Clinical trials: sponsored by IRCCS San Raffaele
Pancreatic Cancer, Interaction
COMMUNIcation and Patient Engagement at Diagnosis of PAncreatic CAncer
BACKGROUND: The diagnosis of pancreatic adenocarcinoma (PDAC) in many cases is completely unforeseen by the patient, who often faces a disease that is already at an advanced stage, with poor prognosis.
- Conditions
- Pancreatic Cancer, Interaction, Diagnosis
- Trial name
- COMMUNICARE (NCT04257955)
- Testing
- Interview and evaluation of Engagement
- Where
- Italy
- Volunteers
- 32 people
- Sponsor
- IRCCS San Raffaele
Male Infertility
Personalized Signature of Chronic Inflammation and Early Aging Predictive of the Comorbidities in Infertile Men
The aim of the project is identify new biomarkers and/or prognostic factors in order to develop personalized strategies to prevent the onset of tumor and/or non tumor comorbidity in infertile men.
- Trial name
- NCT06082362
- Testing
- Collection of clinical and biological material
- Where
- Italy
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Crohn Disease
Unveiling the Microbial Impact on Intestinal Fibrosis
Crohn's disease (CD), belonging to the class of Inflammatory Bowel Diseases, is a chronic inflammatory disorder that may affect any location of the gastrointestinal tract.
- Trial name
- NCT06073288
- Testing
- Surgical specimens of CD and no-IBD patients
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- IRCCS San Raffaele
Colorectal Cancer
The Role of Lipid Transporter MFSD2A in the Resolution of Colorectal Cancer-associated Inflammation
The intrinsic connection between inflammation and tumor promotion is well characterized and is a key pathogenic event in patients with colorectal cancer (CRC), the second most common cause of tumor-related death in western…
- Trial name
- NCT06071598
- Testing
- Surgical specimens of CRC-affected patients
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- IRCCS San Raffaele
Eosinophilic Esophagitis
Monocentric Retrospective Observational Study for Validation of Meta-analysis of the Metatrascryptome and Transcriptome of Eosynophyl Esophagitis
This is a retrospective monocentric observational study involving patients with Eosinophilic esophagitis (EoE), gastroesophageal reflux disease (GERD), and controls (patients without EoE and GERD).
- Trial name
- NCT06071585
- Testing
- Formalin-fixed Paraffin-embedded (FFPE) tissue samples analysis
- Where
- Italy
- Volunteers
- 105 people
- Sponsor
- IRCCS San Raffaele
Healthy Volunteers
Validation of the Consecutive-Letter Substitution Task (CST)
The CST is a new neuropsychological test created to measure information processing speed, which is frequently impaired in patients with multiple sclerosis.
- Trial name
- NCT06066281
- Testing
- Neuropsychological assessment
- Where
- Italy
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
IBD
San Raffaele IBD Biobank
The developments of knowledge and possibilities of investigation in the biomedical field, and in particularly in the field of inflammatory bowel diseases need to be analyzed and study vast cases of biological material carefully…
- Trial name
- NCT06071572
- Testing
- Biological samples collected specifically for the IBD Biobank
- Where
- Italy
- Volunteers
- 3,000 people
- Sponsor
- IRCCS San Raffaele
ST Elevation Myocardial Infarction
Coronary Physiology Testing in Acute Coronary Syndromes
This is an interventional, prospective, multicenter study (5 IRCCS hospitals belonging to the Italian Cardiology Network) in patients with STEMI treated with successful primary PCI to assess the ability of coronary physiology…
- Trial name
- CoPhyTea (NCT04677257)
- Testing
- PCI, invasive coronary physiology and CMR
- Where
- 5 sites in Italy
- Volunteers
- 130 people
- Sponsor
- IRCCS San Raffaele
Left Ventricular Diastolic Dysfunction
Characterization of Patients With Post-ischemic Left Ventricular Dysfunction
This is an observational, prospective, multicenter study (12 hospitals belonging to the Italian Cardiology Network) in patients with STEMI ST elevation myocardial infarction (STEMI) treated successfully with primary percutaneous…
- Trial name
- NCT04699565
- Testing
- Cardiac magnetic resonance
- Where
- 10 sites in Italy
- Volunteers
- 303 people
- Sponsor
- IRCCS San Raffaele
Pancreatic Adenocarcinoma Non-resectable
EUS-Guided Cryothermal Ablation in Patients With Stage III Pancreatic Adenocarcinoma (HybridTherm Study)
In patients with locally advanced tumour, neoadjuvant treatment has been proposed in various modalities as a way to decrease size and downstage the tumour leading to a re-sectable disease.
- Trial name
- NCT02336672
- Testing
- Cryothermal ablation
- Where
- Italy
- Volunteers
- 66 people
- Sponsor
- IRCCS San Raffaele
Multiple Sclerosis
Aerobic Training Effects on Motor and Cognitive Performances in MS: an Exploratory Study With Structural and Functional MRI
Aerobic training (AT) induces cardiovascular, metabolic and muscular changes and has been proposed as a promising rehabilitative approach in elderly adults and in neurological patients to improve both motor and cognitive…
- Trial name
- NCT04097418
- Testing
- Aerobic training compared to conventional motor training
- Where
- Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
IBD
From Nature to Bedside- Algae Based Bio Compound for Prevention and Treatment of Inflammation, Pain and IBD
This study is part of the project funded by the Horizon2020 program for establishing the consortium Algae4IBD (https://algae4ibd.eu/), where OSR participates as a partner.
- Trial name
- NCT06042582
- Testing
- Additional biopsies collection
- Volunteers
- 90 people
- Sponsor
- IRCCS San Raffaele
Eosinophilic Esophagitis
San Raffaele EoE Biobank
Eosinophilic Esophagitis (EoE) is a immuno-mediated disease, characterised by a Th-2 food-antigen driven chronic inflammatory response of the esophagus.
- Trial name
- EoEBiobank (NCT05896891)
- Testing
- esophagogastroduodenoscopy (EGD), buccal swab, blood withdrawal
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- IRCCS San Raffaele
Parkinson Disease
RCT on Telerehabilitation Efficacy in Parkinson's Disease
The implementation of regular prolonged, and effective rehabilitation in people with Parkinson's disease is essential for ensuring a good quality of life.
- Trial name
- REPORT (NCT05842577)
- Testing
- VRRS Tablet (Khymeia s.r.l., Noventa Padovana, Italy), At-home conventional rehabilitation
- Where
- 6 sites in Italy
- Volunteers
- 94 people
- Sponsor
- IRCCS San Raffaele Roma
Neuroendocrine Tumors
Neoadjuvant PRRT With 177Lu-DOTATATE Followed by Surgery for Resectable PanNET
Peptide Receptor Radionuclide Therapy (PRRT) is based on specific somatostatin receptor targeting with radiolabelled analogues 90Y-DOTATOC and 177Lu-DOTATATE.
- Trial name
- NeoLuPaNET (NCT04385992)
- Testing
- 177Lu-Dotatate
- Where
- Italy
- Volunteers
- 31 people
- Sponsor
- IRCCS San Raffaele
SARS-Cov2
COVID-19 Epidemiological Surveillance on Healthcare Workers and Patients in a Rehabilitation Medicine Facility
The recent SARS-CoV2 pandemic has highlighted that the transmission of the virus within health care facilities plays a fundamental role in its propagation and, therefore, in the increase in COVID-19 cases registered among…
- Trial name
- COVID-19 (NCT04913701)
- Testing
- Observation group 1
- Where
- Italy
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele Roma
COPD
Improving Psychosocial Well-being in COPD Patients in Rehabilitation
Because of a lack of clinical trials, there is currently a paucity of evidence on the most effective strategies to identify and address psychological co-morbidity in COPD, or on targeting these interventions to specific patient…
- Trial name
- IMPROVE (NCT03470025)
- Testing
- Psychological Intervention
- Where
- Italy
- Volunteers
- 31 people
- Sponsor
- IRCCS San Raffaele Roma
Progressive Supranuclear Palsy, Parkinson's Disease
Deep TMS for the Treatment of Patients With Parkinson's Disease and Progressive Supranuclear Palsy
Background: Progressive supranuclear palsy (PSP) is a rare neuro-degenerative disease, counted among atypical parkinsonism (AP).
- Trial name
- DeepTMSPARK (NCT02734485)
- Testing
- active Deep TMS
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- IRCCS San Raffaele Roma
Breast Disease
Smart Optical and Ultrasound Diagnostic of Breast Cancer
SOLUS is a trans-disciplinary 48-month project bringing together 9 partners: industries (4), academic and clinical institutions from 5 countries (engineers, physicists and radiologists) representing cutting-edge expertise in…
- Trial name
- SOLUS (NCT05916703)
- Testing
- SOLUS examination
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- IRCCS San Raffaele
Depression
Tolerability, Safety and Efficacy of Vortioxetine
Depression is a psychiatric disorder frequently found in Parkinson's disease (MP), affecting approximately 40-50% of patients and assuming the characteristics of major depression in 17% of cases.
- Trial name
- VorDe-PD (NCT04301492)
- Testing
- Vortioxetine
- Where
- 2 sites in Italy
- Volunteers
- 20 people
- Sponsor
- IRCCS San Raffaele Roma