Clinical trials: completed, sponsored by Duke University
Pancreatic Disease
Outcomes in Minimally Invasive Versus Open Pancreaticoduodenectomy
The purpose of this study is to evaluate the impact of the quality of life in patients undergoing the Whipple procedure (pancreaticoduodenectomy, PD) for pancreatic cancer.
- Trial name
- NCT02638818
- Testing
- minimally invasive pancreaticoduodenectomy, traditional pancreaticoduodenectomy
- Volunteers
- 57 people
- Sponsor
- Duke University
Appendicitis
Point of Care 3D Ultrasound for Pediatric Appendicitis: a Pilot Study
1. Purpose and Objective: The purpose of this study is to test the feasibility of rapid acquisition of point of care 3D ultrasound for pediatric appendicitis.
- Trial name
- NCT02507674
- Testing
- ultrasound
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Duke University
Primary Sclerosing Cholangitis
Quality of Life in Patients With Primary Sclerosing Cholangitis
The purpose of this study is to assess the healthcare-related quality of life (HRQOL), the impact of risk of liver transplant and risk of malignancy on HRQOL, and the complementary and alternative medicine use in patients with…
- Trial name
- QOL in PSC (NCT02712736)
- Testing
- quality of life survey
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Duke University
Rheumatoid Arthritis, Obesity
Rheumatoid Arthritis Coping Enhancement
This study will test an enhanced lifestyle behavioral weight management program that integrates pain coping strategies with a lifestyle intervention that we expect to enhance obese RA patient's ability to cope with pain-related…
- Conditions
- Rheumatoid Arthritis, Obesity, Pain
- Trial name
- EMBRACE (NCT04246827)
- Testing
- Enhanced Lifestyle Weight Management
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Duke University
Intensive Care Unit Survivors, Informal Caregivers (Family and Friends)
Improving Psychological Distress Among Critical Illness Survivors and Their Caregivers
Patients who receive life support in intensive care units commonly suffer from persistent depression, anxiety, and post-traumatic stress disorder (PTSD) symptoms after discharge.
- Trial name
- NCT01983254
- Testing
- coping skills training, education program
- Where
- 4 sites in United States
- Volunteers
- 417 people
- Sponsor
- Duke University
Chronic Pain, Posttraumatic Stress Disorders
Pain Management Using Mobile Technology in Veterans With PTSD and TBI
Up to half of military veterans with traumatic brain injury (TBI) also suffer from co-occurring posttraumatic stress disorder (PTSD).
- Conditions
- Chronic Pain, Posttraumatic Stress Disorders, Traumatic Brain Injury
- Trial name
- NCT02237885
- Testing
- NeuroSky MindWave Mobile
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Duke University
Cigarette Smoking
Effects of Smoking Environments on Craving and Smoking (CameraCue2.0)
The goal of this study is to evaluate the effects of varenicline versus nicotine replacement versus placebo on personal smoking environment cue (PSE) reactivity.
- Trial name
- NCT02551692
- Testing
- Nicotine Patch, Varenicline
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Duke University
ADHD
Effects of Noise Cancelling Headphones on Neurocognitive and Academic Outcomes in ADHD
The purpose of this study is to evaluate performance on the Attention Deficit Hyperactivity Disorder ( ADHD) Battery of the Cambridge Automated Neuropsychological Test Battery (CANTAB), including spatial working memory…
- Trial name
- NCT03216512
- Testing
- Use of Noise Cancelling Headphones
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Duke University
Healthy Volunteers
Utilizing Transcranial Direct Current Stimulation to Enhance Laparoscopic Technical Skills Training
The purpose of this study is to test the influences of transcranial direct current stimulation (tDCS) on the acquisition of laparoscopic surgical skills.
- Trial name
- NCT03083483
- Testing
- transcranial direct current stimulation (tDCS)
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Duke University
Pediatric Sedation
ClinRO Sedation Validation
This study will conduct qualitative interviews to provide evidence for the content validity and comprehension of existing physician-reported measures of sedation levels of children receiving anesthesia to facilitate a diagnostic…
- Trial name
- NCT03956342
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Duke University
Hip Pain Chronic, Hip Disease
Patient Performed Examination for Patients With Intra-articular Hip Pain
The primary objective of this study is evaluate the diagnostic accuracy of a patient self-administered clinical examination of the hip compared with a traditional clinical examination (i.e. index test).
- Trial name
- NCT03248934
- Testing
- Patient Self-Administered Diagnostic Exam, Clinician-Performed Diagnostic Exam
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Duke University
Emotion Regulation, Real Versus Sham Transcranial Magnetic Stimulation (TMS)
Testing a Neurocognitive Model of Distancing Using Transcranial Magnetic Stimulation.
Distancing oneself from a current distressing situation is a mental skill that can help people to manage their emotions. However, little is known about how distancing works in the brain.
- Trial name
- NCT03698591
- Testing
- Transcranial magnetic stimulation task
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Duke University
Arthritis, Knee Osteoarthritis
Stated-Preferences in Knee Arthroplasty
The primary objectives of this study are to apply best-practice stated-preference methods to quantify patient preferences for benefit-risk tradeoffs associated with arthroplasty treatment options for end-stage osteoarthritis of…
- Conditions
- Arthritis, Knee Osteoarthritis, Arthropathy of Knee
- Trial name
- NCT03058380
- Testing
- Stated-Preferences Evaluation Instrument
- Where
- United States
- Volunteers
- 348 people
- Sponsor
- Duke University
Orthopedic Disorder
Role of Social Incentives in PRO Collection
Value-based healthcare is heavily dependent on the accurate measurement of patient outcomes, both immediately after treatment and at long-term intervals.
- Trial name
- NCT03436446
- Testing
- Interview
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Duke University
Heart Failure
Splanchnic Nerve Anesthesia in Heart Failure
Patients admitted for acute heart failure and undergoing right heart catheterization will be enrolled in this study. Subjects will undergo catheterization of the heart to obtain central cardiac pressure and other cardiac…
- Trial name
- NCT02669407
- Testing
- splanchnic nerve anesthesia with a local anesthetic, regional nerve block with a local anesthetic (Lidocaine)
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Duke University
Optical Coherence Tomography (OCT) of the Retina
Low Cost OCT for Point of Care
The purpose of this study is to compare the performance of a prototype optical coherence tomography (OCT) machine with currently available high resolution OCT machines.
- Trial name
- NCT03323307
- Testing
- OCT imaging
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Duke University
Autism Spectrum Disorder
Autologous Umbilical Cord Blood Infusion for Children With Autism Spectrum Disorder (ASD)
This study is a prospective phase 1 single-center trial designed to determine the safety of a single intravenous infusion of autologous umbilical cord blood in children with Autism Spectrum Disorder (ASD) and assess the…
- Trial name
- NCT02176317
- Testing
- Autologous Umbilical Cord Blood
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Duke University
Heart Failure
Cardiac Rehabilitation and Metabolomics in Heart Failure
This is a randomized controlled trial of participants with heart failure randomized into usual care plus integrated cardiac rehabilitation or usual care only.
- Trial name
- CROMe (NCT03743012)
- Testing
- Integrated cardiac rehabilitation, Usual Care
- Where
- Kenya
- Volunteers
- 91 people
- Sponsor
- Duke University
Gram-negative Bacteremia
Rapid Identification and Phenotypic Susceptibility Testing for Gram-Negative Bacteremia
RAPIDS-GN is a multi-center, prospective, randomized, controlled trial to evaluate the following strategies for patients with confirmed gram-negative bacillus bacteremia (GNB): 1.
- Trial name
- RAPIDS-GN (NCT03218397)
- Testing
- Accelerate PhenoTest™ BC Kit, Standard Culture and AST
- Where
- 2 sites in United States
- Volunteers
- 500 people
- Sponsor
- Duke University
Posttraumatic Stress Disorder, Cancer
Cancer Distress Coach Mobile App Trial
The Cancer Distress Coach (CDC) mobile app is a symptom management tool for posttraumatic stress disorder (PTSD) in cancer patients and caregivers.
- Trial name
- NCT02986152
- Testing
- Cancer Distress Coach Mobile App
- Where
- United States
- Volunteers
- 569 people
- Sponsor
- Duke University
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