Clinical trials: sponsored by Hospital for Special Surgery, New York
Cervical Stenosis, Myelopathy
Assessing Microbiome in Primary Anterior Cervical Fusion Patients
Patients who are about to undergo cervical fusion surgery at Hospital for Special Surgery (HSS) are being asked to take part in this research study.
- Conditions
- Cervical Stenosis, Myelopathy, Cervical Spondylosis With Myelopathy, Degenerative Disc Disease
- Trial name
- NCT07877766
- Testing
- Primary Anterior Cervical Discectomy Procedures
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Hospital for Special Surgery, New York
Systemic Sclerosis
Belimumab and Rituximab Combination Therapy for the Treatment of Diffuse Cutaneous Systemic Sclerosis
This is a 52 week, single center, randomized, double-blind, placebo-controlled study. After patients maintain a stable dose of Mycophenolate Mofetil (MMF) for at least 1 month, they will be randomized to treatment with either…
- Trial name
- NCT03844061
- Testing
- Belimumab, Rituximab, MMF
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Hospital for Special Surgery, New York
Motor Neuron Disease, Upper
Use of Dalfampridine in Primary Lateral Sclerosis
This study will comprise an 18-week open label safety and tolerability trial. In this study, a total of 35 subjects with primary lateral sclerosis PLS or upper motor neuron predominate ALS will be enrolled.
- Trial name
- NCT02868567
- Testing
- dalfampridine
- Where
- 3 sites in United States
- Volunteers
- 26 people
- Sponsor
- Hospital for Special Surgery, New York
Osteoporosis, Postmenopausal
Abaloparatide Added to Ongoing Denosumab vs Continued Denosumab Alone
This randomized open label clinical trial will evaluate the effect of continued denosumab alone over 18 months versus denosumab with added abaloparatide for 18 months.
- Trial name
- NCT04467983
- Testing
- Denosumab Injection, Abaloparatide
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Pain, Arthrofibrosis
Intravenous (IV) Hydrocortisone for TKA (Total Knee Arthroplasty)
In this study, total knee replacement patients will be determined to be stiff or non-stiff preoperatively. Stiffness designation is determined by preoperative range of motion (if flexion is < 100 degrees, or extension lag is > 10…
- Conditions
- Pain, Arthrofibrosis, Osteoarthritis, Knee
- Trial name
- NCT04082533
- Testing
- Hydrocortisone, Dextrose 5% in water (D5W)
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Anterior Cruciate Ligament Reconstruction, Medial Patellofemoral Ligament Reconstruction
Anterior Femoral and Adductor Canal Nerve Blocks in Peds Knees
The goal of this pilot clinical trial is to compare anterior femoral cutaneous nerve block (AFCN) to adductor canal block ACB) for pediatric patients undergoing either anterior cruciate ligament (ACL) or medial patellofemoral…
- Trial name
- NCT06590402
- Testing
- Bupivacaine, Dexamethasone in Adductor Canal Block, Bupivacaine, Dexamethasone in Anterior Femoral Cutaneous Nerve Block
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Total Knee Arthroplasty (TKA), Total Knee Arthroplasty \(TKA\)
Suzetrigine in TKA
Total knee replacements are among the most common and painful orthopedic procedures performed worldwide, often requiring intensive analgesia to support early ambulation and recovery.
- Conditions
- Total Knee Arthroplasty (TKA), Total Knee Arthroplasty \(TKA\), Total Knee Replacement, Total Knee Replacement Surgery
- Trial name
- NCT07864896
- Testing
- Suzetrigine
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Shoulder Osteoarthritis
PRP for Glenohumeral Osteoarthritis
The glenohumeral joint is the third most common large joint to be affected by OA. Conservative treatments include physical activity, corticosteroid injections, and medications.
- Trial name
- NCT05675527
- Testing
- Low-dose PRP, High-dose PRP, Saline
- Where
- United States
- Volunteers
- 135 people
- Sponsor
- Hospital for Special Surgery, New York
Lumbar Spine Degenerative Changes
Increasing Long-Term Physical Activity After Lumbar Spine Surgery
After recuperating from low back surgery patients often perpetuate a sedentary lifestyle because they are concerned about injury and recurrent pain.
- Trial name
- NCT02611427
- Testing
- Education/Self-efficacy, Education
- Where
- United States
- Volunteers
- 260 people
- Sponsor
- Hospital for Special Surgery, New York
Spinal Fusion
Abaloparatide vs. Placebo in Post-Menopausal Women and Abaloparatide in Men Receiving Initial Spinal Fusion Surgery
This is a prospective randomized, double-blinded, placebo-controlled, phase 2, 12-month pilot to study the efficacy of abaloparatide in postmenopausal women needing lumbar spinal fusion surgery.
- Trial name
- FAST-Healing (NCT03841058)
- Testing
- Abaloparatide
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- Hospital for Special Surgery, New York
Total Knee Arthroplasty Revision, Inflammatory Markers
Fiber Smoothie Supplement
This study aims to assess the feasibility of a 2-week dietary whole-food smoothie intervention and compare outcomes between two groups: patients that integrated a daily whole food plant-based smoothie into their diet for two…
- Conditions
- Total Knee Arthroplasty Revision, Inflammatory Markers, Gut Microbiota
- Trial name
- NCT06896240
- Testing
- Assigned Interventions
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Hospital for Special Surgery, New York
Chronic Pain, Opioid Use
Enhanced Recovery After Major Surgery and Chronic Pain for Total Knee Arthroplasty
The goal of this interventional clinical trial is to assess opioid consumption 24-48 hrs post anesthesia block among patients undergoing total knee arthroplasty. The main question it aims to answer is: 1.
- Conditions
- Chronic Pain, Opioid Use, Adductor Canal Block, Total Knee Arthroplasty
- Trial name
- NCT05981105
- Testing
- ambIT pump with catheter
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Hospital for Special Surgery, New York
Rotator Cuff Tear, Muscle Atrophy
Stromal Vascular Fraction Cell Therapy to Improve the Repair of Rotator Cuff Tears
Rotator cuff disease is one of the most prevalent musculoskeletal conditions across the world. Patients with chronic rotator cuff tears often have substantial muscle atrophy and fatty infiltration.
- Conditions
- Rotator Cuff Tear, Muscle Atrophy, Tendon Tear
- Trial name
- NCT03332238
- Testing
- Autologous Stomal Vascular Fraction Material, Ringer's solution
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Hospital for Special Surgery, New York
Chondral Lesion of the Knee, Meniscal Injuries
Impact of Bone-Marrow Aspirate Injections in Knee Arthroscopy
This study will examine whether using bone marrow aspirate (BMA) during knee arthroscopy surgery can improve patient outcomes. The investigators will enroll 50 patients who need knee arthroscopy surgery for meniscus injuries or…
- Conditions
- Chondral Lesion of the Knee, Meniscal Injuries, Cartilage Defects of the Knee, Osteoarthritis (OA) of the Knee
- Trial name
- BMA (NCT06893302)
- Testing
- Bone Marrow Aspirate (BMA), Arthroscopic Debridement Surgery, Saline
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Hospital for Special Surgery, New York
Aseptic Revision Knee Arthroplasty, Stiffness Following Revision Knee Arthroplasty
Does Joint Immobilization Following Revision Total Knee Arthroplasty Improve Range of Motion Following Surgery?
The goal of this study is to evaluate if knee immobilization for 10 days following revision total knee arthroplasty (rTKA) improves knee joint range of motion at 3 months postoperatively compared to standard of care postoperative…
- Trial name
- NCT07552415
- Testing
- Knee immobilizer, No Knee Immobilizer
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- Hospital for Special Surgery, New York
Rotator Cuff Tears, Muscle Atrophy or Weakness
E-CEL UVEC Cells as an Adjunct Cell Therapy for the Arthroscopic Rotator Cuff Repair in Adults
This is a phase 1b investigator-initiated clinical trial that will evaluate the safety and feasibility of E-CEL UVEC® cells with the aim of improving outcomes for patients with full-thickness rotator cuff tears who undergo…
- Conditions
- Rotator Cuff Tears, Muscle Atrophy or Weakness, Tendon Rupture - Shoulder, Safety Issues
- Trial name
- NCT04057833
- Testing
- E-CEL UVEC
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Hospital for Special Surgery, New York
Complications; Arthroplasty, Complications; Arthroplasty, Mechanical
Using MRI To Detect Soft Tissue Reactions And Implant Integration As Related To Implant Modularity
Patients with a total hip replacement may require early revision surgery due to an adverse local tissue reaction or bone resorption that occurs due to wear debris released from the implant.
- Trial name
- NCT02255331
- Where
- United States
- Volunteers
- 587 people
- Sponsor
- Hospital for Special Surgery, New York
Lumbar Spine Surgery
Lumoptik BRIGHTPOINT Reflectometer Device for Lumbar Epidural Placement
The goal of this clinical trial is to test the BrightPoint Epidural device as the first system to use multispectral reflectometry to find the epidural space in lumbar neuraxial procedures requiring epidural needle.
- Trial name
- NCT06020508
- Testing
- Group 1 - Lumoptik BrightPoint Epidural Device
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Total Hip Arthroplasty (THA), Total Hip Arthroplasty \(THA\)
Suzetrigine in Total Hip Arthroplasty
Total hip and knee joint replacements are among the most common and painful orthopedic procedures performed worldwide, often requiring intensive analgesia to support early ambulation and recovery.
- Conditions
- Total Hip Arthroplasty (THA), Total Hip Arthroplasty \(THA\), Total Hip Replacement, Total Hip Replacement Surgery
- Trial name
- NCT07226700
- Testing
- Suzetrigine
- Where
- United States
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Joint Infection, Infection of Hip Joint (Disorder)
Alpha-Defensin and Synovial Proteins to Improve Detection of Pediatric Septic Arthritis
Differentiating between septic arthritis and other causes of joint inflammation in pediatric patients is challenging and of the utmost importance because septic arthritis requires surgical debridement as part of the treatment…
- Conditions
- Joint Infection, Infection of Hip Joint (Disorder), Infection of Shoulder Joint, Septic Arthritis
- Trial name
- NCT03704766
- Testing
- Synovial Alpha-defensin assay, Synovial Neutrophil elastase assay, Synovial lactate assay
- Where
- 3 sites in United States
- Volunteers
- 442 people
- Sponsor
- Hospital for Special Surgery, New York