Clinical trials: sponsored by IRCCS San Raffaele
Atrial Fibrillation
Multidetector CT Left Appendage Atrial Thrombosis Exclusion in Patients With Atrial Fibrillation
The aim of the LATE (multidetector CT Lefi Appendage atrial Thrombosis Exclusion in patients with atrial fibrillation) study is to evaluate the diagnostic accuracy of cardiac Computed Tomography (TC) with 64 detectors and double…
- Trial name
- NCT06169332
- Volunteers
- 260 people
- Sponsor
- IRCCS San Raffaele
Prostate Cancer
Development of Artificial Intelligence Models for Segmentation and Characterization of Prostate Cancer: a Single-center Retrospective Observational Study.
Prostate cancer is the second most common cancer in the male population. This pathology represents an oncological and public health problem especially in developed countries, due to a greater presence of elderly men in the…
- Trial name
- NCT06168864
- Testing
- Artificial intelligence models for segmentation and characterization of prostate cancer
- Where
- Italy
- Volunteers
- 350 people
- Sponsor
- IRCCS San Raffaele
Prostate Cancer
Predictive Role of [11C] Choline PET/CT on Survival in Prostate Cancer Patients With Biochemical Failure.
Several studies have shown that the PET/CT study with Choline is of great use in the restaging of patients with prostate cancer who present a recurrence of biochemical disease following primary treatment.
- Trial name
- NCT06168890
- Testing
- PET/CT with choline in the restaging phase of prostate cancer.
- Volunteers
- 195 people
- Sponsor
- IRCCS San Raffaele
Upper Urinary Tract Urothelial Carcinoma
Translational Cancer Observational Protocol
Observational study on relapse occurrence and on the quality of life in patients who underwent nephroureterectomy surgery
- Trial name
- NCT06169436
- Testing
- Nephroureterectomy
- Where
- Italy
- Volunteers
- 1,250 people
- Sponsor
- IRCCS San Raffaele
Non Small Cell Lung Cancer
AIMN Multicenter Study: 18 F-FDG PET-CT With or Without Contrast Medium in the Staging and Radiation of Lung Cancer?
Accurate staging of patients with non-small cell cancer (NSCLC) is of fundamental importance both for the correct choice of treatment plan and for prognosis.
- Trial name
- NCT06168916
- Testing
- PET/CT with contrast medium in a single session.
- Volunteers
- 14 people
- Sponsor
- IRCCS San Raffaele
Lung Cancer
Use of Integrated PET/CT as a First Line Staging and Re-staging Technique in Oncologic Patient.
Positron emission tomoscintigraphy (PET) and contrast computed tomography (CTmdc) are diagnostic methods widely used in the staging and restaging of neoplastic diseases.
- Trial name
- NCT06168877
- Testing
- Execution of 18F-FDG PET/CT and contrast-enhanced CT scan.
- Volunteers
- 30 people
- Sponsor
- IRCCS San Raffaele
Prostate Cancer
Monocentric Observational Study on the Diagnostic and Prognostic Role of 18F-PSMA PET (PET/CT and PET/MR) in Prostate Cancer
The general objective of this retrospective and prospective study is to evaluate the diagnostic and prognostic role of a quantitative analysis of PET images with 18F-PSMA in all stages of the disease in patients with prostate…
- Trial name
- NCT06167629
- Testing
- PET 18F-PSMA
- Where
- Italy
- Volunteers
- 2,500 people
- Sponsor
- IRCCS San Raffaele
Non Muscle Invasive Bladder Cancer, Non-Muscle Invasive Bladder Neoplasms
Study on the Occurrence of Possible Relapses and on the Quality of Life in Patients Who Underwent TURBK.
A database has been created and will be used in which data will be collected in electronic format relating to adult patients who underwent one of the following endoscopic resection surgeries: TURBK, MAPPING, TURBK SECOND LOOK…
- Conditions
- Non Muscle Invasive Bladder Cancer, Non-Muscle Invasive Bladder Neoplasms, Non-Muscle Invasive Bladder Urothelial Carcinoma, Bladder Cancer
- Trial name
- NCT06167356
- Where
- Italy
- Volunteers
- 20,000 people
- Sponsor
- IRCCS San Raffaele
Neuro-Degenerative Disease
Study of Cerebral Glucose Metabolism in Healthy Volunteers Using 18 F-FDG PET: Evaluation of the Effects of Aging, Comparative Evaluation of Neurodegenerative and Psychiatric Pathologies.
The aim of the study is to obtain information on cerebral glucose metabolism measured with the 18F-FDG PET technique in normal subjects without current or previous neurological or psychiatric pathologies in order to use the data…
- Trial name
- NCT06164938
- Testing
- Diagnostic accuracy
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Social Cognition
Study of Social Cognition Processes With Multimodal MRI on Healthy Adult Patients.
The study of higher cognitive functions (learning, memory, language, reasoning, decision making) in humans constitutes an interdisciplinary field, which combines neurobiological and neurological, neuropsychological, as well as…
- Trial name
- NCT06164964
- Testing
- study of higher cognitive functions
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Calculosis
Protocol No. 2016 - Calculosis- Endourology;
Retrospective and prospective study on patients suffering from nephrolithiasis who undergo minimally invasive surgery of the upper excretory system; correlation between the phenotypic and genotypic aspects of the patients and the…
- Trial name
- NCT06163313
- Testing
- Observation of patients suffering from kidney stones who undergo endoscopic surgery
- Where
- Italy
- Volunteers
- 15,000 people
- Sponsor
- IRCCS San Raffaele
Prostate Cancer
Evaluation of the Predictive Role of Choline PET/CT on the Survival of Patients Affected by Prostate Cancer.
the increase in the serum PSA (prostate specific antigen) value following radical treatment commonly involves subsequent treatment which, in the absence of morphological evidence of disease recovery, is conducted empirically…
- Trial name
- NCT06158178
- Testing
- Diagnostic accuracy
- Where
- Italy
- Volunteers
- 520 people
- Sponsor
- IRCCS San Raffaele
Parkinson Disease
Evaluation of Autonomic, Imaging and Genetic Markers for Parkinson-related Dementia : Longitudinal Assessment of a PD Cohort.
Neuropathologically, Parkinson disease (PD) is characterized by the accumulation of intra-neuronal protein aggregates (Lewy bodies and Lewy neurites).
- Trial name
- NCT06156917
- Testing
- diagnostic accuracy
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS San Raffaele
Prostate Cancer
Archive Prostate. Observational Study of Patients Who Underwent Radical Prostatectomy Surgery
This is a single-center, observational, prospective study on quality of life and disease status of patients who underwent radical prostatectomy.
- Trial name
- NCT06154499
- Testing
- Radical prostatectomy
- Where
- Italy
- Volunteers
- 1,784 people
- Sponsor
- IRCCS San Raffaele
Type2diabetes, Obesity
Effect of a Vegetarian Meal on the Physiology of Insulin Response in Patients With Type 2 Diabetes Mellitus and Obesity
The role of diet in determining glucose intolerance and its progression towards T2DM has been extensively investigated. A 2017 meta-analysis showed that a vegetarian diet is inversely associated with the risk of developing…
- Conditions
- Type2diabetes, Obesity, Diet, Healthy, Nutrition, Healthy
- Trial name
- VEG-EAT (NCT06152536)
- Testing
- Vegetarian Meal
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- IRCCS San Raffaele
Subarachnoid Hemorrhage, Aneurysmal, Poor Grade Subarachnoid Hemorrhage
Poor Grade Aneurysmal Subarachnoid Hemorrhage Study Group
Multicentric registry study in order to define outcome, predictors, treatment effects and their modifiers in poor grade aneurysmal subarachnoid haemorrhage patients.
- Trial name
- POGASH (NCT04945603)
- Testing
- Standard management according to international/national guidelines
- Where
- 10 sites in Italy
- Volunteers
- 800 people
- Sponsor
- IRCCS San Raffaele
Renal Cancer
Kidney Cancer Observational Protocol
The aim of this observational study is to gather pre and post surgery clinical data belonging to patients who underwent radical or partial nephrectomy and to evaluate the impact of the surgery on the quality of life of the…
- Trial name
- NCT06147349
- Testing
- Radical or partial nephrectomy
- Where
- Italy
- Volunteers
- 2,500 people
- Sponsor
- IRCCS San Raffaele
Testicular Cancer
WEST-KOaST Study: WES Analysis of Testicular Cancer Patientsand Their First-degree Family Members
The project aims to identify the possible risk factors regarding the onset of the disease and to evaluate genes and gene modifications responsible for the onset od testicular cancer.
- Trial name
- West-KOaSt (NCT06142500)
- Testing
- Analysis of biological samples of saliva from testicular cancer patients and from their first-degree family members
- Volunteers
- 4,500 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Diabetes Mellitus, Type 1, Ulcerative Colitis
Machine Learning Approach to Study the Interactions Between Environment and Intestinal Tissue Homeostasis in IBD
The intestinal epithelial barrier is one of the most important security checkpoints of our body that constrains harmful factors from invading mucosal surfaces and facilitates the absorption of nutrients and water.
- Trial name
- NCT06120322
- Testing
- Environmental factor monitoring; collection of blood, feces and urine. For UC: collection of 8 additional biopsies
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- IRCCS San Raffaele
Urothelial Carcinoma
Liquid Biospy for Urinary Cancers
The project aims to characterize the prognostic role of CTCs in Bladder cancer patients, with the specific aims to better stratify patients with non-muscle invasive bladder cancer at the first transurethral resection of tumor and…
- Trial name
- CIRCE (NCT06116396)
- Testing
- Genetic analysis on isolated cells
- Where
- Italy
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele