Clinical trials: sponsored by Fujian Medical University
Breast Cancer
Internal Mammary Lymph Nodes Irradiation in High-risk Breast Cancer After Neoadjuvant Chemotherapy
The aim of this study is to explore the impact of internal mammary nodal irradiation on disease-free survival in high-risk breast cancer patients (ypN+or supra/subclavicular lymph node positive) after neoadjuvant chemotherapy.
- Trial name
- NCT06559696
- Testing
- internal mammary nodal irradiation, No internal mammary node irradiation
- Where
- China
- Volunteers
- 722 people, healthy volunteers welcome
- Sponsor
- Fujian Medical University Union Hospital
Esophageal Squamous Cell Carcinoma, Immunotherapy
Adebrelimab ±Induction Chemotherapy Followed by Concurrent Chemoradiotherapy for Unresectable Locally Advanced ESCC
To evaluate the efficacy and safety of adebrelimab with or without induction chemotherapy followed by concurrent chemoradiotherapy for unresectable locally advanced esophageal squamous cell carcinoma
- Conditions
- Esophageal Squamous Cell Carcinoma, Immunotherapy, Biomarkers
- Trial name
- RICE (NCT06510660)
- Testing
- adebrelimab
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Fujian Medical University Union Hospital
Acute Lung Injury, Prevention
PirfenidoneVsPlacebo as Prophylaxis Against Acute Radiation-induced Lung Injury Following HFRT in Breast Cancer Patients
The incidence of chest CT manifestations of lung injury after radiotherapy for breast cancer is more than 50%. Although the prognosis and quality of life of patients are rarely affected, it is still necessary to prevent the…
- Trial name
- NCT05704166
- Where
- China
- Volunteers
- 214 people
- Sponsor
- Fujian Medical University Union Hospital
Esophageal Squamous Cell Carcinoma
Biomarker Based Neoadjuvant Strategies for Locally Advanced Resectable ESCC
This study aims to evaluate the impact of the neoadjuvant treatment strategy based on CPS score on the pathological complete response (pCR) rate in patients with resectable locally advanced esophageal cancer.
- Trial name
- ESCC (NCT06601309)
- Testing
- Serplulimab, Paclitaxel+Cisplatin (Neoadjuvant Chemotherapy), Paclitaxel+Cisplatin(Concurrent Chemoradiotherapy)
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Fujian Medical University Union Hospital
Esophageal Squamous Cell Carcinoma
Study Compare Adjuvant Chemotherapy, Chemoradiotherapy and Surgery Alone for pN1-2(pT1b-3N1-2M0) Esophageal Carcinoma
A multi-center prospective randomized controlled study was conducted to compare the effects of adjuvant chemotherapy, chemoradiotherapy and surgery alone for the patients with esophageal cancer.
- Trial name
- NCT04009265
- Testing
- adjuvant treatment
- Where
- China
- Volunteers
- 145 people
- Sponsor
- Fujian Medical University Union Hospital
Prostate Cancer
Phase 2 Clinical Trial of 177Lu-P17-088 for mAPMR Prostate Cancer
PSMA is an ideal target for precision diagnosis and treatment of prostate cancer. P17-088 is a novel albumin-binding PSMA-targeted radioligand.
- Trial name
- NCT07562438
- Testing
- 177Lu-P17-088
- Where
- China
- Volunteers
- 25 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Acute Ischemic Stroke
Tenecteplase in Acute Ischemic Stroke Under Different Transfer Models
This prospective, multicenter, observational cohort study aims to evaluate the safety and effectiveness of intravenous tenecteplase (rhTNK-tPA) in patients with acute ischemic stroke managed under different transfer models.
- Trial name
- NCT07897955
- Testing
- tenecteplase
- Where
- 6 sites in China
- Volunteers
- 2,000 people
- Sponsor
- Fujian Medical University Union Hospital
Gastroenteropancreatic Neuroendocrine Tumors
Incremental Value of Delayed 68Ga-DOTATATE PET/MR in the Detection of Liver Metastases
68-Ga-DOTATATE is a radiotracer targeting somatostatin receptors (SSTR). In this study, we investigated the diagnostic efficacy of delayed ^68^Ga-DOTATATE PET/MR in patients with gastroenteropancreatic neuroendocrine tumors…
- Trial name
- NCT07898904
- Where
- China
- Volunteers
- 46 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Ischemic Stroke, Post-stroke Dysphagia
EEG Feedback-Based Vagus Nerve Stimulation for Post-Stroke Dysphagia
The goal of this clinical trial is to learn if electroencephalogram (EEG) biofeedback-guided transcutaneous auricular vagus nerve stimulation (taVNS) works to treat swallowing difficulties (dysphagia) in adults after a stroke.
- Conditions
- Ischemic Stroke, Post-stroke Dysphagia, Swallowing Disorders
- Trial name
- NCT07894315
- Testing
- EEG Biofeedback-Guided taVNS, Conventional taVNS
- Where
- 6 sites in China
- Volunteers
- 60 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Dementia, Alzheimer Dementia (AD)
Fuzhou Aging Brain Health Initiative
The goal of this observational study is to learn about the pathophysiological characterization and evolutionary patterns of Alzheimer's disease (AD) in older adults in Fujian Province, China.
- Conditions
- Dementia, Alzheimer Dementia (AD), Mild Cognitive Impairment (MCI), Subjective Cognitive Decline (SCD)
- Trial name
- FAITH (NCT07891429)
- Testing
- Fluids biomarker and neuroimaging of AD diagnosis
- Where
- 4 sites in China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Fujian Medical University Union Hospital
Cardiac Surgery With Cardiopulmonary Bypass, Postoperative Delirium
Mechanisms and Intervention Strategies of Perioperative Glycemic Variability on Postoperative Delirium
Delirium is a sudden change in attention, thinking, and awareness that can occur after heart surgery. It may slow recovery and is associated with longer hospital stays and poorer health outcomes.
- Trial name
- NCT07893353
- Testing
- Intranasal insulin-20U, Intranasal insulin-40U, Intranasal Saline
- Where
- China
- Volunteers
- 225 people
- Sponsor
- Fujian Medical University Union Hospital
Prostate Cancer (Adenocarcinoma)
68Ga-P16-093 PET Imaging for Diagnosing Prostate Cancer, a Head-to-head Comparison With mpMRI
68Ga-P16-093 is a novel radiotracer targeting PSMA. In this study, we investigated the diagnostic efficacy of 68Ga-P16-093 PET imaging (PET/CT or PET/MRI) in patients with newly diagnosed, treatment-naive prostate cancer, and…
- Trial name
- NCT07209865
- Testing
- 68Ga-P16-093
- Where
- China
- Volunteers
- 82 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Prostate Cancer
Phase 2 Clinical Trial of 225Ac-LNC1011 in the Treatment of Metastatic Castration-Resistant Prostate Cancer
PSMA is an ideal target for precision diagnosis and treatment of prostate cancer. LNC1011 is a novel albumin-binding PSMA-targeted radioligand.
- Trial name
- NCT07117760
- Testing
- 225Ac-LNC1011, 68Ga-PSMA-11
- Where
- China
- Volunteers
- 24 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Heart Valve Surgery, Acute Kidney Injury
Effects of Remote Ischemic Preconditioning at Different Time Phases in Patients Undergoing Heart Valve Surgery
Patients undergoing heart valve surgery require cardiopulmonary bypass, a procedure that can lead to a temporary reduction in blood flow to major organs and subsequent ischemia-reperfusion injury, thereby triggering postoperative…
- Trial name
- NCT07888634
- Testing
- remote ischemic preconditioning
- Where
- China
- Volunteers
- 291 people
- Sponsor
- Fujian Medical University Union Hospital
Malignant Tumour
Dosimetry and Preliminary Clinical Application Study of a Novel Probe Targeting CD73
As a new CD73-targeted PET radiotracer, 68Ga-dPNE, is promising as an excellent imaging agent applicable to various cancers. In this study, we observed the safety, biodistribution and radiation dosimetry of 68Ga-dPNE in human…
- Trial name
- NCT06995976
- Testing
- 68Ga-dPNE, 18F-FDG
- Where
- China
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Prehypertension
Behaviour Change Wheel Intervention to Promote Healthy Behaviors in Adults With Prehypertension
Prehypertension is an important risk factor for developing hypertension and cardiovascular disease. Promoting healthy lifestyle behaviors among young and middle-aged adults with prehypertension may help reduce the risk of…
- Trial name
- NCT07880990
- Testing
- Behaviour Change Wheel-Based Health-Promoting Behavior Intervention, Routine Health Education
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Fujian Medical University Union Hospital
Tumor
68Ga-FAP-RGD PET/CT : Dosimetry and Preliminary Clinical Translational Studies
As an new dual targeting PET radiotracer, 68Ga-FAP-RGD is promising as an excellent imaging agent applicable to various cancers.
- Trial name
- NCT05515783
- Testing
- 68Ga-FAP-RGD
- Where
- China
- Volunteers
- 70 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Acute Ischemic Stroke, ICAS - Intracranial Atherosclerosis
BASIS Technique for Endovascular Therapy of Acute Large Vessel Occlusion Strokes Due to Intracranial Atherosclerotic Disease
This study will explore the safety and efficacy of BASIS technology in ICAS-LVO lesions through a multicenter, prospective, registry, observational single-arm study.By registering intraoperative recanalization using this…
- Trial name
- NCT06881420
- Testing
- BASIS technique
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Fujian Medical University Union Hospital
Pulmonary Hypertension
PH-DyPred: A Multimodal Dynamic Risk Prediction Study in Pulmonary Hypertension
Pulmonary hypertension (PH) is a progressive cardiopulmonary disease characterized by elevated pulmonary artery pressure and vascular remodeling, which leads to right heart failure and increased mortality.
- Trial name
- PH-DyPred (NCT07131241)
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Chronic Disease, Chronic Disease Management
Taining Golden Lake Comprehensive Chronic Disease Management Initiative
This study aims to establish the first county-level, population-based prospective cohort in Taining County, Fujian Province, China. The cohort will include at least 20,000 residents aged 18 years or older.
- Conditions
- Chronic Disease, Chronic Disease Management, Hypertension, Diabetes Mellitus
- Trial name
- TAIGOLD-CDM (NCT07308314)
- Where
- China
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Fujian Medical University