Clinical trials: sponsored by Federico II University
Myocardial Dysfunction
Effects of L-arginine on Myocardial Energetic Efficiency and Global Longitudinal Strain
The study is designed to evaluate the effects of L-arginine on myocardial structure and function and circulating microRNAs in patients with arterial hypertension.
- Trial name
- BIOCARDIO (NCT04626375)
- Testing
- Bioarginine
- Where
- Italy
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Federico II University
Glaucoma Open-Angle Primary
OCTA Study of Choroidal Vasculature in Open Angle Glaucoma Patients
The aim of the present study was to examine and measure SFCT and CCVD using respectively EDI-OCT and OCTA in preperimetric and advanced glaucomatous eyes, in order to shed light on the vascular pathogenesis of glaucoma disease.
- Trial name
- NCT05455567
- Testing
- OCTA
- Where
- Italy
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Federico II University
Wounds and Injuries, Skin Graft Scar
Effectiveness and Tolerability of Fitostimoline Plus vs Connettivina Bio Plus in Skin Graft
Partial thickness skin grafts are widely used to cover large losses of substance secondary to trauma, burns, ulcers, neoplasms. The donor site (SD), in principle, heals by spontaneous re-epithelialization from the epithelial…
- Conditions
- Wounds and Injuries, Skin Graft Scar, Skin Graft Complications
- Trial name
- FP (NCT05447793)
- Testing
- Fitostimoline plus, Connettivina bio plus
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Federico II University
Acute Coronary Syndrome, STEMI
Platelet Inhibition With Ticagrelor 60 mg Versus Ticagrelor 90 mg in Elderly Patients With ACS
Elderly individuals are increasingly represented among patients with acute coronary syndrome (ACS). Dual antiplatelet therapy (DAPT) with aspirin and an oral P2Y12 receptor inhibitor has an established role in the prevention of…
- Conditions
- Acute Coronary Syndrome, STEMI, NSTEMI, Coronary Artery Disease
- Trial name
- PlinytheElder (NCT04739384)
- Testing
- Ticagrelor 90mg, Ticagrelor 60 mg
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Federico II University
Overweight and Obesity
Plasma SCFAs After Fermentable Cereal Fibres - A Postprandial Study
Circulating SCFAs reflect the net effect of what is produced in the large intestine from dietary fibre fermentation, bioavailability after considerable absorption by the enterocytes and in the liver and the elimination.
- Trial name
- FIFERM (NCT05443828)
- Testing
- Breakfast Control Meal, Breakfast Test Meal
- Where
- Italy
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Federico II University
Food Allergy
Effect of Mediterranean Diet During Pregnancy on the Onset of Overweight and Obesity in the Offspring
The first 1,000 days of life, from the conception to 24 months, are crucial to achieve long-term health outcomes and represent a strategic period to intervene under prevention and public health perspective.
- Trial name
- PREMEDI (NCT03337802)
- Testing
- mediterranean diet
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Federico II University
Incisional Hernia
Prevention of Incisional Hernia With Biosynthetic Mesh at the Site of Temporary Ileostomy Closure (PRINCESS)
Prophylactic mesh reinforcement of the abdominal wall at the site of temporary ileostomy closure is effective in preventing postoperative incisional hernia.
- Trial name
- PRINCESS (NCT05400083)
- Where
- Italy
- Volunteers
- 203 people
- Sponsor
- Federico II University
Congenital Hypothyroidism
Influence of Initial Levothyroxine Dose on Neurodevelopmental and Growth Outcomes in Congenital Hypothyroidism
The primary objective of this study is to evaluate the risk-benefit profile of long-term treatment of two different initials treatment schemes with L-T4 on the neurodevelopmental and auxological outcomes in children with…
- Trial name
- NCT05371262
- Testing
- Levothyroxin
- Volunteers
- 72 people
- Sponsor
- Federico II University
Temporomandibular Disorder, Pain
Evaluation of an Intra Auricular Device as a Treatment for Painful Temporo-Mandibular Disorders
Background: An innovative, non-invasive, and reversible Intra Auricular Device (IAD) has recently been introduced to treat temporomandibular muscle and joint disorders.Aim: To evaluate the effects of the IAD on pain, psychosocial…
- Conditions
- Temporomandibular Disorder, Pain, Psychosocial Impairment, Myofascial Pain
- Trial name
- IAD (NCT05365932)
- Testing
- Intra auricular device (IAD)
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Federico II University
Preterm Labor, Preterm Birth
Aspiration Technique-based Device for Preterm Labor
Premature birth (PTB, birth before 37 weeks of pregnancy) is a global, yet unsolved, problem. With a global amount of approximately 15 M babies born prematurely, PTB is the leading cause of perinatal morbidity and mortality in…
- Trial name
- PREGNOLIA (NCT05355649)
- Testing
- PREGNOLIA SYSTEM
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Federico II University
Choroidal Osteoma, Bilateral
Optical Coherence Tomography Angiography and Choroidal Osteoma
This study evaluates the vessel density of choriocapillary vascular network in eyes affected by choroidal osteoma and in eyes complicated by choroidal neovascularization, using optical coherence tomography angiography.
- Trial name
- NCT05342324
- Testing
- Optical coherence tomography angiography
- Where
- Italy
- Volunteers
- 28 people
- Sponsor
- Federico II University
Obesity, Childhood
Effects of Butyrate Against Pediatric Obesity
Worldwide obesity is a public health concern that is defined by the World Health Organization as abnormal or excessive fat accumulation that may impair health.
- Trial name
- BAPO (NCT04620057)
- Testing
- butyrate
- Where
- Italy
- Volunteers
- 54 people
- Sponsor
- Federico II University
ST-elevation Myocardial Infarction, Thrombus
MGuard Stent in ST-elevation Myocardial Infarction
The Investigators will test the hypothesis that MGuard net protective stent, the investigational device, would be superior to conventional revascularization strategy (i.e.
- Conditions
- ST-elevation Myocardial Infarction, Thrombus, Stents
- Trial name
- GUARDIAN (NCT01124942)
- Testing
- MGuard net protective coronary stent, Bare-metal stent and manual thrombectomy device
- Where
- Italy
- Volunteers
- 350 people
- Sponsor
- Federico II University
Acute Coronary Syndrome
Effects of Beta-blockade on Platelet Aggregation in Acute Coronary Syndrome
The Investigators will test the hypothesis that nonselective beta-blockers would have a more pronounced effect on platelet aggregation than selective beta-blockers in patients with acute coronary syndrome treated with dual anti…
- Trial name
- PLATE-BLOCK (NCT02809820)
- Testing
- Carvedilol, Metoprolol
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Federico II University
Weaning
Complementary Weaning With Adult Food Typical of the Mediterranean Diet
A Randomized Controlled Clinical Trials was conducted to study the medium-long term impact of a complementary weaning using adult foods typical of Mediterranean Diets (MD) on children taste development and eating habits, and on…
- Trial name
- NCT05297357
- Testing
- Mediterranean Diet weaning scheme
- Volunteers
- 394 people, healthy volunteers welcome
- Sponsor
- Federico II University
Vaccination, Rotavirus Infections
A Surveillance Study on Timing and Coverage Of Rotavirus and MenB Vaccine Co-administration in Campania Region, Italy
A two-phases study will be carried out with the following aims 1. st phase (2018-2020) To investigate the vaccination coverage for Rotavirus vaccine (RV) in Campania Region together with other pediatric vaccinations scheduled in…
- Conditions
- Vaccination, Rotavirus Infections, Meningococcal Infections
- Trial name
- STORM (NCT05212935)
- Testing
- Rotavirus Vaccine
- Volunteers
- 2,000 people
- Sponsor
- Federico II University
Cardiac Arrhythmias, Sudden Cardiac Death
REal World Assessment for Patients Implanted With Implantable CardioverTer DefibrIllatOr Using Bluetooth Technology
The objective of this observational study is to assess clinical benefits of innovative features (e.g. Bluetooth technology and smartphone patient applications) in a patient population that is implanted with standard indication…
- Conditions
- Cardiac Arrhythmias, Sudden Cardiac Death, Heart Failure
- Trial name
- REACTION (NCT05175937)
- Testing
- smartphone APP based remote monitoring, bedside transmitter based remote monitoring
- Where
- Italy
- Volunteers
- 1,104 people
- Sponsor
- Federico II University
Perineal Tear
Hands on vs Hands Off for Perineal Laceration
Perineal trauma at the time of vaginal delivery is common, and when the anal sphincter is included, these injuries can be associated with additional morbidity including incontinence, pelvic pain and sexual dysfunction.
- Trial name
- NCT04860102
- Testing
- hands on
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- Federico II University
Macular Neovascularisation
Dark Halo and MNV: a Study Between ICGA and OCTA
The aim of study is to compare the evaluation of dark halo area of macular neovascularization (MNV) between indocyanine green angiography (ICGA) and optical coherence tomography angiography (OCTA) in order to identify OCTA as…
- Trial name
- NCT05108285
- Testing
- Optical Coherence Tomography Angiography (OCTA) and indocyanine green angiography (ICGA)
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Federico II University
Pseudophakic Cystoid Macular Edema
Optical Coherence Tomography Angiography and Pseudophakic Cystoid Edema
This study evaluates the retinal vascular features in macula and papillary regions in patients affected by pseudophakic cystoid edema using optical coherence tomography angiography
- Trial name
- NCT05117411
- Testing
- OCTA and pseudophakin cystoid edema
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Federico II University