Clinical trials: completed, sponsored by Duke University
Breast Neoplasms
Early Detection of Breast Cancer Using Tomosynthesis Imaging
The purpose is to develop digital tomosynthesis to improve the detection of breast cancers. The aims are optimizing digital mammography and tomosynthesis acquisition, creating visualization tools, prospective pilot studies to…
- Trial name
- NCT00637598
- Testing
- Mammography and tomosynthesis imaging
- Where
- United States
- Volunteers
- 385 people, healthy volunteers welcome
- Sponsor
- Duke University
HIV
Treatment of Acute HIV Infection With Quad Fixed-dose Combination (FDC) Tablet
This is a multicenter, single arm, 48-week open-label study of FDC ELV/COBI/FTC/TDF [Stribild] in acute HIV infection. Study sites will be members of the Duke-UNC Acute HIV Infection Study Consortium.
- Trial name
- PHI04 (NCT01694420)
- Testing
- (FDC) ELV/COBI/FTC/TDF
- Where
- 2 sites in United States
- Volunteers
- 33 people
- Sponsor
- Duke University
Childhood Obesity
Integrated Child Obesity Treatment Study: Bull City Healthy and Fit
The primary aim of this study is to reduce body mass index (BMI) among children ages 5-11 who are obese by integrating behavioral treatment strategies in both clinic (Healthy Lifestyles) and community (Bull City Fit) settings.
- Trial name
- BCHF (NCT02573142)
- Testing
- Bull City Healthy and Fit, Healthy Lifestyles Clinic
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- Duke University
Primary Liver Cancer, Metastatic Liver Cancer From Any Cancer Site
Magnetic Resonance Imaging (MRI) Solely For Liver Stereotactic Body Radiation Therapy (SBRT)
This study is a research and development initiative established to explore the use of magnetic resonance imaging (MRI) as a tool for managing organ motion of the liver in cancer patients planning procedures for stereotactic body…
- Trial name
- NCT02722395
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Duke University
Dementia
Mealtime Symptoms in Dementia
The purpose of this study is to combine current evidence-based guidelines with adaptive leadership (AL) training to assist nursing staff to navigate the delicate balance of necessary technical and adaptive work to improve…
- Trial name
- NCT02269956
- Testing
- 12 week feasibility study
- Volunteers
- 132 people
- Sponsor
- Duke University
Heart Failure
Coping Skills and Heart Failure: Outcomes and Mechanisms
This study will evaluate whether heart failure patients receiving a 16 week telephone delivered, intervention using cognitive behavior therapy to facilitate self-management of heart failure will have better clinical outcomes than…
- Trial name
- COPE-HF (NCT00873418)
- Testing
- Coping skills training
- Where
- United States
- Volunteers
- 190 people
- Sponsor
- Duke University
Mild Cognitive Impairment
Oral Health Intervention Pilot Study for Individuals With Memory Problems
The purpose of this study is to pilot test an intervention to improve oral health for individuals with memory problems. The results from this study will assist in developing prevention and intervention programs aimed at…
- Trial name
- NCT01808235
- Testing
- Oral Health Intervention
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Duke University
Preterm Infant Health, Preterm Infant Development
Preterm Infants: Light Effects on Health and Development
Preterm babies cared for in the intensive care nursery are exposed to amounts of light that are very different from the exposures to an unborn baby or the newborn term baby.
- Trial name
- NCT02146287
- Testing
- Cycled Light
- Volunteers
- 121 people
- Sponsor
- Duke University
Posttraumatic Stress Disorder
Group vs. Individual Cognitive Processing Therapy for Combat-related PTSD
The purpose of this study is to conduct a randomized controlled trial to compare group and individual CPT-C for the treatment of PTSD in OIF/OEF military personnel.
- Trial name
- NCT02173561
- Testing
- Group Cognitive Processing Therapy-Cognitive Only, Individual Cognitive Processing Therapy-Cognitive Only
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Duke University
Nocturia, Daytime Sleepiness
Cross-over Study of Armodafinil Treatment of Daytime Sleepiness Associated With Treated Nocturia
The objective of the study is to evaluate armodafinil as a wakefulness-promoting therapy as a means of improving residual daytime sleepiness in patients with treated nocturia.
- Trial name
- NCT02151253
- Testing
- Armodafinil
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Duke University
Healthy Volunteer
Caloric Stimulation on Cerebral Blood Flow
This is a prospective, non-randomized study designed to generate preliminary data to assess the effect of a new portable non-invasive caloric stimulator on EEG waveform and cerebral blood flow on normal healthy volunteers.
- Trial name
- NCT01629901
- Testing
- ThermoNeuroModulation (TNM) Device
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Duke University
Sensory Nerve Conduction, Oxyneurogram Index
Effect of Tourniquet on Sensory Nerve Conduction Threshold (sNCT) and OxyNeuroGram (ONG) Index- A Volunteer Study
There are a number of risk factors for development of chronic pain that have been evaluated including age, gender, type and duration of surgery, duration of pain prior to surgery and tourniquet application.
- Trial name
- NCT01970839
- Testing
- tourniquet, sensory nerve conduction abnormality
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Duke University
Postoperative Nausea and Vomiting
Aprepitant With Dexamethasone Versus Ondansetron With Dexamethasone for PONV Prophylaxis in Patients Having Craniotomy
We hypothesize that the combination of aprepitant with dexamethasone will provide significantly improved prophylaxis against Postoperative nausea and vomiting compared with the combination of ondansetron and dexamethasone, in…
- Trial name
- NCT00734929
- Testing
- Aprepitant + Dexamethasone, Ondansetron + Dexamethasone
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- Duke University
Recurrent Glioblastoma Multiforme, Malignant Glioma
Ph II SAHA and Bevacizumab for Recurrent Malignant Glioma Patients
It has been shown that bevacizumab has significant anti-tumor activity in patients with recurrent glioblastoma multiforme. Vorinostat has modest anti-tumor activity against malignant glioma and can enhance the action of both…
- Conditions
- Recurrent Glioblastoma Multiforme, Malignant Glioma, Adult Brain Tumor
- Trial name
- NCT01738646
- Testing
- Vorinostat, Bevacizumab
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Duke University
Hypertrophic Cardiomyopathy
Ranolazine for the Treatment of Chest Pain in HCM Patients
The purpose of RHYME is to evaluate the safety and efficacy of ranolazine in Hypertrophic Cardiomypathy patients with chest pain or dyspnea despite treatment with standard medical therapy.
- Trial name
- RHYME (NCT01721967)
- Testing
- Ranolazine
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Duke University
Male-factor Infertility
Understanding Adaptive Challenges Associated With Male-factor Infertility
The purpose of this study is to understand the experience of men and their partners when diagnosed with male-factor infertility while trying to achieve a pregnancy and the skills they use to adapt to this diagnosis.
- Trial name
- NCT02607098
- Where
- 2 sites in United States, United Kingdom
- Volunteers
- 24 people
- Sponsor
- Duke University
Continuation Rate of Contraceptive Implant
Immediate vs. Delayed Postpartum Etonogestrel Implant
The investigators are examining if there is a difference in continuation rates of the etonogestrel contraceptive implant between women who have the device placed immediately after delivery, before leaving the hospital, and women…
- Trial name
- NCT01767285
- Testing
- Etonogestrel implant
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Duke University
Normal Eyelid Sensation Distribution
Normal Eyelid Sensation Distribution
The purpose of this study is to determine normal eyelid sensation distribution using a Cochet-Bonett Aesthesiometer.
- Trial name
- NCT02059824
- Testing
- Aesthesiometer
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Duke University
Colorectal Cancer
Reducing Sedentary Behaviors Among Colorectal Cancer Survivors
Interview colorectal cancer survivors and use this input to create a brochure intended to guide reduction of sedentary behaviors in this population. Have colorectal cancer survivors review and comment on a draft of the brochure.
- Trial name
- NCT02442583
- Testing
- Brochure regarding sedentary behavior
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Duke University
Overweight, Obesity, Small for Gestational Age, Prematurity
Novel Screening Tools For the Evaluation and Management of Malnourished Children in the Developing World
The purpose of this study is to evaluate the accuracy of a new device that may be used for the evaluation and management of malnourished infants and children.
- Trial name
- NCT02449408
- Testing
- Measurement of leptin and adiponectin obtained through blood sampling via venipuncture or finger/heelstick using novel screening tool
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Duke University
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