Clinical trials: sponsored by Changhai Hospital
Anal Fistula
Cross-cultural Adaptation of the Chinese Version of QoLAF-Q (Quality of Life in Patients With Anal Fistula Questionnaire) ：A Multi-center Study
The investigators verify the reliability and practicality of the Chinese adaptation results of QoLAF-Q, which helps Chinese doctors better master the methods and techniques of quality of life assessment.
- Trial name
- NCT06962228
- Testing
- Anal fistula surgery
- Volunteers
- 150 people
- Sponsor
- Changhai Hospital
Systemic Lupus Erythematosus (SLE)
An Exploratory Clinical Study of Anti-CD19 CAR NK Cells in the Treatment of Systemic Lupus Erythematosus
A single arm, open-label pilot study is designed to determine the safety and effectiveness of anti-cluster of differentiation antigen 19 (CD19) chimeric antigen receptor (CAR) natural killer (NK) cells (KN5501) in patients with…
- Trial name
- NCT06010472
- Testing
- anti-CD19 CAR NK cells (KN5501)
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Changhai Hospital
Chronic Pancreatitis, Pancreatic Exocrine Insufficiency
Investigation on the Current Situation and Risk Factors Analysis of Exocrine Insufficiency in Chronic Pancreatitis
Pancreatic exocrine insufficiency (PEI) is one of the common complications of chronic pancreatitis (CP). Mild to moderate PEI may present with atypical digestive tract symptoms such as abdominal distension and abdominal pain…
- Trial name
- CP-ESRF (NCT06946108)
- Testing
- Detection of Pancreatic Exocrine Function in Patients with Chronic Pancreatitis (CP)
- Where
- China
- Volunteers
- 1,101 people
- Sponsor
- Changhai Hospital
Rectal Cancer
Neoadjuvant Radiochemotherapy Combined With QL1706 for Low Rectal Cancer
This study investigates the efficacy of neoadjuvant radiotherapy combined with QL1706 in MSS-type low-grade rectal cancer. This study is a prospective multicohort study, with cohort 1 intended to include patients with low grade…
- Trial name
- NCT06931873
- Testing
- SCRT+Capoex+QL706, LCRT+Capoex+QL706
- Volunteers
- 60 people
- Sponsor
- Changhai Hospital
Chronic Pancreatitis
Natural Course and Therapeutic Effect of Chronic Pancreatitis
The goal of this observational study is to establish a prospective cohort of chronic pancreatitis (CP) patients to provide evidence-based guidance for clinical practice and comprehensively optimize diagnostic and treatment…
- Trial name
- NCT06925204
- Testing
- Observation
- Where
- China
- Volunteers
- 5,000 people
- Sponsor
- Changhai Hospital
UTUC, NAC
Neoadjuvant Chemotherapy in High - Risk Upper Tract Urothelial Carcinoma
Upper urinary tract urothelial carcinoma (UTUC) represents a rare yet aggressive malignancy associated with a dismal prognosis. At the point of diagnosis, nearly half of the patients already have invasive disease, and over 70%…
- Trial name
- NCT06927128
- Testing
- Gemcitabine, Cisplatin
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Changhai Hospital
Resectable Simultaneous Colorectal Cancer Liver Metastasis
The Outcomes of Laparoscopic Hybrid Surgery Versus Totally Open Surgery
Simultaneous colorectal cancer liver metastasis (SCRLM) is one of the risk factors for poor prognosis in colorectal cancer. Surgical resection of primary and metastatic lesions is the first choice of treatment for patients with…
- Trial name
- NCT06550700
- Testing
- laparoscopic hybrid surgery (LHS)
- Where
- China
- Volunteers
- 266 people
- Sponsor
- Changhai Hospital
Chronic Pancreatitis, Pancreatic Exocrine Insufficiency
Medication Adherence to Phone-supervised Pancreatic Enzyme Replacement Therapy
This study aims to explore whether regular telephone intervention in patients with chronic pancreatitis can improve their Pancreatic Enzyme Replacement Therapy's Medication Adherence.
- Trial name
- NCT06581653
- Testing
- Phone-based PERT education intervention
- Where
- China
- Volunteers
- 204 people
- Sponsor
- Changhai Hospital
Chronic Pancreatitis
Translation and Validation of Chinese COMPAT-SF
The goal of this observational study is to translate, adapt, and test the reliability of a Chinese version of the Comprehensive Pain Assessment Tool Short Form (COMPAT-SF) for people with chronic pancreatitis.
- Trial name
- COMPAT-SF-CV (NCT06917716)
- Where
- China
- Volunteers
- 356 people
- Sponsor
- Changhai Hospital
EpiDural Hematoma, Traumatic Brain Injury
Acute EpiDural Hematoma Treated With Middle Meningeal Artery Embolization: a Randomized Trial (AEDH-MT)
A prospective, multicenter, randomized controlled, open-label, blinded endpoint evaluation study.
- Trial name
- AEDH-MT (NCT06292585)
- Testing
- MMA embolization plus medical therapy, Medical therapy alone
- Where
- China
- Volunteers
- 194 people
- Sponsor
- Changhai Hospital
Pancreatic Duct Stone, ESWL
Safety of 6 Hours Feeding After Extracorporeal Shock Wave Lithotripsy of Pancreatic Stone
The purpose of this study is to evaluate the safety of eating 6 hours after Extracorporeal Shock Wave Lithotripsy (ESWL). At present, ESWL and Endoscopic Retrograde Cholangiopancreatography (ERCP) are the routine ways to treat…
- Conditions
- Pancreatic Duct Stone, ESWL, Fasting
- Trial name
- SHEEL (NCT05669573)
- Testing
- Early feeding group, Standard fasting group
- Where
- China
- Volunteers
- 216 people
- Sponsor
- Changhai Hospital
Pancreatitis, Chronic, Pancreatic Duct Stone
Aggressive Intravenous Hydration With Lactated Ringer's Solution for Prevention of Post-ESWL Pancreatitis
The goal of this clinical trial is to clarify whether aggressive intravenous hydration with lactated Ringer's solution could reduce the incidence of post-ESWL pancreatitis in patients with chronic pancreatitis.
- Trial name
- HYPER (NCT05772234)
- Testing
- Lactated ringers solution, normal saline
- Where
- China
- Volunteers
- 1,066 people
- Sponsor
- Changhai Hospital
NMIBC
Immediate Chemotherapy Following Resection for High-Risk Non-Muscle-Invasive Bladder Cancer
Residual tumors after transurethral resection of bladder tumors (TURBT) range from 17-70%, and floating tumor cells from traditional segmental resection may lead to recurrence if they re-implant in the bladder wall.
- Trial name
- HIGCrecur (NCT06889623)
- Testing
- Immediate postoperative chemotherapy
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Changhai Hospital
Pancreatic Cancer, Pancreatic Ductal Adenocarcinoma
AI-powered Early Detection for Pancreatic Cancer Via Non-contrast CT in Opportunistic Screening Cohort
Pancreatic ductal adenocarcinoma (PDAC) remains a therapeutic challenge with 5-year survival rates of 13%, primarily attributable to advanced-stage diagnosis (AJCC Stage III/IV in >80% of cases).
- Conditions
- Pancreatic Cancer, Pancreatic Ductal Adenocarcinoma, Pancreatic Intraepithelial Neoplasias, Intraductal Papillary Mucinous Neoplasm
- Trial name
- AI-PANC (NCT06638866)
- Testing
- PDAC, Pancreatic precursor lesions
- Where
- 3 sites in China
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
AIS, ICAS - Intracranial Atherosclerosis
A Randomized Clinical Trial on Urgent Angioplasty for IntraCranial Atherosclerotic Stenosis-related Large-Vessel Occlusion After Mechanical Thrombectomy
A prospective, multicenter, randomized controlled, open-label, blinded outcome evaluation (PROBE) trial
- Conditions
- AIS, ICAS - Intracranial Atherosclerosis, Stroke
- Trial name
- ICAS LVO-MT (NCT06702657)
- Testing
- balloon dilatation and/or stenting, medication
- Volunteers
- 612 people
- Sponsor
- Changhai Hospital
Colonoscopy, Colonoscopy: Bowel Preparation
Risk Factors for Inadequate Bowel Preparation Before Colonoscopy
The primary objectives of this study are twofold: Firstly, to investigate the current status of bowel preparation protocols and their quality across hospitals at various levels in China, particularly following the release of the…
- Trial name
- NCT06878378
- Testing
- Investigation of Factors Influencing Bowel Preparation Quality
- Where
- China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Pronase, Mucosal Clarity
Pronase in Improving Endoscopic Mucosal Clarity During Colonoscopy for Patients with Colitis
Pronase is a proteolytic enzyme known for its ability to clear mucus by breaking down its main component, mucin, through enzymatic hydrolysis.
- Trial name
- NCT06874673
- Testing
- Pronase
- Where
- China
- Volunteers
- 438 people
- Sponsor
- Changhai Hospital
Esophageal Cancer, Gastric Cancer
Effect of Premedication With Pronase on Mucosal Cleanliness During EGD
Gastric cancer and esophageal cancer are common malignant tumors that threaten people's life and health. Esophagogastroduodenoscopy (EGD) is an important tool for screening upper gastrointestinal tumors, especially early tumors…
- Trial name
- NCT06713421
- Testing
- Dimethicone+Pronase, Dimethicone, with Postural Exercise
- Where
- China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Colorectal Polyp, Colorectal Adenoma
Evaluation of a CAM System for Colorectal Polyp Size Measurement
Accurate polyp size measurements are essential for risk stratification, selection of polypectomy techniques, and surveillance interval assignments.
- Trial name
- CAM (NCT06715384)
- Testing
- Polyp size measurement using autonomous AI measurement or AI-assisted human measurement with the CAM system
- Where
- China
- Volunteers
- 168 people
- Sponsor
- Changhai Hospital
Pancreatic Cancer
Adjuvant Chemoradiotherapy Versus Chemotherapy for Pancreatic Cancer (ADJUPANC)
In this trial, we aim to compare the outcomes of adjuvant chemoradiotherapy with chemotherapy for patients with resected pancreatic cancer who are at high risk of disease progressions.
- Trial name
- ADJUPANC (NCT06427447)
- Testing
- Adjuvant chemoradiotherapy, Adjuvant chemotherapy
- Where
- China
- Volunteers
- 770 people
- Sponsor
- Changhai Hospital