Clinical trials: completed, sponsored by Duke University
Bowel Dysfunction
Perioperative Tissue Penetration of Antimicrobials in Infants
This study aims to define the pharmacokinetic (PK) properties of a commonly used antibiotic to treat cIAI, metronidazole, in the intestinal wall tissue of healthy infants undergoing intestinal surgery to optimize intestinal wall…
- Trial name
- NCT04299867
- Testing
- Bowel Surgery with Metronidazole
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Duke University
Diabetic Macular Edema, Diabetic Retinopathy
Imaging Parameters and DME Treatment Response
Diabetic macular edema (DME) is the most common cause of vision loss in diabetic patients. While anti-VEGF treatments and to a lesser extent corticosteroid and macular photocoagulation have improved outcomes in patients with DME…
- Trial name
- NCT02637245
- Testing
- No intervention
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Duke University
Adolescent and Young Adult Cancer Patient
Adolescents and Young Adults (AYAs) With Advanced Cancer
This study aims to develop and test the feasibility and acceptability of a psychosocial symptom management intervention designed to meet the unique needs of Adolescents and Young Adults (AYAs) with advanced cancer.
- Trial name
- NCT05593016
- Testing
- Symptom Management for Improved Physical and Emotional Wellbeing (SMILE), Education Control Arm
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Duke University
Stem Cell Transplant
mPCST for BMT Patients
We used a small randomized controlled trial (n=36) to compare a Mobile Health Pain Coping Skills (mPCST) to Usual Treatment for patients having received hematopoietic stem cell transplant.
- Trial name
- NCT01984671
- Testing
- Mobile Pain Coping Skills Training
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Duke University
Chronic Disease
Patient Initiated Note About Goals
This is a randomized controlled trial of the Patient-Initiated Note about Goals (PING).
- Trial name
- PING (NCT05637489)
- Testing
- PING
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Duke University
Heart Failure
TRANSFORM-HF: ToRsemide compArisoN With furoSemide FORManagement of Heart Failure
TRANSFORM-HF is a large-scale, pragmatic, randomized, unblinded clinical effectiveness study comparing torsemide versus furosemide as treatment for heart failure. Approximately 6,000 patients with heart failure will be enrolled.
- Trial name
- TRANSFORM-HF (NCT03296813)
- Testing
- Torsemide, Furosemide
- Where
- 60 sites in United States
- Volunteers
- 2,973 people
- Sponsor
- Duke University
Laparotomy, Colectomy
QL Block With Exparel in Colectomy
The purpose of this study is to determine if using a different type of injection of local anesthestic (pain medicine) in between the muscle layers of the abdominal wall (called a quadratus lumborum block) will improve pain…
- Trial name
- NCT03827291
- Testing
- Exparel, Thoracic epidural analgesia
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Duke University
Acute Respiratory Failure, Mechanical Ventilation Complication
Assessing Ventilator Safety in Patients on Pressure-Support Ventilation
ASOP is a prospective cohort study comparing three methods for assessing risk of self-induced lung injury in patients with acute respiratory failure being managed with pressure-support ventilation.
- Conditions
- Acute Respiratory Failure, Mechanical Ventilation Complication, Ventilator-Induced Lung Injury
- Trial name
- ASOP (NCT05125952)
- Testing
- Viasys Avea Ventilator, Philips Respironics NM3 device, Servo U ventilator
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Duke University
Infections
Chlorhexidine Gluconate Bathing Education Video Among Hospitalized Patients
Chlorhexidine gluconate (CHG) bathing is an effective intervention to reduce hospitalized patient's risk of acquiring a central line-associated bloodstream infection (CLABSI).
- Trial name
- NCT06112626
- Testing
- CHG Skin Treatment Video
- Where
- 2 sites in United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Duke University
Age Related Macular Degeneration
AREDS 2 Ancillary Spectral Domain Optical Coherence Tomography Study
The purpose of this study is to identify whether changes in age-related macular degeneration (AMD) over time as seen with spectral domain optical coherence tomography (SDOCT) imaging, can be used to predict vision loss and the…
- Trial name
- A2ASDOCT (NCT00734487)
- Where
- 4 sites in United States
- Volunteers
- 470 people, healthy volunteers welcome
- Sponsor
- Duke University
Late-Onset Pompe Disease, Lysosomal Disease
High Dose Inspiratory Muscle Training in LOPD
Study Objectives: 1) assess the safety and feasibility of high-dose inspiratory muscle training (IMT) delivered remotely in Late-onset Pompe Disease (LOPD) and 2) determine its effects on respiratory and patient-reported outcomes.
- Trial name
- NCT05431127
- Testing
- IMT therapy using the Pr02 mobile device
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Duke University
Hematologic Malignancy
Survivorship Post-HCT Optimization Program
The purpose of this project is to investigate the effects of 12 weeks of high-intensity interval training (HIIT) and resistance training on several domains of health including physical function, cognitive function, mental health…
- Trial name
- S-POP (NCT05238376)
- Testing
- Exercise training
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Duke University
Weight Loss
Food is Medicine: Pilot Study
The goal of this study is to determine whether shared medical visits also called "group visits" would be beneficial for patients who are under weight management care.
- Trial name
- NCT06797453
- Testing
- Shared Medical Visits, Full Plate Living
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Duke University
Colorectal Cancer
Initial Testing of a Mobile App Pain Coping Intervention for Outpatient Oncology Settings (PainPac)
PainPac is innovative in its potential to integrate with healthcare systems through electronic medical records (EMRs). PainPac leverages technology to increase patient access to interventions and uses real-time assessment to…
- Trial name
- NCT05686122
- Testing
- PainPac
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Duke University
Domestic Violence
Training Local Leaders to Prevent and Reduce Domestic Violence Evidence From Peru
Leaders in Action (LIA) is a norms-centered intervention that aims to reduce the acceptance and prevent the incidence of Intimate Partner Violence (IPV) in Peru by shifting social norms.
- Trial name
- LIA (NCT05331248)
- Testing
- Leaders in Action: Household Treatment, Leaders in Action: Group Treatment
- Where
- Peru
- Volunteers
- 8,754 people, healthy volunteers welcome
- Sponsor
- Duke University
Chronic Pain, Smoking, Cigarette
Low Nicotine Cigarettes, Smoking, and Chronic Pain
The purpose of this study is to evaluate the effects of switching to very low nicotine content (VLNC) cigarettes versus normal nicotine content (NNC) cigarettes on experiences with craving, withdrawal, and pain among individuals…
- Trial name
- VLNCPain (NCT05032755)
- Testing
- SPECTRUM NRC 102/103 investigational cigarettes, SPECTRUM NRC 600/601 investigational cigarettes
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Duke University
Acute Pain, Postoperative, Regional Anesthesia Block
Dispersion Following ESP Versus ITP Blocks Using Lidocaine Study
Regional anesthesia techniques (or nerve blocks) are used to provide sensory blockade over the chest wall. The most established technique is thoracic epidural.
- Trial name
- DEVILS (NCT06843343)
- Testing
- Intertransverse Process Block with 1.5% Lidocaine, Erector Spinae Plane Block with 1.5% Lidocaine, 1.5% Lidocaine
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Duke University
Atrial Septal Defect, Ventricular Septal Defect
Regional Anesthesia Following Pediatric Cardiac Surgery
The purpose of this study is to evaluate pain control following pediatric cardiac surgery with the use of local anesthesia via an ultrasound guided regional anesthetic technique compared with surgeon delivered wound infiltration.
- Conditions
- Atrial Septal Defect, Ventricular Septal Defect, Pain, Procedural
- Trial name
- NCT05688670
- Testing
- Regional Anesthesia, Wound infiltration, Ropivacaine 0.2% Injectable Solution
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Duke University
Nerve Blocks, Medical Education, Simulation, Crisis Resource Management
Ultrasound-guided Nerve Block Training Model and Evaluation Method
The aim of this study is to assess emergency medicine physician knowledge and technical skill in performance of ultrasound-guided serratus anterior nerve block in a low-fidelity simulation model workshop and to determine the…
- Conditions
- Nerve Blocks, Medical Education, Simulation, Crisis Resource Management, Medical Education in Emergency Ultrasound
- Trial name
- NCT06219005
- Testing
- ultrasound education and simulation workshop
- Where
- United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Duke University
Endometrial Diseases, Pain, Postoperative
Transcutaneous Electrical Nerve Stimulation During Outpatient Endometrial Biopsy
The purpose of this study is to see whether transcutaneous electrical nerve stimulation (or TENS) reduces pain during an endometrial biopsy.
- Trial name
- NCT05472740
- Testing
- TENS 7000
- Where
- United States
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- Duke University
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