Clinical trials: sponsored by Centre Hospitalier Universitaire de Nice
Emergencies, Quality of Life
Quality of Life and Persistent Pain 3 Months After Emergency Surgery Before and After a National Urgency Classification
The aim of this study is to evaluate the impact of implementing a national surgical emergency classification system in the emergency operating room in Nice on patients' quality of life and persistent pain 3 months after surgery.
- Conditions
- Emergencies, Quality of Life, Postoperative Pain
- Trial name
- NCT07819903
- Testing
- Usual-practice emergency-surgery triage, National surgical-emergency classification-based triage
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Geriatric Oncology
Preparation for Medical and Surgical Procedures in Oncogeriatry.
Surgical management is one of the most frequently used interventions in the treatment of many cancers, but it can be associated with a high risk of postoperative complications.
- Trial name
- PRIMECHO (NCT06443138)
- Testing
- Personalized pre-habilitation program
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Chronic Kidney Diseases
Effect of Empagliflozin in Patients With eGFR Between 10 and 20 ml/Min/1.73m2
The proximal tubule remains the main site for sodium reabsorption in patients with advanced renal failure. The investigators therefore hypothesize that SGLT2i should still exert a significant natriuretic effect in patients with…
- Trial name
- EMPA[10-20] (NCT07074418)
- Where
- France
- Volunteers
- 34 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Membranous Nephropathy, Membranous Nephropathy - PLA2R Induced
Single-cell RNA Sequencing (scRNA-seq) to Investigate the Mechanisms Underlying the Induction of Regulatory T Cells in Patients With Extramembranous Glomerulonephritis Treated With Rituximab
Membranous nephropathy is a rare autoimmune kidney disease in which autoantibodies, most commonly anti-PLA2R1 antibodies, target podocyte antigens and may cause nephrotic syndrome.
- Conditions
- Membranous Nephropathy, Membranous Nephropathy - PLA2R Induced, Nephrotic Syndrome
- Trial name
- TRANSCRIPT (NCT07811557)
- Testing
- Peripheral blood immune-cell profiling by single-cell RNA sequencing and in vitro pathway modulation assays
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Women, Tibial Translation
Evaluation of Anterior Tibial Knee Translation in Healthy Women With and Without Hormone Therapy
Women are recognized as being at greater risk of ACL injury, with a risk 6 times higher than that of men. Hyperlaxity is a risk factor for ACL injury, but the pathophysiological basis for this is poorly studied.
- Conditions
- Women, Tibial Translation, Hormone
- Trial name
- LAX (NCT06504953)
- Testing
- Questionnaire, Beighton test, Lachman Test
- Where
- France
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Institutionalized Older Adults
Feasibility Study of an Interactive Wall-Based Intervention Program for Nursing Home Residents and Patients in Long-Term Care Facilities: Mur'Aventure
This prospective, single-arm feasibility study aims to evaluate the feasibility of a 12-week immersive exergame program using an interactive wall in older adults living in nursing homes (EHPAD) or long-term care units (USLD).
- Trial name
- MUR'AVENTURE (NCT07809087)
- Testing
- Immersive Interactive Wall Exergame Program
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Myasthenia Gravis, Generalized
Evaluate the Benefit of Corticoid Sparing in Elderly With Generalized AntiRAch Myasthenia Gravis Treated With IV or SC Efgartigimod
Generalized Myasthenia Gravis (gMG) is a rare chronic autoimmune disorder causing muscle weakness and fatigue, primarily due to autoantibodies that disrupt neuromuscular junction function.
- Trial name
- OPTIMAGE (NCT07072988)
- Testing
- Efgartigimod
- Where
- 9 sites in France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Facioscapulohumeral Muscular Dystrophy Type 2
An 18-month Prospective Natural History Study to Gain Insight Into FSHD2 Pathophysiology and Disease Progression
Facioscapulohumeral muscular dystrophy (FSHD) is one of the most common inherited myopathies in adults. It is associated with genetic and epigenetic deregulation of the D4Z4 locus on the sub-telomeric region of chromosome 4q35…
- Trial name
- INSIGHT FSHD2 (NCT06079567)
- Testing
- Validation of new COMs for FSHD2 patients
- Where
- 9 sites in Belgium, France and 3 more
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Latent Tuberculosis Infection
Latent Tuberculosis Infection Screening Using QuantiFERON at Pre-Employment Assessment in Hospital Workers CHu Nice
This retrospective observational single-center study aims to evaluate the medical and occupational relevance of systematic screening for latent tuberculosis infection using QuantiFERON-TB Gold Plus during pre-employment…
- Trial name
- NCT07608601
- Testing
- QuantiFERON-TB Gold Plus
- Where
- France
- Volunteers
- 1,185 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Generalized Myasthenia Gravis
Monitor the Evolution of Myasthenia Gravis Symptoms in Real-life in Patients With Anti-AChR and Anti-MUSK Generalised Myasthenia Gravis in Therapy With RYSTIGGO® (Rozanolixizumab)
Generalized Myasthenia Gravis (gMG) is a rare autoimmune disease (a disease in which the body attacks its own tissues) that causes muscle weakness and significant fatigue.
- Trial name
- REAL MG PRO (NCT07570589)
- Testing
- Patients diagnosed with generalized myasthenia gravis and treated with Rozanolixizumab
- Where
- 11 sites in France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Myasthenia Gravis
Evaluation of the Condition of Patients Receiving EARLY Ravulizumab and Admitted in ICU for gMG Crisis
Myasthenia Gravis (MG) is a rare autoimmune disease that causes muscle weakness and fatigue. It occurs when the immune system produces antibodies that block communication between nerves and muscles.
- Trial name
- EARLY-MG (NCT07411963)
- Testing
- early use of Ravulizumab
- Where
- 8 sites in France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Lymphedema
Testing for Increased Lipoproteins (a) [LP(a)] in Lymphedema Patients: Li-LY
Lymphedema is a chronic disease that causes lymph to accumulate in the interstitial tissue. The lymphatic network is involved in the metabolism of lipids and lipoproteins, and this accumulation leads to lipid deposits in the…
- Trial name
- LiLY (NCT05962827)
- Testing
- lipoprotein (a)
- Where
- 2 sites in France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Anti-MAG Neuropathy, Peripheral Nervous System Disease
Study Evaluating the Predictive Value of the Terminal Latency Index (TLI) for Treatment Response in Patients With Anti-MAG Neuropathy
"Anti-myelin-associated glycoprotein (anti-MAG) neuropathy is a rare dysimmune peripheral neuropathy, most commonly associated with an IgM monoclonal gammopathy.
- Conditions
- Anti-MAG Neuropathy, Peripheral Nervous System Disease, Anti-Myelin-Associated Glycoprotein Antibodie
- Trial name
- PREDIMAG (NCT07794137)
- Testing
- Electroneuromyography (ENMG) and Terminal Latency Index (TLI) Assessment
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Shoulder Pain, Biceps Tendon Disorder
Tenotomy of Biceps' Long Head by Mini-optics in Consultation (Hyperambulatory): What Advantage Compared to the Operating Room?
Mini-optics has been used in orthopedics for a short time. The Nanoscope used in this study is marketed by Arthrex. Its main indications concern knee, elbow, wrist, carp and small joints of long fingers for diagnostic and…
- Trial name
- NANOBICEPS (NCT05370183)
- Testing
- Hyperambulatory tenotomy, Operating room tenotomy
- Where
- France
- Volunteers
- 14 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Aneurysmal Subarachnoid Hemorrhage
Prevention of Ischemia in Aneurysmal Subarachnoid Hemorrhage Through Remote Ischemic Preconditioning
Aneurysmal subarachnoid hemorrhage (SAH) is a severe form of stroke caused by bleeding around the brain. Despite early treatment of the initial hemorrhage, many patients develop delayed cerebral ischemia several days later, which…
- Trial name
- HMA (NCT07761520)
- Testing
- Remote Ischemic Preconditioning
- Volunteers
- 140 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Acute Respiratory Distress Syndrome
Comparison of Different PEEP Strategies in Moderate-to-Severe ARDS Based on Various Bedside Assessment Tools
Many patients admitted to the intensive care unit (ICU) for a severe lung disease called acute respiratory distress syndrome (ARDS) require mechanical ventilation and positive end-expiratory pressure (PEEP) to improve their…
- Trial name
- OPTI-PEEP (NCT07741916)
- Testing
- Ventilation at different levels of PEP including a test involving a gradual decrease in PEP.
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Aging Disorder
Healthy Aging Together - "Getting to Know You Better": Healthy Aging and Predictive Indicator
A key challenge lies in preventing the loss of autonomy and promoting healthy aging-a concept now widely addressed through multidimensional and multidisciplinary approaches, as evidenced by frailty models, comprehensive geriatric…
- Trial name
- BVE-HAPI (NCT07734246)
- Testing
- Health assessment
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Endometriosis, Chronic Pelvic Pain Syndrome
Identify a Specific Immune Profile in Patients With Chronic Pelvic Pain Resistant to First-line Treatments by Measuring Th1, Th2, Th17, and Treg Cytokines Produced After Non-specific Functional Cell Stimulation - ImmunoCPP
Chronic pelvic pain (CPP) affects more than one in four women. An immune imbalance in the Th1/Th2 balance has been reported in multiple CPP situations, particularly in patients with endometriosis, but with mixed results.
- Trial name
- ImmunoCPP (NCT07429773)
- Testing
- Immune profile
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Pyrophosphate, Fetuin A, IL1, IL6, TNFalpha, Control
Inorganic Pyrophosphate Homeostasis (PPi) in Pediatric Chronic Kidney Disease
The investigator aim to identify the role of inorganic pyrophosphate and other anti-calcifying molecules in vascular disease in children with chronic kidney disease, with a view to developing therapeutic approaches aimed at…
- Trial name
- PPi-DIA (NCT06300788)
- Testing
- PPI and T50 dosing
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Polyneuropathies, Electromyography
Single-Center Study Evaluating the Impact of Age on the Diagnostic Performance of the Sural-to-Radial Sensory Amplitude Ratio in Length-Dependent and Non-Length-Dependent Peripheral Polyneuropathies
This retrospective single-center observational study will evaluate the impact of age on the diagnostic performance of the sural-to-radial sensory nerve amplitude ratio (SRAR) in patients with length-dependent and…
- Conditions
- Polyneuropathies, Electromyography, Diagnostic Techniques
- Trial name
- ASPIRE (NCT07725120)
- Testing
- Retrospective Medical Record Review
- Where
- France
- Volunteers
- 180 people
- Sponsor
- Centre Hospitalier Universitaire de Nice