Clinical trials: open to volunteers, sponsored by Göteborg University
Critical Illness, Ethics
Life Sustaining Treatments in Critically Ill Children
Summary of the Research on Withdrawing and Withholding Life-Sustaining Treatment for Critically Ill Children Background Medical treatments require regular evaluation to ensure they align with the patient's best interests…
- Conditions
- Critical Illness, Ethics, End of Life Care
- Trial name
- LST-Ped-Int (NCT07401420)
- Testing
- There is no intervention
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Göteborg University
Urinary Incontinence (UI)
HIFEM for Incontinence After Menopause High-Intensity Focused Electromagnetic (HIFEM)
It is not difficult to imagine that leaking urine affects life in many contexts. Unfortunately, it is everyday life for far too many people in our society.
- Trial name
- HIM2025 (NCT07260604)
- Testing
- Pelvic floor training as described in point a above, with the addition of HIFEM., Pelvic Floor exercises
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Göteborg University
Depression, Depressive Disorder, Treatment-Resistant
OSU6162 as add-on in SSRI/SNRI-resistant Depression
This is a randomised, placebo-controlled, parallel-group trial comparing OSU6162 at flexible dosage with placebo as add-on to treatment with an SSRI/SNRI in patients with depression that have not responded to treatment with an…
- Conditions
- Depression, Depressive Disorder, Treatment-Resistant, Depressive Disorder, Depressive Episode
- Trial name
- ODEN (NCT05641623)
- Testing
- OSU6162
- Where
- 4 sites in Sweden
- Volunteers
- 180 people
- Sponsor
- Göteborg University
Bipolar Depression
OSU6162 in Bipolar Depression (OBID)
An explorative, open label, single armed, flexible dose, single center, phase IIa study of 8 weeks, initiated in subjects with bipolar depression. The study will consist of 9 visits and 1 safety visit.
- Trial name
- OBID (NCT05296356)
- Testing
- OSU6162
- Where
- Sweden
- Volunteers
- 22 people
- Sponsor
- Göteborg University
Asthma in Children, Transplantation
Digital Delivery of Person-centered Transitional Care
Advances in medical care have extended the life expectancy of individuals with congenital and pediatric-onset diseases, leading to an increased need for effective transition programs as these individuals move from pediatric to…
- Trial name
- DigiStep (NCT06823622)
- Testing
- Stepstones transition program
- Where
- 2 sites in Sweden
- Volunteers
- 100 people
- Sponsor
- Göteborg University
Peri-Implantitis
Air-polishing in the Treatment of Peri-implantitis
The aim of the present study is to evaluate the potential benefit of the adjunctive use of an air-polishing device in the non-surgical treatment of peri-implantitis as compared to mechanical infection control alone.
- Trial name
- NCT04847648
- Testing
- Air-polishing, Mechanical decontamination
- Where
- Sweden
- Volunteers
- 80 people
- Sponsor
- Göteborg University
Appetite, Obesity and Obesity-related Medical Conditions
Metabolic Effects of Short-term Ultra-processed Food Intake (MEST-UPF)
The overall aim of this project is to study the effects of short-term high ultra-processed food intake, compared to nutrient- and energy density matched low ultra-processed food (UPF) intake, on energy intake and appetite.
- Trial name
- NCT07213245
- Testing
- Meal high in energy density, high in ultra-processed food, Meal high in energy density, low in ultra-processed food, Meal low in energy density, high in ultra-processed food
- Where
- Sweden
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Göteborg University
Ectopic Tooth Eruption, Palatal Expansion Technique
The Effectiveness of Early Intervention to Correct the Position of PDC:s
Approximately 2-3% of children will have problems with one or both of their permanent or 'adult' canine teeth in the upper jaw. These canine teeth sometimes fail to erupt properly, because they are displaced into the roof of the…
- Conditions
- Ectopic Tooth Eruption, Palatal Expansion Technique, Randomized Clinical Trial
- Trial name
- PDC (NCT06267989)
- Testing
- Extraction of the primary canine teeth, Expansion
- Where
- 3 sites in Germany, Sweden and 1 more
- Volunteers
- 324 people, healthy volunteers welcome
- Sponsor
- Göteborg University
Non-Small Cell Carcinoma of Lung
Aspects of Quality of Life During Adjuvant Oncological Treatment for Locally Advanced Lung Cancer Which Include Immune Checkpoint Inhibitor.
Current oncological treatment for patients with locally advanced lung cancer comprise adjuvant immunotherapy (immune checkpoint inhibitors-ICI) as an additional one-year treatment after chemoradiotherapy which increases overall…
- Trial name
- NCT07754409
- Where
- Sweden
- Volunteers
- 75 people
- Sponsor
- Göteborg University
Cardiometabolic Risk Factors, Microbiota
Health Effects of Ultra-processed Food Intake
Ultra-processed food (UPF) intake has been related to negative health effects and increased energy intake in previous intervention studies.
- Conditions
- Cardiometabolic Risk Factors, Microbiota, Diet Interventions
- Trial name
- UPFront (NCT07634159)
- Testing
- Diet high in UPF, Diet low in UPF
- Where
- Sweden
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Göteborg University
Blood Pressure Regulation
The Effects of Nitrate-Rich Mouthwash on Vascular Tone
High blood pressure (hypertension) is a major risk factor for cardiovascular disease. One important contributing factor to high blood pressure is reduced availability of nitric oxide (NO).
- Trial name
- NITRATONE (NCT07602764)
- Testing
- Nitrate-rich mouth rinse, Nitrate-rich drink
- Where
- Sweden
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Göteborg University
Chronic Pain, Persistent Pain
Pleasant Touch Perception in Persistent Pain.
The goal of this observational study is to learn how individuals with chronic pain experience pleasant touch and how often they are exposed to such touch in their daily lives.
- Trial name
- NCT07551687
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Göteborg University
Obesity, Pain, Postoperative
Effects of an Opioid Free/Sparing Care Pathway for Patients Undergoing Obesity Surgery
The opioid consumption has exploded in the western world, and for some patient populations such as obese patients, patients with sleep apnoea or patients undergoing cancer treatment, opioid-sparing/ opioid-free strategies could…
- Trial name
- OS-PCC (NCT03756961)
- Testing
- Dexmedetomidine, Person-centred care (PCC), Esketamine
- Where
- 2 sites in Sweden
- Volunteers
- 220 people
- Sponsor
- Göteborg University
Normal Pressure Hydrocephalus Patients, Normal Pressure Hydrocephalus
Non-invasive Diagnostics of Shunt Obstruction in Adult Hydrocephalus
The goal of this RCT is to test whether volumetric assessment of magnetic resonance imaging (MRI) could diagnose shunt obstruction in Adult Hydrocephalus patients, and in addition to explore correlations of blood biomarkers…
- Trial name
- NCT07172841
- Testing
- Intervention group "Virtual OFF", Control group (no change in shunt setting)
- Volunteers
- 60 people
- Sponsor
- Göteborg University
Periodontitis, Furcation Defects
Use of a Bone Substitute Material in the Surgical Therapy of Furcation Defects
The aim of this randomized clinical trial is to evaluate the potential benefit of the use of a bone substitute material in the treatment of furcation degree II-involved molars.
- Trial name
- NCT06270303
- Testing
- Access flap & surgical debridement, Application of bone substitute material (BioOss Collagen)
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Göteborg University
Cancer Uterus Cervix
Respiration After Robot Assisted Laparoscopic Hysterectomy
The study will investigate how respiratory function is affected by robot-assisted surgery. Previous studies have investigated the impact after open and laparoscopic surgery, but there are no studies yet after robot-assisted…
- Trial name
- REHYR (NCT06806280)
- Where
- Sweden
- Volunteers
- 80 people
- Sponsor
- Göteborg University
Endometriosis-related Pain
Transcutaneous Electrical Nerve Stimulation for Endometriosis-related Chronic Pain
The study evaluates the effect of TENS (transcutaneous electrical nerve stimulation) as add-on treatment compared with conventional analgesic treatment in patients with endometriosis-related chronic pain.
- Trial name
- NCT05152264
- Testing
- Transcutaneous electrical nerve stimulation (TENS), Conventional analgesic treatment
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Göteborg University
Volunteers
Cardiometabolic Health and Inflammatory Resolution
The aim of this study is to determine how inflammatory resolution impacts cardiometabolic health and disease in subjects that are either lean (18.5-24.9 kg/m2), overweight (25.0-29.9 kg/m2) or obese (>30.0 kg/m2).
- Trial name
- REX (NCT04256330)
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Göteborg University
Vascular Diseases, Atherosclerosis
Inflammation in Vascular Disease
Increasing evidence suggests that systemic low-grade inflammation may be a driving force of cardiometabolic complications, such as vascular dysfunction, atherosclerosis and ischemic heart disease.
- Trial name
- REBEL (NCT03732612)
- Where
- Sweden
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Göteborg University
Obese
Adipose Inflammation and Diabetes (FAB)
The study investigates whether the addition of resolution molecules can inhibit inflammation and insulin resistance in human tissue taken from obese individuals, and whether the results of these studies correlate with…
- Trial name
- FAB (NCT04255264)
- Where
- Sweden
- Volunteers
- 18 people
- Sponsor
- Göteborg University