Clinical trials: sponsored by Centre Hospitalier Universitaire Dijon
Type 1 Diabetes
Study of High Density Lipoprotein Function in Type 1 Diabetic Patients With Nephropathy
A number of arguments suggest that the deterioration in high density lipoproteins (HDL) functioning may worsen with the development of nephropathy during type 1 diabetes (T1D).
- Trial name
- DID&NEPHRO (NCT03512132)
- Testing
- Blood samples, Urine sample
- Where
- France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Giant Cell Arteritis
MEthotrexate Versus TOcilizumab for Treatment of GIant Cell Arteritis: a Multicenter, Randomized, Controlled Trial
Giant-cell arteritis (GCA) is the most frequent vasculitis after 50 years. It is characterized by a granulomatous inflammation of the wall of large vessels, involving especially the aorta and extra-cranial branches of the…
- Trial name
- METOGiA (NCT03892785)
- Testing
- Prednisone treatment, Tocilizumab treatment, Methotrexate treatment
- Where
- France
- Volunteers
- 230 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Alcoholic Intoxication, Chronic
A Clinical Trial on the Efficacy of tDCS) in Reducing Alcohol Consumption in Non-abstinent Patients (REDSTIM)
The study evaluates the efficacy of 1 week of tDCS (5 sessions) placebo in reducing alcohol consumption within the 24 weeks following the treatment in non-abstinent patients with alcohol use disorders versus placebo.
- Trial name
- REDSTIM (NCT02505126)
- Testing
- Active tDCS
- Where
- France
- Volunteers
- 339 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Seminomas
Epigenetic Integrity of Spermatozoa in Patients With Germinal Testicular Tumours
Recent data suggest that sperm cells carry an epigenetic message during spermatogenesis and that this message is crucial for the future development of the embryo.
- Trial name
- GAMETH (NCT03262207)
- Testing
- Extraction genomic DNA, Analysis of methylation profiles of numerous GSI and TE, Analysis of methylation for the whole genome (sub-population of 15 samples from group 1)
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Bone Reconstruction by Free Fibula Flap
Functional Impact of Reconstructive Surgery by Harvesting a Vascularized Free Fibula Flap Postoperatively.
The fibula is a leg bone that can be used in complex bone reconstruction by reconstructive surgery. This innovative surgical procedure is increasingly used in complex facial (mandibular) reconstructions following cancer and…
- Trial name
- FIBULAM (NCT05641597)
- Testing
- Actimetric measurement, Evaluation of plantar flexion, dorsal flexion and ankle eversion forces, Assessment of static and dynamic balance and quality of life
- Where
- France
- Volunteers
- 8 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Stroke, Implantation of an Implantable Cardiac Monitor
Impact of Atrial Fibrosis Surface Area on the Occurrence of Atrial Fibrillation in Patients With Ischemic Stroke of Undetermined Origin: a Prospective Cardiac MRI Pilot Study.
Atrial fibrillation is a cardiac arrhythmia most often originating in the left atrium, causing anarchic electrical activity and thus a loss of atrial contraction.
- Trial name
- FIBROSIS-MRI (NCT06047782)
- Testing
- Cardiac MRI (with contrast agent)
- Where
- France
- Volunteers
- 157 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Atrial Fibrillation (AF), Cardiac Arrhythmia
Association Between Circulating BDNF Levels and Atrial Cardiomyopathy in Patients Undergoing Ablation for Persistent Atrial Fibrillation
trial fibrillation (AF) is the most common cardiac arrhythmia worldwide, and its prevalence continues to rise. AF is associated with serious complications, including embolic strokes, heart failure, and mortality.
- Conditions
- Atrial Fibrillation (AF), Cardiac Arrhythmia, Atrial Fibrillation Ablation, BDNF
- Trial name
- METAPROFIL 2 (NCT07648329)
- Testing
- blood draw, CT scan
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Medical Termination of Pregnancy, Voluntary Termination of Pregnancy
Mechanisms and Factors Responsible for the Inhibition of Transposons During Fetal Gonad Development in Humans
This is a single-centre study over 36 months for the inclusion of 30 patients. The selection and inclusion of patients will take place according to the criterion of Medical Termination of Pregnancy at 4 different gestational ages…
- Trial name
- NCT02171845
- Testing
- surgical biopsies
- Where
- France
- Volunteers
- 8 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Ischemic Stroke
Stroke-induced Myocardial Dysfunction: Role of GDF-15 (SMOG-15) Clinical Work Package
The aim of this study is to analyze the relationship between the blood biomarker GDF-15 and heart damage after stroke. It is being conducted in France, in the Neurology Department of the Dijon University Hospital (Burgundy).
- Trial name
- SMOG-15 (NCT05683873)
- Testing
- Electrocardiogram, transthoracic echocardiography, standard biology
- Where
- France
- Volunteers
- 130 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Microvascular Angina
The Value of Measuring Retinal Vascular Density by Optical Coherence Tomography-Angiography (OCT-A) in Patients With Microvascular Angina Confirmed by Myocardial Microcirculatory Resistance Index (MRI).
Microvascular angina is thought to affect around 112 million patients worldwide. However, this figure is underestimated due to the difficulty of making the diagnosis.
- Trial name
- EYE-NOCA (NCT06692751)
- Testing
- Blood sampling, Ophthalmological examination, angina severity questionnaire
- Where
- France
- Volunteers
- 52 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Pupillometry, Behavioral Pain Scale
Pupillometry vs. BPS (Behavioral Pain Scale) for Analgesia Management in Inpatient Intensive Care Unit Patients on Invasive Mechanical Ventilation
Patients admitted to the intensive care unit (ICU) and receiving invasive mechanical ventilation (IMV) frequently require sedation and analgesia to ensure their comfort, prevent pain associated with invasive procedures, and…
- Conditions
- Pupillometry, Behavioral Pain Scale, Analgesia Assessment, Intensive Care Unit (ICU)
- Trial name
- GOLDEN EYE (NCT07867678)
- Testing
- PPI Measurement (Pupillary Pain Index), BPS Measurement (Behavioral Pain Scale)
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Smoking Cessation
Effectiveness of Transcranial Magnetic Stimulation (TMS) in Smoking Cessation, Combining Withdrawal Stimulation Followed by Maintenance Stimulation to Prevent Relapse.
Tobacco control is a Public Health priority. Tobacco is directly responsible for 75,000 deaths per year in France. Without help, less than 5% of smokers are still abstinent within 12 months of quitting.
- Trial name
- TabacStim2 (NCT04591743)
- Testing
- Active TCS, nicotine treatment, Questionnaires
- Where
- France
- Volunteers
- 79 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Oropharynx Cancer, Oral Cavity
Oncology, Undernutrition and Sensoriality: Links, Mechanisms and Levers for Action
Cancers of the upper aerodigestive tract account for around 4% of all malignant tumours worldwide. Colon and liver cancer are the most common digestive cancers.
- Conditions
- Oropharynx Cancer, Oral Cavity, Colon Cancer, Liver Cancer
- Trial name
- ONDES (NCT06600295)
- Testing
- tests/questionnaires, biological samples, evaluation
- Where
- France
- Volunteers
- 306 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Idiopathic Parkinson's Disease and Lewy Body Disease
Single-center Study of Gustation in Idiopathic Parkinson's Disease and Lewy Body Disease Using Gustatory Evoked Potential Analysis
The aim of the PI-PEG study is to explore the taste functions of the following 3 groups of participants: healthy volunteers patients with early Parkinson's disease patients with incipient Lewy body disease.
- Trial name
- PI-PEG (NCT06439355)
- Testing
- Fasting blood test, Subject interview, Motor assessment
- Where
- France
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
OCT Angiography, Retinal Microcirculation
Chorioretinal Imaging, Vascular Biomarkers, and Ultra-Trail: A Pilot Study
Retinal and choroidal microcirculation is a relevant biomarker of systemic vascular health and lies at the heart of eye-heart interactions.
- Conditions
- OCT Angiography, Retinal Microcirculation, Choroidal Microcirculation, Physical Exercion
- Trial name
- UTMA-RETINA (NCT07748936)
- Testing
- Retinal imaging evaluation of both eyes without dilation before and after the Mont Afrique Ultra Trail, Retinal imaging evaluation of both eyes without dilation, performed in two stages (T0 and T0+11/24H)
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Cognitive Disorders
Prospective Monocentric Study of Taste in Patients With Minor or Major Cognitive Disorders Such as Alzheimer's, Through the Analysis of Gustatory Evoked Potentials.
Approximately 24 million people worldwide suffer from dementia, with Alzheimer's disease being the most common cause. Alzheimer's disease typically progresses in three stages: presymptomatic, prodromal ("early onset" or minor…
- Trial name
- MAPEG (NCT04860414)
- Testing
- Blood sampling, Cognitive Assessment, Subjective taste tests
- Where
- France
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Sjogren's Syndrome, Autoimmune Diseases
Exploratory Study of the Efficacy of HuMoSCs (Human Monocyte-derived Suppressor Cells) on Glandular Involvement in Sjögren's Syndrome
Sjögren's syndrome is an autoimmune disease. Dry syndrome is a key feature of this condition, almost always leading to dryness of the mouth and eyes.
- Trial name
- Immuno-DRYve (NCT07861828)
- Testing
- Blood sample, Salivary gland biopsy
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Patients With Septic Shock
Study of Subcutaneous Interstitial Pressure During Sepsis
The pathophysiology of sepsis is characterized by the sudden onset of vasodilation and vascular permeability with capillary leakage.
- Trial name
- PISEP (NCT03818269)
- Testing
- Subcutaneous pressure measurement
- Where
- 2 sites in France
- Volunteers
- 31 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Double Diabetes
Effect of Weekly GLP1 Agonist Treatment in "Double Diabetes"
Between 16% and 22% of type 1 diabetic patients present a clinical and biological profile of insulin resistance favored by a family history of type 2 diabetes or metabolic syndrome.
- Trial name
- TOLEDDO (NCT05305794)
- Testing
- Insulin + semaglutide treatment, Usual insulin treatment, Biological check-up
- Where
- France
- Volunteers
- 76 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Pathophysiology
Study of the Hypothalamic Microglial Response as a Function of a Meal's Lipid Content in Humans. A Single-center Prospective Cohort Study in Healthy Male Subjects
Obesity and its complications represent a growing public health problem in our society. A better understanding of the biological mechanisms involved in regulating food intake-and, more broadly, energy metabolism-should lead to…
- Trial name
- GLIPID (NCT07557628)
- Testing
- Blood sample, Brain MRI without contrast, performed on an empty stomach and after a meal, Questionnaires
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon