Clinical trials: sponsored by Chinese PLA General Hospital
Cerebral Small Vessel Disease
Intelligent Analysis and Clinical Validation of Cerebral Small Vessel Disease on Magnetic Resonance Imaging：A Multi-center Study
Cerebral small vessel disease (CSVD) accounts for 20% of ischemic strokes and is the most common cause of vascular cognitive impairment.
- Trial name
- NCT06667635
- Testing
- Artificial intelligence
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Diabetic Kidney Disease, Diabetic Retinopathy
Clinical Trial of Keluoxin Capsules in the Treatment of Diabetic Kidney Disease with Diabetic Retinopathy
The purpose of the study is to evaluate the efficacy of Keluoxin Capsules for the treatment of diabetic kidney disease (DKD) and diabetic retinopathy (DR) compared to placebo on a conventional treatment basis.
- Trial name
- NCT06660940
- Testing
- Keluoxin Capsules, Keluoxin Capsule Simulants, Irbesartan
- Volunteers
- 460 people
- Sponsor
- Chinese PLA General Hospital
Hepatocellular Carcinoma (HCC)
CAR-T Cell Therapy Targeting GPC3 in Patients with Advanced GPC3-Positive Hepatocellular Carcinoma
In this single-center, single-arm, prospective, open-label Phase 1/2 study, the safety and efficacy of autologous GPC3-targeted chimeric antigen receptor (CAR) T-cell therapy will be evaluated in patients with GPC3-positive…
- Trial name
- NCT06641453
- Testing
- GPC3-CART cells, Fludarabine Phosphate for Injection, Cyclophosphamide for Injection
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Chinese PLA General Hospital
Predictive Model
A Prediction Model of Postoperative Anxiety Symptom in Elderly Patients Undergoing Major Noncardiac Surgery
A multicentre, prospective observational study to develop and validate a predictive model for postoperative anxiety symptoms in elderly Chinese patients undergoing non-cardiac major surgery.
- Trial name
- NCT06641986
- Where
- China
- Volunteers
- 5,551 people
- Sponsor
- Chinese PLA General Hospital
Randomized Controlled Trial, Dexmedetomidine
Effect of Dexmedetomidine on Central Nervous System Complications in Patients Undergoing Cardiac Surgery
With the continuous improvement of medical technology, more and more patients need to undergo surgery as a kind of treatment for their diseases.
- Trial name
- NCT06551259
- Testing
- Dexmedetomidine, physiological saline
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Chinese PLA General Hospital
Thyroid Cancer, Papillary Thyroid Microcarcinoma
Multicenter Comparison of Thermal Ablation Versus Thyroid Lobectomy for Subcapsular Papillary Thyroid Microcarcinoma
To compare the clinical outcomes of Thermal ablation with those of thyroid lobectomy in patients with subcapsular papillary thyroid microcarcinoma.
- Trial name
- NCT06583057
- Testing
- Thermal ablation, Thyroid lobectomy
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Chinese PLA General Hospital
Ineligible Or Refused Transplant Patients With Classical Hodgkin Lymphoma
Chidamide+Decitabine Plus Anti-PD-1 Antibody for Patients With R/R cHL Who Are Transplant-ineligible or Refused Transplant.
The prognosis for patients with relapsed/refractory classical Hodgkin lymphoma (cHL) who refuse or are ineligible for transplant is poor.
- Trial name
- NCT06563778
- Testing
- Chidamide; Decitabine; Anti-PD-1 Antibody, Brentuximab Vedotin+ Bendamustine+Anti-PD-1 antibody
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Chinese PLA General Hospital
Hepatocellular Carcinoma Stage III
Image Driven Hepatocellular Carcinoma Invasiveness Evaluation Research
Hepatocellular carcinoma (HCC) is a highly heterogeneous malignant tumor with significant differences in invasion, proliferation ability and patient prognosis.
- Trial name
- NCT06559761
- Testing
- Hepatectomy
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Chinese PLA General Hospital
Coronary Artery Disease
Impact of Low-fat and Full-fat Milk on Lipids and Cardiac Function in Patients With Coronary Artery Disease
This trial aimed to investigate the effects of low-fat and full-fat milk on patients with coronary artery disease (CAD).
- Trial name
- NCT06542172
- Testing
- 500 mL/day of full-fat milk from corn-fed cows (fat >3.8%) for 12 weeks, 500 mL/day of full-fat milk from grass-fed cows (fat >3.8%) for 12 weeks, 500 mL/day of low-fat milk (fat <1.5%) for 12 weeks
- Where
- 7 sites in China
- Volunteers
- 120 people
- Sponsor
- Chinese PLA General Hospital
OA, TKA
A Randomized Study on Sagittal Angle Differences in Lower Limbs Between Normal Individuals and Osteoarthritis Patients
With China gradually entering an aging society, the proportion of the elderly population is gradually increasing, and the number of patients with knee disease is also increasing year by year.
- Conditions
- OA, TKA, EOS
- Trial name
- NCT06527924
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Severe Pneumonia, Biomarkers
Rapid Diagnosis of Severe Respiratory Tract Infectious Diseases and Screening of Biomarkers for Stratified Diagnosis
The purpose of this study is to clarify the biomarkers for rapid diagnosis and stratified diagnosis of severe respiratory tract infectious diseases through clinical experiments.
- Trial name
- NCT06533514
- Volunteers
- 100 people
- Sponsor
- Chinese PLA General Hospital
Arthroplasty, Replacement
A Randomized Controlled Trial of the Sagittal Alignment Difference Between Mako Robotic TKA and Manual TKA
As China transitions into an aging society, the proportion of the elderly population is escalating, with a corresponding rise in the number of patients with knee joint diseases.
- Conditions
- Arthroplasty, Replacement, Knee, Osteoarthritis
- Trial name
- NCT06527911
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Chinese PLA General Hospital
Overall Survival, Disease-free Survival
Microwave Ablation Versus Liver Resection for Intrahepatic Cholangiocarcinoma
Thermal ablation has been recommended by worldwide guidelines as first-line treatment for hepatocellular carcinoma (HCC), while evidence regarding its efficacy for primary intrahepatic cholangiocarcinoma (iCCA) is lacking.
- Trial name
- MALRIC (NCT06462742)
- Testing
- Microwave ablation (MWA) versus Liver Resection (LR)
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Chinese PLA General Hospital
Predictive Model
Development and Validation of a Prediction Model for Depression and Anxiety in Perioperative Elderly Adults
Anxiety and depression in later life are highly prevalent, often appear as comorbid disorders, and have many adverse consequences for both the individual and society.
- Trial name
- NCT05600504
- Testing
- no intervention
- Where
- China
- Volunteers
- 6,386 people
- Sponsor
- Chinese PLA General Hospital
Perioperative Neurocognitive Disorders
Association Between Iron Reserves and Perioperative Neurocognitive Disorders
Iron metabolism disorder have been identified as the pivotal contributor in the pathogenesis and progression of perioperative neurocognitive disorders.
- Trial name
- NCT06502912
- Testing
- no intervention
- Volunteers
- 12,984 people
- Sponsor
- Chinese PLA General Hospital
Ovarian Cancer
A Study of the Pan-immunotherapy in Patients With Relapsed/Refractory Ovarian Cancer
Ovarian cancer is the most lethal gynecological cancer and the 5th leading cause of cancer death in women. Platinum chemotherapy has been widely adopted as a standard treatment for advanced ovarian cancer, the response rates in…
- Trial name
- NCT03989336
- Testing
- Manganese Chloride, nab-paclitaxel, Platinum chemotherapy
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Chinese PLA General Hospital
Postoperative Acute Kidney Injury
Perioperative Database of Chinese Elderly Patients for Postoperative Acute Kidney Injury
To develop and externally validate a risk prediction model for postoperative acute kidney injury (PO-AKI) in elderly patients undergoing major noncardiac surgery, addressing the current gap in predictive tools for this vulnerable…
- Trial name
- NCT06462755
- Testing
- No intervention
- Volunteers
- 57,089 people
- Sponsor
- Chinese PLA General Hospital
ICAS - Intracranial Atherosclerosis, Cerebral Small Vessel Diseases
Feedback Loop Between Intracranial Atherosclerosis and Cerebral Small Vessel Disease
The present study aims at verifying the mutual effects between intracranial large artery atherosclerosis and cerebral small vessel disease on disease progression and prognosis by magnetic resonance imaging, and providing…
- Trial name
- NCT05677607
- Testing
- Magnetic resonance imaging
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Chinese PLA General Hospital
Thrombus, Brain, Thrombosis
Thrombus Imaging and Treatment Analytics in Neurology
In the present study, the investigators use high-resolution MR vessel wall imaging, and select patients with cerebral and cervical artery occlusion to investigate the relationship between the imaging appearance of thrombus and…
- Trial name
- Titan (NCT05663281)
- Testing
- thrombus imaging appearance
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Chinese PLA General Hospital
Lupus Nephritis
Mesenchymal Stem Cell Transfusion for the Treatment of Refractory Lupus Nephritis
Lupus nephritis (LN) is the most common and serious complication of systemic lupus erythematosus (SLE), which can lead to permanent kidney injury and uremia.
- Trial name
- LN (NCT06485648)
- Testing
- Umbilical cord mesenchymal stem cells, Normal saline
- Volunteers
- 96 people
- Sponsor
- Chinese PLA General Hospital