Clinical trials: sponsored by Chinese University of Hong Kong
Idiopathic Parkinson Disease
Non-invasive Vagus Nerve Stimulation for Parkinson's Disease
Although breakthroughs in the management of Parkinson's disease (PD) have emerged in recent decades resulting in better control in symptoms, majority of patients with PD are still living with various disabling motor and non-motor…
- Trial name
- VNS (NCT07908498)
- Testing
- cVNS, eVNS, sVNS
- Volunteers
- 60 people
- Sponsor
- Chinese University of Hong Kong
Prostate Cancer
Artificial Intelligence (AI)-Assisted Risk-based Prostate Cancer Detection
This is a prospective clinical study recruiting 510 men at risk of PCa to undergo urine, blood, AI-assisted ultrasound and AI-assisted MRI investigations to stratify risk of clinically significant PCa (csPCa).
- Trial name
- NCT05443412
- Testing
- Diagnostic test for prostate cancer
- Where
- Hong Kong
- Volunteers
- 510 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Prostate Cancer
To Evaluate an MRI-based Optimized Prostate Cancer Diagnostic Pathway Powered by Artificial Intelligence
It is a prospective paired-cohort study for diagnostic test evaluation. The study aim to determine the accuracy of AI review and investigate whether AI review could detect MRI visible significant cancer as effective as…
- Trial name
- NCT06360523
- Testing
- AI modal, Standard review
- Where
- Hong Kong
- Volunteers
- 629 people
- Sponsor
- Chinese University of Hong Kong
Knee Osteoarthristis
Wearable Device Guided Exercise for Patients on Total Knee Arthroplasty Wait-list
Total knee arthroplasty (TKA) is a cost effective solution for people with end-stage knee osteoarthritis. Given Hong Kong's large senior population and age as the primary risk factor for osteoarthritis, waiting times for total…
- Trial name
- NCT07912333
- Testing
- Wearable Device, Control
- Where
- Hong Kong
- Volunteers
- 106 people
- Sponsor
- Chinese University of Hong Kong
Thyroid Nodule (Diagnosis)
Ultrasound-guided Microwave Ablation of Benign Thyroid Nodules
The goal of this clinical trial is to learn if microwave ablation of benign thyroid nodules under local anaesthesia is a safe and effective procedure compared to open thyroidectomy.
- Trial name
- NCT07906821
- Testing
- ultrasound-guided percutaneous microwave ablation (MWA)
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- Chinese University of Hong Kong
Renal Tumors
The Edison™ System for Treatment of Renal Tumors Using Histotripsy (Histo-Renal Trial)
This is a prospective single-center, single-arm, feasibility trial designed to evaluate the safety of the HistoSonics Histotripsy System for treatment of renal tumors.
- Trial name
- NCT07911527
- Testing
- HistoSonics® Edison System (US)
- Volunteers
- 15 people
- Sponsor
- Chinese University of Hong Kong
Bladder Cancer
The Role of ERBT Plus Adjuvant Intravesical Induction and Maintenance Chemotherapy for Intermediate-Risk NMIBC
This is a prospective, multi-centre randomised trial comparing between ERBT plus 1-year of Ad-MMC, versus ERBT alone, in treating intermediate-risk NMIBC.
- Trial name
- NCT07907575
- Testing
- ERBT and Adjuvant MMC Therapy, ERBT
- Where
- 2 sites in Hong Kong
- Volunteers
- 440 people
- Sponsor
- Chinese University of Hong Kong
Atherosclerosis Cardiovascular Disease
Isometric Resistance Exercise on Accelerated Atherosclerosis in Hypertension
Background: Hypertension (HT) is the most common condition worldwide, predisposing to atherosclerotic disease. However, most HT patients have suboptimal BP control despite anti-HT medications.
- Trial name
- IRE-HT (NCT07665034)
- Testing
- Squatting Exercise, Stretching (Yoga) Exercise
- Where
- Hong Kong
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Influenza Virus, Coronavirus
Tropism and Pathogenesis of Influenza Virus and Coronavirus in Human Brain Explant Culture
Background: Influenza and coronavirus have been repeatedly causing pandemic recently. Like the Influenza A/H7N9 virus has caused five epidemics in China since its first detection in East China in 2013.
- Trial name
- COVID-19 (NCT05375006)
- Where
- Hong Kong
- Volunteers
- 4 people
- Sponsor
- Chinese University of Hong Kong
Chronic Widespread Pain
Fecal Microbiota Transplantation for Patients With Chronic Widespread Pain
This study aims to explore the effect of Fecal Microbiota Transplantation (FMT) on the clinical symptomatology in Chronic Widespread Pain (CWP), to assess the acceptability, tolerability, and safety of FMT in patients with CWP…
- Trial name
- NCT05700331
- Testing
- Fecal Microbiota Transplantation, Sigmoidoscopy
- Where
- Hong Kong
- Sponsor
- Chinese University of Hong Kong
Chronic Widespread Pain
Gut Microbiota in Adults With Chronic Widespread Pain
We aim to identify the gut microbiome composition in adults with CWP. We will collect the stool sample of 120 healthy individuals and 120 Chronic Widespread Pain patients.
- Trial name
- NCT05678387
- Where
- Hong Kong
- Volunteers
- 175 people
- Sponsor
- Chinese University of Hong Kong
Benign Prostatic Hyperplasia (BPH)
To Linguistically and Psychometrically Validate the Hong Kong Chinese Version of the BPH 3-item Questionnaire
This study is to linguistically and psychometrically validate the translated and culturally adapted Hong Kong Chinese version of the BPH 3-item questionnaire.
- Trial name
- NCT05785286
- Testing
- BPH 3-item questionnaire
- Where
- 2 sites in Hong Kong
- Volunteers
- 66 people
- Sponsor
- Chinese University of Hong Kong
Cardiovascular Risk, Prostate Cancer
The Effect of Multidisciplinary Care Approach on CV Risk Modification in CaP Patients Receiving ADT
Prostate cancer is characterised by its slow progression nature, and even for metastatic disease, the 5-year survival is up to 30%.
- Trial name
- NCT06163924
- Where
- Hong Kong
- Volunteers
- 300 people
- Sponsor
- Chinese University of Hong Kong
Renal Stone
Supervised Endoscopic Tele-controlled Intelligent Lithotripsy
This is a phase I feasibility study to investigate the use of a novel intelligent robotic retrograde intrarenal surgery (RIRS) platform.
- Trial name
- SENTINEL-1 (NCT07411391)
- Testing
- RIRS using the TaloStone T1000 RIRS platform
- Where
- 2 sites in Hong Kong
- Volunteers
- 15 people
- Sponsor
- Chinese University of Hong Kong
Voiding Dysfunction, Substance Abuse
Treatment Outcomes Under a Standardized Treatment Protocol in Patients Suffered Substance Abuse Related Voiding Dysfunction
With the increase of substance abuse over the world, substance abuse e.g. ketamine and methamphetamine related voiding dysfunction is becoming an important medical problem.
- Trial name
- NCT03913819
- Testing
- First line treatment: oral NSAID and anticholinergic agents, Second line treatment: additional treatment for pain control, Third line treatment: A course of intravesical hyaluronate will be given.
- Where
- Hong Kong
- Volunteers
- 1,500 people
- Sponsor
- Chinese University of Hong Kong
Prostate Cancer
High-intensity Focused Ultrasound Study
Conventional treatment options for localized prostate cancer include prostatectomy, radiotherapy and active surveillance. However, prostatectomy and radiotherapy carry certain degree of morbidity, including the risks of urinary…
- Trial name
- NCT03927924
- Testing
- High-intensity focused ultrasound
- Where
- Hong Kong
- Volunteers
- 5 people
- Sponsor
- Chinese University of Hong Kong
Bladder Cancer
Artificial Intelligence-assisted Uro-Cam Catheter Assessment System for Diagnosing Bladder Cancer
This is a single-arm study investigating the safety, feasibility and diagnostic performance of AI-assisted Uro-Cam catheter assessment that will be performed at the Prince of Wales Hospital.
- Trial name
- NCT07095751
- Testing
- AI Uro-Cam
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- Chinese University of Hong Kong
Renal Stone
Robotic Flexible Ureteroscopy Versus Standard Flexible Ureteroscopy for Renal Stones
This is a prospective randomized clinical trial which aims to compare the clinical outcomes of robotic flexible ureteroscopy and standard flexible ureteroscopy for the treatment of renal stones.
- Trial name
- NCT06660914
- Testing
- Flexible Ureteroscopy
- Where
- Hong Kong
- Volunteers
- 30 people
- Sponsor
- Chinese University of Hong Kong
Prostate Cancer
To Identify Potential New Urine Markers for the Screening of Prostate Cancer
Prostate gland is a clinically important male sexual organ and its main function is for the production of semen. Globally, it is the second most common cancer in men globally and is also the fifth cancer cause for death in male.
- Trial name
- NCT03914391
- Where
- Hong Kong
- Volunteers
- 10,000 people
- Sponsor
- Chinese University of Hong Kong
Prostate Cancer
Prostate Irreversible Electroporation Study
Conventional treatment options for localized prostate cancer include prostatectomy, radiotherapy and active surveillance. However, prostatectomy and radiotherapy carry certain degree of morbidity, including the risks of urinary…
- Trial name
- NCT06886321
- Testing
- Prostate Irreversible Electroporation
- Where
- Hong Kong
- Volunteers
- 10 people
- Sponsor
- Chinese University of Hong Kong
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