Clinical trials: sponsored by Changhai Hospital
Colorectal Cancer, Colorectal Adenoma
A Study on a Blood-based Dual-target Test for CRC Detection
To evaluate the effectiveness and accuracy of the ctDNA dual-target test kit in a large case-control cohort for the detection of colorectal cancer and advanced adenomas.
- Trial name
- NCT05508503
- Testing
- Test of methylated NTMT1 and MAP3K14-AS1, FIT
- Where
- China
- Volunteers
- 1,378 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Apathy, Minor Stroke
Non-disabling Ischemic Cerebrovascular Event With Apathy
The burden of non-disabling ischemic cerebrovascular events (NICE) is significantly increased. However, few previous studies have focused on affective impairment after transient ischemic attack (TIA) and minor stroke.
- Conditions
- Apathy, Minor Stroke, Transient Ischemic Attack, Stroke
- Trial name
- NCT04917237
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Pancreatic Cancer
Perioperative Treatment in High-risk Resectable Pancreatic Cancer With NALIRIFOX
This multicentric randomized trial will compare the efficacy and safety of neoadjuvant chemotherapy + surgery + adjuvant chemotherapy or surgery + adjuvant chemotherapy in patients with high-risk resectable pancreatic cancer.
- Trial name
- NCT06210360
- Testing
- Irinotecan liposome injection, Oxaliplatin, 5-FU
- Volunteers
- 134 people
- Sponsor
- Changhai Hospital
Oligo-metastatic Prostate Carcinoma
Radiotherapy for Prostate and Oligo-metastatic Lesions in Patients With Low-burden Oligo-metastatic Prostate Cancer
The existing large prospective study demonstrates the benefits of primary radiotherapy in patients with low-volume oligo-metastatic prostate cancer (OMPC), and there is also more evidence of the benefits of local…
- Trial name
- NCT06198387
- Testing
- hormone and RT, ADT combined with abiraterone
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Changhai Hospital
Second-degree Burn Wounds, Skin Graft Wounds
Efficacy of a Transparent Silicone Membrane With Physical Microstructure for Second-degree Burn Wounds and Skin Graft Wounds
The goal of this clinical trial is to comparison of physical microstructure-modified transparent silicone films and current conventional trauma dressings for second-degree burn wounds and post-skin graft wounds.The main question…
- Trial name
- NCT06170008
- Testing
- Physical microstructure-modified transparent silicone film sheet, Decellularized pig skin, Vaseline gauze
- Volunteers
- 40 people
- Sponsor
- Changhai Hospital
Bladder Cancer
Analyzing the Urine During BCG Instillation in Bladder Cancer Patients for Disease Followup
Bacillus Calmette-Guerin (BCG) has been extensively utilized in intravesical instillation therapy for patients with medium to high risk non-muscle invasive bladder cancer (NMIBC) following transurethral resection of bladder tumor…
- Trial name
- NCT06153849
- Testing
- urine sample collection
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Changhai Hospital
Early Gastric Cancer
Confocal Laser Microendoscopy (CellTouch) for the Diagnosis of Early Gastric Cancer: A Multicenter Clinical Study
This study is A prospective, randomized, multicenter clinical trial: The study intends to include subjects suspected of early gastric cancer, including 378 subjects with neoplastic lesions and 200 subjects with non-neoplastic…
- Trial name
- NCT06152783
- Where
- China
- Volunteers
- 578 people
- Sponsor
- Changhai Hospital
Pancreatic Neuroendocrine Tumor G2
Real-world Study on Adjuvant Octreotide Therapy in pNETs
Adjuvant therapy in pancreatic neuroendocrine tumors (pNETs) after radical resection lacks evidence-based data and is controversial.
- Trial name
- NCT06080204
- Testing
- Octreotide LAR
- Volunteers
- 411 people
- Sponsor
- Changhai Hospital
Esophageal Cancer
Endoscopic Submucosal Dissection Versus Esophagectomy for Early Esophageal Carcinoma
Endoscopic submucosal dissection (ESD) is a minimally invasive alternative to esophagectomy for early esophageal squamous cell carcinoma (EESCC), The data of EESCC patients who received ESD or esophagectomy were retrospectively…
- Trial name
- NCT06060106
- Testing
- Endoscopic submucosal dissection, Esophagectomy
- Where
- China
- Volunteers
- 191 people
- Sponsor
- Changhai Hospital
Chronic Pancreatitis, Genetic Mutation
Genetic Factors and CP Pregnancy Outcomes
To explore the impact of chronic pancreatitis (CP) susceptibility genes on pregnancy outcomes.
- Conditions
- Chronic Pancreatitis, Genetic Mutation, Pregnancy Related
- Trial name
- NCT06055595
- Testing
- genetic sequencing
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Changhai Hospital
Esophageal Squamous Carcinoma, HER-2 Protein Overexpression
DV Combined With PD-1 and Platinum-based First-line Treatment in Patients With HER2 IHC2+/3+ ESCC
This is a single-arm, exploratory clinical study.
- Trial name
- NCT06055153
- Testing
- RC48+PD-1+platinum-based
- Volunteers
- 20 people
- Sponsor
- Changhai Hospital
H. Pylori Infection
Oral Helicobacter Pylori Eradication
Helicobacter pylori (H. pylori) is a serious health threat that infects approximately half of the global population. In addition to colonizing the stomach, H.
- Trial name
- NCT06045832
- Testing
- MAXPOWER Biological Antibacterial Liquid, Water
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Changhai Hospital
Chronic HBV Infection, Drug Withdrawal
Effects of T-bet B Cells in Persistent Virus Control After Discontinuance of NAs in CHB Patients
The immune mechanism of the nucleos(t)ide analogs (NAs) in inhibiting HBV replication effectively while having a low sustained virus control rate after drug withdrawal is unclear.
- Trial name
- NCT06029634
- Testing
- T-bet B cell
- Where
- China
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Pancreatic Diseases
Red Cell Lysis Buffer Application Versus Conventional Sample Processing in EUS-FNB
The goal of this clinical trial is to evaluate the application of red cell lysis buffer (RCLB) versus conventional sample processing in endoscopic ultrasonography (EUS)-guided biopsy for solid pancreatic lesions.
- Trial name
- NCT05954221
- Testing
- Red cell lysis buffer (RCLB) application, Conventional processing
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Changhai Hospital
Pancreatic Cancer
Borderline Resectable Pancreatic Cancer Neoadjuvant Chemoradiotherapy Clinicaltrial-1
This study is to investigate whether neoadjuvant chemotherapy plus SBRT results in better outcomes compared with neoadjuvant chemotherapy alone and also compare the efficacy of gemcitabine plus nab-paclitaxel with SBRT and S-1…
- Trial name
- BRPCNCC-1 (NCT03777462)
- Testing
- Neoadjuvant gemcitabine plus nab-paclitaxel, Neoadjuvant gemcitabine plus nab-paclitaxel with SBRT, Neoadjuvant S-1 plus nab-paclitaxel with SBRT
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Changhai Hospital
Pancreatic Cancer, Diabetes
Artificial Intelligence-based Early Screening of Pancreatic Cancer and High Risk Tracing (ESPRIT-AI)
Pancreatic cancer is one of the most fatal malignancies with a 5-year survival rate of only ~6%[1]. The reasons for this high mortality rate can be attributed to several factors, of which perhaps the most important is delayed…
- Conditions
- Pancreatic Cancer, Diabetes, Familial Pancreatic Cancer, Pancreatic Cystic Neoplasm
- Trial name
- ESPRIT-AI (NCT04743479)
- Testing
- high-resolution MRI/CT examinations
- Where
- China
- Volunteers
- 5,000 people
- Sponsor
- Changhai Hospital
Pancreatic Cancer
Personalized Precision Diagnosis and Treatment of Pancreatic Cancer
Pancreatic cancer (PC) is the 4th common cancer in the world and occupied the second place for digestive tumors, of which the incidence has also increased sharply in China.
- Trial name
- PPDTPC (NCT04373928)
- Testing
- Drug guided by Mini-PDX/PDX
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Changhai Hospital
Capsule Endoscopy
MCE-new for Detection of Gastric Lesions
Clinical application of magnetically controlled capsule endoscopy : a prospective self-controlled trial
- Trial name
- NCT06020859
- Testing
- undergo NaviEC-2000Pro Gastro Scan mode, NaviEC-2000Pro Routine gastric examination, NaviEC-1000 Routine gastric examination
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Recurrent Pancreatic Cancer
Tislelizumab Combined With Nab-paclitaxel and Gemcitabine for Recurrent Pancreatic Cancer
To evaluate the efficacy of Tislelizumab combined with Nab-paclitaxel and Gemcitabine in the treatment of recurrent pancreatic cancer
- Trial name
- NCT04902261
- Testing
- Tislelizumab, Nab paclitaxel, Gemcitabine
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Changhai Hospital
Locally Advanced and Metastatic Pancreatic Cancer
Study of Immunotherapy Combined With Chemotherapy in Locally Advanced and Metastatic Pancreatic Cancer
To evaluate the efficacy of PD-L1/CTLA4 BsAb for the second line treatment and the combination with chemotherapy for the first line treatment in pancreatic cancer
- Trial name
- NCT04324307
- Testing
- PD-L1/CTLA4 BsAb, GP, FOLFIRINOX
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Changhai Hospital