Clinical trials: sponsored by Fujian Medical University
Tooth Loss
Research on the Development and Clinical Evaluation of Biomimetic Abutments
This study aims to evaluate the clinical effectiveness of biomimetic abutments in implant restoration.
- Trial name
- NCT06870955
- Testing
- using biomimetic abutments
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Stomatological Hospital Affiliated with Fujian Medical University
Mild Cognitive Impairment, Subthreshold Depression
A Trial of Combined Subthreshold Depression in Older Adults With Mild Cognitive Impairment Participating in Art Games
The presence of subthreshold depression accelerates quality of life decline and cognitive impairment in older adults with mild cognitive impairment, increasing the rate of dementia conversion, while the continuous decline in…
- Trial name
- NCT06706739
- Testing
- Online art game intervention group
- Where
- China
- Volunteers
- 87 people
- Sponsor
- Fujian Medical University
Breast Cancer, Neoadjuvant Chemotherapy
Effect of Neoadjuvant Chemotherapy on Cardiac Function of Perioperative Patients With Breast Cancer and New Strategies for Anesthesia
As is well known, perioperative hemodynamic fluctuations, such as decreased blood pressure and heart rate, and cardiac dysfunction, are common complications after anesthesia.
- Conditions
- Breast Cancer, Neoadjuvant Chemotherapy, Perioperative Period, Anaesthesia
- Trial name
- NCT06497660
- Testing
- Deoxyadrenaline, normal saline
- Where
- China
- Volunteers
- 496 people
- Sponsor
- Fujian Medical University Union Hospital
Treatment of Spontaneous Intracerebral Hemorrhage
Safety and Efficacy of Stereotactic Aspiration Plus Urokinase in Deep Intracerebral Hemorrhage Evacuation
This is a nationwide, multicenter, open-label, randomized controlled trial of early minimally invasive treatment for deep-seated spontaneous cerebral hemorrhage (dICH).
- Trial name
- STAPLE-dICH (NCT04686877)
- Testing
- STAPLE
- Where
- China
- Volunteers
- 400 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Small-cell Lung Cancer
Chemotherapy-immunotherapy-based Split-course Adaptive Hypofractionated Radiotherapy for Extensive-stage SCLC
This study is a prospective, single-arm, phase Ⅱ trial evaluating the safety and efficacy of Chemotherapy-immunotherapy-based split-course adaptive hypofractionated radiotherapy for extensive-stage SCLC
- Trial name
- CISART (NCT06816966)
- Testing
- split-course adaptive hypofractionated radiotherapy
- Where
- China
- Volunteers
- 35 people
- Sponsor
- Fujian Medical University Union Hospital
Thoracoscopic Surgery, Hyperalgesia
Investigation on the Status Quo of Hyperalgesia in Patients After Thoracoscopic Operation and Study on the Effect of Intraoperative Intervention
To explore the status quo and influencing factors of hyperpain in patients after thoracoscopic surgery, and to explore the effect of earphone sound isolation during combined operation of flurbiprofen axidate and binaural beat…
- Trial name
- NCT06790914
- Testing
- Flurbiprofen axidate combined with noise-cancelling headphones music, Flurbiprofen axidate combined with noise-cancelling headphones, Flurbiprofen exate on a drip
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Fujian Medical University Union Hospital
Gastric Cancer
Clinical Study of Envafolimab Combined With Fruquintinib and Chemotherapy for Neoadjuvant Treatment of Gastric Cancer
To observe and evaluate the neoadjuvant treatment of Envafolimab combined with Fruquintinib and chemotherapy for locally advanced gastric/gastroesophageal junction carcinoma
- Trial name
- NCT06791083
- Testing
- Envafolimab, Fruquintinib
- Where
- China
- Volunteers
- 40 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Paget Disease, Extramammary, Scrotum Disease
A Study of RC48-ADC Combined With JS001 for Advanced Extramammary Paget Disease of the Scrotum
The goal of this clinical trial is to learn if Disitamab Vedotin combined with Toripalimab works to treat advanced HER2-positive extramammary Paget disease of the scrotum. It will also learn about the safety of this combination.
- Trial name
- RC48&J for EPD (NCT06791070)
- Testing
- Disitamab Vedotin combined with Toripalimab
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Fujian Medical University Union Hospital
Surgical Incision, Minimally Invasive Surgery
Modified Uniportal Periareolar Incision Versus Conventional Uniportal Video-assisted Thoracic Surgery for Pulmonary Nodules: Protocol for a Prospective, Randomized, Controlled Study
Minimally invasive surgical techniques, including the uniportal approach, have become widely adopted in thoracic surgery. Both surgeons and patients aim to achieve incisions that are as minimally invasive and cosmetically…
- Trial name
- NCT06202053
- Testing
- Type of surgical incision
- Where
- China
- Volunteers
- 174 people
- Sponsor
- Fujian Medical University Union Hospital
Neurodegenerative Disorder
A Registered Cohort Study on Neurodegenerative Associated With Sleep Disorder.
Cognitive impairment often appears in neurodegenerative diseases, and it is expected to further study the mechanism of sleep disorders associated with the progression of neurodegenerative diseases by exploring the clinical…
- Trial name
- NCT05524922
- Testing
- Data collection
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Fujian Medical University Union Hospital
ALK-positive Advanced NSCLC, ALK-positive Non-small Cell Lung Cancer (NSCLC)
Efficacy and Safety of Ensartinib in Neoadjuvant Therapy for Stage IIA - IIIB (Operable or Potentially Operable) ALK-Positive Lung Adenocarcinoma ：A Multicenter, Real-World Clinical Study
According to the Global Cancer Statistics 2022 report, lung cancer is the most common type of cancer (12.4% of the total) and the leading cause of cancer deaths (18.7% of total cancer deaths).
- Conditions
- ALK-positive Advanced NSCLC, ALK-positive Non-small Cell Lung Cancer (NSCLC), MPR, Neoadjuvant Therapy
- Trial name
- NCT06785584
- Testing
- Ensartinib
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Fujian Medical University Union Hospital
Uremia, Uremic Osteodystrophy
Multi-center Clinical Study on Hemoperfusion of KHA80
To evaluate the decreasing rate of blood IL-6, β2-MG and PTH in maintenance hemodialysis patients in the 52nd week compared with routine hemodialysis.
- Conditions
- Uremia, Uremic Osteodystrophy, Dialysis Related Complication
- Trial name
- NCT06233838
- Testing
- KHA80 hemoperfusion treatment
- Where
- China
- Volunteers
- 394 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Gastric Cancer, Surgery
Indocyanine Green Tracer Using in Laparoscopic Radical Gastrectomy for Locally Advanced Gastric Cancer
Patients with locally advanced gastric adenocarcinoma (CT2-4a N0/+ M0) were selected as study subjects to investigate the safety, efficacy, and feasibility of ICG near-infrared imaging tracing in guiding laparoscopic D2 lymph…
- Trial name
- CLASS-11 (NCT04593615)
- Testing
- ICG near-infrared imaging
- Where
- China
- Volunteers
- 1,070 people
- Sponsor
- Fujian Medical University
Tumor
68Ga-FAPI-Biotin PET/CT in Patients With Various Types of Cancer
As a new dual targeting PET radiotracer, 68Ga-FAPI-Biotin is promising as an excellent imaging agent applicable to various cancers.
- Trial name
- NCT06740240
- Testing
- 68Ga-FAPI-Biotin, 68Ga-FAPI/18F-FDG
- Where
- China
- Volunteers
- 30 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Malignant Neoplasm
18F-FAPIBiotin PET/CT: Dosimetry and Biodistribution Study
As a new dual targeting PET radiotracer, 18F-FAPI-Biotin is promising as an excellent imaging agent applicable to various cancers.
- Trial name
- NCT06734572
- Testing
- 18F-FAPIBiotin
- Where
- China
- Volunteers
- 5 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
HR+/HER2- Advanced Breast Cancer
Albumin-bound Paclitaxel、Dalpiciclib and AI in ER-Low (1%-10%) HER2-ABC
This is a prospective, single-arm, single-center, open, exploratory clinical study.. Screening for histopathologically confirmed recurrent or metastatic ER-Low positive (1%-10%) and HER2-negative breast cancer patients who meet…
- Trial name
- NCT06711094
- Testing
- Dalpiciclib
- Volunteers
- 52 people
- Sponsor
- Fujian Medical University
Insomnia Chronic, Subjective Cognitive Decline (SCD)
Efficacy and Safety of Transcranial Magnetic Stimulation in Treatment of Insomnia with Subjective Cognitive Decline
Insomnia is the most common form of sleep disorder, and subjective cognitive decline (SCD) in patients with insomnia may be an ultra-early manifestation of AD.
- Trial name
- NCT06710652
- Testing
- rTMS
- Volunteers
- 66 people
- Sponsor
- Fujian Medical University Union Hospital
Esophageal Squamous Cell Carcinoma (ESCC)
Tumor Regression Grade As Predictor of Adjuvant Therapy
Neoadjuvant therapy followed by surgery is preferred for locally advanced esophageal squamous cell carcinoma, but the necessity of adjuvant therapy remains controversial.
- Trial name
- NCT06710665
- Testing
- Chemotherapy
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Fujian Medical University Union Hospital
Total Knee Arthroplasty, Knee Osteoarthritis (OA)
The Medially Pedicled IPFP flap in TKA
This is a single-center prospective cohort study in which patients were evaluated by inclusion and exclusion criteria before total knee arthroplasty (TKA).
- Trial name
- NCT06704776
- Testing
- "The medially pedicled IPFP flap" group, "Complete IPFP removal" group
- Where
- China
- Volunteers
- 200 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Patients With Depression in the Elderly
The Construction and Application of a Mobile Health Management Program for Elderly Depression Based on the Patterns of Cognitive Function Changes
Based on the changing law of cognitive function, combined with the behavior change wheel theory and the health behavior process orientation model, we constructed a mobile health management program for geriatric depression.
- Trial name
- NCT06709027
- Testing
- Intervention Group (Mobile Health Management Intervention)
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Fujian Medical University