Clinical trials: completed, sponsored by Duke University
Cannabis Use
Cannabis Use and Epigenetic Alterations in Human Male Sperm Cells
This is a follow-up project to a proof-of-concept study to determine if Cannabis use in male humans is associated with changes in deoxyribonucleic acid (DNA) methylation profile of sperm.
- Trial name
- NCT03614637
- Testing
- Cannabis use abstinence for 11 weeks
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Duke University
Elbow Fracture, Joint Contracture
Synovial Fluid Analysis of Intraarticular Elbow Fracture
The objective of this study is to obtain and compare bilateral elbow joint synovial fluid from patients with unilateral intraarticular elbow fracture and a contralateral healthy appearing elbow joint.
- Trial name
- NCT02878941
- Testing
- Synovial Fluid Analysis
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Duke University
Diabetes Mellitus, Type II
Episodic to Real-Time Care in Diabetes Self-Management
This study will use mobile health technologies to provide everyday data to help patients and their care providers better understand illness dynamics and develop adaptive approaches to improve health outcomes in diabetes.
- Trial name
- NCT03012074
- Testing
- Type 2 Diabetes Self-Management
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Duke University
Educational Activities
Parent Educational Discharge Support Strategies
After the initial hospitalization, parents of children newly diagnosed with cancer assume responsibility for assessing and managing their care; however, parents are often overwhelmed with information received throughout the…
- Trial name
- NCT03227068
- Testing
- PEDSS - symptom management, PEDSS - support for the caregiver
- Where
- 16 sites in United States, Saudi Arabia
- Volunteers
- 289 people
- Sponsor
- Duke University
Opioid Use, Unspecified, Prescription Drug Abuse (Not Dependent)
An Opioid Prescribing Nudge
Analyze baseline concurrent opioid prescribing metrics at the individual prescriber level in the Duke Health System on the identified three main outcome measures.
- Conditions
- Opioid Use, Unspecified, Prescription Drug Abuse (Not Dependent), Prescription Drug Abuse and Dependency, Health Behavior
- Trial name
- OHS (NCT04069403)
- Testing
- Automated Reports on prescription patterns for their patients
- Where
- United States
- Volunteers
- 427 people, healthy volunteers welcome
- Sponsor
- Duke University
Osteo Arthritis Knee
Analgesic Value of Adductor Canal vs Femoral Block After Total Knee Arthroplasty
An observational study of the effect of femoral nerve block in addition to an adductor canal block for pain following total knee arthroplasty.
- Trial name
- NCT03395990
- Testing
- Active comparator: chloroprocaine
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Duke University
Opioid-Related Disorders
Feasibility Study of Extended-release Naltrexone (Vivitrol) in Drug Court Settings
In preparation for a large-scale randomized controlled trial (RCT) of Vivitrol® effectiveness in drug courts, investigators propose a feasibility study in the Wake County, North Carolina drug court, where an estimated 50% of…
- Trial name
- DC (NCT02978417)
- Testing
- Naltrexone for extended-release injectable suspension, Oral naltrexone
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Duke University
Barth Syndrome
Heart and Muscle Metabolism in Barth Syndrome
Barth syndrome (BTHS) is an X-linked disorder caused by abnormal cardiolipin metabolism and is characterized by skeletal and cardiomyopathy and high mortality rates.
- Trial name
- NCT01625663
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Duke University
Diffuse Large B-cell Lymphoma
Reduced Radiation in Patients With Diffuse Large B-cell Lymphoma
This study will evaluate whether a reduction in the radiation dose and field size will maintain a high rate of local control while minimizing the risk of acute and late toxicity.
- Trial name
- DLBCL (NCT01186978)
- Testing
- Radiation Therapy
- Where
- 3 sites in United States
- Volunteers
- 63 people
- Sponsor
- Duke University
Respiratory Tract Infection Acute, Transcriptome
A Rapid Test for Acute Respiratory Illness
The primary purpose of this study is to support the development of a host response test for acute respiratory illness to identify bacterial, viral or NB/NV etiologies as compared to a clinical adjudication reference standard.
- Conditions
- Respiratory Tract Infection Acute, Transcriptome, Virus Disease, Bacterial Infections
- Trial name
- Radical (NCT03192072)
- Testing
- Host Gene Expression
- Where
- 10 sites in United States
- Volunteers
- 783 people
- Sponsor
- Duke University
Breast Cancer
An Optical Assay System for Intra Operative Assessment of Tumor Margins in Patients
Our objective is to develop a novel optical assay system for intra operative assessment of tumor margins in partial mastectomy or mastectomy specimens.
- Trial name
- NCT00734955
- Testing
- 49-channel optical spectrometer
- Where
- United States
- Volunteers
- 485 people, healthy volunteers welcome
- Sponsor
- Duke University
Platinum-resistant Ovarian Cancer, Recurrent Ovarian Cancer
H.O.P.E: Helping Ovarian Cancer Patients Cope
The purpose of this study is to test the effect of the gynecologic oncologists with palliative care specialist collaboration (GO-PC) intervention on patient quality of life.
- Conditions
- Platinum-resistant Ovarian Cancer, Recurrent Ovarian Cancer, Palliative Care
- Trial name
- NCT02090582
- Testing
- Structured Palliative Care, Usual Care
- Where
- 2 sites in United States
- Volunteers
- 47 people
- Sponsor
- Duke University
Breast Cancer
Behavioral Weight and Symptom Management for Breast Cancer Survivors and Partners
The objective of the study is to develop and test the feasibility, acceptability, and initial efficacy of a novel couples-based behavioral weight and symptom management intervention for obese breast cancer survivors and their…
- Trial name
- NCT02574507
- Testing
- Couples-Based Behavioral Weight and Symptom Management
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Duke University
Ankle Osteoarthritis
Total Ankle Replacement for Ankle Arthritis
The purpose of this study is to prospectively evaluate the functional outcome and patient satisfaction of total ankle replacement for tibio-talar osteoarthritis.
- Trial name
- TAR1600 (NCT01986244)
- Where
- United States
- Volunteers
- 1,043 people
- Sponsor
- Duke University
Hypotony Ocular, Cornea Folds and Rupture of Bowman's Membrane Both Eyes
Anterior Corneal Striae in Hypotony
The goal of this is to evaluate the biomechanical properties of hypotonous eyes with vertical anterior corneal striae and/or hypotony maculopathy compared to hypotonous eyes without striae.
- Conditions
- Hypotony Ocular, Cornea Folds and Rupture of Bowman's Membrane Both Eyes, Maculopathy
- Trial name
- NCT04023123
- Testing
- Ophthalmic imaging
- Where
- United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Duke University
Breast Cancer
Targeted Pain Coping Skills Training (PCST) for Prevention and Treatment of Persistent Post-Mastectomy Pain
This study looks at whether a coping skills training program can help women manage pain and stress after breast surgery, and lower the risk of developing chronic pain.
- Trial name
- NCT02439437
- Testing
- Psychosocial Intervention
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Duke University
Adolescent Behavior
Harnessing Sleep/Circadian Rhythm Data as a Biomarker to Mitigate Health Risks
The overall goal of this study is to investigate associations between sleep/circadian disturbances and psychiatric health among adolescents recruited from primary and specialty health clinics.
- Trial name
- NCT03843762
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Duke University
Hepatitis C, Chronic, Heart Failure
Hepatitis C Virus(HCV) Heart and Lung Study
This is a multicenter study in Hepatitis C Virus (HCV) infected adult patients who also have advanced cardiac disease or advanced lung disease.
- Conditions
- Hepatitis C, Chronic, Heart Failure, Pulmonary Disease, Chronic Obstructive, Lung Diseases, Interstitial
- Trial name
- NCT02858180
- Testing
- Sofosbuvir/ledipasvir fixed dose combination(SOF/LDV FDC)
- Where
- 4 sites in United States
- Volunteers
- 15 people
- Sponsor
- Duke University
Otorhinolaryngologic Diseases
Psychiatric Comorbidity
The goals of this project are aimed at the following: 1. Identifying psychiatric comorbidity in patients presenting to the HNSCS clinic 1F and Duke Otolaryngology of Raleigh clinic using the validated assessment tool Brief…
- Trial name
- NCT02927652
- Testing
- Questionnaires
- Where
- United States
- Volunteers
- 463 people
- Sponsor
- Duke University
Non Small Cell Lung Cancer, Small Cell Lung Cancer
Esophageal Sparing Intensity-modulated Radiation Therapy (IMRT) for Locally-Advanced Thoracic Malignancies
Hypothesis 1- Using IMRT, the radiation therapy (RT) dose can be safely escalated from 58 Gy to 74 Gy given as 6 fractions/week with concurrent chemotherapy.
- Conditions
- Non Small Cell Lung Cancer, Small Cell Lung Cancer, Thymoma, Thymus Neoplasms
- Trial name
- ESIMRT (NCT00921739)
- Testing
- Esophageal sparing IMRT
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Duke University
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