Clinical trials: sponsored by Fujian Medical University
Mild Cognitive Impairment, Subthreshold Depression
A One-year Trajectory of Depression Status Changes in Older Adults With MCI and SD: a Longitudinal Cohort Study
The purpose of this study is to investigate the one-year trajectory of changes in depression status in older adults with mild cognitive impairment and subthreshold depression, and to explore relevant risk factors for predicting…
- Conditions
- Mild Cognitive Impairment, Subthreshold Depression, Older Adults
- Trial name
- NCT06308627
- Where
- China
- Volunteers
- 466 people, healthy volunteers welcome
- Sponsor
- Fujian Medical University
Gastric Cancer
Impact of TTC Following Neoadjuvant Chemotherapy on the Prognosis of LAGC
he present study retrospectively analyzed the clinicopathological data of 524 patients diagnosed with LAGC who underwent D2 radical gastrectomy after NACT between January 2010 and December 2021 at 2 centers.
- Trial name
- NCT06696963
- Where
- China
- Volunteers
- 524 people
- Sponsor
- Fujian Medical University
Alzheimer Disease
Efficacy, Safety of Astragalus Membranaceus in Mild-to-Moderate Alzheimer's Disease
Alzheimer's disease (AD), the most common cause of dementia, is characterized by cognitive impairment, mental and behavioural abnormalities, and social dysfunction.
- Trial name
- NCT06694597
- Testing
- Astragalus Membranaceus Root
- Where
- China
- Volunteers
- 76 people
- Sponsor
- Fujian Medical University Union Hospital
Malignant Neoplasm
68Ga-JH04 PET/CT: Dosimetry and Biodistribution Studies
68Ga-JH04 is a novel radiotracer targeting fibroblast activation protein (FAP). In this study, we observed the safety, biodistribution, and radiation dosimetry of 68Ga-JH04 in patients with different types of cancer.
- Trial name
- NCT06438250
- Testing
- 68Ga-JH04
- Where
- China
- Volunteers
- 5 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Malignant Neoplasm
68Ga-JH12 PET/CT: Dosimetry and Biodistribution Study
68Ga-JH12 is a novel radiotracer targeting C-X-C motif chemokine receptor 4 (CXCR4). In this study, we observed the safety, biodistribution, and radiation dosimetry of 68Ga-JH12 in patients with different types of cancer.
- Trial name
- NCT06688188
- Testing
- 68Ga-JH12
- Where
- China
- Volunteers
- 5 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Gastric Cancer, Neoadjuvant Chemotherapy
Appraisal of the Modified Cancer Cachexia Index in Locally Advanced Gastric Cancer Patients Undergoing Neoadjuvant Chemotherapy
In this study, consecutive 600 patients with LAGC(cT2-4NanyM0) who underwent NACT between Jan. 2010 and Jun. 2022 were identified from two tertiary hospitals.
- Conditions
- Gastric Cancer, Neoadjuvant Chemotherapy, Computed Tomography, Random Forest Model
- Trial name
- NCT06689462
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Fujian Medical University
Malignant Neoplasm
68Ga-NI-FAPI PET/CT: First-in-human Study
68Ga-NI-FAPI is a novel radiotracer incorporating a hypoxia sensitive nitroimidazole (NI)-moiety and a FAP-targeting. In this study, we observed the safety, biodistribution, radiation dosimetry and diagnostic value of…
- Trial name
- NCT06688305
- Testing
- 68Ga-NI-FAPI
- Where
- China
- Volunteers
- 40 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Total Knee Arthroplasty, Pain Management
Analgesic Efficacy of Preemptive Stepwise Infiltration Anesthesia for Perioperative Analgesia After TKA
This is a single-center prospective cohort study in which patients were evaluated by inclusion and exclusion criteria before total knee arthroplasty (TKA).
- Trial name
- NCT06600815
- Testing
- preemptive stepwise infiltration anaesthesia(PSIA), postoperative local infiltration analgesia(PLIA)
- Where
- China
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Patients with Advanced Metastatic FAP-Positive Tumors
177Lu-JH04 in Patients with FAP-Positive Tumors
This is a pilot study to assess the dosimetry, toxicity and response of 177Lu-JH04, a new FAP-targeted radiopharmaceutical, in patients with FAP-Positive Tumors.
- Trial name
- NCT06636617
- Testing
- 3.70 GBq (100 mCi) of 177Lu-JH04, 5.55 GBq (150 mCi) of 177Lu-JH04, 7.40 GBq (200 mCi) of 177Lu-JH04
- Where
- China
- Volunteers
- 9 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
NMIBC
A Clinical Trial Evaluating the Efficacy and Safety of Disitamab Vedotin Plus Tislelizumab Combined with Re-TURBT in the Treatment of HER-2-high Expression(2+-3+) Non-muscle Invasive Bladder Cancer At High-risk and Very High-risk.
This prospective, multicenter, single-arm phase II trial aims to evaluate the clinical efficacy and safety of the combination therapy of Disitamab Vedotin with Tislelizumab and a second transurethral resection for the treatment…
- Trial name
- NCT06630871
- Testing
- Distitamab Vedotin in combination with Tislelizumab
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Fujian Medical University Union Hospital
Prostate Cancer (Adenocarcinoma)
68Ga-AAZTA-NI-093 PET/CT: First-in-human Study
68Ga-AAZTA-093 is a novel radiotracer incorporating a hypoxia sensitive nitroimidazole(NI)-moiety and a PSMA-targeting. In this study, we observed the safety, biodistribution, radiation dosimetry and diagnostic value of…
- Trial name
- NCT06612580
- Testing
- 68Ga-AAZTA-NI-093
- Where
- China
- Volunteers
- 10 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Patients With More Than or Equal to One of the Following Criteria Were Defined as High-risk Patients
Comparison of Short- and Long-term Efficacy of Robotic Versus Laparoscopic Gastrectomy in High-risk Patients With Gastric Cancer: a Nationwide, Multicentre Cohort Study
Since 2007, robotic gastrectomy (RG) has been considered an option for minimally invasive surgery (MIS)1. In recent years, several randomised trials and retrospective studies have compared short-term efficacy and oncological…
- Trial name
- RL2023 (NCT06603272)
- Testing
- The da Vinci robotic system (Intuitive Surgical, Inc., Sunnyvale, CA, USA) was used for all robotic gastrectomy
- Volunteers
- 534 people
- Sponsor
- Fujian Medical University
Soft Tissue Sarcomas
The Total Neoadjuvant Therapy for Soft Tissue Sarcoma of the Extremities
For localized soft tissue sarcomas (STS) of the extremities, limb-sparing or conservative surgery with perioperative radiotherapy (RT) is the standard of care. However, several challenges persist.
- Trial name
- NCT06593899
- Testing
- Hypofractionated Radiotherapy, 3 cycles of AI
- Where
- China
- Volunteers
- 51 people
- Sponsor
- Fujian Medical University Union Hospital
Graft vs Host Disease
Chimeric Natural Killer Receptor-Universal T Cells for Refractory GVHD
This is a single arm, open-label, multi-center, pilot studies (Investigator Initiated Trial, IIT) to evaluate the safety, tolerability, efficacy, pharmacokinetics and pharmacodynamics of universal T-cells engineered with chimeric…
- Trial name
- NCT06568328
- Testing
- Chimeric Natural Killer Receptor Universal T-cells (CNK-UT)
- Where
- China
- Volunteers
- 17 people
- Sponsor
- Fujian Medical University
Medullary Thyroid Carcinoma
Head-to-head Study of 68Ga-MGS5 Versus 68Ga-DOTATATE PET/CT in Patients With Medullary Thyroid Carcinoma
Cholecystokinin-2 (CCK2) receptor is overexpressed in more than 90% of MTC cases, and preclinical studies have shown that 68Ga-MGS5 (targeting CCK2) has good stability in vivo and is promising for diagnosis and staging of MTC.
- Trial name
- NCT06520319
- Testing
- 68Ga-MGS5
- Where
- China
- Volunteers
- 20 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Gastric Cancer
Impact of Preoperative VFA on Intraoperative Adverse Events in Patients Undergoing Laparoscopic Radical Gastrectomy
Preoperative visceral fat area (VFA) is associated with an increased incidence of postoperative complications in gastric cancer (GC). However, the relationship between VFA and intraoperative adverse events (iAEs) remains unclear.
- Trial name
- NCT06506331
- Volunteers
- 490 people
- Sponsor
- Fujian Medical University
Spinocerebellar Ataxia Type 3, Multiple System Atrophy-cerebellar Type
Treatment of Transcranial Alternating Current Stimulation（tACS）on Cerebellar Ataxia
This is a longitudinal, triple-blind, randomized-controlled, prospective interventional study assessing patients with cerebellar ataxia, including spinocerebellar ataxia type 3 (SCA3) and multiple system atrophy-cerebellar type…
- Trial name
- NCT05557786
- Testing
- Transcranial Alternating Current Stimulation
- Where
- China
- Volunteers
- 164 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Acute Aortic Dissection
A Triple-branched Stent Graft for Aute Debakey Type I Dissection Surgery
Prospective, multicenter, randomized controlled clinical trial plan to evaluate the effectiveness and safety of intraoperative stent system in the treatment of acute type I aortic dissection
- Trial name
- NCT06492980
- Testing
- triple-branched stent graft
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Fujian Medical University
Heart Valve Diseases, Health Behavior
Study of Health Behavior in Patients After Heart Valve Replacement： Longitudinal Studies
To investigates the influencing factors and the pathways of health behavior in patients after heart valve replacement.
- Conditions
- Heart Valve Diseases, Health Behavior, Postoperative Period
- Trial name
- NCT06490952
- Where
- China
- Volunteers
- 219 people
- Sponsor
- Fujian Medical University Union Hospital
Progressive Supranuclear Palsy, Multiple System Atrophy
NMR Based Metabolomic Study of Serum Biomarkers in Patients With Parkinson's Disease and Atypical Parkinsonian Syndrome
At present, the diagnosis of Parkinsons disease(PD) mainly relies on clinical symptoms and is easily confused with atypical Parkinsonian syndrome(APS) in the early stages. There is an urgent need for reliable biomarkers.
- Conditions
- Progressive Supranuclear Palsy, Multiple System Atrophy, Parkinson's Disease
- Trial name
- NCT06490926
- Where
- China
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Fujian Medical University Union Hospital