Clinical trials: sponsored by Henry Ford Health System
Opioid Use, Fractures, Bone
Nonopioid Pain Control Regimen After Open Reduction and Internal Fixation of Traumatic Fractures
An open reduction and internal fixation is a painful procedure requiring intensive postoperative pain management. Traditionally, opioid analgesia has been the gold standard for postoperative pain control.
- Conditions
- Opioid Use, Fractures, Bone, Trauma
- Trial name
- NCT06113211
- Testing
- Narcotic pain medication, Nonnarcotic pain medications
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Henry Ford Health System
Mortality Prediction
BIO-FUNCTION for Prediction Non Relapse Mortality in Transplant and Cell Therapy
The purpose of this research is test if combination of physical tests and blood tests drawn before SCTCT can predict NRM.
- Trial name
- NCT07769151
- Testing
- blood sample to check CXCL9 pre stem cell transplant and cell therapy
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- Henry Ford Health System
Shift-work Disorder
Role of Sleep Reactivity in Shift Work Disorder
The purpose of this project is to test sleep reactivity as an independent cause of Shift Work Disorder (SWD). The primary hypothesis is that those with high sleep reactivity will show persistent SWD symptoms after experimental…
- Trial name
- REACT (NCT05424406)
- Testing
- Active phototherapy, Control phototherapy, Cognitive Behavioral Therapy (CBT)
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Henry Ford Health System
Arthroplasty, Replacement, Hip
Multimodal Analgesic Regimen for Total Hip Arthroplasty: An Initiative to Minimize Postoperative Opioid Use
This study examines whether patients undergoing total hip replacement surgery can manage their pain effectively while using fewer opioid pain medications. Participants will be randomly assigned to one of two groups.
- Trial name
- NCT07672808
- Testing
- Standard Multimodal Analgesic Regimen with Opioid Prescription, Opioid-Reduced Multimodal Analgesic Regimen with Printed Prescription
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Henry Ford Health System
Insomnia, Depression
Improving Negative Stressful Perseverations in Insomnia to Revitalize Expecting Moms (INSPIRE)
Nearly half of women develop insomnia during pregnancy, which is associated with increased risk for developing perinatal depression.
- Trial name
- INSPIRE (NCT05356364)
- Testing
- Cognitive Behavioral Therapy for Insomnia (CBTI), Perinatal Understanding of Mindful Awareness for Sleep (PUMAS)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Henry Ford Health System
Complications of Medical Care
Vaginal Cuff Closure in Robotic Hysterectomy
The purpose of this study is to evaluate the impact of implementing different types of suturing materials and techniques of vaginal cuff closure in robotic assisted laparoscopic hysterectomy on cost, operative time and post…
- Trial name
- NCT02696239
- Testing
- Vaginal cuff closure
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Henry Ford Health System
Arthritis Knee, Postoperative Nausea
Oral Dexamethasone as an Intervention for Postoperative Pain and Nausea Management in Total Knee Arthroplasty
This study aims to determine if oral dexamethasone provides clinically significant improvement in postoperative outcomes, specifically nausea and pain scores.
- Conditions
- Arthritis Knee, Postoperative Nausea, Postoperative Pain
- Trial name
- NCT04432259
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 109 people
- Sponsor
- Henry Ford Health System
Pain, Opioid Use
Healing After Injury to Reduce Opioid Use and Pain Through Preventive Engagement - Open Trial
The goal of this project is to refine the adaptive psychological intervention and assess initial feasibility and acceptability. Results will be used to inform a pilot randomized trial.
- Trial name
- HOPE (NCT07755527)
- Testing
- Psychological Intervention
- Volunteers
- 10 people
- Sponsor
- Henry Ford Health System
HIV Seropositivity
A Multilevel, Multiphase Optimization Strategy for PrEP (MOST:PrEP)
What is known: There are 1.2 million people in the US who meet the indications for PrEP; yet, disparities exist in uptake. For example, only 9% of Black and 16% of Latino individuals, compared to 65% of White individuals, have…
- Trial name
- MOST:PrEP (NCT06334341)
- Testing
- Computer-based simulation training for providers, Best Practice Alert, HIV Risk Assessment
- Where
- United States
- Volunteers
- 1,380 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Tinnitus, Subjective
Effect of Highly Bioavailable Curcumin on Subjective Tinnitus
This study will assess the effectiveness of highly bioavailable curcumin in suppressing subjective tinnitus based on pre- and post-treatment evaluations using the validated Tinnitus Functional Index (TFI) and Tinnitus Handicap…
- Trial name
- NCT04800107
- Testing
- Curcumin-phosphatidylcholine
- Where
- 3 sites in United States
- Sponsor
- Henry Ford Health System
Prostate Cancer
Utilization of Educational Interventions in Completion of Genetic Testing in Black Patients With High-Risk Prostate Cancer
This is a pilot study to improve rates of germline genetic testing for black patients with aggressive prostate cancer as recommended by the updated guidelines by the National Cancer Comprehensive Network (NCCN) in 2018.
- Trial name
- NCT05958082
- Testing
- Educational video
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Henry Ford Health System
Shoulder Arthroplasty, Positive C. Acnes Culture
Post-incision Antimicrobial Wash vs C. Acnes in Shoulder Arthroplasty
The purpose of this randomized controlled trial is to determine the effect of post-incision wash using various novel antimicrobial solutions on the rate of positive C.
- Trial name
- NCT06831422
- Testing
- Povidone-Iodine, Hydrogen Peroxide, Xperience Antimicrobial Wash
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Henry Ford Health System
Upper Tract Urothelial Carcinoma
Photodynamic Diagnosis of Upper Tract Urothelial Carcinoma Using Fluorescence Endoscopy and Oral 5-ALA
This study is evaluating whether a medication called 5-aminolevulinic acid (5-ALA), approved by the FDA for use in brain surgery, can help improve the visibility of upper tract urothelial tumors during surgery.
- Trial name
- NCT06948552
- Testing
- 5-Aminolevulinic acid Hydrochloride (Gliolan®)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Henry Ford Health System
Kidney Cancers
Photodynamic Diagnosis of Kidney Cancer Using Fluorescence Endoscopy and Oral 5-ALA
The goal of this prospective, single-arm feasibility study is to evaluate the safety and feasibility of using Gleolan® (5-aminolevulinic acid), an FDA-approved drug currently used during brain tumor surgery, in adults with…
- Trial name
- NCT07828704
- Testing
- 5-Aminolevulinic acid Hydrochloride (Gliolan®)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Henry Ford Health System
Laparoscopic Surgery, Post Operative Pain, Acute
Maneuvers to Reduce Laparoscopic Pain
Laparoscopic surgery has revolutionized surgical care by reducing morbidity and improving post operative recovery. Laparoscopic surgery involves the use of carbon dioxide for insufflation to achieve optimal visualization.
- Conditions
- Laparoscopic Surgery, Post Operative Pain, Acute, Pneumoperitoneum
- Trial name
- NCT07583433
- Testing
- Smoke Evacuation Group, Recruitment Breath Group, Control Group
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Heart Failure, Hypertension
Project 2: ACHIEVE- HF
This project is part of the ACHIEVE GREATER (Addressing Cardiometabolic Health In Populations Through Early PreVEntion in the GREAT LakEs Region) Center (IRB 100221MP2A), the purpose of which is to reduce cardiometabolic health…
- Trial name
- NCT05330221
- Testing
- PAL2, PHARM-PAL2
- Where
- United States
- Volunteers
- 364 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Ischemic Stroke
Randomized, Controlled Trial of Extended-Release Niacin (Niaspan®) to Augment Subacute Ischemic Stroke Recovery
The purpose of this study is to determine the safety, tolerability, and to explore the possible benefit of extended-release niacin (Niaspan®) in attempting to improve the recovery of patients after ischemic stroke.
- Trial name
- NCT00796887
- Testing
- Extended-Release Niacin
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Henry Ford Health System
To Assess the Feasibility, Visualization Capability, and Optimal Dosing of ICG Fluorescence Imaging for Intraoperative Assessment of Knee Tissue Perfusion
ICG Fluorescence in Knee Arthroscopy Study
The purpose of this study is to first evaluate whether ICG fluorescence angiography can be used to evaluate blood flow of the anterior cruciate ligament (ACL), tendons, and knee structures during an arthroscopic surgery.
- Trial name
- NCT07793266
- Testing
- Intravenous administration of indocyanine green (SPY Agent Green) 2 mL of SPY Agent Green (5.0 mg dose), Intravenous administration of indocyanine green (SPY Agent Green) 3 mL of SPY Agent Green (7.5 mg dose), Intravenous administration of indocyanine green (SPY Agent Green) 4 mL of SPY Agent Green (10 mg dose)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Henry Ford Health System
Depression, Anterior Cruciate Ligament Injuries
Anterior Cruciate Ligament Recovery With Virtual Psychological Intervention
The goal of this parallel arm prospective randomized control trial study is to compare outcomes in Anterior Cruciate Ligament Reconstruction (ACLR) Surgery patients after exposure to a virtual psychological intervention (VPI)…
- Conditions
- Depression, Anterior Cruciate Ligament Injuries, Mental Health Issue
- Trial name
- NCT05965310
- Testing
- Virtual Psychological Intervention: Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Henry Ford Health System
Severe Hypertension, Hypertension
Emergency Department-Initiated Team-Based Care for Severe Hypertension
EDIT-SBP is a pragmatic, randomized clinical trial evaluating whether an emergency department (ED)-initiated team-based care program improves blood pressure control among adults discharged from the ED after severe hypertension…
- Trial name
- EDIT-SBP (NCT07777237)
- Testing
- Emergency Department-Initiated Team-Based Care, Usual Care
- Where
- 4 sites in United States
- Volunteers
- 700 people
- Sponsor
- Henry Ford Health System