Clinical trials: sponsored by Centre Hospitalier Universitaire de Nīmes
Renal Insufficiency, Chronic
Feasibility of Estimating the Prevalence and Management of Stage 4 CKD the Gard, France
The main objective of this study is to evaluate the feasibility of estimating the prevalence of stage 4 and 5 chronic kidney disease in the Gard department of France from data obtained via laboratory databases.
- Trial name
- MRC-Gard (NCT02938611)
- Where
- 4 sites in France
- Volunteers
- 3,375 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Hyperemesis Gravidarum, Nausea and Vomiting of Pregnancy
Diagnostic and Psychometric Validation of the FRENCH HELP Scale in Hyperemesis Gravidarum
Severe forms of nausea and vomiting of pregnancy (NVP) are classified as hyperemesis gravidarum (HG). NVP is debilitating in approximately 35% of women impairing daily life and professional activities while negatively affecting…
- Trial name
- French-HELP (NCT07767071)
- Testing
- HELP score
- Where
- 7 sites in France
- Volunteers
- 300 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
CKD, Cardiovascular Diseases
Hyperlipoproteinemia A as a Marker of Cardiovascular Risk in Patients With Stage 4 Chronic Kidney Disease
The blood level of lipoprotein A (Lp(a)) is linked to mutations in gene 6 and is associated with atherothrombotic risk and clinical manifestations such as myocardial infarction, ischemic stroke, and aortic valve calcification and…
- Trial name
- LPACKD45 (NCT07141628)
- Testing
- lipoprotein A level dosing
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Ventilator Associated Pneumonia ( VAP)
Combined Use of a Respiratory Multiplex PCR and Algorithm-based Therapy to Improve Early Optimization of Antibiotic Therapy in Critically Ill Patients With Ventilator-associated Pneumonia
Assess the impact of a strategy combining respiratory mPCR and algorithm-based therapy developed using local epidemiology on the early optimization of initial antibiotic therapy for ventilator-associated pneumonia (VAP)…
- Trial name
- SMART-VAP (NCT07403474)
- Testing
- strategy combining respiratory mPCR and algorithm-based therapy developed using local epidemiology
- Where
- 2 sites in France
- Volunteers
- 124 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Non-scheduled Care
Coordinated Primary Care Team to Access and Regulate Unscheduled Care
Unscheduled care is care "that does not constitute a life-threatening emergency but for which treatment by a healthcare professional is desirable within 48 hours" and 80% of general practitioners organize their schedules to…
- Trial name
- E-CARE SNP (NCT07862699)
- Where
- 2 sites in France
- Volunteers
- 3,000 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Diabetic Foot Ulcer
Pathogenicity Factors of Staphylococcus Pettenkoferi in Foot Wounds and Osteitis in Diabetic Patients
Gram-positive cocci, particularly Staphylococcus aureus and coagulase-negative staphylococci (SCoN), are the bacteria most frequently isolated from diabetic foot ulcers. Although studies have been carried out on the role of S.
- Trial name
- PETTENK-OS (NCT06688084)
- Testing
- Molecular epidemiology of the collection, Study of the resistome of the S. pettenkoferi population, Study of the virulome of the S. pettenkoferi population
- Where
- France
- Volunteers
- 230 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Bacteremia
Impact of BacT/Alert® VIRTUO®, BioFire® Blood Culture Identification 2-BCID2 and REVEAL® (bioMérieux) on the Optimization of Antibiotic Therapy for Gram-negative Bacteremia in the ICU
Bacteremia is a frequent infection in intensive care units. It is associated with a high mortality rate and the rapid implementation of appropriate antibiotic therapy is strongly correlated to patient clinical outcomes.
- Trial name
- BacteREVEAL (NCT05741424)
- Testing
- Innovative diagnostic technologies, Reference diagnostic technique
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Infant, Premature
Influence of Intestinal Microbiota Implantation in Preterm Infants on Microbiota and Immune Orientation at 3 Years
The main objective of this research is to study the links between changes in the intestinal microbiota (in terms of diversity) during the first 6 weeks of life for preterm infants and the presence / absence of a TH1 immune status…
- Trial name
- PrimiBiota (NCT02738411)
- Where
- 3 sites in France
- Volunteers
- 130 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Biliary Drainage, Endoscopic Ultrasound-Guided Drainage
Real-world Evaluation of Different Endoscopic Biliary Drainage Techniques in Patients With Jaundice of Biliopancreatic Malignant Origin
The incidence of pancreatic cancer is rising. Tumor-induced obstruction of the distal bile duct is a common complication, occurring during the course of nearly 80% of pancreatic tumors.
- Conditions
- Biliary Drainage, Endoscopic Ultrasound-Guided Drainage, Pancreatic Cancer
- Trial name
- PROBILEUS (NCT07817602)
- Testing
- Endoscopic drainage
- Where
- 6 sites in France
- Volunteers
- 300 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Parotid Neoplasm, Bupivacaine
Clinical Tolerance of an Intraparotid Injection of Bupivacaine, Combined With Dexamethasone, After Parotidectomy for Benign Tumor
There has been a paradigm shift toward less invasive surgical techniques for parotidectomies, primarily to mitigate post-surgical complications.
- Conditions
- Parotid Neoplasm, Bupivacaine, Dexamethasone
- Trial name
- PAROCAINE (NCT07812259)
- Testing
- Intraparotid injection of bupivacaine/ dexamethasone
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Inflammatory Bowel Diseases, Crohn's Disease
Intertriginous/Periorificial Dermatoses in Patients With IBD on Anti-TNFα: Relative Abundance of Staphylococcus Aureus Within the Lesion Microbiota and Clinical Correlation (micSPIDER).
The main objective of this study is to evaluate the change in the relative abundance of S. aureus within the lesion-site skin microbiota in SPIDER patients (change between inclusion and 6 months), and to assess whether this…
- Conditions
- Inflammatory Bowel Diseases, Crohn's Disease, Skin Diseases, Dermatitis
- Trial name
- micSPIDER (NCT07812675)
- Where
- 5 sites in France
- Volunteers
- 82 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Lymphoma, Malignant
Efficacy of Patient Management for Lymphoma Diagnosed at Nimes University Hospital From 1999 to 2018. DVR-Lym-Nim
Observation of a cohort of 400 patients with different types of lymphomas.
- Trial name
- DVR-Lym-Nim (NCT04947618)
- Where
- France
- Volunteers
- 136 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Imaging, Diagnostic, Lung Diseases
Image Quality: Ultra-Low Dose Scanner Versus Standard Dose Conventional Scanner for Thoraco-abdominopelvic Scans
The new image reconstruction algorithm (Precise Image, Philips Healthcare) has a strong potential to maintain sufficient image quality suitable for diagnosis with ultra-low dose (ULD) chest and abdomen-pelvis scans.
- Conditions
- Imaging, Diagnostic, Lung Diseases, Abdomen Disease, Pelvis Disease
- Trial name
- UL2DLR (NCT05840003)
- Testing
- Ultra-Low-Dose thoraco-abdominopelvic scan
- Where
- France
- Volunteers
- 116 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Radiology, Interventional, Heart Rhythm Disorders
Dosimetric Reference Levels for Radioguided Interventional Procedures in Rhythmology.
Interventional radiology has become a widespread technique used in various fields of medicine to diagnose or treat numerous pathologies. However, the risk of X-rays must be taken into account.
- Trial name
- NR-Rythmo (NCT06507085)
- Testing
- Radio-guided interventions to correct heart rhythm disorders
- Where
- France
- Volunteers
- 4,219 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Female Genital Mutilation, Woman Abuse
Study on Violence Against Vulnerable Women and Optimizing Support Services
Sexual and gender-based violence in France primarily affects women, who make up 88% of victims, with 670,000 affected annually. Many suffer abuse from partners, including 94,000 rape cases, and minors are heavily impacted.
- Conditions
- Female Genital Mutilation, Woman Abuse, Abuse, Sexual, Spouse Abuse
- Trial name
- ENVVOL (NCT07701629)
- Volunteers
- 70 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Antibiotic Resistance, Enterobacteriaceae Infections
Genomic and Phenotypic Diversity of Carbapenemase-producing Escherichia Coli Strains Circulating in Southern France
Carbapenemase-producing Enterobacteriaceae (CPE) are classified as emerging Highly Resistant Bacteria (eHRB) because they expose infected patients to the risk of treatment failure due to the strains' resistance to last-line…
- Conditions
- Antibiotic Resistance, Enterobacteriaceae Infections, Carbapenem-Resistant Enterobacteriaceae Infection, Colonization
- Trial name
- CARBACOLI (NCT07676513)
- Testing
- MultiLocus Sequence Typing
- Where
- France
- Volunteers
- 163 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Ultrasound Guidance, Central Venous Catheterization
Standard Ultrasound Guidance vs. New Needle-steering Device in Subclavian Venous Catheterization
Up to two-thirds of intensive care unit patients require central venous catheterization for which ultrasound-guided placement is now recommended.
- Trial name
- NEEDLEVISIO2 (NCT06050902)
- Testing
- Subclavian venipuncture for catheter placement using the needle-steering device
- Where
- France
- Volunteers
- 124 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Stenosis, Occlusion
Diagnostic Performance of the Resistance Index (RI) for the Assessment of Cerebral Vasoreactivity in Transcranial Doppler
Routine revascularization of asymptomatic carotid stenosis is questionable as optimal medical therapy has significantly reduced the risk of stroke.
- Trial name
- REVACEIR (NCT05780619)
- Testing
- Transcranial Doppler
- Where
- France
- Volunteers
- 77 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Post Operative Pain, Chronic Pain
Performance and Safety of the ANTALGEEK® Thess Monitoring Medical Device in the Outpatient Management of Acute Pain and Postoperative Recovery
Acute postoperative pain (APOP) is a major public health problem, affecting nearly 10 million patients in France each year. Effective analgesic therapy in the first postoperative week is a key factor in reducing early…
- Trial name
- TRACE (NCT07680998)
- Testing
- Post-operative follow-up using the Thess Telemonitoring device in conjunction with the ANTALGEEK® protocol
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Intubation
Opioid-free Analgesia in Intensive Care Unit
ICU patients experience moderate to severe pain. Studies and guidelines point out the benefits of multimodal analgesia on pain control, opioid spare and on lowering its adverse effects.
- Trial name
- OFICU (NCT05825560)
- Testing
- OFA multimodal analgesia, Standard multimodal analgesia
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes