Clinical trials: sponsored by Chinese PLA General Hospital
Perioperative Complications
Clinical Frailty Assessment and Postoperative Adverse Outcomes and Quality of Life in Elderly Patients
The frailty index may represent a useful decision support tool to optimize modifiable drivers of the quality and cost of digestive surgery care.
- Trial name
- NCT05387850
- Testing
- no intervention
- Where
- China
- Volunteers
- 12,000 people
- Sponsor
- Chinese PLA General Hospital
Nephropathy, Glomerular Diseases
Effect of Huaier Granule on the Treatment of Idiopathic Membranous Nephropathy
This is a prospective, multicenter, randomized, open-label, parallel controlled study. The purpose of this study is to evaluate the efficacy and safety of Huaier granule on the treatment of idiopathic membranous nephropathy…
- Conditions
- Nephropathy, Glomerular Diseases, Idiopathic Membranous Nephropathy
- Trial name
- NCT05839314
- Testing
- Huaier granule, Renin-angiotensin-aldosterone system inhibitors (RASI), Ciclosporin soft capsules
- Where
- China
- Volunteers
- 480 people
- Sponsor
- Chinese PLA General Hospital
Coronary Artery Disease
Role of On-site CT-derived FFR in the Management of Suspect CAD Patients
The primary of this registry is to evaluate whether the availability of CTA/CT-FFR procedure could effectively optimize the flow of clinical practice of stable chest pain versus conventional clinical pathway in decision making…
- Trial name
- TARGET (NCT03901326)
- Testing
- CT-FFR assessment
- Where
- China
- Volunteers
- 1,216 people
- Sponsor
- Chinese PLA General Hospital
Postoperative Pain
the Effect of Preoperative Pain Education by Anesthesia Nurses on Postoperative Pain Among Adult Patients Undergoing Abdominal Surgery
To explore the effects of preoperative pain education on postoperative pain among patients undergoing abdominal surgery.
- Trial name
- NCT06327282
- Testing
- education on pain and related knowledge
- Volunteers
- 116 people
- Sponsor
- Chinese PLA General Hospital
Advanced or Metastatic Solid Tumors
Pan-T Booster Co-expressing MSLN CAR T Cell Therapy in Advanced/Metastatic Solid Tumors
In preclinical study, investigators have demonstrated that the newly developed pan-T booster (harbouring CD40 agonist and one T cell costimulator agonist) co-expressing MSLN CAR T cell possess more powerful antitumor activity…
- Trial name
- NCT05693844
- Testing
- Pan-T booster co-expressing MSLN CAR T cell, Albumin-bound paclitaxel, Cyclophosphamide
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Chinese PLA General Hospital
Stomach Neoplasm
Multimodal Prehabilitation for Resectable Gastric Cancer
Surgical resection is the mainstay for gastric cancer. Surgical stress response, like insulin resistance and catabolism, is inevitable and is a risk factor for postoperative outcome.
- Trial name
- NCT05714878
- Testing
- aerobic exercise; resistance exercise; nutritional support; psychological support
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Chinese PLA General Hospital
Movement Disorders
Retrospective Study on MR Imaging of ET and PD Patients Subjected With MRgFUS Thalamotomy
The technological advance of magnetic resonance-guided focused ultrasound (MRgFUS) has once again brought lesion therapy back to the clinical frontline for the treatment of movement disorder.
- Trial name
- NCT04570046
- Where
- China
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Colorectal Cancer, RAS Mutation
PD-1 Antibody Plus Bevacizumab and CAPOX as First-line Treatment for RAS-mut MSS mCRC
This study is designed to explore the efficacy and safety of anti-PD-1 antibody plus bevacizumab and chemotherapy as first-line treatment for patients with RAS-mutant, microsatellite stable, metastatic colorectal cancer.
- Conditions
- Colorectal Cancer, RAS Mutation, Colorectal Neoplasms, Microsatellite Stable Colorectal Carcinoma
- Trial name
- NCT06206096
- Testing
- oxaliplatin+capecitabine+bevacizumab+PD-1 antibody
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Chinese PLA General Hospital
Electric Impedance, Respiratory Function Tests
Prediction of COPD Severity Using Electrical Impedance Tomography
The purpose of this study is to predict the CT visual score of emphysema with EIT-based parameters, in order to provide a non-invasive and convenient method for the evaluation of lung structure and physiological and pathological…
- Conditions
- Electric Impedance, Respiratory Function Tests, Pulmonary Disease, Chronic Obstructive
- Trial name
- NCT06359145
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Cohort Studies
Effects of Volatile Anaesthetics on Incidence of Postoperative Depression and Anxiety in Elderly Patients
This study is a retrospective analysis of a large-scale multicentre prospective cohort study that investigates the impact of volatile anaesthetics on the incidence of postoperative depression and anxiety among elderly patients.
- Trial name
- NCT06307717
- Testing
- volatile anaesthetic (sevoflurane, isoflurane, desflurane)
- Where
- China
- Volunteers
- 8,000 people
- Sponsor
- Chinese PLA General Hospital
Microgravity, Neuroplasticity
Neuroimage Genome Study of Neuroplasticity Associated With Microgravity
This clinical trial investigates the neuroplasticity and cognitive status changes of the human brain in microgravity. To explore the relationship between cognitive status changes and brain functional activities, gray matter and…
- Conditions
- Microgravity, Neuroplasticity, MRI, Repeatable Battery for the Assessment of Neuropsychological Status
- Trial name
- NCT06350422
- Testing
- Head-Down tilt Bed Rest test
- Where
- China
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Gastric Cancer
A Clinical Study of Adebrelimab Combined With Apatinib and Paclitaxel in Patients With Advanced Gastric Cancer.
Phase II Clinical Study of Adebrelimab Combined with Apatinib and Paclitaxel for Injection(Albumin Bound) as Second-line Therapy in Patients with Advanced Gastric Cancer Previously Treated with Immunotherapy
- Trial name
- NCT06339216
- Testing
- Adebrelimab+Apatinib+Paclitaxel for Injection(Albumin Bound)
- Volunteers
- 30 people
- Sponsor
- Chinese PLA General Hospital
Non-hodgkin Lymphoma,B Cell
Allogeneic TRAC Locus-inserted CD19-targeting STAR T Cell Therapy in r/r B-NHL
The team has developed the synthetic T cell receptor (TCR) and antigen receptor (STAR) T cells which were demonstrated safety in relapsed or refractory (r/r) B-cell non-Hodgkin' s lymphoma (B-NHL) (NCT05631912).
- Trial name
- NCT06321289
- Testing
- Allogeneic CD19-STAR T cell, Fludarabine, Cyclophosphamide
- Where
- 2 sites in China
- Volunteers
- 30 people
- Sponsor
- Chinese PLA General Hospital
Papillary Thyroid Cancer
Image-guided Thermal Ablation vs. Lobectomy for Solitary Papillary Thyroid Microcarcinoma
To evaluate the clinical outcomes of image-guided thermal ablation versus thyroid lobectomy for the treatment of papillary thyroid microcarcinoma
- Trial name
- NCT06325787
- Testing
- thyroid lobectomy, image-guided thermal ablation
- Volunteers
- 1,021 people
- Sponsor
- Chinese PLA General Hospital
S-ketamine, Esketamine
Safety and Efficacy Evaluation of S (+) - Ketamine in Children
A multicenter, randomized, open-label, active controlled pragmatic clinical trial that evaluates the safety and efficacy of S (+) -ketamine for postoperative acute pain in children in perioperative settings.
- Conditions
- S-ketamine, Esketamine, Acute Pain, Postoperative Pain
- Trial name
- NCT04834427
- Testing
- Conventional therapy + S (+)-Ketamine, Conventional therapy
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Chinese PLA General Hospital
Non Hodgkin's Lymphoma
Chidamide Bridging for CAR-T Therapy
The previous research suggests that the low expression of NOXA protein may be an important biomarker for the treatment of drug resistance of chimeric antigen receptor-T (CAR-T) cells.
- Trial name
- NCT05370547
- Testing
- Chidamide, Fludarabine and cyclophosphamide, Anti-CD19 CAR-T cells
- Where
- 13 sites in China
- Volunteers
- 120 people
- Sponsor
- Chinese PLA General Hospital
Hypopharyngeal Cancer
Efficacy and Safety of Toripalimab Combined With AP-induced Chemotherapy Followed in Non-metastatic IVB Hypopharyngeal Cancer
The goal of this type of study: single center exploratory clinical trial is to evaluate the efficacy and safety of Toripalimab combined with AP-induced chemotherapy followed by concurrent chemoradiotherapy and…
- Trial name
- NCT05860335
- Testing
- Cisplatin/Nedaplatin, albumin paclitaxel
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Chinese PLA General Hospital
Pancreatic Neoplasms, Ablation
Clinical Comparative Study of Systematic Therapy Combined With MWA and Systematic Therapy for Pancreatic Cancer
Pancreatic carcinoma (PC) is the deadliest malignant tumors worldwide. Surgical resection is one of the most effective methods for the treatment of PC, but the resectable rate is less than 20% among the patients with PCs, and the…
- Trial name
- NCT06231160
- Testing
- Systematic Therapy Combined With Microwave Ablation
- Volunteers
- 185 people
- Sponsor
- Chinese PLA General Hospital
Microbiome, Immune Function
Microecology and Immunity in Patients With Anti-MDA5 Antibody Positive Dermatomyositis and Interstitial Lung Disease
The purpose of this study was to analyze the relationship between the microbial community, host immunity and the presence or absence of concurrent rapidly progressive interstitial lung disease patients with anti-MDA5 antibody…
- Conditions
- Microbiome, Immune Function, Anti-MDA5 Antibody Positive Dermatomyositis
- Trial name
- NCT06203249
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Chinese PLA General Hospital
Advanced Gastroesophageal Adenocarcinoma
RC48-ADC Combined With S-1 for First-line Treatment of Advanced Gastroesophageal Adenocarcinoma With Moderate Expression of HER2
This study was a single-arm, open, multi-center Phase Ib/II clinical trial to observe and evaluate the efficacy and safety of RC48-ADC plus S-1 in first-line treatment of advanced gastroesophageal adenocarcinoma with moderate…
- Trial name
- NCT05403242
- Testing
- RC48-ADC, S-1
- Where
- 3 sites in China
- Volunteers
- 42 people
- Sponsor
- Chinese PLA General Hospital