Clinical trials: sponsored by Chang Gung Memorial Hospital
Omega 3 Fatty Acids, Dementia
NMDA Enhancement Combined With Omega-3 for Early Dementia
In this 4-year proposed project, we will enroll 140 patients with aMCI or mild AD into a 24-week randomized, double-blind, placebo-controlled drug trial.
- Trial name
- NCT05181189
- Testing
- DAOIB+Omega-3
- Where
- Taiwan
- Volunteers
- 140 people
- Sponsor
- Chang Gung Memorial Hospital
Breast Reconstruction, Breast Cancer Patients
Autologous Nerve Graft Breast Reconstruction Neurotization
The goal of this observational study is to learn about the improvement of quality of life in accordance with breast neurotization in breast cancer patients. The patient-reported outcome was assessed by questionnaire.
- Conditions
- Breast Reconstruction, Breast Cancer Patients, Nipple-sparing Mastectomy
- Trial name
- NCT06629012
- Testing
- Breast reconstruction with neurotization, Breast reconstruction without neurotization
- Where
- Taiwan
- Volunteers
- 250 people
- Sponsor
- Chang Gung Memorial Hospital
Androgenetic Alopecia
A Split-Scalp Study Evaluating the Efficacy and Safety of Fractional Laser Therapy With and Without Exosomes in the Treatment of Androgenetic Alopecia
This trial aims to evaluate the efficacy, safety, and tolerability of fractional laser combined with topical exosome for hair regrowth in patients with androgenetic alopecia. This study is expected to recruit 30 participants.
- Trial name
- NCT07248410
- Testing
- fraction laser
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Chang Gung Memorial Hospital
Elbow Osteochondritis Dissecans
The Effectiveness of Extracorporeal Shock Wave Therapy for Elbow Osteochondritis Dissecans (OCD)
Extracorporeal shock wave therapy was performed on athletes aged 15-18 years with lateral maxillary chondritis of the elbow, and X-ray, blood tests, and MRI were conducted to evaluate the treatment progress.
- Trial name
- NCT07884578
- Testing
- Extracorporeal Shock Wave Therapy, Extracorporeal Shock Wave Therapy(no-energy)
- Where
- Taiwan
- Volunteers
- 9 people
- Sponsor
- Chang Gung Memorial Hospital
Port-a-cath Occlusion, Normal Saline
Normal Saline Versus Heparin Intermittent Flushing for the Prevention of Occlusion in Port-a-Cath
Purpose: An evidence implementation of a randomized controlled trial for whether there is the difference in intermittent flushing 0.9% normal saline and heparin? Design: a single-blind randomized controlled trial Method: This…
- Conditions
- Port-a-cath Occlusion, Normal Saline, Heparin Lock
- Trial name
- NCT05707936
- Testing
- Normal Saline Flush 20 ml, Normal Saline Flush 10 ml, Heparin Flush (1000 USP, 10ml)
- Where
- Taiwan
- Volunteers
- 192 people
- Sponsor
- Chang Gung Memorial Hospital
Nursing Education, Social-Emotional Learning
Augmented Reality Virtual Patient Simulation to Enhance Social-Emotional Competence and Self-Efficacy in Nursing Students
This randomized crossover teaching practice study evaluates whether smart technology and media-integrated friendly childbirth education can improve nursing students' social-emotional competence and self-efficacy.
- Conditions
- Nursing Education, Social-Emotional Learning, Self-Efficacy
- Trial name
- SEL-AR (NCT07874061)
- Testing
- VP-I, VP-AR
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Female, Endometrial Hyperplasia Without Atypia
Longitudinal Follow-up in Women With Endometrial Hyperplasia Without Atypia
This study will prospectively enroll a total of 1000 patients (200 per year) simple hyperplasia/complex hyperplasia (SH/CH) without atypia.
- Trial name
- NCT05292573
- Testing
- Metformin
- Where
- Taiwan
- Volunteers
- 1,000 people
- Sponsor
- Chang Gung Memorial Hospital
Autism Spectrum Disorder
Effects of Lactobacillus Plantarum PS128 in Children With ASD
Autism spectrum disorder (ASD) is a neurodevelopmental disorder that can cause significant social, communication and behavioral deficits. Probiotics are regarded as active microorganisms.
- Trial name
- NCT05307744
- Testing
- PS128
- Where
- Taiwan
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Cataract, Myopia
Measurement of Antioxidant Activity and Oxidative Stress in Patients Undergoing Ophthalmic Surgery.
This trial hypothesized that novel laser refractive surgery techniques (LASIK, KLEx) or laser-assisted cataract surgery (FLACAS) could suppress postoperative inflammation and improve recovery in patients by reducing oxidative…
- Trial name
- NCT06743594
- Where
- 2 sites in Taiwan
- Volunteers
- 60 people
- Sponsor
- Chang Gung Memorial Hospital
High Risk Neuroblastoma
Dinutuximab-beta and Chemotherapy in Newly Diagnosed High-Risk Neuroblastoma
This clinical trial investigates the safety, side effects, and effectiveness of combining an immunotherapy drug called dinutuximab-beta with standard induction chemotherapy for patients newly diagnosed with high-risk…
- Trial name
- NCT07688252
- Testing
- Dinutuximab Beta, Induction chemotherapy
- Where
- 2 sites in Taiwan
- Volunteers
- 30 people
- Sponsor
- Chang Gung Memorial Hospital
Cataract, Anxiety
Multimedia Education to Reduce Anxiety and Improve Care Awareness in Cataract Surgery Patients
This study aims to examine the effectiveness of multimedia health education in reducing preoperative anxiety and enhancing self-care awareness among patients undergoing outpatient cataract surgery.
- Trial name
- NCT07030946
- Testing
- Multimedia Health Education
- Where
- Taiwan
- Volunteers
- 118 people
- Sponsor
- Chang Gung Memorial Hospital
Hepatocellular Carcinoma
Evaluation of Immune Responses and Outcomes in Patients With Hepatocellular Carcinoma Undergoing Radiotherapy
Radiation therapy is a highly effective modality for managing localized solid tumors and has become a fundamental component of treating unresectable hepatocellular carcinoma.
- Trial name
- NCT06379256
- Testing
- Photon or proton radiotherapy
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- Chang Gung Memorial Hospital
Hepatocellular Carcinoma
Atezolizumab and Bevacizumab With Photon Radiotherapy for Unresectable Hepatocellular Carcinoma
Atezolizumab (anti-programmed death-ligand 1; anti-PD-L1) in conjunction with bevacizumab (anti-vascular endothelial growth factor; anti-VEGF) has become the established standard first-line systemic treatment for unresectable…
- Trial name
- PhotonAB (NCT06339424)
- Testing
- Atezolizumab, Bevacizumab, Photon radiotherapy
- Where
- Taiwan
- Volunteers
- 45 people
- Sponsor
- Chang Gung Memorial Hospital
HCC - Hepatocellular Carcinoma, Tremelimumab
Photon Radiotherapy Plus Tremelimumab/Durvalumab for BCLC Stage B and C HCC
Tremelimumab plus durvalumab (the STRIDE regimen) is an approved first-line therapy for unresectable hepatocellular carcinoma (HCC); however, it demonstrates limited efficacy, with an objective response rate (ORR) of only 20.1%.
- Conditions
- HCC - Hepatocellular Carcinoma, Tremelimumab, Durvalumab, Radiotherapy
- Trial name
- Photon-STRIDE (NCT06999707)
- Testing
- Photon radiotherapy, Tremelimumab, Durvalumab
- Where
- Taiwan
- Volunteers
- 45 people
- Sponsor
- Chang Gung Memorial Hospital
HCC - Hepatocellular Carcinoma, Durvalumab
Proton Radiotherapy Plus Tremelimumab/Durvalumab for BCLC Stage B and C HCC
Tremelimumab plus durvalumab (STRIDE regimen) is an approved first-line therapy for unresectable hepatocellular carcinoma (HCC), yet it shows limited efficacy with an ORR of only 20.1%.
- Conditions
- HCC - Hepatocellular Carcinoma, Durvalumab, Tremelimumab, Proton Radiotherapy
- Trial name
- Proton-STRIDE (NCT06999694)
- Testing
- Proton radiotherapy, Tremelimumab, Durvalumab
- Where
- Taiwan
- Volunteers
- 45 people
- Sponsor
- Chang Gung Memorial Hospital
Hepatocellular Carcinoma (HCC)
Hyperpolarized 13C-MRI in Patients With Hepatocellular Carcinoma Undergoing Radiotherapy, Atezolizumab, and Bevacizumab
Increased pyruvate-to-lactate conversion is a hallmark of HCC metabolism. In parallel, activation of pro-inflammatory immune cells triggers a metabolic switch towards anaerobic glycolysis.
- Trial name
- NCT06605664
- Testing
- Hyperpolarized 13C pyruvate MRI
- Where
- Taiwan
- Volunteers
- 45 people
- Sponsor
- Chang Gung Memorial Hospital
Outpatients With Chronic Heart Failure, Heart Failure Chronic
Biomarker Panel Development for Early Identification of Worsening Heart Failure and Improved Post-acute Care
Heart failure is a complex clinical syndrome with high hospitalization rates and high mortality risks. While N-terminal-pro B-type natriuretic peptide (NT-proBNP) is widely used in clinical practice to assist in diagnosis and…
- Trial name
- NCT07838766
- Volunteers
- 800 people
- Sponsor
- Chang Gung Memorial Hospital
Hemodialysis, Difficult Vascular Access Cannulation
Pre-Cannulation Ultrasound Vascular Mapping Combined With Handgrip Exercise and Local Cryotherapy in Hemodialysis Patients With Difficult Cannulation
This pilot randomized controlled trial evaluated a multicomponent intervention for adult maintenance hemodialysis patients with difficult vascular access cannulation.
- Trial name
- NCT07842939
- Testing
- Pre-Cannulation Ultrasound Vascular Mapping, Handgrip Exercise, Local Cryotherapy
- Where
- Taiwan
- Volunteers
- 69 people
- Sponsor
- Chang Gung Memorial Hospital
Sleep Fragmentation, Poor Sleep Quality
Acupuncture for Sleep Fragmentation in Older Adults: A Single-Arm Pilot Study
This single-group pilot study will enroll 20 adults aged 60 years or older with persistent poor sleep. All participants will receive a standardized 6-week acupuncture program.
- Trial name
- NCT07841938
- Testing
- Acupuncture
- Where
- 2 sites in Taiwan
- Volunteers
- 20 people
- Sponsor
- Chang Gung Memorial Hospital
Spine Injury, Cord Injury, Spinal
The Outcome of Injured Cervical Spinal Cord With Uncontrolled Swelling Under Duraplasty
Overall Objective: To assess whether incorporating duraplasty alongside bony decompression enhances motor function outcomes in individuals following Traumatic Spinal Cord Injury (TSCI).
- Conditions
- Spine Injury, Cord Injury, Spinal, Cord Infarction Spinal, Incomplete Spinal Cord Injury
- Trial name
- NCT06552507
- Testing
- Duroplasty
- Where
- Taiwan
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
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