Clinical trials: sponsored by Chinese PLA General Hospital
Hematopoietic Stem Cell Transplantation
Population PK-guided ATG Dosing in Haplo-HSCT
To evaluate the safety and efficacy of a population pharmacokinetics (PK)-guided targeted ATG dosing strategy in haploidentical stem cell transplantation and to observe the GVHD-free, relapse-free survival (GRFS) in the cohort…
- Trial name
- NCT07791576
- Testing
- Anti Thymocyte Globulin
- Where
- China
- Volunteers
- 63 people
- Sponsor
- Chinese PLA General Hospital
Hepatocellular Carcinoma, Liver Cancer, Adult
A Study Combining Personalized Neoantigen-based Dendritic Cell Vaccine With Microwave Ablation for the Treatment of Hepatocellular Carcinoma
This is a single-center, open-label, non-randomized, parallel-group phase 1 study evaluating a personalized neoantigen-based dendritic cell vaccine following microwave ablation in patients with hepatocellular carcinoma.
- Trial name
- NCT03674073
- Testing
- Neoantigen Vaccines, Microwave Ablation
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Chinese PLA General Hospital
Depression, Anxiety
Postoperative Anxiety and Depression Among Older Chinese Patients
A multicenter, prospective observational study to describe the socioeconomic characteristics and the occurrence of postoperative anxiety and depression in the Chinese old population.
- Conditions
- Depression, Anxiety, Elderly Patients, Non-cardiac Surgery
- Trial name
- NCT06495840
- Testing
- no intervention
- Where
- China
- Sponsor
- Chinese PLA General Hospital
B-cell Lymphoma
In Vivo CD19/CD20 CAR T-Cell Therapy for Relapsed/Refractory B-Cell Lymphoma
This Phase 1, open-label, single-arm, dose-escalation study is designed to evaluate the safety and tolerability of SL1617 Injection in patients with relapsed or refractory B-cell lymphoma.
- Trial name
- NCT07775508
- Testing
- SL1617 Injection
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Chinese PLA General Hospital
Newly Diagnosed Acute Myeloid Leukemia (AML), Elderly Patients
Venetoclax-Azacitidine in Combination With Chidamide and CAG in Fit Older Patients With Acute Myeloid Leukaemia
This study is a multicenter, prospective, randomized, controlled clinical trial, observing the efficacy and safety of the CACAG+Venetoclax regimen (Chidamide + Azacitidine + Aclarubicin + Cytarabine + Recombinant Human…
- Trial name
- NCT07514936
- Testing
- the standard "3+7" regimen, Azacytidine; Cytarabine; Aclacinomycin; Chidamide; Venetoclax; Granulocyte
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Chinese PLA General Hospital
Carotid Artery Stenosis, Carotid Atherosclerosis
Photon-Counting CT Versus Conventional CT for Carotid Plaque Assessment in Patients With Carotid Artery Stenosis
This prospective observational study aims to compare photon-counting detector computed tomography angiography (PCD-CTA) with conventional energy-integrating detector computed tomography angiography (EID-CTA) for the assessment of…
- Conditions
- Carotid Artery Stenosis, Carotid Atherosclerosis, Carotid Atherosclerotic Plaque
- Trial name
- NCT07762664
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Chinese PLA General Hospital
Coronary Artery Disease, Percutaneous Coronary Intervention (PCI)
Cold-Region Exposure and Cardiac Remodeling After PCI
This multicenter prospective observational cohort study aims to investigate the association between cumulative cold-region exposure and adverse left ventricular remodeling and cardiovascular outcomes in patients with coronary…
- Conditions
- Coronary Artery Disease, Percutaneous Coronary Intervention (PCI), Left Ventricular Remodeling, Cold Exposure
- Trial name
- COLD-PCI (NCT07773870)
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Chinese PLA General Hospital
Neovascular Age-related Macular Degeneration(nAMD), Wet Macular Degeneration
LEAP Strategy for Neovascular Age-Related Macular Degeneration
Background: Age-related macular degeneration (AMD) is a common eye disease that can cause blindness in older adults. The "wet" form of AMD, called neovascular AMD, happens when abnormal blood vessels grow under the retina and…
- Trial name
- LEAP (NCT07744204)
- Testing
- Laser photocoagulation, Anti-VEGF agents
- Volunteers
- 240 people
- Sponsor
- Chinese PLA General Hospital
Neoplasm
Multimodal Artificial Intelligence for Detecting the Psychological State of Cancer Patients
Artificial intelligence (AI) technology is expected to assist clinical doctors in promptly identifying cancer patients at risk of developing psychological issues and to develop preemptive management plans, thereby enhancing their…
- Trial name
- AIPSY (NCT07751757)
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Chinese PLA General Hospital
Cardiovascular Diseases
Photon-Counting Cardiac CT in Post-PCI Patients
This study takes patients who have undergone percutaneous coronary intervention as the research subjects and employs a prospective observational cohort design, aiming to develop and validate a "one-stop" photon-counting computed…
- Trial name
- NCT07763340
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Chinese PLA General Hospital
Benign Prostatic Hyperplasia (BPH)
Clinical Study on Prostate Thermal Vapor Ablation Guided by MRI/TRUS Fusion Imaging
Objective of the Clinical Trial The objective of this clinical trial is to preliminarily assess the feasibility and safety of performing precise prostate thermal vapor ablation under MRI/TURS guidance.
- Trial name
- NCT06817733
- Testing
- Transurethral Thermal Vaporization of the Prostate, Rezūm Water Vapor Thermal Therapy System
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Chinese PLA General Hospital
Chronic Postoperative Pain
Effect of Intraoperative Dexmedetomidine on Postoperative Pain in Elderly Patients Undergoing Major Abdominal Surgery: a Secondary Analysis Based on Prospective Data
This study is a secondary analysis of multicenter prospective data, including elderly patients who underwent elective major abdominal surgery between April 2020 and April 2022 from a perioperative database of elderly patients in…
- Trial name
- NCT07744308
- Where
- China
- Volunteers
- 2,754 people
- Sponsor
- Chinese PLA General Hospital
Depression, Anxiety
Preoperative Anxiety and Depression Among Older Chinese Patients
A multicenter, cross-sectional study to characterize the clinical profiles of the Chinese elderly population and to determine the prevalence of preoperative anxiety and depression.
- Conditions
- Depression, Anxiety, Elderly Patients, Non-cardiac Major Surgery
- Trial name
- NCT07744295
- Volunteers
- 8,000 people
- Sponsor
- Chinese PLA General Hospital
Cohort Studies
The Impact of Preoperative Depression on Postoperative Delirium in Elderly Chinese Patients: A Retrospective Multicenter Observational Study
This study is a retrospective analysis of a large-scale multicentre prospective cohort study that investigates the impact of preoperative depression on the incidence of postoperative delirium among elderly Chinese patients…
- Trial name
- NCT07744282
- Volunteers
- 8,000 people
- Sponsor
- Chinese PLA General Hospital
Axial Spondyloarthritis (AxSpA), Spondyloarthritis (SpA)
Multicenter Validation of the 2025 Classification Criteria for Axial Spondyloarthritis
This study aims to validate the 2025 ASAS-SPARTAN revised classification criteria for axial spondyloarthritis (axSpA) in the Chinese population through a multicenter, prospective, cross-sectional observational study.
- Conditions
- Axial Spondyloarthritis (AxSpA), Spondyloarthritis (SpA), Chronic Back Pain
- Trial name
- MVAS2025 (NCT07724847)
- Testing
- Diagnostic Assessment
- Where
- China
- Volunteers
- 247 people
- Sponsor
- Chinese PLA General Hospital
Helicobacter Pylori, Early Gastric Cancer
Helicobacter Pylori Infection Status and Pathological Features for Predicting Gastric Cancer Biological Behavior and Prognosis: A Real-World Observational Study
This multicenter retrospective and prospective real-world observational study will evaluate the relationship of Helicobacter pylori (H.
- Trial name
- NCT07724496
- Testing
- 13C-Urea Breath Test, Serum Helicobacter pylori Antibody Testing, Pathological Assessment of Gastric Tissue
- Where
- 3 sites in China
- Volunteers
- 1,500 people
- Sponsor
- Chinese PLA General Hospital
Immunoglobulin G4-Related Disease
Efficacy and Safety of Lenalidomide in Patients With IgG4-Related Disease
Immunoglobulin G4-related disease (IgG4-RD) is a chronic immune-mediated disorder characterized by inflammation, fibrosis, and involvement of multiple organs.
- Trial name
- LENITY (NCT07719543)
- Testing
- Lenalidomide
- Where
- 3 sites in China
- Volunteers
- 146 people
- Sponsor
- Chinese PLA General Hospital
Benign Prostatic Hyperplasia, Bladder Outlet Obstruction
Thulium Laser Enucleation With Bladder Neck Incision for Small-Volume Benign Prostatic Hyperplasia
This study will evaluate the safety and effectiveness of different surgical treatments for men with small-volume benign prostatic hyperplasia (BPH).
- Conditions
- Benign Prostatic Hyperplasia, Bladder Outlet Obstruction, Lower Urinary Tract Symptoms (LUTS)
- Trial name
- ThuLEP-BNI (NCT07569874)
- Testing
- Thulium Laser Enucleation of the Prostate Combined With Bladder Neck Incision, Thulium Laser Enucleation of the Prostate, Transurethral Resection of the Prostate
- Where
- China
- Volunteers
- 932 people
- Sponsor
- Chinese PLA General Hospital
Ann Arbor Stage II Follicular Lymphoma, Grade 1 Follicular Lymphoma
Combination of Zanubrutinib, Rituximab and Venetoclax in Patients With Previously Untreated Follicular Lymphoma
This is a single center, open label, single arm phase II clinical trial. The objective of this study is to assess the feasibility and efficacy of zanubrutinib combined with venetoclax and Rituximab in patients with previously…
- Conditions
- Ann Arbor Stage II Follicular Lymphoma, Grade 1 Follicular Lymphoma, Ann Arbor Stage III Follicular Lymphoma, Ann Arbor Stage IV Follicular Lymphoma
- Trial name
- NCT06471738
- Testing
- Zanubrutinib, Rituximab, Venetoclax
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Chinese PLA General Hospital
Non-Hodgkin's Lymphoma
Safety and Efficacy of KSVCBD Injection in B-cell Non-Hodgkin's Lymphoma Expressing CD19 and/or BCMA
KSVCBD injection is an in vivo Chimeric Antigen Receptor T-Cell (CAR-T cell) therapy product. This multicenter, single-arm, open-label, early exploratory clinical study is designed to evaluate the preliminary safety and efficacy…
- Trial name
- NCT07620314
- Testing
- KSVCBD injection
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Chinese PLA General Hospital