Clinical trials: sponsored by Chinese PLA General Hospital
Advanced Gastroesophageal Adenocarcinoma, First-line Therapy
CAPOX + Bevacizumab + Tislelizumab Treating PD-L1 CPS < 5 Locally Advanced or Metastatic GEA
his study was a single-arm, open, single-center Phase ii clinical trial to observe and evaluate the efficacy and safety of CAPOX+ bevacizumab + tislelizumab in first-line treatment of ADVANCED gastroesophageal adenocarcinoma with…
- Conditions
- Advanced Gastroesophageal Adenocarcinoma, First-line Therapy, PDL1 CPS < 5
- Trial name
- NCT05299476
- Testing
- CAPOX combined with bevacizumab and Tislelizumab
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Chinese PLA General Hospital
Regional Anaesthesia, Postoperative Delirium (POD)
Association of Transversus Abdominis Plane Block (TAPB) with Postoperative Delirium (POD) in Elderly Patients Undergoing Major Gastrointestinal Surgery
Postoperative delirium can increase postoperative adverse reactions and prognosis in elderly patients undergoing gastrointestinal surgery.
- Conditions
- Regional Anaesthesia, Postoperative Delirium (POD), Transversus Abdominis Plane Block (TAP Block)
- Trial name
- NCT06829108
- Volunteers
- 5,220 people
- Sponsor
- Chinese PLA General Hospital
Thyroid Nodule (Benign)
Ultrasound-guided Thermal Ablation for Benign Thyroid Nodules
To evaluate long-term outcomes of ultrasound-guided thermal ablation for benign thyroid nodules
- Trial name
- NCT06729762
- Testing
- ultrasound-guided thermal ablation
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Chinese PLA General Hospital
Recurrent Thyroid Cancer
Ultrasound-guided Thermal Ablation for Recurrent Thyroid Cancer
To evaluate the long-term outcomes of ultrasound-guided thermal ablation for recurrent thyroid cancer
- Trial name
- NCT06733766
- Testing
- ultrasound-guided thermal ablation
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Chinese PLA General Hospital
Thyroid Nodule
Ultrasound-guided Thermal Ablation for Bethesda III/IV Thyroid Nodules
To evaluate the long-term outcomes of ultrasound-guided thermal ablation for Bethesda III/IV thyroid nodules
- Trial name
- NCT06733753
- Testing
- ultrasound-guided thermal ablation
- Where
- 2 sites in China
- Volunteers
- 600 people
- Sponsor
- Chinese PLA General Hospital
Papillary Thyroid Cancer
Ultrasound-guided Thermal Ablation for Papillary Thyroid Carcinoma
To evaluate long-term outcomes of ultrasound-guided thermal ablation for the treatment of papillary thyroid carcinoma
- Trial name
- NCT06733740
- Testing
- ultrasound-guided thermal ablation
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Chinese PLA General Hospital
Hepatocellular Carcinoma
Fusing Ultrasound and Magnetic Resonance Imaging to Intelligently Plan Highly Conformal Ablation Thermal Field for Hepatocellular Carcinoma
Thermal ablation is an important minimally invasive treatment for hepatocellular carcinoma (HCC), but local tumor progression (LTP) after ablation restricts the efficacy and status of ablation technology and seriously threatens…
- Trial name
- NCT06798194
- Testing
- Post-ablation MRI is used to evaluate whether the ablation area of the tumor is consistent with the highly conformal ablation thermal field provided by the AI model.
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Chinese PLA General Hospital
ST Elevation (STEMI) Myocardial Infarction
Impact of Persistent Microvascular Obstruction by Cardiac Magnetic Resonance on Prognosis for ST-segment Elevation Myocardial Infarction
The aims of the study were to evaluate the predictive value of persistent microvascular obstruction (MVO) by cardiac magnetic resonance for main adverse cardiac events in ST-segment elevation myocardial infarction patients.
- Trial name
- IMCOME (NCT06759532)
- Where
- China
- Volunteers
- 344 people
- Sponsor
- Chinese PLA General Hospital
HCC - Hepatocellular Carcinoma, Microvascular Invasion (MVI)
Microvascular Invasion Artificial Intelligence Prediction Via Contrast-enhanced Ultrasound With Explainability
An artificial intelligence (AI) model to predict MVI of HCC using contrast-enhanced ultrasound was constructed. This model also has biological explainability.
- Trial name
- MAPUSE (NCT06760494)
- Testing
- the MAPUSE model
- Where
- 2 sites in China
- Volunteers
- 250 people
- Sponsor
- Chinese PLA General Hospital
Pancreatic Cancer, PDAC - Pancreatic Ductal Adenocarcinoma
Surufatinib Plus Camrelizumab and AS in First Line Treatment of Advanced Metastatic Pancreatic Cancer
This study is designed to explore the efficacy and safety of surufatinib combined with camrelizumab and AS (nab-paclitaxel and S-1) as first-line treatment compared with AG (nab-paclitaxel and gemcitabine) in unresectable…
- Conditions
- Pancreatic Cancer, PDAC - Pancreatic Ductal Adenocarcinoma, Pancreas Cancer, Pancreatic Neoplasms
- Trial name
- NCT05218889
- Testing
- surufatinib + camrelizumab + nab-paclitaxel + S-1, nab-paclitaxel + gemcitabine
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Chinese PLA General Hospital
Fracture of Neck of Femur
Medial Enhancement Technique for the Treatment of Old Femoral Neck Fractures
A prospective, multi-center, randomized controlled study was conducted to validate the safety and effectiveness of employing the medial augmentation technique (incorporating the dynamic condylar screw and medial support plate)…
- Trial name
- NCT06713031
- Testing
- cannulated compression screws + iliac bone graft, DCS + medial support plate + iliac bone graft
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Chinese PLA General Hospital
Fracture of Neck of Femur
Orthopedic Intelligent Navigation System in the Treatment of Fresh Femoral Neck Fractures
The goal of this clinical trial is to verify the safety and effectiveness of orthopaedic surgical navigation system in the treatment of fresh femoral neck fractures.
- Trial name
- NCT06713018
- Testing
- Three cannulated compression screws by navigation system, Traditional three cannulated compression screws
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Chinese PLA General Hospital
Cytomegalovirus Infections, Infection Reactivation
ATG Individualized Dosing Model in URD-PBSCT.
Anti-thymocyte globulin (ATG) is widely used in allogeneic hematopoietic stem cell transplantation to prevent severe graft-versus-host disease (GVHD) and graft failure.
- Conditions
- Cytomegalovirus Infections, Infection Reactivation, Stem Cell Transplant Complications
- Trial name
- NCT06572462
- Testing
- individualized ATG dosing strategy
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Chinese PLA General Hospital
Achievement Rate, Efficacy and Safety
Thermal Ablation Versus Parathyroidectomy for Secondary Hyperparathyroidism
Secondary hyperparathyroidism (SHPT), which is frequently associated with chronic kidney disease, leads to problems such as bone pain, fractures, and cardiovascular issues, thereby affecting patients' quality of life.
- Conditions
- Achievement Rate, Efficacy and Safety, PTH, Calcium
- Trial name
- NCT06709586
- Testing
- Thermal ablation, parathyroidectomy
- Volunteers
- 612 people
- Sponsor
- Chinese PLA General Hospital
Cure Rate, Complication Rate
Thermal Ablation Versus Parathyroidectomy for Primary Hyperparathyroidism
This study is a prospective, multicenter study designed to compare the efficacy and safety of surgical treatment versus ablation therapy (including radiofrequency ablation and microwave ablation) for patients with primary…
- Conditions
- Cure Rate, Complication Rate, Efficacy and Safety
- Trial name
- NCT06708871
- Testing
- Thermal ablation, Parathyroidectomy
- Volunteers
- 520 people
- Sponsor
- Chinese PLA General Hospital
Coronary Arterial Disease (CAD), Acute Coronary Syndromes
Identification Of High-risk Coronary Plaques By Multimodal Intravascular Imaging
This study is a multicenter prospective observational clinical study, which will be conducted in 11 hospitals, and approximately 500 subjects will be enrolled.
- Trial name
- PlaqueVision (NCT06681155)
- Testing
- Assessment of plaque morphology, structure, and stability in non-culprit lesions
- Where
- 11 sites in China
- Volunteers
- 500 people
- Sponsor
- Chinese PLA General Hospital
Acute Myeloid Leukemia
Clinical Study of Venetoclax Combined with CACAG Regimen in the Treatment of Newly Diagnosed Acute Myeloid Leukemia
The purpose of this study is to evaluate the efficacy and safety of venetoclax combined with CACAG regimen in the treatment of newly diagnosed acute myeloid leukemia.
- Trial name
- NCT05659992
- Testing
- azacytidine;cytarabine;aclamycin;Chidamide;venetoclax;granulocyte
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Chinese PLA General Hospital
Parkinson's Diseases, MRI
7.0T Magnetic Resonance Imaging Study of Parkinson's Disease
This clinical trial study is conducted to detect the imaging characteristics of the patients with Parkinson's diseases (PD) by 7-Tesla (7T) magnetic resonance imaging (MRI).
- Trial name
- NCT06449404
- Testing
- 7T-MRI scaning
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Essential Tremor, Essential Tremor, Movement Disorders
A Study to Evaluate the Safety and Efficacy of Staged Bilateral Magnetic Resonance-Guided Focused Ultrasound Thalamotomy for the Treatment of Essential Tremor
The objective of this prospective, single-arm, open-label study is to asses the safety and efficacy of the staged bilateral thalamotomy using transcranial magnetic resonance guided focused ultrasound system ExAblate 4000…
- Trial name
- ET-Bi-MRgFUS (NCT06676501)
- Testing
- ExAblate
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Chinese PLA General Hospital
Cohort Studies
Effect of Dexmedetomidine on Postoperative Mental Disorders and Long-term Survival in Elderly Patients
China's aging population is causing an increase in the number of senior persons undergoing surgery. More and more clinicians are paying attention to the postoperative survival and mental health of elderly surgical patients.
- Trial name
- NCT06362408
- Testing
- Dexmedetomidine
- Where
- China
- Volunteers
- 6,000 people
- Sponsor
- Chinese PLA General Hospital