Clinical trials: sponsored by Federico II University
Ischemic Heart Disease, Heart Failure
SNORD3A IN ISCHEMIC HEART DISEASE AND HEART FAILURE
This is a prospective, non-randomized, single center, open label clinical study enrolling patients affected by 1) chronic ischemic heart disease with evidence or suspect significant myocardial ischemia (group 1, CCS) or 2) acute…
- Trial name
- SENSITISE (NCT06678802)
- Testing
- Blood sampling
- Where
- Italy
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Federico II University
Full Macular Hole
Changes InMPOD After Full-thickness Macular Hole Closure
The notable increase in MPOD following successful surgery suggests its potential role as a valuable adjunctive biomarker associated with a good visual prognosis following this type of macular hole surgical interventions.
- Trial name
- NCT06664515
- Testing
- Ciro Costagliola
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Federico II University
Preterm Birth
Transvaginal Ultrasound Cervical Length Screening in Singleton Pregnancy With Prior Spontaneous Preterm Birth
Preterm birth (PTB) is the major cause of perinatal morbidity and mortality. Worldwide, about 15 million babies are born too soon every year, causing 1.1 million deaths, as well as short- and long-term disability in countless…
- Trial name
- NCT02923973
- Testing
- Transvaginal ultrasound cervical length screening
- Where
- 2 sites in Italy
- Volunteers
- 500 people
- Sponsor
- Federico II University
Multiple Sclerosis, Relapsing-Remitting, Caloric Restriction
Calorie Restriction in Multiple Sclerosis
There is a strong relationship between metabolic state and immune tolerance through a direct control exerted on immune cells by specific intracellular nutrient-energy sensors.
- Trial name
- Calorie-MS (NCT04042415)
- Testing
- Caloric restriction, Caloric restriction without cow's milk and gluten
- Where
- Italy
- Volunteers
- 93 people
- Sponsor
- Federico II University
Allergy, Cow's Milk Allergy
Hypoallergenicity of a New Formula in Subjects With Cow's Milk Allergy
Cow's milk protein allergy (CMA) is an immune-mediated reaction which can either be antibody-driven (IgE-mediated) or cell-mediated (non-IgE-mediated) or mixed, and elicits reactions which are reproducible upon re-exposure to…
- Trial name
- NIQA (NCT06134466)
- Testing
- Liquid Extensively hydrolyzed cow's milk protein infant formula
- Where
- Italy
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Federico II University
Endometrial Cancer, Endometrial Diseases
Virtual Reality's Role in See&Treat Hysteroscopy
The aim of the study is to evaluate the feasibility and effectiveness of virtual reality technology in outpatient hysteroscopy to improve pain and anxiety management and spread the diffusion of see \& treat philosophy.
- Conditions
- Endometrial Cancer, Endometrial Diseases, Myoma;Uterus, Endometrial Hyperplasia
- Trial name
- NCT06524934
- Testing
- Use of virtual reality during the hysteroscopic procedure
- Where
- Italy
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Federico II University
Allergy Milk, Allergy;Food
Dietary Choice for the Management of Cow's Milk Allergy Influences Other Allergic Manifestations
Food allergy is a common chronic condition in childhood. Recent studies have suggested that the natural history of food allergy has changed during the last two decades, with an increased prevalence, severity of clinical…
- Conditions
- Allergy Milk, Allergy;Food, Allergic Asthma, Allergic Conjunctivitis
- Trial name
- ATMAII (NCT03861910)
- Testing
- hypoallergenic formulas
- Where
- Italy
- Volunteers
- 365 people
- Sponsor
- Federico II University
Infant Colic
EFFICACY OF A MIXTURE OF SIMETHICONE AND TYNDALLIZED BACILLUS COAGULANS IN INFANT COLIC: A PILOT STUDY
: A pilot study was conducted on a group of 41 infants with diagnosis of Infant Colic according to Rome IV criteria. We administered to all the enrolled infants a mixture of Tyndallized bacillus coagulans and Simethicone for 28…
- Trial name
- NCT06458881
- Testing
- Mixture of Simethicone and Tyndallized Bacillus Coagulans
- Where
- Italy
- Volunteers
- 42 people
- Sponsor
- Federico II University
Cataract, Macular Edema
The Role of Radial Peripapillary Vessel Density in Irvine-gass Syndrome
Pseudophakic cystoid macular edema (PCME), also known as Irvine-Gass syndrome (IGS), is an accumulation of fluid in the macula that occurs after cataract surgery, with an early or late presentation (cut-off 3 months) .
- Trial name
- OCTA and PMCE (NCT06436170)
- Testing
- OCTA
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Federico II University
Macular Degeneration Choroidal Neovascularization
Deep Learning Optical Coherence Tomography (OCT) and OCT Angiography (OCTA) in NVC
To evaluate the activity of neovascular macula degeneretion as assessed by SD-OCTand OCT-A using a split-person study design and deep-learning quantification.
- Trial name
- OCTA (NCT05969418)
- Testing
- Diagnostic test: using artificial intelligence to evaluate the changes OCT and OCTA parameter
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Federico II University
Waldenstrom Macroglobulinemia
Optical Coherence Tomography (OCT) and OCT Angiography(OCTA) Deep Learning in Waldenström's Macroglobulinemia Patients
This study evaluates the ability of deep learning to improve the knowledge about structural and vascular retinal changes in Waldenström's Macroglobulinemia patients, using optical coherence tomography angiography.
- Trial name
- OCTA (NCT06084650)
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Federico II University
Cardiac Amyloidosis
Exercise Training and Rehabilitation In Cardiac Amyloidosis
Notwithstanding the dramatic improvement associated with Tafamidis in Heart Failure (HF) due to wild-type transthyretin cardiac amyloidosis (ATTRwt-CA), remarkable morbidity and mortality still burden this disease.
- Trial name
- ERICA (NCT06412432)
- Testing
- Exercise training (ET1+ET2), Optimal Medical Therapy (No-ET)
- Where
- Italy
- Volunteers
- 34 people
- Sponsor
- Federico II University
Autism Spectrum Disorder
Dietetic Pattern in Children With Autism Spectrum Disorders
To date, it is well documented that the gut microbiota (GM) influences numerous physiological processes in the healthy "host". The alteration of the composition and function of the intestinal microbiota, commonly referred to as…
- Trial name
- NCT04719923
- Testing
- Children with autism spectrum disorders
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Federico II University
Periodontal Bone Loss, Periodontal Pocket
Treatment of Intraosseous Periodontal Defects With Hyaluronic Acid
The aim of the present investigation will be evaluate the healing of periodontal intraosseous defects following Minimally Invasive Non Surgical Debridement (MINSD) and application of a hyaluronic acid-based gel, compared to MINSD…
- Trial name
- NCT05188898
- Testing
- MINSD and Hyaluronic acid, MINSD
- Where
- Italy
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Federico II University
Myeloproliferative Neoplasm, Polycythemia Vera
Ultrasound Examination for Spleen Volume Evaluation in Myeloproliferative Neoplasms
Adult patients (>18 years) with newly diagnosis of Ph negative myeloproliferative neoplasms (MPNs) according to WHO 2016 criteria, will be recruited to this study.
- Conditions
- Myeloproliferative Neoplasm, Polycythemia Vera, Essential Thrombocythemia, Primary Myelofibrosis
- Trial name
- NCT06371573
- Testing
- ULTRASOUND EXAM AND MRI SCAN
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- Federico II University
Depression, Pregnancy Related
Exercise in Pregnancy and Risk of Postpartum Depression
The prevalence of postpartum depression (PPD) varies between 11.9% and 19.2% during the perinatal period. PPD refers to minor and major depression incidents that occur during pregnancy or shortly after (up until 12 months after…
- Trial name
- NCT06355375
- Testing
- exercise in pregnancy
- Where
- Italy
- Volunteers
- 398 people
- Sponsor
- Federico II University
Hemophilia A
Intensive Replacement Treatment in Haemophilia Patients With Synovitis
Background: Joint haemorrhage represents the most common type of bleeding episode in persons with hemophilia (PwH). In the absence of an adequate prophylaxis with Factor VIII (for hemophilia A) or FIX (for hemophilia B)…
- Trial name
- NCT04784988
- Testing
- EHL-FVIII, FVIII concentrate
- Where
- Italy
- Volunteers
- 64 people
- Sponsor
- Federico II University
Peripartum Cardiomyopathy
Creation of a Multicenter National Registry for Peripartum Cardiomyopathy.
Peripartum cardiomyopathy (PPCM) is a rare, severe and potentially life-threatening disorder of largely unknown etiology and pathophysiology, with unexplained geographical differences and heterogeneous presentation.
- Trial name
- PPCMREGISTRY (NCT05878041)
- Testing
- Molecular and genetic screening
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Federico II University
Pain, Chronic, Lumbosacral Radiculopathy
Focal Microvibration and Chronic Lumbosacral Radicular Pain
The goal of this clinical trial is to investigate the effectiveness of focal microvibration on patients affected by chronic lumbosacral radicular pain.
- Conditions
- Pain, Chronic, Lumbosacral Radiculopathy, Radicular; Neuropathic
- Trial name
- NCT06301061
- Testing
- Equistasi®, Gabapentin; Pregabalin; Duloxetine; Amitriptyline
- Volunteers
- 150 people
- Sponsor
- Federico II University
Angina CCS Classe II-IV - IMR, RFR, FFR,CFR
Characterization of Different Phenotypes of Microvascular Dysfunction and Their Impact on Angina Severity in Patients With Chronic Angina in the Absence of Obstructive Coronary Artery Disease.
The aim of the present study will be to identify different phenotypes of microvascular dysfunction and their associations with the severity of anginal symptoms assessed through the Seattle Angina Questionnaire(SAQ-7).
- Trial name
- MiVa (NCT05686707)
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- Federico II University