Clinical trials: sponsored by Hospices Civils de Lyon
Epilepsy, Drug-resistant Focal Epilepsy
Impact of Epilepsy on the Brainstem Adenosine Pathway and Its Relation With Arousal and Respiratory Reactivity
Despite the continuous development of new antiseizure medications over the past 25 years, 30% of patients with epilepsy suffer from drug-resistant seizures and are at risk of epilepsy-related complications, like cognitive…
- Conditions
- Epilepsy, Drug-resistant Focal Epilepsy, Healthy Controls
- Trial name
- BRAVE (NCT07249034)
- Testing
- 1 Hypercapnic challenge while participant is awake, PET/MRI acquisition
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Obstructive Sleep Apnea, Down Syndrome (Trisomy 21)
Effects of a Pacifier on Obstructive Sleep Apnea and Its Repercussions in Infants With Down Syndrome
Obstructive Sleep Apnea (OSA) is characterised by repetitive collapse of the upper airway during sleep, inducing breathing disturbances that can result in oxygen desaturation and frequent arousals.
- Trial name
- TET21 (NCT07658053)
- Testing
- CURAPROX pacifier use, Pacifier diary, Polysomnography (PSG) to explore OSA
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Hospices Civils de Lyon
Metastatic Ovarian Carcinoma, Peritoneal Carcinomatosis
Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) Associated With Systemic Chemotherapy in Women With Advanced Ovarian Cancer
Women with history of tumor response insufficient to allow complete cytoreductive surgery after three cycles of previous neoadjuvant systemic carboplatin-paclitaxel chemotherapy will be prospectively recruited in this trial.
- Conditions
- Metastatic Ovarian Carcinoma, Peritoneal Carcinomatosis, Stage III Ovarian Cancer, Stage III Fallopian Tube Cancer
- Trial name
- PIPACOVA (NCT04811703)
- Testing
- Combined PIPAC / IV chemotherapy treatment
- Where
- 6 sites in France
- Volunteers
- 15 people
- Sponsor
- Hospices Civils de Lyon
Shock State, Hemodynamics Instability
Correlation Between Capillary Refill Time and Perfusion Index in Critically Ill Patients
Assessment of capillary refill time (CRT) is a cornerstone of tissue perfusion monitoring in critically ill patients. CRT measurement is performed by applying brief and gentle pressure (for a few seconds) to a small area of skin…
- Conditions
- Shock State, Hemodynamics Instability, Microcirculation, Monitoring
- Trial name
- CRIPI (NCT07555041)
- Testing
- Microcirculation monitoring
- Where
- 2 sites in France
- Volunteers
- 267 people
- Sponsor
- Hospices Civils de Lyon
Glucose Metabolism Disorders in Cystic Fibrosis
Reproducibility of Continuous Glucose Monitoring (CGM) in the Assessment of Glucose Metabolism Disorders in Children With Cystic Fibrosis
Glucose metabolism disorders in cystic fibrosis (CF-GMD) are common and have a negative clinical impact. Screening currently relies on the oral glucose tolerance test (OGTT); however, this procedure is burdensome and complex for…
- Trial name
- CGMUCODIAB (NCT07851831)
- Testing
- Continuous Glucose Monitoring, Eating Habits Questionnaire, Use of an actigraphy watch
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Hospices Civils de Lyon
Nosocomial Infections
Nosocomial Respiratory Virus Infection
Hospital-acquired Viral Respiratory Infections (HAVRI) are associated with substantial burden on health care systems. The prevention and control of these viral infections rely on multiple measures such as hand hygiene or wearing…
- Trial name
- NOSOVIRUS (NCT06643039)
- Testing
- Nasopharyngeal swab, Questionnaire
- Where
- 6 sites in France
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Acute Stress Disorder, Post Traumatic Stress Disorder PTSD
Assessment of the Preventive Effect of Defusing on Traumatic Kindling
The exposure to a potential traumatic event (PTE) is common in the general population. This exposure may lead to psychiatric disorders such as acute stress disorder (ASD) and post-traumatic stress disorder (PTSD).
- Trial name
- PREDEKIT (NCT07850193)
- Testing
- Defusing, Psychological First Aid (PFA)
- Where
- 4 sites in France
- Volunteers
- 70 people
- Sponsor
- Hospices Civils de Lyon
Human Immunodeficiency Virus Infection (HIV)
Innate-like and NK Signatures in Chronic-Treated HIV Infection INSTINCT-HIV
Infection with the human immunodeficiency virus (HIV) is a chronic condition requiring lifelong antiretroviral therapy (ART). Despite prolonged virological control under suppressive ART, HIV persists in the form of a stable viral…
- Trial name
- INSTINCT-HIV (NCT07849933)
- Testing
- Blood test
- Volunteers
- 100 people
- Sponsor
- Hospices Civils de Lyon
Neuromuscular Diseases
Reliability Study of a Motor Function Measure Digitalized Playful Completion Modules
Neuromuscular diseases include more than 200 rare disorders affecting muscles or the nervous system. Functional scales assessing motor function are tools allowing to measure the evolution of motor impairment of patients with a…
- Trial name
- MFM-Play (NCT05227274)
- Testing
- Items completion with or without a MFM-Play
- Where
- 10 sites in France
- Volunteers
- 70 people
- Sponsor
- Hospices Civils de Lyon
Proximal Junctional Kyphosis
Efficacy of Sub-laminar and/or Interspinous Tethers to Prevent Proximal Junctional Kyphosis After Surgical Correction of Adult Spinal Deformity
PJK (proximal junctional kyphosis) at the upper end of spinal fusions after surgical correction of adult spinal deformity is not uncommon.
- Trial name
- TRANSITION (NCT07618897)
- Testing
- Tether strategy, Reference
- Where
- 6 sites in France
- Volunteers
- 128 people
- Sponsor
- Hospices Civils de Lyon
Arrhythmia
Quality of Life Before and After Transcatheter Ablation in Children With Arrythmias
The goal of this clinical trial is to evaluate the improvement in the quality of life after the transcatheter ablation in children from 5 to 17 years old suffering for arrythmia who need a transcatheter ablation (according to…
- Trial name
- QUALICATRYTHM (NCT06808204)
- Testing
- Peds QL 4.0 (Pediatric Quality of Life), Ricci and Gagnon questionnaire, State and Trait Inventory
- Where
- 7 sites in France
- Volunteers
- 200 people
- Sponsor
- Hospices Civils de Lyon
Vascular Anomaly, Osler Rendu Disease
Pregnancy in Women With Rare Multisystemic Vascular Diseases: COGRare5 Study
There are no prospective studies of pregnancies for the diseases studied here in (Heredity Hemorrhagic Telangiectasia, Marfan syndrome or related, primary lower limb lymphedema, superficial arteriovenous malformations, and…
- Conditions
- Vascular Anomaly, Osler Rendu Disease, Marfan Syndrome or Related, Lymphedema Primary
- Trial name
- COGRare5 (NCT04194619)
- Testing
- Questionnaire
- Where
- 37 sites in France
- Volunteers
- 400 people
- Sponsor
- Hospices Civils de Lyon
Systememic Lupus Erythematosus, Systemic Sclerosis (SSc)
Investigation of Type I Interferon Excess in Patients With Systemic Autoimmune Diseases and Genetic Type I Interferonopathies
Systemic autoimmune diseases associated with type I interferon (IFN-I) dysregulation, such as systemic lupus erythematosus, systemic sclerosis, myositis, and mixed or undifferentiated connective tissue diseases, and genetic type…
- Conditions
- Systememic Lupus Erythematosus, Systemic Sclerosis (SSc), Inflammatory Myopathies, Connective Tissue Diseases
- Trial name
- SAFRAN (NCT07837986)
- Testing
- biological samples
- Where
- 3 sites in France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Idiopathic Scoliosis
Multicentric Evaluation of Enhanced Recovery After Surgery Protocol in Adolescent Idiopathic Scoliosis Surgery
Adolescent idiopathic scoliosis is a deformation of the spine affecting 2 to 4% of under 18 years old population. This can have severe physical or psychological impact during adulthood.
- Trial name
- EMRACSIA (NCT06908213)
- Testing
- Posterior vertebral fusion surgery with Enhanced Recovery After Surgery (ERAS) procedure, Posterior vertebral fusion surgery with standard of care procedure
- Where
- 11 sites in France
- Volunteers
- 316 people
- Sponsor
- Hospices Civils de Lyon
Epilepsy, SUDEP
Intracranial CArtography of Cortical Contribution to Respiratory Load Compensation in Epilepsy
30% of patients with epilepsy suffer from drug-resistant seizures and have a greater risk of premature mortality than the general population.
- Trial name
- ICARE (NCT07599150)
- Testing
- SEEG monitoring, Comprehensive respiratory monitoring, Cardio-respiratory monitoring
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Hospices Civils de Lyon
Neonatal Late Onset Sepsis
Validation of Biomarkers Performance to Reduce Antibiotics overUse in newBorns With Suspected Clinical Signs of InfectionS
Late-onset neonatal sepsis (LOS), occurring in newborn of at least 7 days of life, is frequently observed in Neonatal Intensive Care Units (NICUs) and potentially severe (mortality, neurologic and respiratory impairments).
- Trial name
- RUBIS (NCT06058819)
- Testing
- Newborns suspected of Infections
- Where
- 3 sites in France
- Volunteers
- 285 people
- Sponsor
- Hospices Civils de Lyon
Shock
The Prevalence of the Aortic to Radial Pressure Gradient in States of Shock, Outside the Context of Cardiac Surgery, a Prospective Study
First described in cardiac surgery, the aortic to radial pressure gradient (ATRAP) is the cause of an underestimation of the aortic pressure with a measure assumed with a radial catheter, and he can concert 1 of 3rd patients.
- Trial name
- PARECHOC (NCT06460519)
- Testing
- Non-invasive blood pressure measurements
- Where
- 9 sites in France, Guadeloupe
- Volunteers
- 180 people
- Sponsor
- Hospices Civils de Lyon
Sarcoidosis, Pulmonary
Hydroxychloroquine as a Steroid-sparing Agent in Extrapulmonary Sarcoidosis
Sarcoidosis is a systemic granulomatous disease of unknown aetiology, mainly affecting the lungs and lymphatics. It affects people worldwide (incidence, 4.7-64/100000; prevalence, 1-36/100000/year).
- Trial name
- CAESAR (NCT05841758)
- Testing
- Hydroxychloroquine
- Where
- 21 sites in France
- Volunteers
- 140 people
- Sponsor
- Hospices Civils de Lyon
ARDS
Assessment of Blood Viscosity in ARDS (Acute Respiratory Distress Syndrome)
Acute respiratory distress syndrome (ARDS) is characterized by damage to the alveolar-capillary membrane, resulting in hypoxemia, decreased pulmonary compliance, and hemodynamic changes.
- Trial name
- VISC-ARDS (NCT07823296)
- Testing
- Blood draws (peripheral venous puncture), Blood draws (arterial catheter, central venous line, or Swan-Ganz catheter)
- Where
- France
- Volunteers
- 46 people
- Sponsor
- Hospices Civils de Lyon
Gynecologic Surgical Procedures
Optical Biopsy in Gynecological Surgery
Optical biopsy is a new technology that generates a real-time, cell-based, high-resolution view and analysis of tissues. Observation is instantaneous and non-invasive.
- Trial name
- GYNECOPTIC (NCT04154683)
- Testing
- Cellvizio®
- Where
- 2 sites in France
- Volunteers
- 80 people
- Sponsor
- Hospices Civils de Lyon
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