Clinical trials: sponsored by Chinese PLA General Hospital
Relapsed Non-Hodgkin Lymphoma, Refractory Non-Hodgkin Lymphoma
Study Evaluating the Efficacy and Safety With CD19CAR-T for Relapsed or Refractory Non-Hodgkin Lymphoma
This study is a single-arm, open label, phase I clinical trial to evaluate the safety and feasibility of CD19CAR-T in treatment of relapsed / refractory non-hodgkin lymphoma
- Trial name
- NCT04012892
- Testing
- CD19 CART
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Chinese PLA General Hospital
Relapsed Acute Lymphoblastic Leukemia, Refractory Acute Lymphoblastic Leukemia
Study Evaluating the Efficacy and Safety With CD19CAR-T for Relapsed or Refractory Acute Lymphoblastic Leukemia
This study is a single-arm, open label, phase I clinical trial to evaluate the safety and feasibility of CD19CAR-T in treatment of relapsed / refractory acute lymphoblasic leukemia.
- Trial name
- NCT04012879
- Testing
- CD19 CART
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Chinese PLA General Hospital
AML
Decitabine Based Chemotherapy Followed by Haploidentical Lymphocyte Infusion for Elderly Patients With AML
Demethylating agent decitabine enhances the immunogenicity of leukemia cells by inducing the expression of cancer testis antigens (CTAs),MHC class I and II molecules,costimulatory molecules and adhesion molecules.
- Trial name
- NCT02662647
- Testing
- Decitabine 20 mg/m²/day for 5 days
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Chinese PLA General Hospital
Coronary Artery Calcification
Melatonin and Coronary Artery Calcification
The investigators planned to research the association between plasma melatonin and coronary artery calcification in a Chinese population.
- Trial name
- NCT03967366
- Where
- China
- Volunteers
- 574 people
- Sponsor
- Chinese PLA General Hospital
Coronary Artery Calcification
Melatonin on Coronary Artery Calcification
We planned to evaluate the effects of melatonin on progression of coronary artery calcification (CAC) in patients with moderate calcified coronary atherosclerosis.
- Trial name
- MelonCAC (NCT03966235)
- Testing
- Melatonin 3 mg
- Where
- China
- Volunteers
- 74 people
- Sponsor
- Chinese PLA General Hospital
Hepatocellular Carcinoma
By Developing a Radiomics Model to Predict the Prognosis of Patients With Hepatocellular Carcinoma After Microwave Ablation
Developing a radiomics model to predict the prognosis of patients with hepatocellular carcinoma after microwave ablation to provide advice for their treatment.
- Trial name
- NCT03880721
- Testing
- Microwave abaltion
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Chinese PLA General Hospital
Advanced Solid Tumors
A Real World Study of Anti-PD-1/PD-L1 Antibodies for the Treatment of Advanced Solid Tumors
The study was designed to analyze the efficacy and safety of anti-PD-1/PD-L1 antibodies for the treatment of advanced solid tumors.
- Trial name
- NCT03787953
- Testing
- Anti-PD-1/PD-L1 antibodies
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Chinese PLA General Hospital
Hematopoietic/Lymphoid Cancer, Adult Acute Lymphoblastic Leukemia in Remission
Treatment of Relapsed and/or Chemotherapy Refractory B-cell Malignancy by Tandem CAR T Cells Targeting CD19 and CD22
RATIONALE: Placing a tumor antigen chimeric receptor that has been created in the laboratory into patient autologous or donor-derived T cells may make the body build immune response to kill cancer cells.
- Conditions
- Hematopoietic/Lymphoid Cancer, Adult Acute Lymphoblastic Leukemia in Remission, B-cell Adult Acute Lymphoblastic Leukemia, B-Cell Chronic Lymphocytic Leukemia in Relapse (Diagnosis)
- Trial name
- NCT03185494
- Testing
- anti-CD19/22-CAR vector-transduced T cells
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Chinese PLA General Hospital
Coronary Artery Disease
efficAcy and Safety of Home-baSed Cardiac rehabIlitation in ChineSe Revascularized patienTs
Home-based CR (HBCR) was reported to improve the clinical outcomes of coronary artery disease (CAD) patients. There is no data published to investigate whether HBCR is also effective for Chinese CAD patients who have been…
- Trial name
- ASSIST (NCT03102346)
- Testing
- home-based cardiac rehabilitation
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Chinese PLA General Hospital
Hodgkin Lymphoma
SHR-1210 Alone or in Combination With Decitabine in Relapsed or Refractory Hodgkin Lymphoma
This is a two-stage, Phase II clinical trial for patients with relapsed or refractory Hodgkin Lymphoma. The purpose of stage I is to evaluate whether treatment with the study drug decitabine in combination with SHR-1210 is safe…
- Trial name
- NCT03250962
- Testing
- SHR-1210, Decitabine
- Where
- China
- Volunteers
- 280 people
- Sponsor
- Chinese PLA General Hospital
Focal Liver Lesions, Ultrasonics
Utility of Ultrasound Imaging for Diagnosis of Focal Liver Lesions: A Radiomics Analysis
Ultrasound (US) as first-line imaging technology in detecting focal liver lesions,also plays a crucial role in evaluating image and guiding ablation which is the main treatment for liver lesions.
- Conditions
- Focal Liver Lesions, Ultrasonics, Intelligent Diagnosis, Ablation
- Trial name
- NCT03871140
- Testing
- diagnosis
- Where
- China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Immunoglobulin G4 Related Sclerosing Disease
Leflunomide for Maintenance of Remission in IgG4 Related Disease
The study has been designed as a 12-month, open-label, randomized, controlled study comparing the use of prednisone mono-therapy and prednisone and leflunomide combination therapy in treating patients with IgG4-related disease.
- Trial name
- NCT02703194
- Testing
- Prednisone, Leflunomide
- Where
- China
- Volunteers
- 68 people
- Sponsor
- Chinese PLA General Hospital
CHD - Coronary Heart Disease, Percutaneous Coronary Intervention
Optical Coherence Tomography Guided Percutaneous Coronary Intervention for Drug-eluting In-stent Restenosis
This study is a prospective, registry trial aimed to compare the clinical and angiographic outcomes of OCT-guided and angiography-guided PCI in patients with coronary DES-ISR.
- Conditions
- CHD - Coronary Heart Disease, Percutaneous Coronary Intervention, In-stent Restenosis
- Trial name
- NCT03809754
- Testing
- Percutaneous Coronary Intervention under OCT, Percutaneous Coronary Intervention under Angiography
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Chinese PLA General Hospital
Moyamoya Disease, Magnetic Resonance Imaging
Predicative Value of Multimodal MRI in Moyamoya Disease
Moyamoya disease (MMD) is a nonatherosclerotic cerebrovascular abnormality, characterized by a progressive stenosis or occlusion of the intracranial internal carotid arteries (ICAs) and their proximal branches, with subsequent…
- Trial name
- NCT03785171
- Testing
- surgical revascularization
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Chinese PLA General Hospital
Donor Lymphocyte Infusion, Peripheral Blood Stem Cell Transplantation
Prophylactic Donor Lymphocyte Infusion After Allo-PBSCT for Patients With Very High-risk Hematologic Malignancies
Unmanipulated allogenic peripheral blood stem cell transplantation (allo-PBSCT) has been an established treatment to cure high-risk leukemia/lymphoma.
- Conditions
- Donor Lymphocyte Infusion, Peripheral Blood Stem Cell Transplantation, Relapse, Graft-versus-host Disease
- Trial name
- NCT03771222
- Testing
- Prophylactic DLI
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Chinese PLA General Hospital
Coronary Heart Disease
The Effect of Simvastatin Combined With Ezetimibe in Patients With Stable Angina and Diabetes
In this study, simvastatin combined with Ezeimebum was used to enhance lipid reduction, and IVUS was used to evaluate the volume and composition of coronary plaque before and after treatment.
- Trial name
- NCT03771053
- Testing
- Ezetimibe with simvastatin, Simvastatin
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Chinese PLA General Hospital
Multiple Myeloma
A Feasibility and Safety Study of Dual Specificity CD38 and BCMA CAR-T Cell Immunotherapy for Relapsed or Refractory Multiple Myeloma
CAR-T cell therapy has shown promising results for the treatment of relapsed or refractory Multiple Myeloma,however, a subset of patients relapse due to the loss of target in tumor cells.Dual Specificity CD38 and BCMA CAR-T cells…
- Trial name
- NCT03767751
- Testing
- Dual Specificity CD38 and bcma CAR-T Cells
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Chinese PLA General Hospital
Relapsed B-cell Acute Lymphoblastic Leukemia After CD19 CAR-T ACI
A Feasibility and Safety Study of CD38 CAR-T Cell Immunotherapy for Relapsed B-cell Acute Lymphoblastic Leukemia After CD19 CAR-T Adoptive Cellular Immunotherapy
CD19-directed CAR-T cell therapy has shown promising results for the treatment of relapsed or refractory B-cell malignancies; however, a subset of patients relapse due to the loss of CD19 in tumor cells.
- Trial name
- NCT03754764
- Testing
- Specificity CD38 CAR-T Cells
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Chinese PLA General Hospital
To Evaluate the Diagnostic Value of Candida Antigen Antibody Detection for Candida Infection
Antigenic and Antibody Detection of Candida
In this study, a multicenter, prospective, synchronous blind, and controlled study was adopted to set the cut-off values of candida specific IgG, IgM, and Mn with the blood culture results as the gold standard, so as to evaluate…
- Trial name
- NCT03766932
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Primary Mediastinal Large B-cell Lymphoma
Two Stage Study of Combination of Chemotherapy, SHR-1210 and/or Decitabine for Relapsed/Refractory PMBCLs
This is a two stage, Phase I/II clinical trial for patients with relapsed or refractory primary mediastinal large B-cell lymphoma (rrPMBCL).
- Trial name
- NCT03346642
- Testing
- Decitabine, GVD chemotherapy, SHR-1210
- Where
- 2 sites in China
- Volunteers
- 30 people
- Sponsor
- Chinese PLA General Hospital