Clinical trials: sponsored by Centre Hospitalier Universitaire Dijon
EMCO-VA
Vaso-inotropic Score and ECMO-VA Support in Post-cardiotomy Cardiogenic Shock.
Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is a well-established lifesaving treatment for refractory cardiogenic shock, with or without concomitant respiratory failure.
- Trial name
- ECMOVIS (NCT05412303)
- Testing
- data collection
- Where
- France
- Volunteers
- 2,769 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Cardiogenic Shock
Evaluation of Oxiris Membrane as a Treatment for Ischemia-reperfusion Syndrome in Cardiogenic Shock Treated With Extracorporeal Life Support (ECMO/ECLS): A Randomized Pilot Study ECMORIX
The Oxiris membrane is an AN-69 membrane whose surface is treated with polyethyleneimine (PEI) grafted with heparin. This property allows the removal of lipopolysaccharide and cytokines from the blood.
- Trial name
- ECMORIX (NCT04886180)
- Testing
- Oxiris membrane, Prismaflex membrane, Blood tests
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Central Visual Impairment, Peripherical Visual Impairment
A Study of Taste- and Olfactory-Evoked Potentials in Patients With Visual Impairment: Taste, Smell, and Vision
Visual impairment, whether central or peripheral, may influence the plasticity of other sensory modalities, such as taste and smell.
- Conditions
- Central Visual Impairment, Peripherical Visual Impairment, Macular Retinal Dystrophy, Peripherical Macular Dystrophy
- Trial name
- GOUSTAVIS (NCT07707219)
- Testing
- Taste and smell evaluation, Recording of evoked potentials (EP)
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Ascending Aortic Aneurysm
A Study of Lipid Metabolism and Mitochondrial Function in Myeloid Cells and Total Aortic Tissue in Patients With Ascending Thoracic Aortic Aneurysm (ATA) and Bicuspid (BA) or Tricuspid (TA) Aortic Valves.
Ascending aortic aneurysms (AAAs) are serious conditions that can lead to aortic dissections or ruptures, carrying a high risk of mortality.
- Trial name
- PROMETA (NCT07695545)
- Testing
- Additional blood samples, Collection of discarded ascending aortic tissue
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Patients With Resected Stage II Colon Cancer
CIRCULATING TUMOR DNA BASED DECISION FOR ADJUVANT TREATMENT IN COLON CANCER STAGE II
The objective of CIRCULATE trial is to improve care of patients after colon tumor surgery, based on an innovative marker: circulating tumor DNA.
- Trial name
- CIRCULATE (NCT04120701)
- Testing
- mFOLFOX6
- Where
- France
- Volunteers
- 1,980 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Metastatic Non-small Cell Lung Cancer
Pilot Study of the Contribution of Fractional Exhaled Nitric Oxide as a Prognostic Marker of Response to Anti-PD-L1 Immunotherapy in Non-small Cell Lung Cancer
Based on the use of the patient's natural defences, immunotherapy mobilizes the immune system to recognize and destroy cancer cells, and it has revolutionized the treatment of lung cancer.
- Trial name
- FENOTYPE (NCT05985330)
- Testing
- Measurement of FeNO
- Where
- France
- Volunteers
- 56 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Developmental Abnormality
The Diagnostic Observatory: Combating Diagnostic Wandering and Impasse Within the AnDDI-Rares Network
The Direction Générale de l'Organisation des Soins (DGOS) and the Banque Nationale de Données Maladies Rares (BNDMR) have launched a call for a letter of commitment for the implementation of a diagnostic observatory in order to…
- Trial name
- Obs du Diag (NCT05448326)
- Testing
- Questionnaire to assess expectations of a diagnosis, Questionnaire to assess understanding of previously reported results and expectations of a diagnosis, Blood sample +/- skin biopsy
- Where
- France
- Volunteers
- 1,280 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Newborn Screening Programmes for Rare Diseases
A Pilot Study to Assess the Feasibility and Acceptability of Newborn Screening Using in Silico Panel-based Solo Genome Sequencing in France
Newborn Screening (NBS) based on genome sequencing (GS) is currently the subject of particular attention at both European and international levels.
- Trial name
- PGC1 (NCT06875089)
- Testing
- pGS-NBS, Satisfaction questionnaire, interview with HSS researcher
- Where
- 5 sites in France
- Volunteers
- 5,000 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Presbyacousie
STUDY OF THE EFFECT OF RHYTHMIC AND NON-RHYTHMIC MUSICAL PRIMING ON THE SYNTAX CAPACITY OF PRESBYACOUSTIC OLDER ADULTS
Presbyacusis, or age-related hearing loss, is a public health problem, affecting 20% of men and 30% of women over the age of 70 according to the WHO. In the most incapacitating cases, hearing aids are required.
- Trial name
- AMORCAGE MUSIC (NCT06282601)
- Testing
- Audiogram, Musical priming for the syntax test, Test MMSE
- Where
- France
- Volunteers
- 55 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Mother Who Has Given Birth to a Singleton Newborn, Mother-newborn Dyad
Olfactory Communication in the First Days of Life: From Chemical Mechanisms to Improved Breastfeeding
For a newborn, locating and latching onto the mother's breast is the foundational social interaction. This pivotal moment not only influences the newborn's survival but also determines the mother's physiological (lactation) and…
- Conditions
- Mother Who Has Given Birth to a Singleton Newborn, Mother-newborn Dyad, Singleton Newborn
- Trial name
- OD-ALL (NCT07616076)
- Testing
- Chemical description of the scent of the breast or a newborn, Breast secretion samples, The newborn and its role in colostrum secretion
- Where
- France
- Volunteers
- 364 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Neuroendocrine Tumors, MEN1 Mutation
Study of the Value of hPG80 (Circulating Progastrin) for the Diagnosis of Neuroendocrine Tumours in Patients With an MEN1 Mutation
Multiple Endocrine Neoplasia type 1 (MEN1) is an autosomal dominant disease with a high degree of penetrance (>80% of patients). It is caused by the presence of the MEN1 mutation located on chromosome 11q13.
- Trial name
- PRO-NEM1 (NCT06430021)
- Testing
- blood sample
- Where
- France
- Volunteers
- 297 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Proven Pathogenic or Probably Pathogenic TBR1 Variant
A Study Evaluating 24 Months of Lithium Carbonate Treatment in Patients With TBR1-related Neurocognitive Disorder
TBR1 is a human gene encoding a brain-specific transcription factor, principally expressed in the excitatory neurons of the neocortex.
- Trial name
- ESALIT (NCT06776848)
- Testing
- Observation phase, Lithium treatment, biological monitoring
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Colon or Upper Rectum Adenocarcinoma
Investigate the Efficacy of Chemotherapy in Patients With Positive ctDNA After Surgery and Adjuvant Chemotherapy for a Stage III Colorectal Cancer
Phase III multicentric, open-label, randomized study The main objective is to assess the efficacy on time to disease recurrence (TTR) of treating minimal residual disease diagnosed by the presence of ctDNA after full treatment…
- Trial name
- CIRCULATE PAC (NCT06197425)
- Testing
- "FOLFIRI" cures, Trifluridine cures, BIOLOGICAL ASSESSMENT
- Where
- France
- Volunteers
- 1,660 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Amyotrophic Lateral Sclerosis (ALS)
Influence of Olfacto-gustatory Sensoriality on the Nutritional Status of Patients With Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterised by progressive diffuse muscular paralysis due to the inexorable loss of motor neurons in the primary motor cortex, the corticospinal tract, the…
- Trial name
- GOUSLA (NCT06608004)
- Testing
- test taking
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Patient Under Mechanical Ventilation
Use of Ultrasound for Early Identification of Patients at Risk of Swallowing Disorders Acquired in the ICU
Swallowing disorders (SD) are particularly common after extubation in the ICU and may be associated with an increased risk of lung disease, increased length of hospital stay, and a higher risk of early reintubation.
- Trial name
- EIDAR (NCT05922085)
- Testing
- Ultrasound, nasofibroscopie
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Giant Cell Arteritis
TocilizuMab discontinuAtion in GIant Cell Arteritis
Giant cell arteritis (GCA) is a large-vessel vasculitis that typically occurs in people over the age of 50. Corticosteroids (GC) are the cornerstone of treatment for GCA.
- Trial name
- MAGICA (NCT06037460)
- Testing
- Tocilizumab treatment, questionnaires, Blood samples
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Type 1 Diabetes
The Effect of Improved Glycemic Control on the Composition and Function of High-Density Lipoproteins (HDL) in Patients With Type 1 Diabetes
The HAGI-T1D study aims to determine the effect of improved glycemic control on the composition and function of high-density lipoproteins (HDL) in patients with type 1 diabetes (T1D).
- Trial name
- HAGI-T1D (NCT07564752)
- Testing
- Blood test, Urine sample
- Where
- France
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Smoking-related Disorder
Digital Mindfulness Training Programme for Smoking Cessation and Maintenance
Although there are several effective medicinal approaches for smoking cessation, relapses are frequent and the proportion of people who remain abstinent is low (around 15-25% 6 months after withdrawal).
- Trial name
- HowToMind (NCT06500117)
- Testing
- eMind application, questionnaires, focus groupe
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Nephrostomy, Retinal Vascularisation
Evaluation of the Degradation of Renal Function Post Nephrectomy According to Retinal Vascularisation Parameters
Chronic kidney failure in the single remaining kidney is one of the dreaded complications of nephrectomy in patients operated on for cancer-related reasons (1).
- Trial name
- NEPHRIN (NCT04855123)
- Testing
- retinal imaging, paraclinical surveillance
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Psychomotor Disadaptation Syndrome
The Benefits of Virtual Reality in the Care of Elderly People With Psychomotor Disadaptation Syndrome
Psychomotor Disadaptation Syndrome (PMDS) is characterised by a deterioration in postural function, gait and psychomotor automatisms in the elderly.
- Trial name
- VIR-AGE (NCT07026890)
- Testing
- Evaluation visits, Rehabilitation sessions, Virtual reality sessions
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire Dijon