Clinical trials: sponsored by Federico II University
Central Serous Chorioretinopathy
Eplerenone Versus PDT: Comparative Study by OCTA
The study aims to analyze the changes in OCTA parameters and in choroidal thickness in patients affected by central serous chorioretinopathy treated by oral eplerenone and half-fluence photodynamic therapy.
- Trial name
- NCT05104138
- Testing
- Eplerenone, The patients underwent half fluence photodynamic therapy for 6 months
- Volunteers
- 30 people
- Sponsor
- Federico II University
Allergy
Potential Role of AGEs in Paediatric Allergies
Food allergy (FA) is "an adverse health effect arising from a specific immune response that occurs reproducibly" according to the 2010 National Institute of Allergy and Infectious Diseases, National Institutes of Health…
- Trial name
- NCT04273152
- Testing
- advanced glycation endproducts reader
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Federico II University
Erectile Dysfunction Following Radical Prostatectomy
Study of Retinal and Choriocapillary Vascular Changes in Patients Undergoing Tadalafil 20mg
This study evaluates the retinal and choriocapillary vascular features in patients under the effects of Tadalafil 20mg using optical coherence tomography angiography.
- Trial name
- NCT04164355
- Testing
- Tadalafil 20 MG
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Federico II University
Preterm Birth
Pessary as Adjunctive Therapy to Cerclage for the Prevention of Preterm Birth
Cervical cerclage was devised in the 1950's for women with prior early preterm births (PTB) who developed a dilated cervix detected by manual exam in the second trimester.
- Trial name
- NCT02678026
- Testing
- Cervical pessary
- Where
- Italy
- Sponsor
- Federico II University
Post Partum Hemorrhage
Effect of Delayed vs Immediate Umbilical Cord Clamping on Maternal Blood Loss in Term Spontaneous Vaginal Delivery
Policies for timing of cord clamping vary, with early cord clamping generally carried out in the first 60 seconds aLer birth, whereas latercord clamping usually involves clamping the umbilical cord greater than one minute after…
- Trial name
- NCT04353544
- Testing
- delayed cord clamping
- Where
- Italy
- Volunteers
- 122 people
- Sponsor
- Federico II University
Cesarean Scar Defect
Isthmocele After Two Different Sutures in Cesarean Section
Cesarean delivery (CD) rates are rising globally. about 30% of women delivered by CD in 2015 only in the USA. This increasing CD rate has stimulated an interest in the potential short- and long-term morbidity of CD scars.
- Trial name
- NCT04073264
- Testing
- monofilament
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Federico II University
Preterm Birth
Activity Restriction for Women With Arrested Preterm Labor
to test the hypothesis that activity restriction in women with singleton gestations and with arrested PTL would reduce the rate of PTB.
- Trial name
- NCT03501030
- Testing
- Activity restriction
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Federico II University
Diabetes Mellitus
AS-OCT Study in Diabetic Retinopathy
This study evaluates the corneal features using anterior segment - optical coherence tomography in patients affected by type 2 diabetes mellitus
- Trial name
- NCT04992325
- Testing
- Anterior segment-optical coherence tomography
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Federico II University
Allergy
Microbiota and Allergy
Food allergy derives from a dysregulation of oral tolerance mechanisms. Studies suggest a crucial role for gut microbiota in oral tolerance development.
- Trial name
- MATFA I (NCT04750980)
- Testing
- food allergy, respiratory allergy, healthy controls
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Federico II University
Peripheral Artery Disease
Campania Registry On Peripheral Artery Disease
The CAmpania REgistry on Peripheral Artery Disease (CARE-PAD) is a single-center observational study which has the purpose to collect clinical, laboratory, instrumental, procedural and follow-up data and to evaluate the outcome…
- Trial name
- CARE-PAD (NCT04903912)
- Testing
- Vascular ultrasound or other imaging methods according to current guidelines, Laboratory tests, Medical treatment according to current guidelines
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- Federico II University
Gastric Cancer
Enterotomy Closure and Minimally Invasive Gastrectomy
All consecutive patients from January 2009 to december 2019 who underwent minimally invasive partial gastrectomy for gastric cancer at thirteen high volume institutions will be retrospective analysed to assess the better way to…
- Trial name
- NCT04901585
- Testing
- Totally intracorporeal distal gastrectomy
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- Federico II University
Pituitary Adenoma
Predictive OCTA Biomarkers After Endoscopic Endonasal Pituitary Surgery
This study evaluates the structural parameters, by spectral domain optical coherence tomography (OCT), retinal vessel density, using OCT angiography, and visual acuity in patients that received endoscopic endonasal approach for…
- Trial name
- NCT04840771
- Testing
- Endoscopic Endonasal Pituitary Surgery
- Where
- Italy
- Volunteers
- 8 people
- Sponsor
- Federico II University
Labor Pain
Use of Virtual Reality in Active Labor
Labor is widely recognized as one of the most painful experience possible. The standard analgesic treatment currently consists of pharmacological methods.
- Trial name
- NCT04862039
- Testing
- Virtual Reality (VR) devices
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Federico II University
Covid19
A Simplified Test to Assess Flavor in COVID-19 Patients
The Flavor test has been developed and validated by our group to assess retro-nasal olfactory performances. The original flavor test has been simplified, with the great advantage to be self-administrable for COVID-19 patients in…
- Trial name
- NCT04840966
- Testing
- Flavor test, Self-assesment questionnaire
- Where
- Italy
- Volunteers
- 111 people
- Sponsor
- Federico II University
Preterm Birth
Universal Transvaginal Cervical Length Screening Program for Prevention of Preterm Birth in Singletons Without Prior Preterm Birth
This is a non-blinded randomized screening trial of asymptomatic singleton pregnancies without prior spontaneous preterm birth who are randomized to either transvaginal ultrasound cervical length screening program (i.e.
- Trial name
- NCT03591042
- Testing
- cervical length screening
- Where
- 2 sites in Italy
- Volunteers
- 1,334 people
- Sponsor
- Federico II University
Hypercholesterolemia, Familial
Subclinical Atherosclerosis in Patients With Familial Hypercholesterolemia Treated With Evolocumab®
Protein convertase subtilisin kexin type 9 (PCSK-9) inhibitors demonstrated efficacy in cholesterol reduction and in the prevention of cardiovascular events.
- Trial name
- NCT04313270
- Testing
- Evolocumab
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- Federico II University
Type 1 Diabetes
Polyphenol Enriched Extra-virgin Olive Oil and Postprandial Glycemia in Type 1 Diabetes (DOP)
The aims of this study are to investigate the short term effects of MUFA alone vs. MUFA plus Polyphenols contained in the extra-virgin olive oil (EVOO) on the postprandial glycemic response in patients with type 1 diabetes and to…
- Trial name
- DOP (NCT04764786)
- Testing
- EVOO+POLY, OO-POLY
- Where
- Italy
- Volunteers
- 22 people
- Sponsor
- Federico II University
Pituitary Adenoma
Long-term Follow up for Retinal Vascular Changes After Endoscopic Endonasal Pituitary Surgery.
This study investigates the retinal vascular features, using optical coherence tomography angiography, in patients during one year's follow up after the endoscopic endonasal surgery to remove an intra-suprasellar pituitary…
- Trial name
- NCT04546386
- Testing
- Endoscopic endonasal pituitary surgery
- Where
- Italy
- Volunteers
- 14 people
- Sponsor
- Federico II University
Thalassemia
The Role of OCTA in Patients Affected by Beta Thalassemia
To investigate, using optical coherence tomography angiography (OCTA), the retinal and choriocapillaris vascular features in patients affected by Beta Thalassemia.
- Trial name
- NCT04582110
- Testing
- Optical coherence tomography angiography
- Where
- Italy
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Federico II University
Psychological Distress, COVID
COVID-19 Pandemic Burden in Severe Mental Disease Patients
Despite being originated in Wuhan, in the China mainland region of the Hubei, Italy has been the hardest-hit country in the world by the COVID-19 pandemic during the month of March.
- Conditions
- Psychological Distress, COVID, Severe Mental Disorder
- Trial name
- PsyCOVID (NCT04357769)
- Testing
- PSS (Perceived Stress Scale), GAD-7 (7-item Generalized Anxiety Disorder), PHQ-9 (9-item Patient Health Questionnaire)
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- Federico II University