Clinical trials: completed, sponsored by Duke University
Misophonia
Exploring Two Treatments for Misophonia
While the investigators continue to work on better understanding Misophonia, it is also important to identify treatments that can help people who are currently suffering.
- Trial name
- NCT04198597
- Testing
- Unified Protocol for Transdiagnostic Treatment of Emotional Disorders, Process-based Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Duke University
Edema, Pulmonary, Immersion
Sildenafil for Swimming-Induced Pulmonary Edema (SIPE) Prevention
This trial is testing the effectiveness of a single oral dose of sildenafil (50 mg) taken 1 hour before a provocative event on the subsequent development of swimming-induced pulmonary edema.
- Conditions
- Edema, Pulmonary, Immersion, Diving
- Trial name
- NCT03686813
- Testing
- Sildenafil Citrate
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Duke University
Delirium
Investigating NeuroinflammaTion UnderlyIng Postoperative Brain Connectivity Changes, POCD, Delirium in Older Adults
(From NIH reporter) Each year >16 million older Americans undergo anesthesia and surgery, and up to 40% of these patients develop postoperative cognitive dysfunction (POCD), a syndrome of postoperative thinking and memory…
- Trial name
- INTUIT (NCT03273335)
- Testing
- Millipore biomarker assay plate
- Where
- United States
- Volunteers
- 201 people
- Sponsor
- Duke University
Obesity
Pattern - Reach Aim 2
The purpose of this research study is to learn about different approaches to promoting healthy growth among infants, and understanding parents' likes and dislikes of an approach to reducing risk factors for obesity later in life.
- Trial name
- NCT04216264
- Testing
- Standard response, Targeted response
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Duke University
Depression
Latinx Teen Depression Treatment Study
The purpose of this study is determine facilitators of and barriers to receiving evidence-based psychotherapy for depression for Latinx adolescents from multiple stakeholder perspectives.
- Trial name
- NCT04819295
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Duke University
Preterm Birth
Improving the Clinical Encounter to Enhance Delivery of an Individualized Prematurity Prevention Plan
The purpose of this study is to pilot an intervention that was developed to improve uptake and adhere to an Individualized Prematurity Prevention Plan (IP3) for preterm birth prevention.
- Trial name
- NCT04149002
- Testing
- Intervention Arm Weekly IP3 text messages, Active Control Arm General pregnancy text messages
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Duke University
Sickle Cell Disease, Genetic Disease
Implementing an Individualized Pain Plan (IPP) for ED Treatment of VOE's in Sickle Cell Disease
The overall purpose of this proposed study is to improve management of vaso-occlusive episodes (VOEs) in adult EDs. We aim to implement NHLBI recommendations for VOE treatment by embedding Individualized Pain Plans (IPPs) in the…
- Conditions
- Sickle Cell Disease, Genetic Disease, Hematologic Diseases, Anemia, Sickle Cell
- Trial name
- ALIGN (NCT04584528)
- Testing
- Electronic Health Record (EHR) Embedded Individualized Pain Plan (IPP)
- Where
- 8 sites in United States
- Volunteers
- 279 people, healthy volunteers welcome
- Sponsor
- Duke University
Cervical Cancer
mHealth-supported Telecolposcopy for Cervical Cancer Programs in Low-resource Settings: Evaluation (mIVAA)
The central hypothesis is that use of mIVAA (mobile Inspección Visual con Ácido Acético - Spanish for Visual Inspection with Acetic Acid (VIA)) will increase the proportion of VIA positive women who complete follow-up clinical…
- Trial name
- NCT04421131
- Testing
- Pocket colposcope/Mobile phone camera, mIVAA
- Where
- Peru
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Duke University
Children and Youth With Special Healthcare Needs, Care Coordination
Learning Health for Pediatric Complex Care Integration (PCCI)
The study team will conduct a mixed methods evaluation of the implementation of an evidence-based clinical program -- the Pediatric Complex Care Integration (PCCI) program - for improvement of care integration for children and…
- Trial name
- NCT05056480
- Testing
- Surveys
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Duke University
Prostate Cancer
Abiraterone, Radiotherapy and Short-Term Androgen Deprivation in Unfavorable Localized Prostate Cancer
The addition of abiraterone acetate to standard treatment of radiotherapy and short-term androgen deprivation will increase the frequency of undetectable PSA.
- Trial name
- NCT01717053
- Testing
- Abiraterone acetate, Androgen deprivation, Radiation Therapy
- Where
- 3 sites in United States
- Volunteers
- 37 people
- Sponsor
- Duke University
Health Behavior, HIV
Integrating Mental Health Into a HIV Clinic to Improve Outcomes Among Tanzanian Youth
The purpose of this study is to evaluate if a group-based mental health intervention called Sauti ya Vijana (The Voice of Youth) designed to address mental health challenges faced by adolescents in Tanzania is acceptable and…
- Conditions
- Health Behavior, HIV, Mental Health
- Trial name
- NCT02888288
- Testing
- Mental Health Intervention, Standard of Care
- Where
- Tanzania
- Volunteers
- 140 people
- Sponsor
- Duke University
Cardiorespiratory Fitness
Step, Walk, Bike: Comparisons of Fitness Assessments
To compare cardiorespiratory fitness parameters (oxygen consumption and respiratory ventilation) measured during two sub-maximal exercise tests (six minute step test, 6MST \& six minute walk test, 6 MWT) with maximal exercise…
- Trial name
- NCT04830306
- Testing
- Exercise
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Duke University
Disinfection
Measuring the Impact of an Enhanced Strategy for Daily Disinfection in Acute Care Hospital Rooms
To determine the effectiveness of an enhanced strategy for daily disinfection in acute care hospital rooms comparing the addition of sani24 to routine daily cleaning versus the control of routine daily cleaning.
- Trial name
- NCT05560321
- Testing
- Sani24, Routine Disinfection
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Duke University
Venous Thromboembolism, Ovarian Cancer
Aspirin for Prevention of Venous Thromboembolism Among Ovarian Cancer Patients Receiving Neoadjuvant Chemotherapy
This is a pilot study to determine the safety and efficacy of low dose aspirin for the prevention of venous thromboembolism among women with advanced ovarian cancer receiving neoadjuvant chemotherapy.
- Trial name
- NCT04352439
- Testing
- Aspirin
- Where
- 2 sites in United States
- Volunteers
- 19 people
- Sponsor
- Duke University
Physical Activity, Exercise
Physical Activity to Improve Patient Reported Outcomes for Adults With Acute Leukemia
The purpose of this study is to test the efficacy of an evidence-based tailored physical activity program adapted for adults with acute leukemia.
- Conditions
- Physical Activity, Exercise, Acute Leukemia, Consolidation
- Trial name
- Build Stamina (NCT04552912)
- Testing
- Build Stamina Program
- Where
- 2 sites in United States
- Volunteers
- 49 people
- Sponsor
- Duke University
Triple Negative Breast Cancer
Phase II Multicenter Study of Durvalumab and Olaparib in Platinum tReated Advanced Triple Negative Breast Cancer (DORA)
This is a randomized, international, multicenter, Phase II study designed to explore the efficacy of olaparib or olaparib in combination with durvalumab in platinum-treated mTNBC.
- Trial name
- DORA (NCT03167619)
- Testing
- Olaparib Oral Product, Olaparib Oral Product in combination with Durvalumab
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Duke University
Misophonia
Exploring the Acceptability and Efficacy of a Transdiagnostic Treatment for Misophonia
Despite increasing recognition of misophonia, there are currently no evidence-based treatments to help those who are suffering. Therefore, the primary purpose of this study is to assess the acceptability, feasibility, and…
- Trial name
- NCT04612374
- Testing
- Unified Protocol for Transdiagnostic Treatment of Emotional Disorders, Revised Unified Protocol for Transdiagnostic Treatment of Emotional Disorders
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Duke University
Lung Cancer Stage III, Lung Cancer Stage IV
Self-System Therapy for Older Adults With Lung Cancer
The purpose of this study to use Self-system therapy (SST), to treat depression and lung-cancer-related distress in older adults (65 years and older).
- Trial name
- NCT04057196
- Testing
- Self-System Therapy for Older Adults with Advanced Lung Cancer (SST-LC)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Duke University
Lung Transplant; Complications
4DX Functional Lung Imaging in the Diagnosis of Chronic Lung Allograft Dysfunction After Lung Transplantation
This is a pilot study to determine the utility of Novel Functional Lung Imaging and Ventilation (4DxV) Analysis software in measurement of lung ventilation abnormalities and diagnosis of chronic lung allograft dysfunction (CLAD)…
- Trial name
- NCT04892719
- Testing
- Fluoroscopic chest imaging with 4Dx technology software analysis
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Duke University
C3PI Study Testing Group
Tasso-SST OnDemand Comparator Pilot Study
Purpose and objective: The purpose of this pilot study is participant user acceptance testing of the Tasso-SST OnDemand device to collect blood for antibody testing.
- Trial name
- NCT04713748
- Testing
- Tasso-SST on Demand, Regular Phlebotomy
- Where
- United States
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Duke University
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