Clinical trials: sponsored by Heinrich-Heine University, Duesseldorf
CIDP - Chronic Inflammatory Demyelinating Polyneuropathy
Multimodal Characterization of Movement Trajectories in Chronic Inflammatory Demyelinating Polyneuropathy
This prospective, longitudinal study aims to evaluate the usefulness of high-resolution whole-body motion data captured by wearable sensors to assess functional status and longitudinal changes in CIDP (chronic inflammatory…
- Trial name
- MOVE CIDP (NCT07882797)
- Testing
- Xsens motion suit
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Dental Implant, Implant Therapy
Do Immediate Digital Workflows Increase Patient Value?
This two-center randomized controlled trial will evaluate whether an immediate digital posterior implant workflow provides greater patient-defined value than a delayed digital workflow in adults requiring single posterior implant…
- Conditions
- Dental Implant, Implant Therapy, Immediate Dental Implant Placement, Delayed Implant
- Trial name
- ITI PROM RCT (NCT07656597)
- Testing
- Immediate digital posterior implant workflow, Delayed digital posterior implant workflow
- Where
- 2 sites in Germany, Hong Kong
- Volunteers
- 50 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Alzheimer Disease
German Registry of Alzheimer's Disease Treated With Transcranial Pulse Stimulation
This study will primarily investigate the safety and secondarily the effect and applicability of Transcranial Pulse Wave Stimulation (TPS) for the treatment of Alzheimer's disease in the context of a PMCF study (Post-Market…
- Trial name
- GE-R-A-TPS (NCT06313944)
- Testing
- Registry
- Where
- 6 sites in Germany
- Volunteers
- 100 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
NIRS, Tissue Oxygenation
CHECK-NIRS2D-Study
The study investigates how external, physiological, and behavioral factors influence the measurement of regional tissue oxygenation using two-dimensional near-infrared spectroscopy (NIRS) imaging in healthy volunteers.
- Conditions
- NIRS, Tissue Oxygenation, Microvascular Perfusion, Vascular Occlusion Test
- Trial name
- NCT07854431
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Heinrich-Heine University, Duesseldorf
Myelodysplastic Syndromes, Secondary Acute Myeloid Leukemia
Venetoclax in Addition to Sequential Conditioning With Fludarabine / Amsacrine / Ara-C (FLAMSA) + Treosulfan for Allogeneic Blood Stem Cell Transplantation in Patients With MDS, CMML or sAML
This trial aims to find the MTD of Venetoclax when added to Fludarabin, Amsacrine and Ara-C + Treosulfan and to evaluate whether the addition of Venetoclax to sequential conditioning with FLAMSA + Treosulfan is safe for…
- Conditions
- Myelodysplastic Syndromes, Secondary Acute Myeloid Leukemia, Chronic Myelomonocytic Leukemia
- Trial name
- NCT05807932
- Testing
- Venetoclax, Amsacrine, Ara-C
- Where
- 6 sites in Germany
- Volunteers
- 38 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Prostate Cancer
Influence of Electronic Patient Reported Outcomes (ePROMs) in Surgical Therapy for Prostate Cancer on Postoperative Outcome
The study investigates the influence of structured follow-up using ePROMS in the 1st year after prostatectomy on the postoperative course.
- Trial name
- PRO-P (NCT05644821)
- Testing
- complex intervention, current clinical practice
- Where
- 5 sites in Germany
- Volunteers
- 260 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Muscle Invasive Bladder Cancer (MIBC)
RESTORE-BLADDER (REgistry on STrategies for Organ pREservation in Muscle-invasive BLADDER Cancer)
Removal of the urinary bladder (radical cystectomy) is a major surgical procedure that can have a permanent impact on a patient's quality of life.
- Trial name
- NCT07744958
- Testing
- None. Registry.
- Volunteers
- 100 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Hormone Replacement Therapy, Cardiovascular Diseases
A Prospective Multicenter Cohort Study of Contemporary Menopausal Hormone Therapy and Cardiovascular Outcomes
This prospective registry study investigates the impact of new hormone replacement therapy (HRT) delivery methods, such as creams, gels, and sprays, on cardiovascular risk in postmenopausal women.
- Conditions
- Hormone Replacement Therapy, Cardiovascular Diseases, Hormone Replacement Therapy, Post-Menopausal, Menopause
- Trial name
- CATCH-Menopaus (NCT07394049)
- Where
- 2 sites in Germany
- Volunteers
- 3,408 people, healthy volunteers welcome
- Sponsor
- Heinrich-Heine University, Duesseldorf
Testicular Cancer, Testicular Germ Cell Tumor
Minimally-invasive ICG-guided Retroperitoneal Sentinel Lymph Node Dissection in the Primary Staging of Testicular Cancer Versus Standard of Care
Testicular cancer is highly curable, but approximately 20-30% of patients with clinical stage I disease harbor occult retroperitoneal lymph node metastases that are not detected by conventional imaging.
- Trial name
- RAISN 2 (NCT07699640)
- Testing
- ICG-Guided Retroperitoneal Sentinel Lymph Node Biopsy, Radical Inguinal Orchiectomy
- Where
- 10 sites in Finland, Germany
- Volunteers
- 171 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Aortic Stenosis, Imaging
Mechanisms Of Disease Progression in Aortic Stenosis - the MODAS Study
Biomarkers and mechanisms in the progression of aortic valve stenosis are sometimes not sufficiently understood. The current project will take into account image morphological and immunological aspects that predict the…
- Conditions
- Aortic Stenosis, Imaging, Pathogenesis, Disease Progression
- Trial name
- NCT05851209
- Where
- 3 sites in Germany
- Volunteers
- 938 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Psychotic Disorders, Prevention
Computer-assisted Risk Evaluation in the Early Detection of Psychotic Disorders
Multicenter randomized controlled trial (RCT) with artificial intelligence (AI)-staged early diagnostics and risk-adapted treatment (RAB) as interventional treatment arm and treatment-as-usual (TAU) as control treatment arm for…
- Trial name
- CARE (NCT05813080)
- Testing
- "pronia.ai" medical device for high risk psychosis prognosis, Treatment-as-usual (TAU)
- Where
- 21 sites in Germany
- Volunteers
- 260 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Systemic Lupus Erythematosus
LUPUS-BEST - Treat-to-target in Systemic Lupus Erythematosus
Multicenter, national, two-armed cluster-randomized controlled trial to evaluate the effect of a treat-to-target (T2T) strategy in in systemic lupus erythematosus (SLE).
- Trial name
- Lupus-Best (NCT05714930)
- Testing
- Treat-to-target as a new treatment concept
- Where
- 14 sites in Germany
- Volunteers
- 606 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
CIDP - Chronic Inflammatory Demyelinating Polyneuropathy
Subcutaneous Immunoglobulin Therapy Effectiveness Monitoring in CIDP Patients Using Smart Devices
Chronic inflammatory demyelinating polyneuropathy (CIDP) is a rare autoimmune disease that affects the peripheral nerves. It causes progressive weakness and sensory loss in the arms and legs, which can severely limit daily…
- Trial name
- STEPS (NCT07273903)
- Where
- 2 sites in Germany
- Volunteers
- 35 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Amyloidosis Cardiac, Heart Failure
Screening, Characterization, and Longitudinal Follow-up of Patients With Cardiac Amyloidosis
Cardiac amyloidosis is a progressive disorder caused by extracellular deposition of amyloid fibrils in the heart, leading to heart failure and impaired cardiac function.
- Conditions
- Amyloidosis Cardiac, Heart Failure, Cardiac MRI, Spectroscopic Analysis
- Trial name
- NCT07577466
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Alzheimer Disease (AD), Early Onset Alzheimer Disease
A Study Testing Whether Low-Dose Radiation Could Help the Immune System and Possibly Improve Early-Onset Alzheimer's Disease.
The goal of this randomized clinical trial is to investigate whether low-dose whole-brain radiotherapy has a potential immunomodulatory effect that may influence disease progression in patients with early-stage Alzheimer's…
- Trial name
- HOPE (NCT07564700)
- Testing
- Low-Dose Whole-Brain Radiotherapy, Control Condition (No Radiotherapy)
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Heart Failure With Reduced Ejection Fraction (HFrEF)
RELIEVE METAB Study
This prospective, single-center post-market-follow-up study aims to fill knowledge gaps by combining advanced cardiac MRI/MRS with systemic mitochondrial assays and exercise testing to characterize the energetic and functional…
- Trial name
- NCT07555925
- Testing
- cardiac MRI, Functional Testing
- Where
- Germany
- Volunteers
- 15 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Paraneoplastic Neurological Syndromes
Liquid Biopsy in Paraneoplastic Neurological Syndromes
The main objective of the study is to assess whether circulating tumor cells (CTCs) can be detected in the peripheral blood of patients with paraneoplastic neurological syndromes (PNS) by diagnostic leukapheresis (DLA) combined…
- Trial name
- LiB-PNS (NCT07491328)
- Testing
- CTC & ctDNA analysis
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Intermediate-risk Prostate Cancer, High-risk Prostate Cancer
COMBINED PSMA-PET/CT AND MRI STAGING IN INTERMEDIATE AND HIGH-RISK PATIENTS PROSTATA-CANCER (COMBINE-P)
This retrospective, multicentre comparative analysis aims to evaluate a new staging method for i) improved detection of intraprostatic index lesions, ii) local T-staging and iii) lymph node (LN) staging in men with clinically…
- Trial name
- COMBINE-P (NCT07455097)
- Testing
- PSMA-11
- Where
- 10 sites in Austria, Belgium and 5 more
- Volunteers
- 600 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Multiple Sclerosis, Remitting-Relapsing Multiple Sclerosis
Cognitive Performance, Sleep Disturbances and Fatigue in Multiple Sclerosis
Fatigue is a prevalent symptom in patients with multiple sclerosis (MS) and is associated with considerable impairment in quality of life as well as loss of occupational capacity.
- Conditions
- Multiple Sclerosis, Remitting-Relapsing Multiple Sclerosis, Primary Progressive Multiple Sclerosis, Secondary Progress Multiple Sclerosis
- Trial name
- NCT07426991
- Testing
- No Intervention: Observational Cohort
- Where
- 2 sites in Germany
- Volunteers
- 837 people, healthy volunteers welcome
- Sponsor
- Heinrich-Heine University, Duesseldorf
Heart Failure, Type2diabetes
Mitochondrial Substrate Utilization in the Diabetic Human Heart
Diabetes can lead to heart failure independently, but the underlying causes remain incompletely understood. The main aim of this study is to identify differential regulation of mitochondrial substrate utilization and complex…
- Conditions
- Heart Failure, Type2diabetes, Insulin Resistance, Mitochondrial Diseases
- Trial name
- NCT05958706
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- Heinrich-Heine University, Duesseldorf