Clinical trials: sponsored by Chinese PLA General Hospital
Solid Tumor, Adult
Study of PD-1 Gene-knocked Out Mesothelin-directed CAR-T Cells With the Conditioning of PC in Mesothelin Positive Multiple Solid Tumors
Multiple solid tumors have positive targets of mesothelin expressed on the surfaces of the tumor cells, the investigators use the technique of CRISPR-Cas9 to knocked out the PD-1 of the chimeric antigen receptor (CAR) T cells…
- Trial name
- NCT03747965
- Testing
- Mesothelin-directed CAR-T cells
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Chinese PLA General Hospital
Acute Coronary Syndrome, Percutaneous Coronary Intervention
Effectiveness of Artificial Intelligent Based mHealth System to Reduce ACS Patients Bleeding Events After PCI
The present study was designed to observe the effectiveness of artificial intelligent based mHealth system(Chronic disease management system) to reduce bleeding events in ACS patients undergoing PCI.
- Conditions
- Acute Coronary Syndrome, Percutaneous Coronary Intervention, Bleeding
- Trial name
- NCT03738930
- Testing
- AI based mHealth system
- Where
- China
- Volunteers
- 420 people
- Sponsor
- Chinese PLA General Hospital
Small Intestinal Bacterial Overgrowth, Elderly
Characteristic of Intestinal Flora in Male Elderly With Small Intestinal Bacterial Overgrowth
We will focus on the intestinal flora structure, risk factors and clinical features of male elderly with SIBO in our study.
- Conditions
- Small Intestinal Bacterial Overgrowth, Elderly, Male, 16s rRNA
- Trial name
- IFOSIBO (NCT03659175)
- Testing
- SIBO
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Atherosclerosis Type 2 Diabetes Mellitus Dipeptidyl Peptidase-4 Inhibitor GLP-1
Effects of a Dipeptidyl Peptidase-4 Inhibitor Sitagliptininsulin on the Progression of Coronary Atherosclerosis in Patients With Type 2 Diabetes
This study was to investigate the Effect of Sitagliptin, a dipeptidyl peptidase-4 inhibitor, on progression of coronary atherosclerosis in patients with type 2 diabetes.
- Trial name
- NCT03602638
- Testing
- Sitagliptin, Acarbose
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Reperfusion Injury, Myocardial
Empagliflozin on Cardiac-renal Injury in Patients With STEAMI Patients After Primary PCI
This study is a single-center, prospective controlled trial addressing effectiveness of empagliflozin on cardiac-renal injury in patients with STEMI.
- Trial name
- NCT03591991
- Testing
- Empagliflozin
- Volunteers
- 128 people
- Sponsor
- Chinese PLA General Hospital
Gastroesophageal Reflux Disease, Dyspepsia
Endoscopic Tri-Modal Imaging to Distinguish Functional Dyspepsia From Reflux Disease
Endoscopic Tri-Modal Imaging which combines Narrow-band Imaging(NBI), Autofluorescence Imaging (AFI) and White-light Imaging (WLI) could be used to identify the indistinct changes in the gut caused by reflux disease,either acid…
- Conditions
- Gastroesophageal Reflux Disease, Dyspepsia, Bile Reflux
- Trial name
- NCT02685150
- Testing
- Endoscopic Tri-Modal Imaging, Omeprazole, Analysis of gastric juice
- Where
- China
- Volunteers
- 157 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Diffuse Coronary Artery Lesions
Comparison of Safety and Efficacy of Coronary Drug-coated Balloon (DCB) Combined With Spot Stenting of Drug-eluting Stent (DES) Versus Second-generation DES for Treating Diffuse Coronary Artery Lesions: a Prospective, Randomized, Controlled Clinical Trial
The prospective, randomized, controlled clinical trial aims to evaluate the safety and efficacy of paclitaxel-eluting PTCA-balloon catheter (SeQuent® Please) combined with provisional spot stenting of DES versus DES for treating…
- Trial name
- NCT03589157
- Testing
- drug-coated balloon (DCB) combined with spot stenting of drug-eluting stent (DES), drug-coated balloon (DCB) combined with second-generation of drug-eluting stent (DES)
- Volunteers
- 140 people
- Sponsor
- Chinese PLA General Hospital
Renal Dialysis, Hemoperfusion
Combination of Hemodialysis With Hemoperfusion：A Clinical Study
This study is a prospective, randomized, controlled multicenter clinical study. The aim of the study is to investigate whether the combination of maintenance hemodialysis (MHD) with hemoperfusion (HP) could improve the clearance…
- Conditions
- Renal Dialysis, Hemoperfusion, Quality of Life
- Trial name
- NCT02461953
- Testing
- hemoperfusion apparatus, low flux dialyzer, high flux dialyzer
- Where
- China
- Volunteers
- 440 people
- Sponsor
- Chinese PLA General Hospital
Hemodialysis
Evaluation of Domestic Hemodialysis Machine: A Multi-center Clinical Study
An important reason for the costs of hemodialysis treatment in China are expensive is the hemodialysis machine and related products mainly rely on imports.
- Trial name
- NCT02904343
- Testing
- domestic hemodialysis machine, imported hemodialysis machine
- Sponsor
- Chinese PLA General Hospital
Esophageal Cancer
A Observational Study to Compare Effectiveness and Safety of the Surgeries in Patients With Esophageal Cancer
The study was designed to compare effectiveness and safety of the surgeries of Ivor-Lewis and Mckeown in patients with esophageal cancer
- Trial name
- NCT03428074
- Testing
- Surgeries
- Where
- 9 sites in China
- Volunteers
- 1,862 people
- Sponsor
- Chinese PLA General Hospital
Psoriasis, Adoptive Immunotherapy
Autologous Cytokine Induced Killer Cells (CIK) for Patients With Severe Psoriasis
to determine the therapeutic roles of CIK cells on patients with psoriasis
- Trial name
- NCT01894373
- Testing
- Adoptive Immunotherapy, CIK
- Where
- China
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Gastric Cancer
Apatinib Plus Docetaxel Versus Docetaxel as Second-line Treatment in Advanced Gastric Cancer (AHEAD-301)
Apatinib plus docetaxel versus docetaxel as second-line treatment in advanced gastric cancer.
- Trial name
- NCT02596256
- Testing
- Apatinib, Docetaxel
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Chinese PLA General Hospital
B Cell Leukemia
A Feasibility and Safety Study of Concomitant Therapy With Allo-CAR-T Cells and Allo-HSCT in Patients With Relapse or Refractory Leukemia
Allogenic hematopoietic stem cell transplant (Allo-HSCT) is routinely used for treatment of aggressive hematological malignancies.
- Trial name
- NCT03463928
- Testing
- donor-derived CD19/22 bispecific CAR-T cells or CD19-directed CAR-T cells; donor-derived-HSCT
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Chinese PLA General Hospital
Non Small Cell Lung Cancer
Liquid Biopsy for Detection of Driver Mutation in NSCLC
The purpose of this study is to evaluate the diagnostic and prognostic efficacy of liquid biopsy in different specimens and in different methods compared with tissue detection .
- Trial name
- NCT02778854
- Testing
- detection of driver mutation
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Chinese PLA General Hospital
Chemotherapy
DCHA as Postremission Therapy for AML With t(8;21)
Acute myelocytic leukemia ( AML) is a highly heterogeneous group of malignant hematopathy. Chromosomal translocation with t (8; 21) (q22; q22) , about 10 ~ 15% incidence in AML and 40% incidence in the AML-M2 type of leukemia, is…
- Trial name
- NCT03453255
- Testing
- Chemotherapy
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Chinese PLA General Hospital
AML, Relapse
Chidamide Plus DCAG for Relapsed/Refractory AML
Despite advances in understanding the complexities of acute myeloid leukaemia (AML), the treatment of refractory or relapsed AML (rrAML) remains a daunting clinical challenge.The investigators designed a new regimen, including…
- Trial name
- NCT02886559
- Testing
- Chidamide plus DCAG regimen
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Chinese PLA General Hospital
Acute Coronary Syndrome, Percutaneous Coronary Intervention
Registry of Bleeding Risk in Real World Chinese Acute Coronary Syndrome Patients-II
The present study was designed to observe the incidence of bleeding events and characteristics of bleeding and exploratively analyse bleeding related biomarkers and gene polymorphisms in ACS patients undergoing PCI.
- Conditions
- Acute Coronary Syndrome, Percutaneous Coronary Intervention, Bleeding
- Trial name
- NCT03402711
- Where
- China
- Volunteers
- 5,500 people
- Sponsor
- Chinese PLA General Hospital
B Cell Leukemia, B Cell Lymphoma
A Feasibility and Safety Study of Universal Dual Specificity CD19 and CD20 or CD22 CAR-T Cell Immunotherapy for Relapsed or Refractory Leukemia and Lymphoma
CD19-directed CAR-T cell therapy has shown promising results for the treatment of relapsed or refractory B-cell malignancies; however, a subset of patients relapse due to the loss of CD19 in tumor cells.
- Trial name
- NCT03398967
- Testing
- Universal Dual Specificity CD19 and CD20 or CD22 CAR-T Cells
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Chinese PLA General Hospital
Type 2 Diabetes Mellitus
Effect of Probiotics on Pre-diabetes and Diabetes in China
This study is aimed at verifying the effects of probiotics (KAWAI:dead S.thermophilus) on glucos management among T2DM and pre-diabetes Chinese adult.
- Trial name
- NCT03377946
- Testing
- probiotics
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Chinese PLA General Hospital
Colorectal Cancer
A Study of Apatinib in Combination With Raltitrexed Treatment in Patients With Advanced Colorectal Cancer
30 patients with advanced colorectal cancer will be enrolled to observe the efficacy and safety of raltitrexed combined with apatinib as a third-line treatment.
- Trial name
- NCT03344614
- Testing
- raltitrexed combined with apatinib
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Chinese PLA General Hospital