Clinical trials: open to volunteers, sponsored by Chinese PLA General Hospital
Hypoxemia
Extubation Safety Via Microstream EtCO₂ (IPI) Monitoring
The goal of this clinical trial is to evaluate whether extubation guided by the Integrated Pulmonary Index (IPI)-a composite respiratory score derived from microstream sidestream end-tidal carbon dioxide (EtCO₂)…
- Trial name
- NCT06975553
- Testing
- endotracheal intubation-type end-tidal carbon dioxide sampling tube
- Where
- China
- Volunteers
- 632 people
- Sponsor
- Chinese PLA General Hospital
Migraine Disorders
A Prospective Study of Rimegepant for Short-term Preventive Treatment of Night-shift-related Migraine in Healthcare Professionals
Background and Objectives: Medical professionals frequently work night shifts and rotating schedules. Night shift work, accompanied by sleep deprivation and stress, is a significant trigger for migraine attacks.
- Trial name
- NIGHTCAP (NCT07918053)
- Testing
- Rimegepant 75 mg ODT, Standard Care
- Where
- China
- Volunteers
- 260 people
- Sponsor
- Chinese PLA General Hospital
Benign Prostatic Hyperplasia (BPH)
Clinical Study on Prostate Thermal Vapor Ablation Guided by MRI/TRUS Fusion Imaging
This study evaluates a new imaging-guided approach for treating benign prostatic hyperplasia (BPH), also known as enlarged prostate. BPH is a common condition in older men that can cause bothersome urinary symptoms.
- Trial name
- NCT06817733
- Testing
- Procedure/Surgery: MRI/TRUS Fusion-Guided Transurethral Water Vapor Thermal Therapy, Rezūm Water Vapor Thermal Therapy System with MRI/TRUS Fusion and Electromagnetic Navigation
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Chinese PLA General Hospital
Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD)
Safety and Efficacy of Secukinumab Versus Mycophenolate Mofetil in Relapsing Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease (SMART)
The goal of this clinical trial is to evaluate the safety and efficacy of secukinumab versus mycophenolate mofetil in relapsing myelin oligodendrocyte glycoprotein antibody-associated disease.
- Trial name
- SMART (NCT07917247)
- Testing
- Secukinumab, Mycophenolate mofetil (MMF)
- Volunteers
- 130 people
- Sponsor
- Chinese PLA General Hospital
Chronic Non-specific Low Back Pain, Lumbar Multifidus Muscle Injury
The Intervention Effect of Exercise on Lumbar Multifidus Muscle Injuries
This is a single-center, prospective interventional study. The main purpose is to use ultrasound radiomics to analyze changes in multifidus muscle ultrasound imaging features before and after rehabilitation therapy in patients…
- Trial name
- NCT07892846
- Testing
- Lumbar multifidus muscle rehabilitation exercise
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Chinese PLA General Hospital
Non-Hodgkin's Lymphoma
BEX101 in B-cell Non-Hodgkin's Lymphoma
BEX101 injection is an extracorporeal anti-CD19 Chimeric Antigen Receptor T-Cell (CAR-T cell) therapy product. This single-arm, open-label, phase I/II clinical study is designed to evaluate the safety and efficacy of BEX101…
- Trial name
- NCT07882641
- Testing
- BEX101 injection
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Chinese PLA General Hospital
Postoperative Pain Control, Coronary Artery Disease
Serratus Anterior Plane Block for Recovery After Minimally Invasive CABG
Coronary artery bypass surgery is an important treatment method for severe coronary heart disease. Among them, minimally invasive bypass surgery, although having less trauma, requires a small incision on the left chest.
- Trial name
- NCT07877532
- Testing
- Ultrasound-guided Serratus Anterior Plane Block with Ropivacaine, Ultrasound-guided Serratus Anterior Plane Block with Normal Saline
- Volunteers
- 168 people
- Sponsor
- Chinese PLA General Hospital
Chronic Migraine Headache
Low-Intensity Focused Ultrasound Targeting the Dorsolateral Prefrontal Cortex for Preventive Treatment of Chronic Migraine
Chronic migraine is a disabling neurological disorder characterized by frequent headache attacks and significant impairment of quality of life.
- Trial name
- NCT07857109
- Testing
- Low-Intensity Focused Ultrasound Stimulation
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Chinese PLA General Hospital
Hepatocellular Carcinoma
Combination Therapy of Microwave Ablation and Cellular Immunotherapy for Hepatocellular Carcinoma
The study is to observe safety, survival effect and peripheral T-lymphocyte subsets of combination therapy with percutaneous microwave ablation (MWA) and adoptive immunotherapy in hepatocellular carcinoma(HCC).
- Trial name
- NCT02851784
- Testing
- adoptive immunotherapy, MWA
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Chinese PLA General Hospital
Ovarian Cancer
A Phase 3 Study of Manganese-primed Immunochemotherapy in Patients With Advanced Ovarian Cancer
Epithelial ovarian cancer is the most lethal gynecologic malignancy, and most patients eventually relapse and develop resistance to available therapies.
- Trial name
- NCT07822646
- Testing
- Manganese Chloride, Nab-paclitaxel, Platinum chemotherapy
- Where
- 6 sites in China
- Volunteers
- 120 people
- Sponsor
- Chinese PLA General Hospital
Ceftobiprole
Individualized Precision Therapy With Ceftobiprole Guided by PK/PD in Geriatric Populations
Ceftobiprole, a fifth-generation cephalosporin, exhibits potent antibacterial activity against MRSA, penicillin-resistant Streptococcus pneumoniae (PRSP), and certain Gram-negative bacteria (e.g., Pseudomonas aeruginosa).
- Trial name
- NCT07127185
- Testing
- LS/MS
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Chinese PLA General Hospital
Multiple Myeloma
Safety and Efficacy of KSVCBD Injection in Multiple Myeloma Expressing CD19 and/or BCMA
KSVCBD injection is an in vivo Chimeric Antigen Receptor T-Cell (CAR-T cell) therapy product. This multicenter, single-arm, open-label, early exploratory clinical study is designed to evaluate the preliminary safety and efficacy…
- Trial name
- NCT07620275
- Testing
- KSVCBD injection
- Where
- 3 sites in China
- Volunteers
- 9 people
- Sponsor
- Chinese PLA General Hospital
ANCA-Associated Glomerulonephritis (AAGN), ANCA-Associated Vasculitis (AAV)
Obinutuzumab Beta Combined With Low-dose Glucocorticoid in New-onset ANCA-Associated Glomerulonephritis
This study is an open-label, single-arm, exploratory study designed to evaluate the efficacy and safety of Obinutuzumab beta combined with a rapid-tapering glucocorticoid regimen in patients with new-onset ANCA-associated…
- Trial name
- NCT07746180
- Testing
- Obinutuzumab beta, Glucocorticoids
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Chinese PLA General Hospital
Non Hodgkin's Lymphoma
Allogenic CD19-targeting CAR-γδT Cell Therapy in R/R NHL
This is a single center, prospective, open-label, single-arm, phase 1/2 study for patients with r/r B-cell NHL to evaluate the safety and efficacy of gene edited allogenic CD19 CAR-γδT cells.
- Trial name
- NCT05554939
- Testing
- Allogenic CD19 CAR-γδT cell, Fludarabine, Cyclophosphamide
- Where
- 2 sites in China
- Volunteers
- 30 people
- Sponsor
- Chinese PLA General Hospital
Acute Kidney Injury, Hepatectomy
Renal Oxygenation-Guided AKI Reduction Trial
Acute kidney injury (AKI) is a common complication after major liver surgery. This study will evaluate whether intraoperative management guided by renal regional oxygen saturation (RrSO₂), measured using near-infrared…
- Trial name
- ROGAR (NCT07816640)
- Testing
- INVOS 5100C regional oxygen saturation monitoring system, RrSO2-guided perioperative management, Usual perioperative management
- Where
- 20 sites in China
- Volunteers
- 1,200 people
- Sponsor
- Chinese PLA General Hospital
Acute Gastrointestinal Graft-versus-host Disease
Prospective Randomized Controlled Study: Amimaitosai Injection Combined With Corticosteroids for Gastrointestinal aGVHD
This study focuses on patients with gastrointestinal-dominant acute graft-versus-host disease (aGVHD) after allogeneic hematopoietic stem cell transplantation.
- Trial name
- NCT07803978
- Testing
- Amimaitosai injection, Methylprednisolone
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Chinese PLA General Hospital
Benign Breast Nodules
Ultrasound-Guided Emulsification Therapy in the Clinical Treatment of Benign Breast Nodules
Background： Benign breast nodules are common breast diseases in women, including fibroadenomas, hyperplastic nodules, and other benign lesions.
- Trial name
- NCT07797257
- Testing
- CUSA Minimally Invasive Resection
- Volunteers
- 30 people
- Sponsor
- Chinese PLA General Hospital
Lipoma
Ultrasound-Guided Emulsification Therapy in the Clinical Treatment of Subcutaneous Lipomas
Background:Lipomas are the most common benign soft tissue tumors, traditionally treated by open surgical excision. However, open surgery is associated with relatively large incisions, prolonged recovery, and visible scarring.
- Trial name
- NCT07797270
- Testing
- CUSA Minimally Invasive Resection
- Volunteers
- 30 people
- Sponsor
- Chinese PLA General Hospital
Hematopoietic Stem Cell Transplantation
Population PK-guided ATG Dosing in Haplo-HSCT
To evaluate the safety and efficacy of a population pharmacokinetics (PK)-guided targeted ATG dosing strategy in haploidentical stem cell transplantation and to observe the GVHD-free, relapse-free survival (GRFS) in the cohort…
- Trial name
- NCT07791576
- Testing
- Anti Thymocyte Globulin
- Where
- China
- Volunteers
- 63 people
- Sponsor
- Chinese PLA General Hospital
B-cell Lymphoma
In Vivo CD19/CD20 CAR T-Cell Therapy for Relapsed/Refractory B-Cell Lymphoma
This Phase 1, open-label, single-arm, dose-escalation study is designed to evaluate the safety and tolerability of SL1617 Injection in patients with relapsed or refractory B-cell lymphoma.
- Trial name
- NCT07775508
- Testing
- SL1617 Injection
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Chinese PLA General Hospital