Clinical trials: completed, sponsored by Duke University
Metastatic Castration-resistant Prostate Cancer (mCRPC), Metastatic Urothelial Carcinoma
INJECT: A Pilot Study of Intra-tumoral Injections in Metastatic Urological Cancers
The purpose of this study is to plan for future clinical trials in patients with metastatic urological cancers. Diluted iodinated contrast will be injected intra-tumorally under CT fluoroscopy guidance into bone, lymph node, soft…
- Conditions
- Metastatic Castration-resistant Prostate Cancer (mCRPC), Metastatic Urothelial Carcinoma, Metastatic Renal Cell Carcinoma
- Trial name
- NCT03071328
- Testing
- Isovue-M 200
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Duke University
Hematologic Malignancy, Leukemia, Acute
Screening for Colonization With Resistant Enterobacterales in Neutropenic Patients With Hematologic Malignancies
This is a prospective, observational cohort study to assess the frequency with which neutropenic patients with hematologic malignancies and hematopoietic cell transplant (HCT) recipients are colonized with…
- Conditions
- Hematologic Malignancy, Leukemia, Acute, Neutropenia, Bloodstream Infection
- Trial name
- SCENE (NCT04710212)
- Testing
- No intervention.
- Where
- 6 sites in United States
- Volunteers
- 168 people
- Sponsor
- Duke University
Occupational Stress
Selah Trial of Stress Interventions for Clergy: Mindfulness Based Stress Reduction, Daily Examen, and Stress Inoculation
Certain populations may be particularly susceptible to the adverse effects of chronic stress, particularly chronic work-related stress. One such population is that of clergy doing ministry work.
- Trial name
- NCT04625777
- Testing
- Mindfulness Based Stress Reduction, Daily Examen spiritual practice, Stress inoculation combination
- Where
- United States
- Volunteers
- 390 people, healthy volunteers welcome
- Sponsor
- Duke University
Aging
CALERIE: Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy
The purpose of this study is to test the hypothesis that two years of sustained 25% caloric restriction (CR) in men age 21-50 (inclusive) and women age 21-47 (inclusive) will slow aging and protect against age-related disease…
- Trial name
- NCT00427193
- Testing
- Caloric Restriction (CR), Control
- Where
- 3 sites in United States
- Volunteers
- 238 people, healthy volunteers welcome
- Sponsor
- Duke University
Diabetes
I HEAL for Breast Cancer Survivors With Diabetes
The proposed randomized clinical trial evaluates a diabetes coping skills training (DCST) intervention for improving breast cancer survivors' abilities to manage symptoms and adhere to recommended diabetes self-management.
- Trial name
- I HEAL (NCT02970344)
- Testing
- Diabetes Coping Skills Training (DCST)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Duke University
Platelet Aggregation Inhibitors, Aspirin
GM03 - Platelet RNA Signatures of Aspirin
This study will involve healthy volunteers and patients with Type 2 diabetes. Eligible healthy volunteers will be invited to enroll into one of two protocols (A or B) and eligible patients with diabetes will be enrolled into…
- Conditions
- Platelet Aggregation Inhibitors, Aspirin, Ticagrelor, RNA
- Trial name
- NCT05278637
- Testing
- Aspirin, Ticagrelor
- Where
- United States
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Duke University
Pelvic Organ Prolapse
Expedited Versus Restrictive: Limitations on Activity Following Surgical Treatment of Prolapse
The objective of the EVeRLAST study is to determine whether expedited resumption of postoperative activity levels is non-inferior to standard activity restrictions with respect to short-term anatomic prolapse outcomes.
- Trial name
- EVeRLAST (NCT04329715)
- Testing
- Expedited postoperative activity instructions, Standard postoperative activity restructions
- Where
- United States
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Duke University
Alzheimer Disease, Aging
Bilateral Brain Dynamics in Cognition and Aging
This project is focused on the gap in understanding of bilateral brain interactions and their role in helping normative and clinical elderly populations maintain cognitive health.
- Conditions
- Alzheimer Disease, Aging, MCI
- Trial name
- NCT03224988
- Testing
- TMS
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Duke University
Invasive Candidiasis
BIOPIC: Fungal Biomarkers for Diagnosis and Response to Therapy for Pediatric Candidemia
The purpose of the study is to 1) define the operating characteristics of fungal biomarker assays in pediatric patients at high-risk for developing invasive candidiasis, 2) determine the change in fungal biomarker assay results…
- Trial name
- BIOPIC (NCT02220790)
- Where
- 22 sites in United States, Greece and 2 more
- Volunteers
- 515 people
- Sponsor
- Duke University
Postoperative Bracing for Spinal Deformity
Utility of Postoperative Bracing
The study is being done to assess if the use of bracing helps improve quality of life of patients that are undergoing a spinal fusion for deformity.
- Trial name
- NCT03947541
- Testing
- Thoracolumbosacral (TLSO) brace, No Bracing
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Duke University
Medication Compliance
The Integration of a Mobile App Platform With Biomarkers in Kidney Transplantation
The purpose of this study is to examine the feasibility and acceptability of a mobile app to improve self-management skills and medication adherence in kidney transplantation, to assess the clinical benefit of mobile app in…
- Trial name
- NCT04382248
- Testing
- Smartphone App, Tailored education
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Duke University
Ovarian Cancer, Fallopian Tube Cancer
A Pilot Study Investigating the Effect of Chemotherapy on the Tumoral Immunoprofile of Gynecologic Cancers
The investigators propose to collect biologic samples (i.e. tumor tissue, ascites, and/or blood), from patients undergoing standard of care therapy for a gynecologic malignancy.
- Conditions
- Ovarian Cancer, Fallopian Tube Cancer, Peritoneal Cancer, Uterine Endometrial Cancer
- Trial name
- NCT02824328
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Duke University
Schizophrenia Spectrum and Other Psychotic Disorders, Mental Disorders, Severe
Family Psychoeducation for Adults With Psychotic Disorders in Tanzania
The goal of this study is to pilot test a culturally tailored Family Psychoeducation model (KUPAA) for adults with psychotic disorders and their relatives that is appropriate for cultural settings inclusive of both traditional…
- Trial name
- NCT04013932
- Testing
- KUPAA Intervention Group (Culturally Tailored Family Psychoeducation)
- Where
- 2 sites in Tanzania
- Volunteers
- 66 people
- Sponsor
- Duke University
COVID 19
MURDOCK Cabarrus County COVID-19 Prevalence and Immunity (C3PI) Study
The objectives of this research is to: Assess perceptions, concerns, and practices related to the COVID-19 pandemic and mitigation strategies using the MURDOCK Study Community Registry and Biorepository population as a measure of…
- Trial name
- C3PI (NCT04424004)
- Testing
- COVID-19 PCR and serology testing
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Duke University
Prebiotics and Human Behavior and Cognition
Measuring Effects of Prebiotics on Human Behavior and Cognition
This study is designed to test the effects of prebiotics on cognition, behavior and physiology in healthy volunteers.
- Trial name
- NCT04055246
- Testing
- Inulin
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Duke University
Prostate Cancer
Race-related Alternative Splicing: Novel Targets in Prostate Cancer
Data from evaluating prostate cancer (PCa) biopsy tissue from AA and white patients has led to the discovery of alternative splicing as a novel molecular mechanism underlying more aggressive PCa in AA men.
- Trial name
- PCaP splicing (NCT03424213)
- Testing
- No interventions - retrospective data collection
- Where
- United States
- Volunteers
- 169 people
- Sponsor
- Duke University
Retinal Diseases, Optic Nerve Diseases
Long-Working Distance OCT for Children
Young children age 6 month to 6 years are often not able to cooperate for advanced OCT eye imaging. The purpose of this study is to investigate the use of a novel long-working distance swept source (SS) optical coherence…
- Trial name
- LWDOCT (NCT02582164)
- Testing
- Duke Biomedical Engineering's Long-working distance OCT
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Duke University
Pediatric Invasive Candidiasis
PEACE: Pediatric Antifungal Comparative Effectiveness
The overarching objective is to develop new evidence-based treatment guidelines for invasive fungal diseases in children. To accomplish that, this protocol will focus on two specific aims: 1) Compare the effectiveness of…
- Trial name
- PEACE (NCT01869829)
- Testing
- Observational antifungal therapy
- Where
- 35 sites in United States, Canada and 6 more
- Volunteers
- 750 people
- Sponsor
- Duke University
Prostate Cancer
Stereotactic Body Radiotherapy (SBRT) for Prostate Cancer
The purpose of this study is to evaluate the incidence of urinary and gastrointestinal acute and late side effects in patients treated with stereotactic body radiotherapy (SBRT) to the prostate.
- Trial name
- SMART (NCT00941915)
- Testing
- SBRT Prostate
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Duke University
Heart Failure
Depression and Heart Failure Disease Progression
Heart failure is the most costly diagnosis in the Medicare population. Clinical depression is strikingly common in heart failure patients, and not only diminishes their quality of life, but also is associated with a markedly…
- Trial name
- NCT02131428
- Where
- United States
- Volunteers
- 186 people
- Sponsor
- Duke University
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