Clinical trials: completed, sponsored by Duke University
Acute Pain, Chronic Pain
Dexamethasone and Pain Following Total Knee Arthroplasty
The purpose of the study is three fold. First to determine the ideal dose of dexamethasone intraoperatively that will reduce acute pain and opioid consumption.
- Trial name
- NCT02271698
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Duke University
Neovascular Age-Related Macular Degeneration
Neovascular Morphology and Persistent Disease Activity Among Patients With NV AMD
Neovascular Age-Related Macular Degeneration (NV AMD) remains the leading cause of vision loss among people over 65. Intravitreal injections with drugs that block VEGF have revolutionized treatment of NV AMD.
- Trial name
- NCT02367365
- Testing
- No Intervention
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Duke University
Primary Open Angle Glaucoma
The Effect of Sponge Versus No-Sponge Placement of Mitomycin-C on the Outcomes of Trabeculectomy With Ex-PRESS Glaucoma Filtration Device
The primary focus of this study is to assess intraocular pressure and complication rates between patients who receive mitomycin-C using a sponge versus no-sponge.
- Trial name
- NCT02016898
- Testing
- Placement of the sponge, Mitomycin-C
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Duke University
Fever
The Effect of Prophylactic Antipyretics on Immune Responses and Fever After 2014-2015 and 2015-2016 Inactivated Influenza Vaccine
This study aims to conduct a double-blind, placebo-controlled study to assess the effect of prophylactic antipyretics on the immune responses and rates of fever after inactivated influenza vaccine (IIV) in children 6 through 47…
- Trial name
- NCT02212990
- Testing
- Acetaminophen Arm, Ibuprofen Arm
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Duke University
Psychological Distress, Depression
Mobile Mindfulness to Improve Psychological Distress After Critical Illness
Many survivors of the intensive care unit (ICU) suffer from persistent symptoms of depression, anxiety, and post-traumatic stress disorder (PTSD).
- Conditions
- Psychological Distress, Depression, Anxiety, Post-traumatic Stress Disorder
- Trial name
- NCT02701361
- Testing
- mobile mindfulness, standard mindfulness, education
- Where
- 2 sites in United States
- Volunteers
- 90 people
- Sponsor
- Duke University
Peripheral Artery Disease
Verizon mHealth Solution for Patients With Peripheral Artery Disease (PAD)
The purpose of this study is to understand the effects that a three month lifestyle-based mobile health (mHealth) peripheral artery disease (PAD) prevention program will have on improving physical activity, fitness, important PAD…
- Trial name
- NCT02472561
- Testing
- Fitbit Physical Activity Monitor, mHealth Glucometer, mHealth Blood Pressure
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Duke University
Coronary Artery Disease
VIDA Mobile Health Cardiovascular Prevention Program
The purpose of this study is to understand the effects of a mobile health cardiovascular prevention program in patients who have recently graduated from cardiac rehabilitation.
- Trial name
- NCT02431546
- Testing
- Mobile Health Application
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Duke University
Coronary Heart Disease
Stress Management and Biomarkers of Risk in Cardiac Rehabilitation
The purpose of this study is to assess the extent to which combining exercise and stress management training (SMT) is more effective at improving biomarkers in vulnerable cardiac patients compared to exercise-based cardiac…
- Trial name
- ENHANCED (NCT00981253)
- Testing
- SMT-enhanced Cardiac Rehabilitation, Standard Cardiac Rehabilitation
- Where
- 2 sites in United States
- Volunteers
- 164 people
- Sponsor
- Duke University
Infant Immunity Response and Immunoglobulin Diversity
Infant Immunity Comparison of Breastfed and Bottlefed Infants
This study will follow 40 healthy, vaginally delivered infants that are primarily (>/- 75%) breast fed and 40 infants that are exclusively formula fed for at least the first 4 months of life from birth until 12 month age.
- Trial name
- NCT02568579
- Testing
- blood sample/ stool sample
- Where
- 3 sites in United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Duke University
Advanced Non-clear Cell Renal Cell Carcinoma
Phase II Study of Afinitor vs. Sutent in Patients With Metastatic Non-Clear Cell Renal Cell Carcinoma
To compare the anti-tumor activity of everolimus and sunitinib in subjects with metastatic renal cell carcinoma (mRCC) with non-clear cell pathology.
- Trial name
- ASPEN (NCT01108445)
- Testing
- Everolimus, Sunitinib
- Where
- 18 sites in United States, Canada and 1 more
- Volunteers
- 131 people
- Sponsor
- Duke University
Cancer
Using a Geriatric Oncology Assessment to Link With Services
The objective of this study is to implement a brief geriatric oncology assessment (GOA) in a community-based oncology clinic, the Scotland Cancer Treatment Center - a clinic within the Duke Cancer Network, located in the rural…
- Trial name
- GOAL (NCT02906592)
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Duke University
Sepsis, Severe Sepsis
Epidemiology, Acute Management, and Outcomes of Patients With Sepsis Presenting to a Referral Hospital in Western Kenya
Sepsis is a clinical syndrome representing deranged hemodynamics (such as tachycardia) secondary to severe infection. In high-income countries (HICs), early resuscitation of septic patients with protocol-driven therapy, including…
- Conditions
- Sepsis, Severe Sepsis, Septic Shock
- Trial name
- NCT02346331
- Testing
- WHO algorithm of fluid boluses guided by physical examination, Frequent patient monitoring, Early administration of empiric antibiotics
- Where
- Kenya
- Volunteers
- 198 people
- Sponsor
- Duke University
Smoking
Feasibility and Smokers' Reactions to DNA Feedback
The purpose of the study is to explore how feedback of cellular DNA (Deoxyribonucleic Acid) damage, as a marker of exposure to the genotoxic agents of tobacco smoke, promotes cessation.
- Trial name
- NCT02922790
- Testing
- standard health information, standard health information plus info. on DNA damage, Subjects will review standard health information and information on DNA damage, plus pictures of their DNA damage
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Duke University
Bacteremia
Treatment Algorithm to Reduce the Use of Vancomycin in Adults With Blood Stream Infection
The purpose of this study is to accurately determine the length of appropriate drug treatment for staphylococcal blood stream infection.
- Trial name
- Bacteremia (NCT01191840)
- Testing
- Vancomycin
- Where
- 15 sites in United States, Spain
- Volunteers
- 509 people
- Sponsor
- Duke University
Anemia, Sickle Cell
MBSR for Pain Catastrophizing in SCD
Significance: The purpose of this exploratory study is to test the feasibility, accessibility, and effects of a mindfulness-based stress reduction program (MBSR) on reducing pain catastrophizing in persons with sickle cell…
- Trial name
- NCT02394587
- Testing
- Mindfulness-based Stress Reduction
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Duke University
Cancer
Williams LifeSkills - Cancer Caregiver Intervention
The purpose of the pilot is to test the feasibility of developing and implementing the Williams LifeSkills Cancer Care (WLSCC) and examining its preliminary impact on caregiver well-being and patient well-being.
- Trial name
- NCT03174626
- Testing
- WLSCC, Usual Care
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Duke University
Breast Cancer, Depression
Survival TRaining for ENhancing Total Health (STRENGTH)
RATIONALE: A home-based exercise and/or diet program may improve the quality of life of breast cancer patients by preventing an increase in body fat and weight and a loss of lean body tissue.
- Conditions
- Breast Cancer, Depression, Weight Changes
- Trial name
- NCT00068458
- Testing
- Calcium-Rich Diet, Arm 2: Exercise + Calcium-Rich Diet, Exercise + Fruit & Vegetable, Low Fat + Calcium Diet
- Where
- 4 sites in United States
- Volunteers
- 39 people
- Sponsor
- Duke University
Nicotine Addiction
Acute and Chronic Nicotine Modulation of Reinforcement Learning
The purpose of this study is to use functional magnetic resonance imaging (fMRI) to investigate the acute and chronic effects of nicotine on motivational behavior and prediction error-related neural activation.
- Trial name
- NicLearning (NCT01830842)
- Testing
- Nicotine polacrilex, satiety, abstinence
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Duke University
Limited Dorsiflexion, Limited Ankle Range of Motion
Triceps Surae Trigger Point Size and Muscle Extensibility
The purpose of this study is to determine the effectiveness of dry needling in improving ankle range of motion and functional outcomes.
- Trial name
- NCT02087969
- Testing
- Dry Needling, Stretching
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Duke University
Prostate Cancer, Renal Cancer
Feasibility of a Consumer Based Accelerometer in Monitoring Outpatient Physical Activity: A Study in Patients With Cancer and Amyotrophic Lateral Sclerosis
This is a parallel group, single institution, prospective clinical study. The purpose of this study is to assess whether the Jawbone Up 24, a consumer based accelerometer, can be a feasible tool to study physical activity in…
- Conditions
- Prostate Cancer, Renal Cancer, Brain Cancer, ALS
- Trial name
- NCT02457715
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Duke University
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