Clinical trials: sponsored by Charles University, Czech Republic
Urinary Incontinence , Stress, Laser Therapy
Standardized 4D Transperineal Ultrasound Assessment of Urethrovesical Junction Mobility After Vaginal Laser Treatment for Stress Urinary Incontinence.
This prospective single-center observational cohort study will assess changes in urethrovesical junction (UVJ) mobility and urethral morphology after vaginal Er:YAG laser treatment in 40 adult women with pure stress urinary…
- Trial name
- NCT07907016
- Where
- Czechia
- Volunteers
- 40 people
- Sponsor
- Charles University, Czech Republic
Trauma, Brain
Risk Assessment of Mild Traumatic Brain Injury in Military Training
The SNIPER-TBI study aims to identify and quantify the risk of mild traumatic brain injury (mTBI) in soldiers of the Czech Armed Forces during specific high-risk training activities, including parachute jumps, high-caliber…
- Trial name
- NCT06992570
- Testing
- Quantification of mild trauma brain injury risk, Biomechanical Analysis of Head Impact Forces
- Where
- Czechia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Leg Ulcer
Topical Sevoflurane for Treatment of Chronic Leg Ulcers
Patients with painful non-healing leg ulcer will be enrolled in the clinical single-blinded randomized study. The active treatment group will have sevoflurane applied at approximately 1 ml/cm2 at the start of wound treatment, the…
- Trial name
- NCT05303805
- Testing
- Sevoflurane, Cyteal
- Where
- Czechia
- Volunteers
- 50 people
- Sponsor
- Charles University, Czech Republic
Obesity & Overweight
Influence of the Urolithin A on the Population With BMI Higher Than 30 During Restricted Eating.
Purpose. This study will test whether daily Urolithin A (500 mg) for 6 months helps adults with obesity lose weight while preserving functional muscle mass and improving markers of mitochondrial health, inflammation, and…
- Trial name
- Obesity UroA (NCT07377136)
- Testing
- Urolithin A 500mg
- Where
- Czechia
- Volunteers
- 102 people
- Sponsor
- Charles University, Czech Republic
Cognitive Impairment
PAMNEU - Memory in Neurology
Memory in Neurology project (PAMNEU) aims to map the distribution and severity of cognitive impairment in patients of outpatient neurologic offices across the geographical area of the Czech Republic.
- Trial name
- NCT06154564
- Where
- Czechia
- Volunteers
- 600 people
- Sponsor
- Charles University, Czech Republic
Cognitive Impairment
PAPSY - Memory in Psychiatry
Memory in Psychiatry project (PAPSY) aims to map the distribution and severity of cognitive impairment in patients of outpatient psychiatric offices across the geographical area of the Czech Republic.
- Trial name
- PAPSY (NCT05843357)
- Where
- Czechia
- Volunteers
- 1,000 people
- Sponsor
- Charles University, Czech Republic
Orofacial Pain
The Use of tDCS in the Orofacial Pain
The trial´s main goal is to explore the use of transcranial direct current stimulation (tDCS) as a treatment option for persons suffering from orofacial pain.
- Trial name
- NCT05584384
- Testing
- Transcranial Direct Current Stimulation
- Sponsor
- Charles University, Czech Republic
Acute Peripheral Vestibulopathy Following Surgical Procedure
The Use of Virtual Reality in Rehabilitation in Patients After Vestibular Schwannoma Surgery.
Resection of the vestibular schwannoma leads to acute peripheral or combined vestibular loss caused by a surgical lesion to the branches of the vestibular nerve and, less frequently also the lesion of the cerebellum.
- Trial name
- NCT05578560
- Testing
- Prehabituation, 3D optokinetic stimulation in virtual reality space, Vestibular training
- Where
- Czechia
- Volunteers
- 60 people
- Sponsor
- Charles University, Czech Republic
Obesity, Physical Inactivity
Exercise Snacks Enabled by an mHealth Intervention Delivered in General Practice to Promote a Sustainable Active Lifestyle in Adults With Obesity
Adults with obesity gain as much from regular physical activity as anyone else, but structured exercise programmes are hard to sustain once the programme ends.
- Conditions
- Obesity, Physical Inactivity, Sedentary Behavior
- Trial name
- SnackFIT (NCT07867665)
- Testing
- Exercise snacks programme, Conversational agent, Wrist-worn activity tracker
- Where
- 3 sites in Czechia
- Volunteers
- 306 people
- Sponsor
- Charles University, Czech Republic
Vision Disorder, Stroke
Visual Impairment and Functional Visual Performance Following Acquired Brain Injury: A Cross-Sectional Study
This cross-sectional observational study aims to characterize acquired visual impairment in adults with acquired brain injury and to examine the relationship between objectively identified visual impairment and self-reported…
- Conditions
- Vision Disorder, Stroke, Brain Injuries
- Trial name
- NCT07858708
- Where
- Czechia
- Volunteers
- 108 people
- Sponsor
- Charles University, Czech Republic
Brain Injuries
Pilot Study of Individualized Neurovisual Rehabilitation Following Acquired Brain Injury
This prospective single-group pilot study will evaluate the feasibility and preliminary outcomes of an individualized neurovisual rehabilitation program for adults with visual impairment following acquired brain injury.
- Trial name
- NCT07849582
- Testing
- Individualized Neurovisual Rehabilitation
- Where
- Czechia
- Volunteers
- 30 people
- Sponsor
- Charles University, Czech Republic
Ovarian Cancer, Ovarian Cancer Stage III
Prehabilitation in Gynaecological Cancer Patients
Prehabilitation refers to interventions aiming to improve patients' resilience and functional capacity before a known stressful event, e.g., scheduled surgery.
- Conditions
- Ovarian Cancer, Ovarian Cancer Stage III, Ovarian Cancer Stage IV, Endometrial Cancer
- Trial name
- PHOCUS (NCT04789694)
- Testing
- Physiological intervention, Psychological intervention, Nutritional intervention
- Where
- Czechia
- Volunteers
- 64 people
- Sponsor
- Charles University, Czech Republic
Atrial Fibrillation (AF)
Extended Ablation Versus Pulmonary Vein Isolation to Treat Persistent Atrial Fibrillation
The aim is to determine the effect of extended ablation (pre-specified linear PF/RF lesion set) in addition to PVI in symptomatic persistent AF patients on AF/AT/AFL recurrence.
- Trial name
- EXTEND-PVI (NCT07424326)
- Testing
- PVI-plus, PVI-only
- Where
- 4 sites in Czechia
- Volunteers
- 450 people
- Sponsor
- Charles University, Czech Republic
COVID-19, SARS-CoV-2
Molnupiravir and COVID-19 Mortality Reduction in the Omicron Era
This retrospective real-world target trial emulation uses complete Czech nationwide registry data to evaluate whether molnupiravir treatment is associated with lower COVID-19 mortality during the Omicron era.
- Trial name
- MOLCOVred (NCT07720596)
- Testing
- Molnupiravir
- Where
- Czechia
- Volunteers
- 1,795,570 people
- Sponsor
- Charles University, Czech Republic
Neonatology
EXTERNAL NEGATIVE PRESSURE DURING LISA
The goal of this clinical trial is to evaluate the feasibility, safety, and preliminary effectiveness of applying external continuous negative pressure (ECNP) during less invasive surfactant administration (LISA) in preterm…
- Trial name
- ENCP LISA (NCT07271368)
- Testing
- ENCP
- Where
- Czechia
- Volunteers
- 25 people
- Sponsor
- Charles University, Czech Republic
Endometriosis, Endometriosis (Diagnosis)
Deep Endometriosis Affecting the Urogenital Tract: Long-term Outcomes and Impact on Renal Function
Endometriosis is a chronic estrogen-dependent disease characterized by the presence and growth of endometrium-like tissue outside the uterine cavity.
- Conditions
- Endometriosis, Endometriosis (Diagnosis), Urinary Tract Diseases
- Trial name
- RENDO (NCT07776574)
- Where
- Czechia
- Volunteers
- 20 people
- Sponsor
- Charles University, Czech Republic
Atrial Fibrillation (AF)
Remimazolam-Fentanyl Mild Conscious Sedation Regimen in Pulsed-Field Ablation for Paroxysmal Atrial Fibrillation
This prospective single-arm study will evaluate whether mild conscious sedation using remimazolam with fentanyl is a feasible alternative to deeper sedation or general anaesthesia during FARAPULSETM pulsed-field ablation for…
- Trial name
- ReFeR-PFA (NCT07734194)
- Where
- Czechia
- Volunteers
- 20 people
- Sponsor
- Charles University, Czech Republic
Spinal Muscular Atrophy
Equine-Assisted Physiotherapy for Spinal Muscular Atrophy
This prospective interventional study evaluates the immediate and sustained effects of intensive equine-assisted physiotherapy in children with spinal muscular atrophy (SMA).
- Trial name
- HIPOSMA (NCT05341453)
- Testing
- Individual physiotherapy (SMA-SOC-N), Equine-Assisted Physiotherapy Based on Neuroproprioceptive Facilitation and Inhibition, Therapeutic grooming
- Where
- Czechia
- Volunteers
- 21 people
- Sponsor
- Charles University, Czech Republic
Type 2 Diabetes, PreDiabetes
mHealth Intervention to Increase Physical Activity in Prediabetes and Type 2 Diabetes
Sedentary behaviour has a detrimental effect on the mortality, morbidity, and well-being of patients with type 2 diabetes and prediabetes, and general practitioners should advise patients on how to self-monitor and increase their…
- Trial name
- ENERGISED (NCT05351359)
- Testing
- mHealth, phone counselling, Fitbit tracker
- Where
- Czechia
- Volunteers
- 343 people
- Sponsor
- Charles University, Czech Republic
Asthma, Asthma in Children
Prospective Multicentre Study on Symptoms in First-onset Bronchial Asthma in Children and Adolescents
Bronchial asthma may present with symptoms other than the commonly reported complaints (cough, chest tightness, shortness of breath and wheezing).
- Conditions
- Asthma, Asthma in Children, Dyspnea, Cough
- Trial name
- NCT06201494
- Where
- Czechia
- Volunteers
- 80 people
- Sponsor
- Charles University, Czech Republic