Clinical trials: sponsored by Chinese PLA General Hospital
Ultrasound
Sonazoid Contrast-enhanced Ultrasound in Assessing Effectiveness of Neoadjuvant Chemotherapy in Breast Cancer Patients.
Sonazoid as a new generation of ultrasound contrast agent.This study based on the features of Sonazoid specific angiography and high mechanical index,the role of Sonazoid in assessing effectiveness of neoadjuvant chemotherapy in…
- Trial name
- NCT04657341
- Where
- China
- Volunteers
- 1,012 people
- Sponsor
- Chinese PLA General Hospital
Refractory or Relapsed Aggressive r/r B-NHL With Huge Tumor Burden
Decitabine-primed Tandem CD19/CD20 CAR T Cells Plus Epigenetic Agents in Aggressive r/r B-NHL With Huge Tumor Burden
This open-label, multi-cohorts, phase 1/2 study has the primary objective of comparing decitabine-primed tandem CART 19/20 solo, with decitabine-primed tandem CART 19/20 plus chidamide, decitabine-primed tandem CART 19/20 plus…
- Trial name
- NCT04553393
- Testing
- Chidamide, Decitabine, Chidamide and Decitabine
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Chinese PLA General Hospital
Contrast Enhanced Ultrasound
Diagnostic Value of Sonazoid Contrast-enhanced Ultrasound in Renal Tumors
The incidence and mortality of renal cell carcinoma are increasing year by year. Contrast-enhanced ultrasound is helpful for early diagnosis and treatment to renal tumor, and is of great importance to distinguish benign from…
- Trial name
- NCT04626115
- Where
- China
- Volunteers
- 223 people
- Sponsor
- Chinese PLA General Hospital
Ringer Bicarbonate, Elderly Abdominal Surgery
Safety and Efficacy of Sodium Bicarbonate Ringer Injection
Objectives 1. To observe whether sodium bicarbonate Ringer injections can reduce the incidence of postoperative complications in elderly patients undergoing abdominal surgery. 2.
- Conditions
- Ringer Bicarbonate, Elderly Abdominal Surgery, Safety, Effectiveness
- Trial name
- NCT04596956
- Testing
- sodium bicarbonate Ringer injection, Lactated Ringer's solution
- Volunteers
- 5,000 people
- Sponsor
- Chinese PLA General Hospital
Peripheral Blood Stem Cell Transplantation
Ruxolitinib and Decitabine for High Risk Hematological Malignancies
The purpose of this study is to determine the efficacy and safety of Ruxolitinib and Decitabine intensified Conditioning Regimen in Patients with High Risk hematological malignancies undergoing allogeneic peripheral blood stem…
- Trial name
- NCT04582604
- Testing
- modified By/Cy conditioning regimen intensified by Ruxolitinib and Decitabine
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Chinese PLA General Hospital
Solid Tumor
Study of SHR2150 (TLR7 Agonist) in Combination With Chemotherapy Plus PD-1 or CD47 Antibody in Subjects With Unresectable/ Metastatic Solid Tumors
This phase I/II trial aims to evaluate safety and efficacy of SHR2150 in combination with chemotherapy plus PD-1 or CD47 antibody in subjects with unresectable/ metastatic solid tumors.
- Trial name
- NCT04588324
- Testing
- SHR2150, Anti-Cancer Agent
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Chinese PLA General Hospital
MSCs Derived Pleiotropic Factors on Wound Healing in Endonasal Surgeries
Effects of MSCs Derived Pleiotropic Factors on Wound Healing in Endonasal Surgeries
Nasal trauma, deviated nasal septum, sinusitis, nasal polyps and other nasal benign diseases are common clinical diseases and require endoscopic sinus surgery.
- Trial name
- NCT04536233
- Testing
- MSCs Derived Pleiotropic Factors, physiological saline
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Ultrasound
Prospective Multicenter Study on Clinical Application of Sonazoid in Liver Tumor
Sonazoid as a new generation of ultrasound contrast agent.This study based on the features of Sonazoid specific angiography and his mechanical index, the role of Sonazoidin in the differential diagnosis of benign and malignant…
- Trial name
- NCT04563897
- Volunteers
- 1,300 people
- Sponsor
- Chinese PLA General Hospital
Non-small Cell Lung Cancer
A Study of Combination Therapy in NSCLC
This trial is a single arm, two cohorts, phase II study. All patients are stage IIIB-IV NSCLC, Eastern Cooperative Oncology Group (ECOG) performance status 0-1 and no sensitizing mutation of the epidermal growth factor receptor…
- Trial name
- NCT04544644
- Testing
- AK104+anlotinib
- Volunteers
- 30 people
- Sponsor
- Chinese PLA General Hospital
Acute Myeloid Leukemia, in Relapsed or Refractory, Acute Myeloid Leukemia, Elderly, Unfit
Combined Inhibition of PD-1 and DNA Hypomethylating Agent +/- Chemotherapy in High-risk AML or Elderly Patients With AML Who Are Unfit for Intensive Chemotherapy
This phase II trial studies how well tislelizumab combined with DNA hypomethylation agent +/- CAG regimen (cytarabine, idarubicin / Aclarithromycin, rhG-CSF/ PEG-rhG-CSF) work in treating patients with high-risk acute myeloid…
- Conditions
- Acute Myeloid Leukemia, in Relapsed or Refractory, Acute Myeloid Leukemia, Elderly, Unfit, Acute Myeloid Leukemia With Positive Minimal Residual Disease
- Trial name
- NCT04541277
- Testing
- Tislelizumab
- Where
- China
- Volunteers
- 55 people
- Sponsor
- Chinese PLA General Hospital
MSCs-PFs in Treating Poorly Healed Wounds of Postoperative Incision
Mesenchymal Stem Cell-derived Pleiotropic Factor in Treating Poorly Healed Wounds of Postoperative Incision
Poor incision healing is a common complication after abdominal surgery, mainly manifested as incision dehiscence, subcutaneous fat liquefaction, malnutrition, and incision infection.
- Trial name
- NCT04538885
- Testing
- The pleiotropic factor derived from mesenchymal stem cells
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Hematopoietic/Lymphoid Cancer, Adult Acute Lymphoblastic Leukemia in Remission
Treatment of Relapsed and/or Chemotherapy Refractory B-cell Malignancy by Tandem CAR T Cells Targeting CD19 and CD20
RATIONALE: Placing a tumor antigen chimeric receptor that has been created in the laboratory into patient autologous or donor-derived T cells may make the body build immune response to kill cancer cells.
- Conditions
- Hematopoietic/Lymphoid Cancer, Adult Acute Lymphoblastic Leukemia in Remission, B-cell Adult Acute Lymphoblastic Leukemia, B-cell Chronic Lymphocytic Leukemia
- Trial name
- NCT03097770
- Testing
- anti-CD19/20-CAR vector-transduced T cells
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Chinese PLA General Hospital
Stroke Volume Variation, Pulse Pressure Variation
SVV and PPV Predict Fluid Responsiveness in Mechanically Ventilated Elderly Patients Under General Anesthesia
Although individualized or goal-directed approach has been advocated, a reliable index is still required to help monitor the volume status timely and efficiently.
- Conditions
- Stroke Volume Variation, Pulse Pressure Variation, Fluid Responsiveness, Fluid Therapy
- Trial name
- NCT04388995
- Testing
- volume expansion
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Chinese PLA General Hospital
General Surgery
Effects of Different Kinds of Hypotensive Drugs on Dynamic Hemodynamic Changing in Patients Under Surgeries
SVV is clinically affected by a variety of factors, such as abdominal pressure, body position, tidal volume, type and temperature of liquid treatment, etc. There are few reports on the effects of drugs on SVV.
- Trial name
- NCT03497351
- Testing
- Nicardipine, Urapidil
- Where
- China
- Volunteers
- 59 people
- Sponsor
- Chinese PLA General Hospital
PEG-rhG-CSF, Pancreatic Cancer
PEG-rhG-CSF in Secondary Prevention of Nab-Paclitaxel Combined With S-1 in Advanced Pancreatic Cancer
A prospective, open, single-arm clinical study to evaluate the efficacy and safety of jinyouli（PEG-rhG-CSF） in the first-line treatment of advanced pancreatic cancer with nab-paclitaxel combined with S-1.Chemotherapy regimen: (1)…
- Trial name
- NCT04518800
- Testing
- Jin Youli(PEG-rhG-CSF)
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Chinese PLA General Hospital
Hodgkin Lymphoma, Anti-PD-1 Antibody Resistant
The Clinical Trial of Chidamide+Decitabine+Camrelizumab Versus Decitabine+Camrelizumab in Anti-PD-1 Antibody Resistant Patients With Classical Hodgkin Lymphoma.
This open-label, randomized, two-arm, phase 2 study has the primary objective of comparing the ORR obtained with Chidamide+Decitabine+Camrelizumab against that obtained with Decitabine+Camrelizumab in patients with Hodgkin…
- Trial name
- NCT04514081
- Testing
- Chidamide; Decitabine; Camrelizumab, Decitabine+Camrelizumab
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Chinese PLA General Hospital
Hodgkin Lymphoma
Addition of Chidamide to the Combination Treatment of Decitabine Plus Camrelizumab in Combination Treatment Resistant/Relapsed Patients With Classical Hodgkin Lymphoma
This is a Phase II clinical trial for Decitabine plus Camrelizumab resistant/relapsed patients with Hodgkin Lymphoma. The purpose is to evaluate the efficacy and safety of the combination therapy of Chidamide plus Decitabine Plus…
- Trial name
- NCT04233294
- Testing
- Chidamide, Camrelizumab, Decitabine
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Chinese PLA General Hospital
Hodgkin Lymphoma
Camrelizumab Plus Decitabine in Anti-PD-1 Treatment-naive Patients With Relapsed/Refractory Classical Hodgkin Lymphoma
This is an open-label, Phase 2/3，multicenter and single-arm clinical trial of Camrelizumab plus decitabine for Anti-PD-1 treatment-naive patients with relapsed or refractory Hodgkin Lymphoma.
- Trial name
- NCT04510610
- Testing
- Camrelizumab and Decitabine
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Chinese PLA General Hospital
Solid Tumor, Adult
Study of CRISPR-Cas9 Mediated PD-1 and TCR Gene-knocked Out Mesothelin-directed CAR-T Cells in Patients With Mesothelin Positive Multiple Solid Tumors.
Multiple solid tumors have positive targets of mesothelin expressed on the surfaces of the tumor cells, we use the technique of CRISPR-Cas9 to knocked out the PD-1 and TCR of chimeric antigen receptor (CAR) T cells to effect the…
- Trial name
- NCT03545815
- Testing
- anti-mesothelin CAR-T cells
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Chinese PLA General Hospital
Transversus Abdominis Plane Block, Simulation Training
Study on Application of Simulated Training in Ultrasound Guided Transversus Abdominis Plane Block
With the development of society and the enhancement of people's awareness of law and self-protection, it is necessary to use simulation technology to create a simulated human and clinical environment to replace the traditional…
- Conditions
- Transversus Abdominis Plane Block, Simulation Training, Learning Curve
- Trial name
- NCT04388423
- Testing
- simulated puncture training, traditional bedside teaching
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Chinese PLA General Hospital