Clinical trials: sponsored by Chang Gung Memorial Hospital
Insomnia Chronic, Hypnotics and Sedatives
Physical Activity Interventions for Sleep Improvement and Sedative-Hypnotic Reduction in Middle-Aged and Older Adults: Investigating the Role of Sarcopenia
Background: The prevalence of sedative-hypnotic use among middle-aged and older adults in Taiwan has continued to rise, highlighting the need to better understand the underlying factors contributing to sleep disturbances and…
- Conditions
- Insomnia Chronic, Hypnotics and Sedatives, Physical Activities
- Trial name
- NCT07896603
- Testing
- resistance training, Relaxation training
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Chang Gung Memorial Hospital
Inguinal Hernia, Without Mention of Obstruction or Gangrene
Evaluating the Efficacy and Safety of a New Laparoscopic Non-mesh Hernia Needle Set Designed for Indirect Inguinal Hernia
This is a prospective, single-blinded and randomized clinical trial, and will be conducted at Chang Gung Memorial Hospital Chiayi branch in Taiwan. 1. Why is this study being done? Inguinal hernia is a common condition in adults.
- Trial name
- NCT07902167
- Testing
- non-mesh inguinal hernia needle, conventional needle set
- Where
- Taiwan
- Volunteers
- 96 people
- Sponsor
- Chang Gung Memorial Hospital
Clinical Competence, Communication Skills
Generative AI Simulated Patients Versus Expert Demonstration Videos for Psychiatric Interview Training in Occupational Therapy Students
The goal of this study is to compare two methods for teaching psychiatric work-history interviewing to third-year occupational therapy students: practice with a generative AI simulated patient and an expert demonstration video.
- Conditions
- Clinical Competence, Communication Skills, Self Efficacy
- Trial name
- NCT07896525
- Testing
- Generative AI simulated patient, Expert demonstration video
- Where
- Taiwan
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Pain (Knee), Pain and Anxiety
A Comparison of Heart Rate Variability Biofeedback, Mindfulness, and Psychoeducation-based Interventions on Clinical Recovery Outcomes in Patients Undergoing Total Knee Arthroplasty
The goal of this clinical trial is to compare the effects of heart rate variability biofeedback (HRVB), mindfulness meditation, and psychological education in patients undergoing total knee arthroplasty (TKA).
- Conditions
- Pain (Knee), Pain and Anxiety, TKA
- Trial name
- NCT07896954
- Testing
- Heart rate variability biofeedback, Mindfulness, psychoeducation
- Where
- 2 sites in Taiwan
- Volunteers
- 120 people
- Sponsor
- Chang Gung Memorial Hospital
HIV-1-infection, Non-Adherence, Medication
Outcomes of the PLHIV With Suboptimal Viral Suppression to Injectable Long-acting Antiretrovirals
This study aims to determine whether people living with HIV (PLHIV) with suboptimal medical adherence can achieve better viral suppression with long-acting antiretrovirals (LA) compared to all-oral antiretrovirals.
- Trial name
- SUPLA (NCT06507059)
- Testing
- cabotegravir/rilpivirine (600mg/ 900mg), Antiretroviral Combinations
- Where
- 4 sites in Taiwan
- Volunteers
- 40 people
- Sponsor
- Chang Gung Memorial Hospital
Long COVID
DAOIB for the Treatment of Brain Fog
This is a 24-week open trial. We will enroll long-COVID patients with cognitive impairments. All patients will receive DAOIB for 24 weeks.
- Trial name
- NCT05764538
- Testing
- DAOIB
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Chang Gung Memorial Hospital
Radiation Treatment, Neurovascular Complications
Long-term Neurovascular Complications After Radiation Therapy in Head and Neck Cancer
Head and neck cancer is a group of cancers develop from the soft tissues, salivary gland, mucosa of the upper respiratory or digestive system covering the oral and nasal cavity.
- Trial name
- NCT06111430
- Where
- Taiwan
- Volunteers
- 800 people
- Sponsor
- Chang Gung Memorial Hospital
Breast Reconstruction, Breast Cancer Patients
Autologous Nerve Graft Breast Reconstruction Neurotization
The goal of this observational study is to learn about the improvement of quality of life in accordance with breast neurotization in breast cancer patients. The patient-reported outcome was assessed by questionnaire.
- Conditions
- Breast Reconstruction, Breast Cancer Patients, Nipple-sparing Mastectomy
- Trial name
- NCT06629012
- Testing
- Breast reconstruction with neurotization, Breast reconstruction without neurotization
- Where
- Taiwan
- Volunteers
- 250 people
- Sponsor
- Chang Gung Memorial Hospital
Stroke, Cerebrovascular Disorders
Mixed Reality and Virtual Reality Technology With Mirror Therapy for Stroke Rehabilitation
The specific study aims will be: 1. To design and develop the hardware and software of the VR+MT and MR+MT systems. 2. To test the feasibility of the VR+MT and MR+MT systems from the patients and to collect the feedback of users…
- Conditions
- Stroke, Cerebrovascular Disorders, Central Nervous System Diseases
- Trial name
- NCT05903235
- Testing
- Virtual Reality-based Mirror Therapy (VR+MT), Mixed Reality-based Mirror Therapy (MR+MT), Traditional Mirror Therapy (MT)
- Where
- Taiwan
- Volunteers
- 45 people
- Sponsor
- Chang Gung Memorial Hospital
Omega 3 Fatty Acids, Dementia
NMDA Enhancement Combined With Omega-3 for Early Dementia
In this 4-year proposed project, we will enroll 140 patients with aMCI or mild AD into a 24-week randomized, double-blind, placebo-controlled drug trial.
- Trial name
- NCT05181189
- Testing
- DAOIB+Omega-3
- Where
- Taiwan
- Volunteers
- 140 people
- Sponsor
- Chang Gung Memorial Hospital
Mild Cognitive Impairment
Cognitive Effects and Potential Mechanisms of TBS in Subjects With MCI
This study aims to examine the effects and potential mechanisms of theta-burst stimulation (TBS) on cognitive function in individuals with mild cognitive impairment (MCI).
- Trial name
- NCT05448768
- Testing
- TBS for Amyloid-positive MCI, TBS for Amyloid-negative MCI
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Chang Gung Memorial Hospital
Stroke, Stroke (6 Months or More After Onset)
Co-Designed Digital Education and Peer Support for Young and Middle-Aged Stroke Survivors
Stroke survivors often experience persistent unmet needs during long-term recovery. Young and middle-aged stroke survivors may face additional challenges in balancing rehabilitation with work and family responsibilities.
- Trial name
- NCT07725666
- Testing
- Patient-Centered Digital Education and Peer Support Program, Usual Post-Stroke Care
- Volunteers
- 148 people
- Sponsor
- Chang Gung Memorial Hospital
Healthy
Building Core Competencies of Taiwanese Care Food Specialists: Curriculum Design and Outcome Assessment
Background: As Taiwan faces an aging population, the demand for long- term care services continues to rise, increasing the need for skilled care workers.
- Trial name
- NCT07384481
- Testing
- Core Competency Training Course for Eating Support Healthcare Aides (20-Hour Course)
- Where
- Taiwan
- Volunteers
- 150 people
- Sponsor
- Chang Gung Memorial Hospital
Alzheimer Disease, Early Onset
Theta-burst Stimulation on Cognitive Function in the Patients With Young-onset Alzheimer's Disease Dementia
Young-onset dementia (YOD) is a devastating condition, and it produces substantial psychosocial impacts on individual's functioning and family's care burden. Alzheimer's disease (AD) dementia is the most common type in YOD.
- Trial name
- NCT04042532
- Testing
- Theta-burst stimulation (TBS)
- Where
- Taiwan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Androgenetic Alopecia
A Split-Scalp Study Evaluating the Efficacy and Safety of Fractional Laser Therapy With and Without Exosomes in the Treatment of Androgenetic Alopecia
This trial aims to evaluate the efficacy, safety, and tolerability of fractional laser combined with topical exosome for hair regrowth in patients with androgenetic alopecia. This study is expected to recruit 30 participants.
- Trial name
- NCT07248410
- Testing
- fraction laser
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Chang Gung Memorial Hospital
Sudden Hearing Loss
Efficacy and Safety of Hydroxychloroquine in the Treatment of Sudden Sensorineural Hearing Loss
Sudden sensorineural hearing loss (SSNHL) is diagnosed when there's a sudden drop in hearing of at least 30 decibels across three consecutive frequencies, emerging within up to 72 hours.
- Trial name
- NCT06467526
- Testing
- Hydroxychloroquine, Steroid
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Chang Gung Memorial Hospital
Rectal Neoplasms Malignant
FAPI in Rectal Cancer TNT
The goal of the trial is to observe the changes of 68Ga FAPI signal before and after total neoadjuvant therapy for rectal cancers, and the correlation between the image parameters, immune checkpoints expression as well as the…
- Trial name
- NCT06157463
- Testing
- Ga-68 FAPI
- Where
- Taiwan
- Volunteers
- 99 people
- Sponsor
- Chang Gung Memorial Hospital
Dental Implants, Early Peri-Implant Bone Remodeling
Buccal Prosthetic Contour Angles and Peri-Implant Tissue Changes Around Dental Implants
This retrospective observational study aims to evaluate the association between buccal prosthetic profile angles at different supraplatform zones and peri-implant tissue changes around bone-level dental implants restored with…
- Conditions
- Dental Implants, Early Peri-Implant Bone Remodeling, Peri-Implant Soft Tissue Remodeling
- Trial name
- B-PROFILE (NCT07637864)
- Testing
- Implant-Supported Prosthetic Restoration
- Where
- Taiwan
- Volunteers
- 72 people
- Sponsor
- Chang Gung Memorial Hospital
Port-a-cath Occlusion, Normal Saline
Normal Saline Versus Heparin Intermittent Flushing for the Prevention of Occlusion in Port-a-Cath
Purpose: An evidence implementation of a randomized controlled trial for whether there is the difference in intermittent flushing 0.9% normal saline and heparin? Design: a single-blind randomized controlled trial Method: This…
- Conditions
- Port-a-cath Occlusion, Normal Saline, Heparin Lock
- Trial name
- NCT05707936
- Testing
- Normal Saline Flush 20 ml, Normal Saline Flush 10 ml, Heparin Flush (1000 USP, 10ml)
- Where
- Taiwan
- Volunteers
- 192 people
- Sponsor
- Chang Gung Memorial Hospital
Elbow Osteochondritis Dissecans
The Effectiveness of Extracorporeal Shock Wave Therapy for Elbow Osteochondritis Dissecans (OCD)
Extracorporeal shock wave therapy was performed on athletes aged 15-18 years with lateral maxillary chondritis of the elbow, and X-ray, blood tests, and MRI were conducted to evaluate the treatment progress.
- Trial name
- NCT07884578
- Testing
- Extracorporeal Shock Wave Therapy, Extracorporeal Shock Wave Therapy(no-energy)
- Where
- Taiwan
- Volunteers
- 9 people
- Sponsor
- Chang Gung Memorial Hospital
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