Clinical trials: sponsored by Fujian Medical University
Recurrent/Refractory B-cell Lymphoma
Clinical Study of Universal CD19 CAR-γδT Cell Injection in the Treatment of Adult Relapsed/Refractory B-cell Lymphoma
This study is an open-label, single-arm clinical trial designed to evaluate the safety and tolerability of QH103 cell injection solution in adult subjects with relapsed/refractory CD19-positive B-cell lymphoma.
- Trial name
- NCT07367685
- Testing
- QH103 Cell Injection, Cyclophosphamide, Fludarabine
- Where
- China
- Volunteers
- 6 people
- Sponsor
- The Second Affiliated Hospital of Fujian Medical University
Prostate Cancer (Adenocarcinoma)
The Value of GRPR PET Imaging for Diagnosis and Staging in Prostate Cancer
The gastrin-releasing peptide receptor (GRPR) is highly expressed in prostate cancer (77%-100%). Numerous studies have confirmed that GRPR PET imaging has emerged as a significant molecular imaging modality in prostate cancer…
- Trial name
- NCT07363382
- Testing
- 68Ga-G21, 68Ga-G23
- Where
- China
- Volunteers
- 6 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Prostate Cancer
Sequential Study of 225Ac-LNC1011 in the Treatment of Metastatic Castration-Resistant Prostate Cancer
PSMA is an ideal target for the precise diagnosis and treatment of prostate cancer. LNC1011 is a novel albumin-binding PSMA-targeted compound.
- Trial name
- NCT07363486
- Testing
- 225Ac-LNC1011
- Where
- China
- Volunteers
- 9 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Melasma
Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes in the Treatment of Melasma
Melasma is a refractory skin disease with a complex pathogenesis and difficult treatment. Research has found that mesenchymal stem cell-derived exosomes have effects such as anti-wrinkle formation, anti-inflammation, antioxidant…
- Trial name
- NCT06677931
- Testing
- 1565 non-ablative fractional laser combined with umbilical cord mesenchymal stem cell-derived exosomes.
- Where
- 2 sites in China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Fujian Medical University Union Hospital
Gastric (Stomach) Cancer
Clinical Efficacy of Pucotenlimab Combined With Lenvatinib and SOX Versus SOX Alone in Patients With HER2-Negative Advanced Gastric or Gastroesophageal Junction Adenocarcinoma
The purpose of this study is to evaluate the objective response rate (ORR) of Pembrolizumab combined with Lenvatinib and SOX compared with SOX alone in the treatment of patients with HER2-negative advanced gastric or…
- Trial name
- FUGES032 (NCT07356466)
- Testing
- Pucotenlimab Combined with Lenvatinib, Oxaliplatin plus S-1 regimen
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Fujian Medical University
Adrenal Cortex Hormones, Arthroplasty, Replacement, Knee
Comparing Different Doses of Corticosteroids in Local Infiltration Analgesia (LIA) for Total Knee Arthroplasty
This study aims to compare the efficacy of different doses of glucocorticoids in local infiltration analgesia (LIA) during total knee arthroplasty (TKA) through a prospective single-center randomized controlled trial, and to…
- Conditions
- Adrenal Cortex Hormones, Arthroplasty, Replacement, Knee, Anesthesia, Local
- Trial name
- NCT07337772
- Testing
- LIA with different doses of Diprospan
- Where
- China
- Volunteers
- 120 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Renal Clear Cell Carcinoma, HIF-2α
Predicting HIF-2α Levels in Clear Cell Kidney Cancer Using Machine Learning
This project aims to conduct a multicenter retrospective study to collect clinical, CT imaging, and pathological data from patients.
- Conditions
- Renal Clear Cell Carcinoma, HIF-2α, Radiomics, Nomogram
- Trial name
- NCT07332923
- Where
- China
- Volunteers
- 500 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Gastric Cancer, Surgery
Clinical Efficacy of Adebrelimab With or Without Apatinib Mesilate and SOX Neoadjuvant Therapy in Locally Advanced Gastric Cancer
Exploring the pathological complete response rate (pCR) of locally advanced gastric cancer treated with adebelimab combined or not combined with apatinib mesylate and SOX neoadjuvant therapy
- Trial name
- SOP-XH-IRB (NCT07314203)
- Testing
- Apatinib Mesylate Tablets
- Where
- China
- Volunteers
- 118 people
- Sponsor
- Fujian Medical University
Periprosthetic Joint Infection
Rifampin-combined Antibiotic Therapy for Staphylococcal PJI
This is a prospective, multicenter, randomized controlled study. Patients were evaluated through inclusion and exclusion criteria. Patients who meet the conditions will sign an informed consent form.
- Trial name
- NCT07313215
- Testing
- Rifampicin (R)
- Where
- China
- Volunteers
- 428 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Chronic Heart Failure With Reduced Ejection Fraction
A Prospective, Single-center, Randomized Controlled Clinical Study Evaluating the Efficacy and Safety of Hyperbaric Oxygen Therapy as an Adjunctive Treatment for Chronic Heart Failure
This study aims to investigate whether adjunctive hyperbaric oxygen therapy, compared to guideline-directed medical therapy with the "New Four Pillars" (ARNI/ACEI/ARB + β-blocker + MRA + SGLT2 inhibitor) alone, improves cardiac…
- Trial name
- NCT07311109
- Testing
- hyperbaric oxygen therapy
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Fujian Medical University
Esophageal Cancer, Sentinel Lymph Node
The Value of Indocyanine Green-guided Near-infrared Fluorescence Technology in Tracing Sentinel Lymph Nodes During Esophagectomy
Sentinel lymph nodes, as the primary site of tumor metastasis, play a pivotal role in assessing patient prognosis and planning subsequent treatment strategies.
- Conditions
- Esophageal Cancer, Sentinel Lymph Node, Lymphadenectomy, Indocyanine Green
- Trial name
- NCT07303231
- Testing
- Minimally invasive surgery for esophageal cancer using near-infrared indocyanine green fluorescence to visualize the sentinel lymph node
- Where
- China
- Volunteers
- 144 people
- Sponsor
- Fujian Medical University Union Hospital
Temporomandibular Joint Disorders
Application of the Visualization of Treatment Objective (VTO) Analyses in Fabricating Anterior Repositioning Splints
This study conducted a randomized controlled clinical trial to evaluate the effect of the the therapeutic position of the anterior repositioning splint determined by VTO analyse compared with traditional method for the treatment…
- Trial name
- NCT05362201
- Testing
- therapeutic position of the anterior repositioning splints
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Fujian Medical University
Muscle Invasive Bladder Cancer (MIBC)
Neoadjuvant Zanidatamab + Tislelizumab + Chemotherapy for Selective Bladder Preservation in HER2-Positive MIBC
This is a multicenter, open-label, prospective, single-arm, phase II study designed to evaluate the efficacy and safety of neoadjuvant zanidatamab combined with tislelizumab and chemotherapy, followed by selective bladder…
- Trial name
- HARBOR (NCT07296705)
- Testing
- Zanidatamab, Tislelizumab, Cisplatin
- Where
- 12 sites in China
- Volunteers
- 25 people
- Sponsor
- Fujian Medical University Union Hospital
Prostate Adenocarcinoma
Personalized Optimization of Systematic Prostate Biopsy
Targeted biopsy combined systematic biopsy is the gold standard for diagnosis of prostate cancer. Excessive cores in systematic biopsy increases the risk of puncture trauma， bleeding and infection.
- Trial name
- NCT05998278
- Testing
- Personalized Optimization of Systematic Prostate Biopsy
- Where
- China
- Volunteers
- 330 people
- Sponsor
- Fujian Medical University Union Hospital
Peri-implant Soft Tissue Healing
Spatiotemporal Single-cell Atlas of Peri-implant Soft Tissue Healing
This study aims to explore the dynamic changes in different cell types and their molecular regulatory mechanisms during the healing process of peri-implant soft tissues, using single-cell RNA sequencing (scRNA-seq) and spatial…
- Trial name
- NCT07279090
- Testing
- Healing Abutment Gingival Healing Post-Implantation
- Where
- China
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Stomatological Hospital Affiliated with Fujian Medical University
Education
Effect of Preoperative Individualized Education on Anxiety and Recovery.
Researchers aim to investigate whether individualized preoperative education for patients is beneficial in reducing perioperative anxiety, promoting postoperative recovery, and enhancing postoperative quality of life.
- Trial name
- NCT06419088
- Testing
- Preoperative individualized education
- Where
- China
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Fujian Medical University Union Hospital
Chronic Hepatitis B
Combined Use of Bacteroides Fragilis and BCAAs on HBsAg Clearance
The goal of this prospective observational study is to determine the effects of concomitant administration of Bacteroides fragilis and Branched-Chain Amino Acids on hepatitis B virus clearance.
- Trial name
- NCT07257562
- Testing
- PegIFNα2b+Nucleoside analog, PegIFNα2b+Nucleoside analog+Bacteroides fragilis+Branched-Chain Amino Acids
- Where
- China
- Volunteers
- 40 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Esophageal Neoplasm, Immunotherapy
Camrelizumab in Combination With Radiotherapy for Neoadjuvant Esophageal Carcinoma.
This is an exploratory phase II clinical study designed to evaluate the safety and efficacy of Camrelizumab in combination with standard radiotherapy as preoperative neoadjuvant therapy for patients with resectable esophageal…
- Conditions
- Esophageal Neoplasm, Immunotherapy, Radiotherapy
- Trial name
- NCT05176002
- Testing
- Camrelizumab
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Fujian Medical University Union Hospital
Total Knee Arthroplasty, Reinfection
Reinfection and Re-revision Rates of Periprosthetic Knee Infection Under Four Different Surgical Strategies
A single-center retrospective cohort study was conducted in the Department of Orthopedics, the First Affiliated Hospital of Fujian Medical University.
- Conditions
- Total Knee Arthroplasty, Reinfection, Aseptic Loosening, Revision
- Trial name
- NCT07232771
- Where
- China
- Volunteers
- 200 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Graft-Versus-Host Disease(GVHD)
Effects of Omega-3 Fatty Acids on Acute Graft-versus-Host Disease After Allogeneic Stem Cell Transplantation.
Study Title: A Study on the Effects and Mechanisms of Omega-3 Polyunsaturated Fatty Acids on Acute Graft-Versus-Host Disease (aGVHD) Following Allogeneic Hematopoietic Stem Cell Transplantation Study Type: Open-label, randomized…
- Trial name
- NCT07162688
- Testing
- Omega-3 Lipid Emulsion
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Fujian Medical University