Clinical trials: sponsored by Huashan Hospital
Rectal Neoplasms
Study of Brain-Gut Function Reconstruction After Intersphincteric Resection for Ultra-Low Rectal Tumors
To investigate the effects of intersphincteric resection (ISR) of ultra-low rectal tumor on the brain-rectoanal function of patients, and to precisely localize the cerebral functional regulatory regions for intervention targets…
- Trial name
- NCT06082648
- Testing
- Transcranial magnetic stimulation
- Where
- China
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital
Ischemic Stroke
Tenecteplase Thrombolytic Therapy for Acute Ischemic Stroke in China
The objective of the study is to investigate the effectiveness and safety of rhTNK-tPA in acute ischemic stroke patients within 4.5 hours of symptom onset in a real-world clinical setting.
- Trial name
- TTT-AIS CHINA (NCT06078995)
- Testing
- Tenecteplase, Alteplase
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- Huashan Hospital
Myasthenia Gravis, Myasthenic Crisis
Study of Myasthenic Crisis in China
This study is a multicenter, prospective, observational research. It will register the basic demographic information, medical history characteristics, clinical features, auxiliary examinations, treatment, outcomes of tracheal…
- Trial name
- NCT04837625
- Testing
- no interventions
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Huashan Hospital
Glioma
MMR/MSI Phenotypes in Prediction of Tumor Vaccine Benefit for Gliomas
Glioblastoma (GBM) is the most malignant primary intracranial tumor with a median survival of about 18 months, and new therapies are urgently needed.
- Trial name
- NCT06043232
- Testing
- DC vaccine
- Where
- China
- Volunteers
- 360 people
- Sponsor
- Huashan Hospital
Respiratory Infectious Diseases
Promotion and Application of a New Three-level Etiological Diagnosis Strategy for Fever Clinics in Respiratory Infectious Diseases
Relying on fever clinics, this project evaluates the clinical diagnostic efficiency of the three-level pathogen diagnostic system, monitors changes in respiratory pathogens, and realizes real-time monitoring and early warning of…
- Trial name
- NCT05965128
- Where
- 12 sites in China
- Volunteers
- 1,255 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital
Hepatitis C Virus Infection
Simplification and Test and Treat Strategies Towards Hepatitis C Eliminationplatform" in China(STAT)
The present study aims to establish a " one-sample testing platform " and assess the prevalence of hepatitis C in individuals taking routine physical examination or outpatient visit in mainland China.
- Trial name
- STAT (NCT05906459)
- Testing
- Anti-HCV antibody and HCV core antigen testing
- Where
- 3 sites in China
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital
COVID-19
The Standard of Care Combined With Glucocorticoid in Elderly People With Mild or Moderate COVID-19
This study is aimed to explore the dual-dimensional early intervention strategy of standard of care combined with host immunomodulation in elderly patients with mild and moderate COVID-19.
- Trial name
- NCT05855395
- Testing
- Glucocorticoid
- Where
- 15 sites in China
- Volunteers
- 5,815 people
- Sponsor
- Huashan Hospital
Hepatitis B, Chronic
Real-world Study Optimizing Nucleotide-analogues
The goal of this multicenter, observational, prospective study is to observe and compare different anti-viral treatment strategies in a real-world cohort of patients with CHB managed in routine clinical settings in China.
- Trial name
- NCT05937178
- Testing
- ETV/TAF/TDF/TMF/IFN, ETV/TAF/TDF/TMF
- Where
- 44 sites in China
- Volunteers
- 20,000 people
- Sponsor
- Huashan Hospital
Moyamoya Disease, Remote Ischemic Conditioning
Remote Ischemic Conditioning in Adult Moyamoya Disease Patients
Remote ischemic conditioning (RIC) is a non-invasive therapeutic approach for protecting organs or tissue against the detrimental effects of acute ischemia-reperfusion injury.
- Trial name
- NCT05860946
- Testing
- Remote ischemic conditioning
- Volunteers
- 44 people
- Sponsor
- Huashan Hospital
Gastic Antrum
A Deep Learning Approach to Identify Patients With Full Stomach on Ultrasonography
Preoperative gastric ultrasonography is a newly developed tool used to evaluate gastric content and volume in assessing perioperative aspiration risk and guide anaesthetic management.
- Trial name
- NCT05846607
- Testing
- Intervention oral supplement
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Huashan Hospital
Chronic Hepatitis B
Efficacy and Safety of TAF for 48 Weeks in HBeAg Positive CHB Patients
The objective of this clinical study was to observe the changes of HBsAg levels after a sequential 48 weeks-treatment of TAF in ETV experienced CHB patients and to monitor the levels of cytokines such as IFN-λ3, IP-10, IL-12…
- Trial name
- NCT04864366
- Testing
- Tenofovir Alafenamide 25 MG [Vemlidy]
- Where
- 3 sites in China
- Volunteers
- 150 people
- Sponsor
- Huashan Hospital
Positron-Emission Tomography, Alpha Synuclein Pathology
Study of 18F-0502B PET Imaging Targeting α-synuclein in the Diagnosis of α-synuclein-related Diseases
To explore the diagnostic value of 18F-0502B brain imaging for α-Syn protein-related diseases in patients with PD. To evaluate the imaging range of α-Syn protein density in patients with α-Syn protein-related diseases and to…
- Trial name
- NCT05757804
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital
Ileostomy - Stoma, Rectal Cancer
Alterations of Gut Microbiome, Function, and Its Intervention After Defunctioning Ileostomy
This study focused on the alterations of gut microbiome and function during defunctioning ileostomy, and observed the effects of probiotic intervention on intestinal microbiome and function.
- Conditions
- Ileostomy - Stoma, Rectal Cancer, Microbial Disease, Intestinal Functional Disorder
- Trial name
- NCT05759741
- Testing
- MIYAIRI 588
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Huashan Hospital
Apatinib
mFOLFOX6 Chemotherapy With Apatinib as Postoperative Treatment in Stage IIIB or IIIC Colorectal Cancer
This study will focus on postoperative patients of stage IIIB or stage IIIC colorectal cancer. These patients will start to accept chemotherapy in 3-4 weeks after operation, these patients were randomly divided into two groups…
- Trial name
- NCT03365765
- Testing
- Apatinib, Oxaliplatin, 5-fluorouracil
- Where
- China
- Volunteers
- 63 people
- Sponsor
- Huashan Hospital
Liver Cirrhosis, Diabetes
Research on Optimal Strategy of Hypoglycemic Therapy for Cirrhosis With Diabetes
Poor blood glucose control in liver cirrhosis can aggravate the poor prognosis of patients. Under the background of the increasing number of liver cirrhosis patients with metabolic abnormalities, how to optimize treatment is…
- Trial name
- NCT05641337
- Testing
- Insulin Degludec and Insulin Aspart
- Where
- China
- Volunteers
- 184 people
- Sponsor
- Huashan Hospital
Weight Change, Body
Comparison of Body Weight Change Through Different Smeglutide Administration Methods
Investigators determined to detect the effect of smeglutide on body weight and metabolic indexes among overweight and obese participants through two different dosing programs.
- Trial name
- NCT05616052
- Testing
- Semaglutide
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Huashan Hospital
Glioma, Recurrent Glioma
Low-dose Bevacizumab With HSRT vs BVZ Alone for GBM at First Recurrence
This randomized phase II trial studies how well lose dose bevacizumab with Hypofractionated Stereotactic Radiotherapy (HSRT) works versus bevacizumab alone in treating patients with glioblastoma at first recurrence.
- Trial name
- NCT05611645
- Testing
- Hypofractionated Stereotactic Radiotherapy, Bevacizumab
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Huashan Hospital
Chronic Hepatitis B
Pegylated Interferon(Peg-IFN) in Reducing Relapse Rate in Patients After Discontinuation of NUC Therapy
This study evaluates whether Peg-IFN alfa-2a can reduce the recurrence rate of hepatitis B in 96 weeks after nucleoside analogue (NUC) withdrawal.
- Trial name
- NCT02594293
- Testing
- PegIFN alfa-2a
- Where
- 19 sites in China
- Volunteers
- 180 people
- Sponsor
- Huashan Hospital
Chordoma of Clivus
Study to Evaluate the Efficacy of Afatinib in Skull Base Chordoma
This is a single arm, open label, single center, and prospective, interventional study to explore clinical efficacy of afatinib in patients with chordoma of skull base.
- Trial name
- NCT05519917
- Testing
- Afatinib
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Huashan Hospital
Pituitary Neoplasms
Radiomic and Pathomic Study of Pituitary Adenoma Using Machine Learning
Refractory pituitary adenoma is characterized by invasive tumor growth, continuous growth and/or hormone hypersecretion in spite of standardized multi-modal treatment such as surgeries, medications or radiations.
- Trial name
- NCT05108064
- Testing
- Artificial intelligence model
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Huashan Hospital