Clinical trials: open to volunteers, sponsored by Columbia University
Substance Use Risk, Structural Stressors
Structural Stressors, Reward Related Decision Making and Substance Use Risk
The goal of this observational study, which has a pilot phase (R61) and a second, larger phase (R33), is to learn about the impact of indicators of structural stressors (SS) on substance use risk in Puerto Rican adolescents…
- Trial name
- NCT06221839
- Where
- 2 sites in United States, Puerto Rico
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Columbia University
Spinal Cord Injuries, Tetraplegia
MyHand-SCI: An Active Hand Orthosis for Spinal Cord Injury
The purpose of this study is to develop and test the hardware and software components of the MyHand-SCI device to assist with hand function for individuals with C6-C7 spinal cord injury.
- Trial name
- NCT05553457
- Testing
- Testing of MyHand-SCI Device
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Columbia University
Breast Cancer
Decision Support for Chemoprevention
The purpose of this study is to find out whether electronic tools that provide information and reminders to people at high risk for breast cancer and their healthcare providers can increase the use of medications, such as…
- Trial name
- NCT07899151
- Testing
- RealRisks Decision Aid
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Columbia University
Modeling of Recruitment Curves
Adaptive Recruitment Curve Analysis Using Bayesian Modeling
The purpose of this study is to better understand how electrical or magnetic stimulation affect the nervous system by optimizing the way researchers measure muscle responses.
- Trial name
- NCT07561372
- Testing
- Algorithm: Uniform Sampling, Algorithm: hbMEP-adaptive algorithm (version 1), Algorithm: hbMEP-adaptive algorithm (version 2)
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Columbia University
Hereditary Hemorrhagic Telangiectasia (HHT), Epistaxis
Topical TOR-582 Treatment of Epistaxis in HHT
People with hereditary hemorrhagic telangiectasia (HHT) often experience frequent and severe nosebleeds that can disrupt daily life and lead to anemia, medical procedures, and reduced quality of life.
- Trial name
- NCT07667413
- Testing
- Topical sirolimus ointment
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Columbia University
HIV Testing, STI
HIV/STI/HCV Testing and Overdose Prevention Among Survivors of Sex Trafficking
This project will assess whether a digital survivor crowdsourced intervention can increase HIV/STI/HCV testing and overdose prevention kit utilization among survivors of sex trafficking living in New York City.
- Conditions
- HIV Testing, STI, HCV, Overdose, Drug
- Trial name
- NCT07264582
- Testing
- Sex Trafficking Survivor-Developed Digital Crowdsourced Intervention
- Where
- United States
- Volunteers
- 368 people, healthy volunteers welcome
- Sponsor
- Columbia University
Suicidal Ideation, Suicidal Behaviors
Pilot Study of a Modified Safety Planning Intervention for Elementary School-Aged Children - Main Study
The goal of this study is to finalize a version of the Safety Planning Intervention suitable for 6-12-year-old children. This intervention provides individuals with strategies to reduce the risk of suicidal behavior.
- Trial name
- NCT07564583
- Testing
- Child - Safety Planning Intervention, C-SPI+ecological momentary assessment
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Columbia University
Internalizing Disorders, Substance Use Disorders
Family Support Protocol for Adolescent Internalizing Disorders
This R34 will develop and test an adjunctive treatment protocol for addressing co-occurring internalizing disorders among adolescents enrolled in usual care for substance use problems.
- Trial name
- Fam-AID (NCT06413979)
- Testing
- Family Support Protocol for Adolescent Internalizing Disorders (Fam-AID)
- Where
- 3 sites in United States
- Volunteers
- 60 people
- Sponsor
- The National Center on Addiction and Substance Abuse at Columbia University
Traumatic Brain Injury (TBI) Patients, Intracerebral Hemorrhage
Smartphone Enabled Detection of Cognitive Motor Dissociation in the ICU
The purpose of this research study is to evaluate whether a smartphone-enabled EEG (electroencephalography) system can be used to detect Cognitive Motor Dissociation (CMD) in patients with acute neurological injuries who appear…
- Conditions
- Traumatic Brain Injury (TBI) Patients, Intracerebral Hemorrhage, Subarachnoid Hemorrhage, Cardiac Arrest (CA)
- Trial name
- SMART-CMD (NCT07917728)
- Where
- 9 sites in United States, Brazil and 3 more
- Volunteers
- 240 people
- Sponsor
- Columbia University
Anxiety, Osteoarthritis
Preoperative Music Intervention for Anxiety in Hip and Knee Arthroplasty
Many patients feel anxious before joint replacement surgery. This anxiety is common - affecting roughly 1 in 3 patients - and research has shown that patients who are more anxious before surgery tend to have more pain afterward…
- Trial name
- NCT07845695
- Testing
- Music via Headphones
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Columbia University
Lymphoma, T-Cell, Cutaneous, Lymphomatoid Papulosis
Tissue Repository: CTCL Collection Protocol
This document is a protocol for a non-interventional human research study in which the investigator hopes to better understand the changes that take place in T cells in Cutaneous T-cell lymphoma (CTCL).
- Conditions
- Lymphoma, T-Cell, Cutaneous, Lymphomatoid Papulosis, Sézary Syndrome
- Trial name
- NCT02840747
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Columbia University
Colon and Rectal Cancer
Gemcitabine, Cisplatin, Nab-paclitaxel (GAP) and Cemiplimab for Locally Advanced Biliary Tract Cancer (BTC)
This study is being conducted to find out if treatment with gemcitabine, cisplatin, nab-paclitaxel, and cemiplimab can shrink previously inoperable tumors enough for surgery.
- Trial name
- GAP Cemi (NCT07433673)
- Testing
- Cemiplimab
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Columbia University
LVAD (Left Ventricular Assist Device) Thrombosis, Heart Failure
SWITCH: Apixaban vs Vitamin K in HM3
This study is being done to learn the safety and efficacy of a new anticoagulant therapy with apixaban as compared to warfarin to prevent thrombotic events while protecting from bleeding complications in patients with advanced…
- Conditions
- LVAD (Left Ventricular Assist Device) Thrombosis, Heart Failure, Bleeding, Thrombosis; Artery
- Trial name
- NCT07471139
- Testing
- Warfarin, Apixaban
- Where
- United States
- Volunteers
- 460 people
- Sponsor
- Columbia University
Stigma, HIV
Ending the HIV Epidemic: An All-facility Intervention for Patient and Healthcare Staff Well-being
The scope of this study is to engage Ryan White HIV/AIDS Program (RWHAP) funded organizations in the South/East US to co-develop context-responsive programs utilizing evidence-informed interventions to reduce stigma against…
- Conditions
- Stigma, HIV, Well-Being, Psychological
- Trial name
- NCT05785169
- Testing
- All-facility Training
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Columbia University
Pediatric Asthma, Acute Asthma
Bilevel Positive Airway Pressure (BPAP) for Severe Asthma
The goal of this clinical trial is to assess the feasibility of early initiation of bilevel positive airway pressure (BPAP) in the emergency department (ED) for children with severe asthma exacerbations.
- Conditions
- Pediatric Asthma, Acute Asthma, BiPAP, Non-invasive Positive Pressure Ventilation
- Trial name
- NCT07582211
- Testing
- Bilevel positive airway pressure ventilation
- Where
- 3 sites in United States
- Volunteers
- 36 people
- Sponsor
- Columbia University
Traumatic Brain Injury (TBI) Patients, Intracerebral Hemorrhage (ICH)
Sleep to Predict Recovery In Unconscious Patients With Acute Brain Injury
Severe brain injuries can leave people in states where they are unconscious or only partly aware, such as a coma. These conditions are common after injuries like head trauma or bleeding in the brain.
- Trial name
- SPRINT (NCT07794605)
- Where
- 2 sites in United States
- Volunteers
- 230 people
- Sponsor
- Columbia University
Cesarean Delivery, Cesarean Delivery; Neuraxial Opioids
Adding Dexmedetomidine or Clonidine to Spinal Anesthesia for Cesarean Delivery
This study will examine whether addition of dexmedetomidine or clonidine (two alpha-2 adrenergic agonists) will improve the comfort of patients during spinal anesthesia for cesarean delivery.
- Conditions
- Cesarean Delivery, Cesarean Delivery; Neuraxial Opioids, Spinal Anesthesia for Cesarean Section, Dexmedetomidine
- Trial name
- NCT07567495
- Testing
- Clonidine, Dexmedetomidine
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Columbia University
ACL, Opioid Use
VibraCool Device to Reduce Pain and Opioid Use After Anterior Cruciate Ligament Reconstruction (ACLR)
The goal of this project is to test the effects of the VibraCool mechanical stimulation neuromodulatory therapeutic device on post-operative pain and opioid use following anterior crucitate ligament reconstruction (ACLR), and…
- Conditions
- ACL, Opioid Use, Cryotherapy Effect, Vibration; Exposure
- Trial name
- NCT06456268
- Testing
- VibraCool mechanical stimulation and neuromodulatory therapeutic device, Cryocompression (Game Ready, Bregs) device, Standard ice packs
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Columbia University
Hypernatremia
Rapid Rehydration for Severe Hypernatremia
The goal of this study is to show the feasibility of rapid identification, consenting, randomization, treatment, and follow-up of patients with severe hypernatremia (Na ≥ 155 mEq/L).
- Trial name
- RaRe Treat (NCT07783191)
- Testing
- Intravenous Dextrose 5% solution
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Columbia University
Blood Pressure, Sleep Health
The Sleep2BWell Trial
Improving multiple domains of cardiometabolic health (CMH) through contextual behavioral interventions has the potential to substantially reduce persistent chronic disease disparities.
- Conditions
- Blood Pressure, Sleep Health, Diet, Healthy, Physical Activity
- Trial name
- NCT06565104
- Testing
- Multidimensional Sleep Health Sessions, Healthy Diet Sessions, Physical Activity Sessions
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Columbia University