Clinical trials: sponsored by Federico II University
Chronic Kidney Disease Stage 3-5
Effect of Sevelamer on P-cresol Levels in CKD
The accumulation of p-cresol, a product of the metabolism of aromatic aminoacid operated by resident intestinal bacteria increases the cardiovascular risk of chronic kidney disease (CKD) patients.
- Trial name
- NCT02199444
- Testing
- Sevelamer
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Federico II University
Type 1 Diabetes
Fats And Carbohydrates Quality on Postprandial glycemIc Response in Type 1 Diabetes
The purpose of this study is to determine whether dietary fats may affect postprandial glycemic response differently according to their quality, and these effects may differ whether they are assumed in the context of meals with…
- Trial name
- FACILE (NCT02330939)
- Testing
- Low fat- Low glycemic index meal, MUFA- Low glycemic index meal, SAFA- Low glycemic index meal
- Where
- Italy
- Volunteers
- 14 people
- Sponsor
- Federico II University
Hemodialysis
Effect of Short-term Synbiotic Treatment on Plasma P-cresol Levels in Hemodialysis Patients
The interest on gastrointestinal (GI) dysfunction in hemodialysis has been growing in the last years. it is now accepted that GI dysfunction in dialyzed patients may contribute to systemic microinflammation by promoting gut…
- Trial name
- NCT02311868
- Testing
- SYNBIOTIC (Probinul neutro®)
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Federico II University
Short Chain Fatty Acids Concentration in Breast Milk
Study on Short Chain Fatty Acids Concentration in Breast Milk and Its Correlation With the Maternal Diet
The purpose of this study is to determine whether the acetate, butyrate and propionate concentration in breast milk and to evaluate the possible correlation of these concentrations with maternal diet.
- Trial name
- NCT02301728
- Testing
- sampling of breast milk, obtaining information about the maternal diet
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Federico II University
Headache
Effects of Changes in Dietary Intake and Headache's Attacks
Headache is a frequently disabling disorder, which occurs in about 30% of the adult population, particularly in overweight/obese women.
- Trial name
- NCT01917474
- Testing
- low lipid diet, normal lipid diet
- Where
- 2 sites in Italy
- Volunteers
- 150 people
- Sponsor
- Federico II University
Hypertension, Body Weight
Increasing Calcium Dietary Intake Helps to Control Blood Presure and Body Weight
Mediterranean diet is relatively poor in calcium (about 700 mg/daily) whilst there are several reports indicating beneficial effects of calcium-rich diets.
- Trial name
- NCT02295852
- Testing
- LOW-SODIUM LOW LIPID CALCIUM RICH DIET, LOW-SODIUM LOW LIPID DIET
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Federico II University
Metabolic Syndrome
Mesoglycan, Vascular Reactivity and Metabolic Syndrome
The purpose of the study was to characterize the action of mesoglycan on vascular endothelium through the non-invasive assessment of vascular reactivity humeral artery by comparing effects of mesoglycan on Flow Mediated…
- Trial name
- NCT02254850
- Testing
- Flow Mediated Dilation, Mesoglycan
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Federico II University
Crohn's Disease
A Prospective, Placebo Controlled, Double-Blind, Cross-over Study on the Effects of a Probiotic Preparation (VSL#3) on Metabolic Profile, Intestinal Permeability, Microbiota, Cytokines and Chemokines Expression and Other Inflammatory Markers in Pediatric Patients With Crohn's Disease
Background VSL#3 has been reported as an effective adjuvant therapy both in inducing and maintaining remission in pediatric patients affected by Ulcerative Colitis.
- Trial name
- NCT01632462
- Testing
- VSL#3
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Federico II University
Anemia, Chronic Kidney Disease
Paricalcitol Effect on Anemia in CKD
Current activated Vitamin D therapies are approved for treating secondary hyperparathyroidism in chronic kidney disease (CKD), and a large body of experimental data in animals confirms the effects of Vitamin D that extend beyond…
- Trial name
- NCT01768351
- Testing
- Paricalcitol, Calcitriol
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Federico II University
Iron Deficiency Anemia, Chronic Kidney Disease
Endovenous Versus Liposomal Iron in CKD
Anemia is a common complication in patients with chronic kidney disease (CKD). In addition to erythropoietin deficiency, many studies have identified iron deficiency as a cause of anemia in CKD patients.
- Trial name
- NCT01864161
- Testing
- gluconate iron, Liposomal iron
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Federico II University
Renal Insufficiency, Chronic
Effect of Pre- and Probiotics on P-cresol Plasma Levels in Patients Bearing a Kidney Allograft
The purpose of this study is to establish whether a short treatment with the synbiotic combination Probinul neutro® may decrease the plasma concentration of the uremic toxin p-cresol in patients bearing a kidney allograft.
- Trial name
- NCT02179229
- Testing
- CONTROL, SYNBIOTIC
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Federico II University
Metabolic Syndrome
Wholegrain Cereal Diet and Insulin Sensitivity
A diet with the multiple beneficial characteristics of whole grains and, more in general, of "healthy cereals" favorably influences glucose and insulin metabolism in subjects with metabolic syndrome.
- Trial name
- NCT00945854
- Testing
- Wholegrain cereal diet, Refined cereal diet
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Federico II University
Cow's Milk Allergy
Evaluation of the Efficacy of a New Infant Formula in Subjects With Cow's Milk Allergy
Cow's milk protein allergy is defined as an immunological reaction to one or more milk proteins. A variety of symptoms can be suggestive for cow's milk protein allergy .
- Trial name
- NCT02149134
- Testing
- TeHF2013-01
- Where
- Italy
- Volunteers
- 29 people
- Sponsor
- Federico II University
Cow's Milk Allergy
Hypoallergenicity To Substitutive Formulas In Children With Cow's Milk Allergy
The management of children with confirmed cow's milk allergy is based on complete avoidance of cow's milk proteins and leaves the physician with several dietary options, none of which, given the prevalence, spectrum and potential…
- Trial name
- NCT02144428
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Federico II University
Autosomal Dominant Polycystic Kidney Disease, Glomerular Filtration Rate > 40 ml/Min
Effects of Somatostatin on ADPKD Heart
Autosomal dominant polycystic kidney disease (ADPKD) is associated with early onset hypertension and left ventricular (LV) hypertrophy.
- Trial name
- NCT02119013
- Testing
- Octeotride
- Volunteers
- 35 people
- Sponsor
- Federico II University
Autosomal Dominant Polycystic Kidney Disease
Effects of Somatostatin on Liver in ADPKD
Autosomal dominant polycystic kidney disease (ADPKD) is associated with the development of a variety of extrarenal manifestations of which polycystic liver disease is most common.
- Trial name
- NCT02119052
- Testing
- octeotride
- Volunteers
- 35 people
- Sponsor
- Federico II University
Atopic Dermatitis
Prebiotics in Prevention of Atopy
The study objective is to evaluate whether a specific prebiotic (GOS/PDX) may have an effect in preventing atopic dermatitis, food allergy, intestinal and/or respiratory infections in infants at risk of atopy.
- Trial name
- PIPA (NCT02116452)
- Testing
- Supplemented Formula
- Where
- Italy
- Volunteers
- 380 people
- Sponsor
- Federico II University
Fabry Disease, Proteinuria
Paricalcitol in Fabry Disease
Proteinuria is the predominant risk factor for renal disease progression in Fabry disease (FD). When urine protein excretion is controlled to <0.50 g/24 hr, the rate loss of glomerular filtration rate (GFR) is not significantly…
- Trial name
- NCT02090608
- Testing
- Paricalcitol
- Where
- Italy
- Volunteers
- 14 people
- Sponsor
- Federico II University
Cow's Milk Allergy
Parmigiano-Reggiano Cheese as a Possible Strategy to Acquire Oral Tolerance in Children With Cow's Milk Allergy
Cow's milk allergy is the most common food allergy in children. The scenery clinical and epidemiological of cow's milk allergy is significantly changed in the last decade.
- Trial name
- NCT02081651
- Testing
- Parmigiano Reggiano cheese
- Volunteers
- 90 people
- Sponsor
- Federico II University
Ischemic Heart Disease, Cardiomyopathy
Growth Hormone Deficiency in Chronic Heart Failure: an Observational Study
Aim of this study is to define the possible detrimental effect of a lack of growth hormone, on the well-being and life expectation of patients affected by heart failure.
- Conditions
- Ischemic Heart Disease, Cardiomyopathy, Heart Failure, Growth Hormone Deficiency
- Trial name
- NCT00511927
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- Federico II University