Clinical trials: sponsored by Chinese PLA General Hospital
Allogeneic Hematopoietic Stem Cell Transplantation (HSCT)
Ruxolitinib-Decitabine Intensified Conditioning Regimen for AML: A Randomized Trial
This study aims to determine whether the recurrence rate of high-risk acute myeloid leukemia CR1 patients who received allogeneic hematopoietic stem cell transplantation with the Ruxolitinib, Decitabine combined with Bu/Cy or BuF…
- Trial name
- NCT07101588
- Testing
- Ruxolitinib, Decitabine
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Chinese PLA General Hospital
Papillary Thyroid Cancer
The Clinical Outcomes and Prediction of Thermal Ablation for Low-risk Papillary Thyroid Carcinoma
1. To evaluate the clinical outcomes of ultrasound-guided thermal ablation and thyroid surgery for the treatment of papillary thyroid carcinoma; 2.
- Trial name
- NCT06316895
- Testing
- thyroid surgery, ultrasound-guided thermal ablation
- Where
- China
- Volunteers
- 3,772 people
- Sponsor
- Chinese PLA General Hospital
Thyroid Nodules
The Outcomes of Ultrasound-guided Thermal Ablation for Benign Thyroid Nodules
1. To evaluate the clinical outcomes of ultrasound-guided thermal ablationfor the treatment of benign thyroid nodules; 2. To develop and validate a artificial intelligence model to predict the outcomes of ultrasound-guided…
- Trial name
- NCT06340945
- Testing
- ultrasound-guided thermal ablation
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Chinese PLA General Hospital
Postoperative Delirium (POD), Postoperative
Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Postoperative Delirium and Negative Emotions in Patients Undergoing Cardiac Surgery
A multicenter, randomized, double-blind, sham-controlled trial to investigate the effects of intraoperative transcutaneous auricular vagus nerve stimulation (taVNS) on the incidence of postoperative delirium and negative…
- Conditions
- Postoperative Delirium (POD), Postoperative, Anxiety, Depression
- Trial name
- NCT07476742
- Testing
- Active taVNS
- Where
- China
- Volunteers
- 270 people
- Sponsor
- Chinese PLA General Hospital
Postoperative Analgesia
The Impact of Intrapleural Block on Postoperative Pain Caused by Drainage Tubes After Thoracoscopic Surgery
the investigators hereby invite participants to participate in a study entitled "The Impact of Intrapleural Block via Thoracoscopic Surgery on Postoperative Pain Caused by Drainage Tubes".
- Trial name
- NCT07294755
- Testing
- normal saline, Investigational drug 20 mL of 0.5% ropivacaine, 0.5% ropivacaine + 25 mg tetracaine, made up to a total volume of 20 mL
- Volunteers
- 300 people
- Sponsor
- Chinese PLA General Hospital
Neuromyelitis Optica Spectrum Disorder Attack
Therapy in the Acute Phase of NMOSD: A Multicenter Prospective Real-World Study
This project is a multi-center, prospective, real-world cohort study that collects clinical data of Chinese patients with AQP4-positive NMOSD in the acute stage.
- Trial name
- ETA/PETA-NMOSD (NCT07410039)
- Testing
- Eculizumab+IVMP, IVIG+IVMP, IVMP
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Chinese PLA General Hospital
Depression, Postoperative
Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Perioperative Negative Emotions in Breast Cancer Surgery Patients
A multicenter, randomized, double-blind, sham-controlled trial to investigate the effects of a single session of intraoperative transcutaneous auricular vagus nerve stimulation (taVNS) on perioperative negative emotions (anxiety…
- Conditions
- Depression, Postoperative, Anxiety, Breast Surgery
- Trial name
- NCT07458646
- Testing
- Active taVNS
- Where
- 2 sites in China
- Volunteers
- 232 people
- Sponsor
- Chinese PLA General Hospital
Treatment for Advanced Colorectal Cancer, Treatment for Advanced Pancreatic Cancer
Efficacy of Tunlametinib in Combination With Anti-EGFR Monoclonal Antibody in Patients With RAS-Mutated Advanced Gastrointestinal Malignancies
Efficacy of Tunlametinib in Combination With Anti-EGFR Monoclonal Antibody in Patients With RAS-Mutated Advanced Gastrointestinal Malignancies
- Trial name
- NCT07446270
- Testing
- Colorectal cancer: Tunlametinib + cetuximab β, Pancreatic cancer: Tunlametinib + cetuximab β, Pancreatic cancer: Tunlametinib +Nimotuzumab
- Volunteers
- 90 people
- Sponsor
- Chinese PLA General Hospital
Colorectal Cancer, Adult
PIN in Combination With Sintilimab in Previously Treated pMMR/MSS CRC With Hepatic Metastases
In this single-center,open-label, phase I study, the safety and efficacy of PIN in combination with anti-programmed cell death -1 (anti-PD1) antibody therapeutic regimen (sintilimab) will be evaluated in patients with advanced…
- Trial name
- NCT07411781
- Testing
- PIN+sintilimab
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Chinese PLA General Hospital
Postoperative Depression
The Impact of Preoperative Chronic Pain on Postoperative Depressive States in Elderly Patients Undergoing Joint Replacement Surgery: A Secondary Analysis Based on Prospective Data
Background: Postoperative depression is a significant complication that hinders recovery in elderly patients undergoing joint replacement surgery.
- Trial name
- NCT07403838
- Where
- China
- Volunteers
- 575 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Colorectal Cancer
GSL Synthetase Inhibitor Plus Immune Checkpoint Inhibitor and/or Regorafenib in Previously Treated pMMR/MSS CRC.
In this single-center,open-label, randomized, phase II study, the efficacy and feasibility of GSL synthetase inhibitor in combination with immune checkpoint inhibitor and/or regorafenib therapeutic regimen will be evaluated in…
- Trial name
- NCT06558773
- Testing
- Regorafenib+Immune checkpoint inhibitor, Eliglustat+Immune checkpoint inhibitor, Eliglustat+Immune checkpoint inhibitor +Regorafenib
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Chinese PLA General Hospital
Pneumonia
Effectiveness of OLE Airway Clearance Therapy in ICU Patients With Pulmonary Infections
This study aims to explore the application of Electrical Impedance Tomography (EIT) in evaluating the effectiveness of OLE (Oscillatory Lung Expansion) airway clearance therapy for ICU patients with pulmonary infections.
- Trial name
- NCT07395297
- Testing
- Oscillatory Lung Expansion (OLE) Therapy
- Where
- China
- Volunteers
- 62 people
- Sponsor
- Chinese PLA General Hospital
Pneumonia, Aspiration
The Clinical Application Value of "Showering Cells" in the Diagnosis of Aspiration Pneumonia
Based on our team's previous discovery of a unique type of squamous epithelial cell in the bronchoalveolar lavage fluid (BALF) of patients with aspiration pneumonia (AP) using microbiological rapid on-site evaluation (M-ROSE)…
- Trial name
- NCT07395310
- Where
- China
- Volunteers
- 94 people
- Sponsor
- Chinese PLA General Hospital
Pulmonary Disease
Evaluation of the Effect of Pulmonary Rehabilitation on Patients With High Flow Oxygen Therapy
Evaluation of the effect of pulmonary rehabilitation on patients with high flow oxygen therapy
- Trial name
- NCT04441151
- Testing
- Pulmonary rehabilitation therapy
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Chinese PLA General Hospital
Advanced Colorectal Cancer
Clinical Study on the First-line Treatment of Advanced Colorectal Cancer With Simultaneous Infusion of Levozolinate for Injection and 5-FU
Phase II study of simultaneous infusion of levozolinate for injection and 5-FU as first-line treatment for advanced colorectal cancer
- Trial name
- NCT07391618
- Testing
- mFOLFOX/FOLFIRI ( Standard Chemotherapy)
- Where
- China
- Volunteers
- 583 people
- Sponsor
- Chinese PLA General Hospital
Migraine
ARISE-A Chinese Real-world Study of Rimegepant for the Acute Treatment of Migraine
Research question and objectives Primary endpoint To evaluate the effectiveness of Rimegepant in the acute treatment of migraine as measured by most severe pain, onset of pain relief, satisfaction with pain relief, and…
- Trial name
- NCT06439628
- Testing
- Rimegepant
- Where
- 3 sites in China
- Volunteers
- 3,000 people
- Sponsor
- Chinese PLA General Hospital
Coronary Artery Disease, Chronic Kidney Disease
Hydration Guided by Remote Dielectric Sensing (ReDS) System for Preventing Acute Kidney Injury in Elderly Patients With Renal Insufficiency for Coronary Angiography and Intervention
Explore the effectiveness and safety of tailored hydration guided by lung water index monitor system for prevention of acute kidney injury after percutaneous coronary intervention for elderly patients with renal insufficiency.
- Conditions
- Coronary Artery Disease, Chronic Kidney Disease, Elderly
- Trial name
- HISTORY (NCT07394959)
- Testing
- Tailored hydration guided by ReDS system
- Where
- China
- Volunteers
- 320 people
- Sponsor
- Chinese PLA General Hospital
Depression, Anxiety
Effect of Continuous Intraoperative Esketamine Infusion on Perioperative Negative Emotions in Breast Cancer Surgery Patients With Mild-to-Severe Depression
A Dual-Center, Randomized, Controlled, Blinded, Prospective Study on the Effects of Esketamine on Perioperative Negative Emotions in Breast Cancer Surgery Patients with Mild-to-Severe Depression
- Conditions
- Depression, Anxiety, S-ketamine, Breast Cancer
- Trial name
- NCT07374198
- Testing
- Esketamine 0.3mg/kg, normal saline
- Volunteers
- 142 people
- Sponsor
- Chinese PLA General Hospital
Depression, Anxiety
Effect of Esketamine on Perioperative Negative Emotions in Breast Cancer Surgery Patients With Severe Depression
This project employs a prospective, randomized, controlled, blinded, dual-center study design to investigate the effects of intraoperative esketamine on perioperative anxiety and depression symptoms in patients with severe…
- Conditions
- Depression, Anxiety, S-ketamine, Breast Cancer
- Trial name
- NCT07374211
- Testing
- Esketamine 0.3mg/kg, normal saline
- Volunteers
- 242 people
- Sponsor
- Chinese PLA General Hospital
Pain Management
Anesthetic Management Guided by the Medstrom Instrument
This clinical trial seeks to evaluate the feasibility of the Medstrom device for integrated real-time monitoring of pain, sedation, and neuromuscular blockade during laparoscopic radical colectomy.
- Trial name
- NCT07089017
- Testing
- medstrom仪器
- Volunteers
- 30 people
- Sponsor
- Chinese PLA General Hospital