Physiological
"Evolution of Sexual Symptoms in Paraphilic Sexual Offenders With/Without Antiandrogen or SSRI Treatment"
The ESPARA study is a multicenter observational research project aiming to monitor, over a three-year period, the evolution of sexual symptoms in male sexual offenders with paraphilia, divided into three groups: receiving…
- Trial name
- ESPARA (NCT07144943)
- Testing
- For subjects on SSRIs: bone densitometry
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier St Anne
Brain Activity
Neurocognitive Correlates of the Influence of Number Word Syntax on Magnitude Processing
Linguistic irregularities in number naming systems, such as the inversion of number words, affect the processing of Arabic numerals. Recently, it has been claimed that there is even a syntactic representation of number words.
- Trial name
- NUMWORD (NCT07133230)
- Where
- France
- Volunteers
- 84 people
- Sponsor
- Centre Hospitalier St Anne
Disorders of Consciousness Due to Severe Brain Injury
Consciousness Prognosis Evaluation Using Olfactory Stimulations in Comatose Patients)
The goal of this observational study is to determine whether the clinical response to olfactory stimulation (known as the "sniff" response) can help predict 3-month neurological outcomes in ICU patients with persistent disorders…
- Trial name
- CEOS (NCT07127224)
- Testing
- Olfactory stimulation
- Where
- France
- Volunteers
- 96 people
- Sponsor
- Centre Hospitalier St Anne
FTD, AD
Metabolic Characterization of Alzheimer's Disease and Frontotemporal Dementia by 23Na-MRI and FDG-PET
Alzheimer's disease (AD) and frontotemporal dementia (FTD) are the most common forms of neurodegenerative dementia. However, their differential and timely diagnosis can be challenging for clinicians, therefore often closing the…
- Conditions
- FTD, AD, Healthy Controls
- Trial name
- MetaAD_FTD (NCT07100470)
- Testing
- Sodium MRI
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier St Anne
Stroke
Endarterectomy Versus Stenting in Patients With Symptomatic Severe Carotid Stenosis - 2
Carotid stenosis caused by atherosclerosis is a significant risk factor for ischemic stroke, accounting for up to 15% of all strokes and transient ischemic attacks.
- Trial name
- EVA3S-2 (NCT07054060)
- Testing
- carotid endarterectomy, Carotid artery stenting
- Where
- France
- Volunteers
- 600 people
- Sponsor
- Centre Hospitalier St Anne
Quality of Life, Meningioma
Translation and Validation of the MQOL Self-questionnaire Into French for Assessing Quality of Life in Patients With Meningiomas
Meningiomas, which account for about 40% of primary central nervous system tumors, have significant psychological and social impacts, even without treatment.
- Trial name
- MenQOL (NCT07044076)
- Testing
- Quality of life
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier St Anne
Psychiatric Hospitalization
Effectiveness of a Temporal and Sound Space in the Paramedical Management of "Crisis"
This project could potentially lead to better crisis management in psychiatry, using music as a mediator. The integration of a well-designed sound device could help caregivers build trust with patients, alleviate anxiety, and…
- Trial name
- PsySon (NCT06904443)
- Testing
- PsySon is an innovative device that uses music in crisis management in hospitals
- Volunteers
- 172 people
- Sponsor
- Centre Hospitalier St Anne
Alcohol Use Disorder, Alcohol Withdrawal
Bright Light Therapy During Residential Alcohol Withdrawal
This is a randomized controlled trial assessing the effectiveness of light therapy versus placebo in patients undergoing alcohol withdrawal.
- Trial name
- LUNA (NCT06878287)
- Testing
- Light exposure
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier St Anne