Clinical trials: sponsored by IRCCS San Raffaele
Insomnia
Digital Cognitive-behavioral Therapy for Insomnia: a Randomized Controlled Trial
The study investigates whether online Cognitive-Behavioral Therapy for insomnia is as effective as the standard in-person group treatment, using clinical and sleep-related outcomes in adult patients.
- Trial name
- DCBT-I (NCT06939790)
- Testing
- Digital Cognitive-Behavioral Therapy for Insomnia (dCBT-I), standard face-to-face group-based Cognitive-Behavioral Therapy for Insomnia (CBT-I)
- Volunteers
- 60 people
- Sponsor
- IRCCS San Raffaele
Temporomandibular Disorders (TMD), Sleep
ASSOCIATION BETWEEN TEMPOROMANDIBULAR DISORDERS AND SLEEP DISORDERS
ASSOCIATION BETWEEN TEMPOROMANDIBULAR DISORDERS AND SLEEP DISORDERS
- Trial name
- Gnathology TMD (NCT06975709)
- Testing
- Questionnaire and Physical Exam
- Where
- 2 sites in Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS San Raffaele
Biliary Tract Diseases
ERCP Biliary Cannulation Success Using ESGE Algorithm
Papillary cannulation attempts have been shown to be an independent predictor of post-ERCP pancreatitis (PEP) when they are repeated more than 5 times or for 5 minutes or when the pancreatic duct is opacified or cannulated by…
- Trial name
- BILINCE (NCT06380543)
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- IRCCS San Raffaele
Multiple Sclerosis
Exercise Therapy in Multiple Sclerosis
Exercise or active rehabilitation is a non-pharmacological approach increasingly used for people with Multiple Sclerosis (MS), in support of disease-modifying therapies (DMTs), with the aim of improving the quality of life and…
- Trial name
- RehaMS (NCT04294979)
- Testing
- Physical Therapy
- Where
- Italy
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele Roma
PROM
H2O-F - A PROSPECTIVE, MULTI-COUNTRY, MULTI-CENTRE, MULTI-CONDITION FEASIBILITY STUDY EVALUATING THE ESTABLISHMENT OF THE NATIONAL HEALTH OUTCOMES OBSERVATORY (H2O) ECOSYSTEM
The primary objective of this study is to assess the progress of the national H2O Health Outcomes Observatory ecosystem towards a fully functional and operational state.
- Trial name
- H2O (NCT06833892)
- Where
- Austria
- Sponsor
- IRCCS San Raffaele
Lung Cancer
Cutting-edge IMAGING Technologies to Improve the SAFEty and the Sustainability of LUNG Cancer Screening and the Accuracy of Non-invasive Lung Nodules Characterization
Low-dose computed tomography (LDCT) is used in individuals at high risk of developing lung cancer (smokers over 50 years of age), as it allows for the identification of pulmonary nodules, which, in a small percentage of cases…
- Trial name
- NCT06963515
- Testing
- Magnetic Resonance Imaging
- Volunteers
- 250 people
- Sponsor
- IRCCS San Raffaele
Aortic Arch, Aneurysm
Arch Size Study for Anatomical Variations
The aortic arch with a common origin of the innominate and left carotid artery (CILCA) prevalence in the general population is 13.6%.
- Conditions
- Aortic Arch, Aneurysm, Dissection, Aortic
- Trial name
- NCT06235619
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- IRCCS San Raffaele
Thrombosis, Venous
Acute and Subacute Iliofemoral and/or Caval Deep Vein Thrombosis: Evaluation of Mechanical Thrombectomy Systems
This is a physician-initiated, observational, monocentric, retrospective and prospective Study. The study is intended to assess the feasibility of mechanical thrombectomy of caval and iliofemoral veins according to normal…
- Trial name
- ASTER (NCT06288906)
- Testing
- mechanical thrombectomy of caval and iliofemoral veins
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- IRCCS San Raffaele
Covid19
Artificial Intelligence - SARS-CoV-2 (COVID-19) Risk Evaluation
The management of COVID-19 patients in overwhelmed hospital facing the pandemic is a clinical challenge. The improvement of decision making may allow a better allocation of available resources and a better treatment of patients…
- Trial name
- AI-SCoRE (NCT04834934)
- Where
- Italy
- Volunteers
- 2,000 people
- Sponsor
- IRCCS San Raffaele
Cervical Dystonia
Physiotherapy and Botox for Cervical Dystonia: Impact of Sensory Tricks and Brain Imaging Insights
The primary aim of this study is to investigate improvements of dystonia severity in patients with cervical dystonia (CD) with (DYT-trick) and without sensory trick (DYT-no-trick) following 6 weeks of physiotherapy combined with…
- Trial name
- NCT06881147
- Testing
- Multimodal physiotherapy program
- Where
- Italy
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Pancreatic Neuroendocrine Tumor
Development of New Personalised 3D Preclinical Models of Pancreatic Neuroendocrine Tumours
The goal of this prospective observational study is to generate new personalised 3D preclinical models of pancreatic neuroendocrine tumors.
- Trial name
- 3DPanNET (NCT06121622)
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- IRCCS San Raffaele
Migraine Disorders
EptinezuMaB in ReAl-world evidenCE: Multicenter, Real Life, Cohort Study in Migraine.
The object of this study is to assess the effectiveness, safety, and tolerability of eptinezumab in a real life migraine population.
- Trial name
- EMBRACE (NCT05570149)
- Testing
- Eptinezumab 100 mg or Eptinezumab 300 mg administered intravenously in 100 mL saline solution
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- IRCCS San Raffaele Roma
IgG4 Related Disease
Adaptive and Trained Immunity in the Pathogenesis of IgG4-Related Disease
Enquire involvement of trained immunity in the pathogenesis of IgG4RD
- Trial name
- TRIM4 (NCT06844864)
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Gynecologic Cancers
The Effect of Previous Pregnancies in Patients With Gynecological Neoplasms Treated With PD-1/PD-L1 Inhibitors
Despite the fact that immunotherapy has radically changed the therapeutic landscape in multiple types of tumors, to date the only predictive factor for response to treatment with immune checkpoint inhibitors (ICI), although with…
- Trial name
- FECONDE (NCT06945601)
- Testing
- ICI monotherapy or combinations of chemo- immunotherapy
- Volunteers
- 150 people
- Sponsor
- IRCCS San Raffaele
Prostate Cancer
18F-PSMA PET/MRI for the Diagnosis of Clinically Significant Prostate Cancer
This project aims to evaluate the role of fully hybrid PET/MRI with 18F-PSMA and multiparametric MR imaging (mpMRI) as one-stop approach for the diagnosis of clinically significant prostate cancer (csPCa).
- Trial name
- NCT05815316
- Testing
- 18F-PSMA-1007
- Sponsor
- IRCCS San Raffaele
Risk of Falling, Elderly (People Aged 65 or More)
Risk of Falling and Cardiac Rehabilitation
Background and Rationale Cardiac rehabilitation (CR) is a key intervention for patients with chronic heart disease or recent acute cardiovascular events.
- Conditions
- Risk of Falling, Elderly (People Aged 65 or More), Cardiovascular Diseases
- Trial name
- CARDIO-BALANCE (NCT06908759)
- Testing
- EXERCISE TRAINING WITH OR WITHOUT MEDICATION
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- IRCCS San Raffaele Roma
Stroke, Acute Stroke
The Effects of Gait Rehabilitation After Stroke by Treadmill-based Robotics Versus Traditional Gait Training
This multicenter non-randomized controlled trial aims to investigate the effectiveness (an increase of the walking speed in the 10 Meter Walk Test - 10MWT) of the robotic treatment with exoskeleton or end-effector system compared…
- Conditions
- Stroke, Acute Stroke, Chronic Stroke
- Trial name
- TREAD_STROKE (NCT03688165)
- Testing
- Treadmill-based Robotic Gait Training, Traditional Over-ground Gait Training
- Where
- 4 sites in Italy
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele Roma
Breast Cancer, Sentinel Lymph Node
Axillary Staging in Early Breast Cancer: SNB vs PET/MRI
The gold standard of surgical treatment for patients with early breast cancer (BC) is breast conservation and sentinel node biopsy (SNB).
- Conditions
- Breast Cancer, Sentinel Lymph Node, Early-stage Breast Cancer
- Trial name
- NCT04829643
- Testing
- PET/MRI
- Where
- Italy
- Volunteers
- 246 people
- Sponsor
- IRCCS San Raffaele
Post-Thrombotic Syndrome of Both Legs
Inflow Improve for Deep Vein ThrombOsis with Ultrasound AcceLerated ThrombOlysis and Venoplasty
Aim of the IDOLO study is to investigate clinical efficacy on ultrasound accelerated thrombolysis and venoplasty in patients with post-thrombotic syndrome secondary to chronical femoro-popliteal vein occlusion for previous deep…
- Trial name
- NCT06198816
- Testing
- ultrasound accelerated thrombolysis and venoplasty
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- IRCCS San Raffaele
Hypertrophic Cardiomyopathy (HCM)
Role of Cardiovascular Imaging in the Early Diagnosis of Hypertrophic Cardiomyopathy in Women
Hypertrophic cardiomyopathy (HCM) is the most common genetic cardiac disorder worldwide with a prevalence of 1:500 in the general population.
- Trial name
- IMAGE-HCM (NCT06882668)
- Where
- Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele