Clinical trials: sponsored by Georgetown University
Breast Cancer, Hereditary Breast/Ovarian Cancer (brca1, brca2)
Standard Genetic Counseling With or Without a Decision Guide in Improving Communication Between Mothers Undergoing BRCA1/2 Testing and Their Minor-Age Children
RATIONALE: A study that evaluates the support of a decision guide used together with genetic counseling may improve communication between mothers undergoing BRCA1/2 testing and their minor-age children.
- Trial name
- NCT00685256
- Testing
- counseling intervention, educational intervention, survey administration
- Where
- 2 sites in United States
- Volunteers
- 245 people
- Sponsor
- Georgetown University
Chronic Pain
The Effects of Water Temperature on the Cold Pressor Test
This current study is intended to be completed under the umbrella of the current GHUCCTS IRB- approved study "Opioid-Induced Hyperalgesia In Prescription Opioid Abusers: Effects of Pregabalin" (Lyrica study) (PRO00000669).
- Trial name
- NCT03083626
- Testing
- Cold pressor test
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Breast Cancer, Cancer of the Breast
Estrogen in Postmenopausal Women With ER Positive Metastatic Breast Cancer After Failure of Sequential Endocrine Therapy
This trial seeks to confirm the response rate for estrace treatment in a patients with hormone receptor positive metastatic breast cancer heavily pre-treated with modern endocrine therapies.
- Conditions
- Breast Cancer, Cancer of the Breast, Neoplasms, Breast
- Trial name
- NCT00661531
- Testing
- Estrace, Anastrozole
- Where
- 3 sites in United States
- Volunteers
- 11 people
- Sponsor
- Georgetown University
Breast Cancer
Telephone-Based Genetic Counseling or Standard Genetic Counseling in Women at Risk of Carrying the BRCA1 or BRCA2 Mutation
RATIONALE: Genetic counseling may work as well over the telephone as it does in-person. It is not yet known whether genetic counseling by telephone is more effective than standard (in-person) genetic counseling in women at risk…
- Trial name
- NCT00287898
- Testing
- Telephone Genetic Counseling, Usual Care
- Where
- 4 sites in United States
- Volunteers
- 669 people
- Sponsor
- Georgetown University
Breast Cancer
Genetic Counseling in Women at Risk for BRCA1 or BRCA2 Mutations
RATIONALE: Genetic counseling and using an interactive computer program may help women at risk for breast cancer make medical decisions about treatment.
- Trial name
- NCT00416754
- Testing
- counseling intervention
- Volunteers
- 1,109 people
- Sponsor
- Georgetown University
Hypothyroidism Primary
Effect of Age, Weight and Sex on Levothyroxine Pharmacokinetics
This study was a prospective, single-center, open-label, non-randomized, pharmacokinetic study using stable isotope carbon-13 labeled levothyroxine
- Trial name
- NCT03102177
- Testing
- Administration of stable Isotope labeled levothyroxine
- Volunteers
- 41 people
- Sponsor
- Georgetown University
Preterm Delivery
Measurement of Hormone Levels in Patients Receiving 17-HPC for Preterm Delivery
The purpose of this study is to measure hormones in the blood known to affect the timing of delivery after a single injection of 17-P in order to help understand its mechanism of action in preventing preterm delivery.
- Trial name
- NCT00457886
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Physical Activity, Metabolic Syndrome
Exercise Intervention Metabolic Syndrome Prostate Cancer Black Men
The main purpose of this study is to examine the feasibility of an exercise intervention on metabolic syndrome (MetS) components and biomarkers related to prostate cancer in Black men with MetS who are at increased risk of…
- Conditions
- Physical Activity, Metabolic Syndrome, Prostate Cancer
- Trial name
- STRONG (NCT02379559)
- Testing
- Exercise, Attention Control
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Solid Tumors, Lymphoma
Phase I Study of CS-7017 and Bexarotene
This study is for patients with advanced solid tumors. The purpose of this study is to test the safety and effectiveness of a new combination of drugs, CS-7017 and Bexarotene in patients with advanced cancer.
- Conditions
- Solid Tumors, Lymphoma, Multiple Myeloma
- Trial name
- NCT01504490
- Testing
- CS-7017 and Bexarotene
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Georgetown University
Pancreatic Cancer
Study of Gemcitabine and Abraxane for Pancreas Cancer
A Phase II trial of gemcitabine plus nab-paclitaxel in the second line setting
- Trial name
- NCT02242409
- Testing
- Gemcitabine and Abraxane
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Georgetown University
Hemophilia A
Trial of Rituximab Versus Oral Cyclophosphamide to Eradicate or Suppress Autoimmune Anti-Factor VIII Antibodies in Acquired Hemophilia A
The purpose of this study is to evaluate the rate of response when administering rituximab to suppress or eliminate the anti-body in a patient's blood that inhibits the effectiveness of their factor replacement product compared…
- Trial name
- NCT00306670
- Testing
- Rituxan, prednisone
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Compliance, Chronic Pain
Evaluation of a Compliance Marker in Prescription Opioid Abusers With Chronic Pain
In a small, well-characterized sample of prescription opioid abusers (POAs) with chronic pain and on buprenorphine therapy, this study will investigate the utility and feasibility of two novel tracer compounds, and in combination…
- Trial name
- NCT02276989
- Testing
- acetazolamide, Quinine, Riboflavin
- Where
- United States
- Sponsor
- Georgetown University
Chronic Pain
Increased Sensitivity to Pain Caused by Opioids in People Who Have Abused Prescription Opioids
Managing pain in patients who abuse prescription opioids presents many challenges, including the development of opioid-induced hyperalgesia (OIH).
- Trial name
- NCT01821430
- Testing
- Pregabalin
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Georgetown University
Type II Diabetes
Januvia (Sitagliptin) in Healing Chronic Diabetic Foot Ulcers
The primary objective of this study is to compare the rate of healing as well as percent of wounds healed in Type II diabetic patients with chronic foot ulcerations receiving sitagliptin versus placebo.
- Trial name
- NCT02015910
- Testing
- Sitagliptin
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Georgetown University
Wound Infection
Comparing Outcomes for Prontosan Versus Normal Saline for Negative Pressure Wound Therapy With Instillation
This is a prospective, randomized trial comparing the outcomes for Prontosan versus normal saline as the solution for negative pressure wound therapy with instillation (NWPTi).
- Trial name
- NCT01939145
- Testing
- Normal saline, Prontosan
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Georgetown University
Healing of Donor Site, Pain Level
Study Evaluating AWBAT-D Versus the Standard of Care of Split-thickness Skin Graft Donor Sites
Use of AWBAT-D on split thickness skin graft sites will reduce healing time and pain level.
- Trial name
- NCT01252836
- Testing
- AWBAT-D
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Georgetown University
Meningitis
Lumbar Punctures in Neonates: Improving Success Rates and Minimizing Pain
The purpose of this study is to compare two medications used to numb an infant's back when performing a lumbar puncture. A lumbar puncture (LP) is often needed in newborns to obtain cerebrospinal fluid (CSF).
- Trial name
- NCT01606150
- Testing
- 1% lidocaine, topical lidocaine
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Quality of Life, Mastectomy
Registry of Mastectomy for Breast Cancer Risk Reduction
This is a registry for patients who have a risk-reduction mastectomy ("prophylactic mastectomy") due to being at high risk for developing breast cancer, followed by breast reconstruction.
- Conditions
- Quality of Life, Mastectomy, Breast Neoplasms, Genetic Predisposition to Disease
- Trial name
- NCT00555503
- Where
- United States
- Volunteers
- 261 people
- Sponsor
- Georgetown University
Solid Tumors
Phase I Study of Intravenous Artesunate for Solid Tumors
This is a Phase One study to determine the safety, tolerability, and maximum tolerated dose of intravenous artesunate in patients with solid tumors.
- Trial name
- NCT02353026
- Testing
- Intravenous Artesunate
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Georgetown University
Smoking, Lung Cancer
Lombardi Comprehensive Cancer Center/Legacy Pilot Study to Reduce Adverse Smoking Outcomes in the Context of Lung Cancer Screening
In 2011, the National Lung Screening Trial (NLST) reported that lung cancer mortality was reduced by 20% with spiral computed tomography (CT) compared to chest X-ray.
- Trial name
- NCT02267096
- Testing
- Telephone Counseling, Minimal Treatment
- Where
- 3 sites in United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Georgetown University