Clinical trials: completed, sponsored by Duke University
Locally Advanced Esophageal and Gastric Cancers (EGC)
Pembrolizumab, Radiotherapy, and Chemotherapy in Neoadjuvant Treatment of Malignant Esophago-gastric Diseases (PROCEED)
This is a single-institution, prospective phase II trial with an initial safety run-in to evaluate the efficacy and safety of neoadjuvant pembrolizumab combined with chemoradiotherapy and adjuvant pembrolizumab in patients with…
- Trial name
- PROCEED (NCT03064490)
- Testing
- Pembrolizumab
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Duke University
Weight Loss, Obesity
Charge: A Text Messaging-based Weight Loss Intervention
This study evaluates different versions of a text messaging-based app for weight loss. This study will place participants to 1 of 32 experimental conditions that reflect different texting components and levels.
- Trial name
- NCT03254940
- Testing
- Charge
- Where
- United States
- Volunteers
- 534 people, healthy volunteers welcome
- Sponsor
- Duke University
Hearing Loss
Evaluation of Unilateral vs Bilateral Hearing Aids for the Treatment of Age-related Hearing Loss
This study aims to evaluate the benefit of bilateral hearing aid use compared to a unilateral hearing aid. Patients with mild to moderate bilateral hearing loss who are considering the purchase of a commercially available hearing…
- Trial name
- NCT04739436
- Testing
- Hearing amplification
- Where
- 2 sites in United States
- Volunteers
- 278 people
- Sponsor
- Duke University
Grief, Post Traumatic Stress Disorder
Building and Sustaining Interventions for Children: Task-sharing Mental Health Care in Low-resource Settings
The BASIC study will take place in Kanduyi/Bungoma South Sub-County, in western Kenya, and focuses on children orphaned by one or two parents.
- Conditions
- Grief, Post Traumatic Stress Disorder, Depression
- Trial name
- BASIC (NCT03243396)
- Testing
- Trauma-Focused Cognitive Behavioral Therapy
- Where
- Kenya
- Volunteers
- 956 people
- Sponsor
- Duke University
Rheumatoid Arthritis
Weight Loss and Exercise To Improve Rheumatoid Arthritis Cardiovascular Risk
This is a small exploratory, randomized, controlled trial. Twenty-six older (ages 60-80 yr.), obese (BMI 28-40 kg/m2) persons with rheumatoid arthritis (RA) (seropositive or erosive) will be randomized to 16 weeks of a counseling…
- Trial name
- SWET/CHAT (NCT04356183)
- Testing
- SWET: Supervised Weight loss and Exercise Training, CHAT: Counseling Health As Treatment
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Duke University
Post-traumatic Osteoarthritis, Unspecified Ankle and Foot, Localized, Primary Osteoarthritis of the Ankle and/or Foot
Prospective Subtalar, Double, or Triple Arthrodesis Study With CCS Screws
The objective of this study is to prospectively evaluate the mid-term results and intraoperative and postoperative complication rate in patients who underwent double or triple arthrodesis using CCS screws.
- Trial name
- NCT02619838
- Testing
- Aptus CCS 5.0 or/and 7.0 screws
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Duke University
Lung Transplant Failure and Rejection
Clinical Trials in Organ Transplantation Extension Study
The purpose of the study is to continue to follow subjects who were enrolled in the CTOT-20 CLAD Phenotypes study. Subjects will provide clinical data and complete quality of life questionnaires that will be used to determine the…
- Trial name
- CTOT-ES (NCT04126746)
- Where
- 5 sites in United States, Canada
- Volunteers
- 501 people
- Sponsor
- Duke University
Neonatal Critical Illness, Pediatric Critical Illness
Decision Making Support for Parents and Caregivers
The purpose of this study is to test the feasibility and acceptability of a tool to support decision making for parents of critically ill infants.
- Trial name
- NCT05733975
- Testing
- Decision Making Guide
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- Duke University
Adherence, Patient, Pre-Exposure Prophylaxis
mHealth Technologies to Enhance PrEP Adherence Among Thai MSM
This study aims to: 1) adapt the theory-based P3 (Prepared, Protected, emPowered) app designed to improve pre-exposure prophylaxis (PrEP) adherence, retention in PrEP clinical care, and PrEP persistence among young gay, bisexual…
- Conditions
- Adherence, Patient, Pre-Exposure Prophylaxis, HIV/AIDS
- Trial name
- P3-T (NCT04413708)
- Testing
- P3-T PrEP Adherence App
- Where
- Thailand
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Duke University
Dementia, Stress
Stress Management Toolkit for People Living With Dementia and Their Care Partners
The purpose of this study is to develop a prototype of a home-based, dyadic tangible toolkit comprised of simple tools to help people living with dementia (PLWD) and their care partners manage stress at home.
- Conditions
- Dementia, Stress, Caregiver Burden
- Trial name
- NCT05465551
- Testing
- Stress Management Toolkit
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Duke University
Immunization
mHealth-Assisted Conditional Cash Transfers to Improve Timeliness of Vaccinations (D0271)
Vaccination is a cost-effective strategy for conferring immunity against a host of preventable diseases, however, rates of timely childhood vaccinations remain inadequate in resource-limited settings.
- Trial name
- MINT (NCT03252288)
- Testing
- Reminders, Conditional financial transfers
- Where
- Tanzania
- Volunteers
- 412 people
- Sponsor
- Duke University
Mental Health Issue, Family Relations
An Evaluation of a Family Counseling Intervention ("Tuko Pamoja") in Kenya
The purpose of this study is to evaluate a family counseling intervention, entitled "Tuko Pamoja" (Translation "We are Together" in Kiswahili).
- Conditions
- Mental Health Issue, Family Relations, Family Conflict, Child Mental Disorder
- Trial name
- C0058 (4C) (NCT06417918)
- Testing
- Tuko Pamoja, "We are Together" in Kiswahili
- Where
- Kenya
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Duke University
Influenza Viral Infections
Single Dose Texas 2017 (H3N2) Challenge Study
The overall objective of the present study is to utilize the recombinant H3N2 (A/Texas/71/2017 (H3N2, clade 3C3a)) influenza virus for a controlled human infection model to study host responses to influenza virus with the aim of…
- Trial name
- NCT06476275
- Testing
- Influenza A/Texas/71/2017 (H3N2)
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Duke University
Autism Spectrum Disorder
Open Label Phase I hCT-MSC in Toddlers With Autism Spectrum Disorder
This is a single site, prospective study of one intravenous infusion of human umbilical cord tissue-derived mesenchymal stromal cells (hCT-MSC) in toddlers with autism spectrum disorder (ASD).
- Trial name
- TACT (NCT04294290)
- Testing
- hCT-MSC infusion
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Duke University
Dog Therapy
Impact of Therapy Dog Presence on Pediatric Echocardiogram
Young children with known or suspected heart disease frequently have difficulty cooperating with a clinically ordered echocardiogram. Current distraction techniques vary in efficacy.
- Trial name
- NCT03059407
- Testing
- Dog therapy only, Dog plus standard distraction tech, Standard distraction techniques only
- Where
- United States
- Volunteers
- 138 people
- Sponsor
- Duke University
Patient Satisfaction, Clinician Satisfaction
Ambient Digital Scribes Populating Clinical Notes
The purpose of this study is to assess the impact of Ambient Digital Scribes that will automatically record clinical encounters and use AI technology to populate clinical notes.
- Trial name
- NCT06519123
- Testing
- Ambient Digital Scribes
- Where
- United States
- Volunteers
- 261 people, healthy volunteers welcome
- Sponsor
- Duke University
All
Family History in a Singaporean Healthy Population
The purpose of this study is to better understand the linkages between family health history (FHH) and genomics in a Singaporean population.
- Trial name
- NCT03114553
- Testing
- MeTree
- Where
- Singapore
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Duke University
Breast Cancer
Family History in a Singapore Oncology Population
This study will create a Breast Cancer Clinical Decision Support Module in MeTree and validate and pilot the Breast Cancer Clinical Decision Support Module in a clinical setting within SingHealth.
- Trial name
- NCT04639934
- Testing
- MeTree
- Where
- Singapore
- Volunteers
- 102 people
- Sponsor
- Duke University
AIDS/HIV - RelatedDisease Associated With AIDS
Making an Early Diagnosis of Talaromycosis Using a Novel Antigen Test
This is a research study to determine whether a new antigen detection test called Mp1p EIA can make an early diagnosis of talaromycosis from the blood and urine of patients.
- Trial name
- NCT04033120
- Where
- 2 sites in Vietnam
- Volunteers
- 1,411 people
- Sponsor
- Duke University
Antibiotic Stewardship
The DETOURS Trial: De-escalating Empiric Treatment: Opting Out of Rx for Selected Patients With Suspected Sepsis - Opt-Out Protocol Trial
The objective of this study is to implement an opt-out protocol to guide appropriate de-escalation of antibiotics in qualifying patients.
- Trial name
- NCT03517007
- Testing
- Opt-Out Protocol
- Where
- 10 sites in United States
- Volunteers
- 762 people
- Sponsor
- Duke University
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