Clinical trials: sponsored by Chinese PLA General Hospital
Invasive Mechanical Ventilation ARDS
Clinical Empirical Research of ARDS
According to the ARDS Berlin definition, patients with severe concurrent invasive mechanical ventilation were selected, and clinical data and prognosis were collected.
- Trial name
- NCT05922826
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Chinese PLA General Hospital
End-stage Renal Disease
Comparative Study of Prognosis and QOL Between APD-RPM and CAPD
This is an observational, multicenter, parallel control study, planning to enroll 750 eligible patients to receive automated peritoneal dialysis with remote patient management (APD-RPM) and continuous ambulatory peritoneal…
- Trial name
- NCT05738525
- Testing
- APD-RPM
- Where
- China
- Volunteers
- 750 people
- Sponsor
- Chinese PLA General Hospital
Relapsed or Refractory Hodgkin Lymphoma
SHR1701 Alone or in Combination With SHR2554 in Relapsed or Refractory Classical Hodgkin Lymphoma
This is an open-label, phase I/II dose escalation and expansion trial. The primary objective of dose escalation phase I study is to evaluate the safety and feasibility of SHR1701 in patients with relapsed or refractory classical…
- Trial name
- NCT05896046
- Testing
- SHR2554+ SHR1701, SHR-1701
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Chinese PLA General Hospital
Fluid Overload
Primary Clinical Evaluation of Wearable Filtrating Artificial Kidney Device for On-site Medical Rescue
Fluid overload is a common feature of diseases such as heart failure and kidney injury, which can lead to pulmonary edema or even death if not treated in time.
- Trial name
- NCT05906355
- Testing
- the wearable filtrating artificial Kidney Device, traditional hemodialysis machine
- Where
- China
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Uremia
A Comparative Study of Two Kinds of Hemodialysis Filters
This study exploring the expression characteristics of different cells of peripheral blood after exposure to two kinds of hemodialysis filter membrane materials will help to elucidate the key mechanisms of hemodialysis filter…
- Trial name
- NCT05899283
- Testing
- OCI-HF160, FX800HDF
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Chinese PLA General Hospital
Unilateral Deafness
Evaluation of Rehabilitation Results in the Single-sided Deafness With Cochlear Implantation
Single-sided deafness (SSD) refers to severe to profound sensorineural hearing loss on one side (average pure-tone hearing threshold≥70 dB HL at 0.5, 1, 2, and 4kHz) while the opposite side maintains normal hearing or mild…
- Trial name
- NCT05435612
- Testing
- cochlear implant
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Chinese PLA General Hospital
Tinnitus
Effects of CI on Tinnitus and Its Symptoms
Abnormal activity in the central auditory system is the cause of subjective experience of tinnitus. Electrical stimulation can inhibit the abnormal activity of auditory related neurons in patients with tinnitus.
- Trial name
- NCT05453019
- Testing
- Cochlear Implant
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Diabetic Nephropathy Type 2, Diabetic Kidney Disease
Multidimensional Accurate Diagnosis and Treatment Technology and Clinical Transformation of Type 2 Diabetes Nephropathy
Diabetes nephropathy (DN) is one of the most serious microvascular complications of diabetes, and also an important cause of death and disability of diabetes patients.
- Conditions
- Diabetic Nephropathy Type 2, Diabetic Kidney Disease, Type 2 Diabetes
- Trial name
- NCT05888909
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Chinese PLA General Hospital
Perioperative Complications, Perioperative/Postoperative Complications
Perioperative Database of Chinese Elderly Patients
The investigators aim to establish a prospective database of perioperative elderly patients from multiple regions and centers. Collected data involves postoperative complications of the central nervous system, cardiovascular…
- Conditions
- Perioperative Complications, Perioperative/Postoperative Complications, Perioperative Adverse Events
- Trial name
- PDCEP (NCT04911530)
- Testing
- no intervention
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Chinese PLA General Hospital
Inert Non Hodgkin's Lymphoma
IBI376 Plus Rituximab in Patients With Untreated Indolent Lymphoma.
Follicular lymphoma (FL) and marginal zone lymphoma (MZL) are the most common inert non Hodgkin's lymphoma (iNHL). The standard first-line treatment of advanced FL / MZL is based on rituximab.
- Trial name
- NCT05073250
- Testing
- IBI376, Rituximab
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Chinese PLA General Hospital
Diffuse Large B Cell Lymphoma, Relapse/Recurrence
Decitabine and Anti-PD-1 in R/R DLBCL
Patients with relapsed/refractory diffuse large B cell lymphoma with extranodal (esp. central nervous system) involvement treated with Low-Dose Decitabine plus anti-PD-1 regimen.
- Conditions
- Diffuse Large B Cell Lymphoma, Relapse/Recurrence, Extranodal Extension, Central Nervous System Lymphoma
- Trial name
- NCT05816746
- Testing
- Low-Dose Decitabine plus anti-PD-1
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Chinese PLA General Hospital
Locally Advanced or Metastatic Solid Tumors
IFNα Expressing Mesenchymal Stromal Cells for Locally Advanced/Metastatic Solid Tumors
The goal of this first-in-human, single-center, prospective, open-label, phase 1/2 trial is to evaluate the safety and efficacy of the interferon alpha expressing mesenchymal stromal cells (MSC-IFNα) combined with or without…
- Trial name
- NCT05699811
- Testing
- MSC-IFNα, Nab paclitaxel, Cyclophosphamide
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Chinese PLA General Hospital
nk/T-cell Lymphoma, Newly Diagnosed
Clinical Study of XPO1 Inhibitor Selinexor Combined With COPL in Newly Diagnosed Advanced NK/T-cell Lymphoma
Patients with newly diagnosed, pathologically confirmed NK/T-cell lymphoma of stage III-IV treated with XCOPL regimen. 3 weeks for a cycle, with a total of 6-8 cycles.
- Conditions
- nk/T-cell Lymphoma, Newly Diagnosed, Advanced Lymphoma
- Trial name
- NCT05833893
- Testing
- XPO1 inhibitor
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Chinese PLA General Hospital
Cardiovascular and Cerebrovascular Diseases
Correlation Between Coronary Artery and Brain Study
To explore the pathogenesis of cardiovascular and cerebrovascular diseases through study on cardio-cerebral integration based on multimodal imaging technology, and clinical evaluation of its secondary diseases and intervention…
- Trial name
- NCT05813405
- Testing
- Experimental: Antihypertensive therapy Hypotension and improved ventilation treatment Intervention treatment for other risk factors
- Volunteers
- 1,000 people
- Sponsor
- Chinese PLA General Hospital
Haploidentical Hematopoietic Stem Cell Transplantation
Individualized Dose Study of ATG in Haploidentical Hematopoietic Stem Cell Transplantation
The purpose of this study is to determine the response and toxicity rate of two different dosages (Individualized dosage VS. fixed dosage) of ATG as a prophylaxis for acute GVHD in haploidentical peripheral blood stem cell…
- Trial name
- NCT04778618
- Testing
- Antithymocyte Globulin
- Where
- China
- Volunteers
- 63 people
- Sponsor
- Chinese PLA General Hospital
Movement Disorders
MRgFUS Thalamotomy for Therapy-Resistant Tremor-related Disease With Low SDR Value
A study to evaluate the effectiveness and safety of ExAblate transcranial MRgFUS Thalamotomy treatment of medication refractory tremor-related diseases subjects with low skull density ratio (SDR) value.
- Trial name
- NCT05624385
- Testing
- MRgFUS treatment
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Chinese PLA General Hospital
Stroke
Stroke Mechanism Evolution in Intracranial Atherosclerotic Stenosis
Predictors of the risk of recurrent stroke for patients with symptomatic intracranial atherosclerotic stenosis (ICAS) remain unknown.
- Trial name
- NCT02705599
- Where
- 2 sites in China
- Volunteers
- 230 people
- Sponsor
- Chinese PLA General Hospital
Overall Survival, Progression-free Survival
Microwave Ablation Versus Laparoscopic Hepatectomy for 3-5cm Hepatocellular Carcinoma
As the most common subtype of liver cancer (85% ~ 90%), HCC is highly malignant; thus, one of the crucial issues in HCC management is an effective therapy for tumors at an early stage, which is vital for improving the prognosis…
- Conditions
- Overall Survival, Progression-free Survival, Cost
- Trial name
- NCT05796700
- Testing
- Microwave Ablation
- Volunteers
- 1,585 people
- Sponsor
- Chinese PLA General Hospital
CMV Infection After Allogenic HSCT
CMV-TCR-T Cells for CMV Infection After Allogenic HSCT
This is a multi-center, single arm, open-label, phase I study to determine the safety and effectiveness of CMV-TCR-T cell immunotherapy in treating CMV virus infection after allogenic HSCT.
- Trial name
- NCT05140187
- Testing
- CMV-TCR-T cells
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Chinese PLA General Hospital
Muscle-Invasive Bladder Carcinoma
Clinical Study of Neoadjuvant Therapy Outcome Prediction of Muscle-invasive Bladder Cancer Based on PTC Drug Sensitivity Detection
In this study, investigators plan to conduct the 3D in vitro culture PTC drug sensitivity testing of fresh tumor specimen which obtained by endoscopic biopsy or other methods.
- Trial name
- NCT05767528
- Testing
- Patient-derived tumor-like cell clusters (PTC) drug sensitivity testing
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Chinese PLA General Hospital