Clinical trials: sponsored by IRCCS San Raffaele
Migraine
Study of the Glymphatic System in Migraine
This study aimed to investigate the role of the glymphatic system in the initiation of migraine attacks, using non-invasive magnetic resonance imaging techniques and a validated model of migraine induction by nitroglycerin…
- Trial name
- NCT05907655
- Testing
- Nitroglycerin 0.3 MG, MRI, Blood sampling
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
C.Surgical Procedure; Cardiac
Effects on Organ Damage and Surgical Outcome of a New Cardiopulmonary Pass System (EVADO)
The primary purpose of this study is to assess the effects of the use of EVADO with respect to a conventional cardio-pulmonary bypass (CBP) system on surgical morbidity and mortality.
- Trial name
- EVADO (NCT01805466)
- Testing
- EVADO, Conventional CPB
- Where
- 4 sites in Italy
- Volunteers
- 300 people
- Sponsor
- IRCCS San Raffaele Roma
COPD, COPD Exacerbation
Ultrasonographic Evaluation of Diaphragm and Quadriceps in Chronic Obstructive Pulmonary Disease (COPD) Patients
The purpose of this study is to evaluate the prognostic role of echographic diaphragmatic assessment and vastus lateralis muscle ultrasound (US) in two independent populations of patients hospitalized for exacerbated Chronic…
- Trial name
- EDIFEB (NCT04509128)
- Volunteers
- 200 people
- Sponsor
- IRCCS San Raffaele Roma
IBD
The Gut Virome as a Trigger for IBD: From Metagenomics to Pathogenesis
Alterations in the composition of the intestinal microbiota (dysbiosis) are well known involved in the pathogenesis of gastrointestinal disorders, such as inflammatory bowel disease (IBD), which includes ulcerative colitis (UC)…
- Trial name
- NCT05906680
- Testing
- Additional biopsies collection
- Where
- Italy
- Volunteers
- 69 people
- Sponsor
- IRCCS San Raffaele
Systemic Lupus Erythematosus
Neuron-specific Humoral and Cellular Immune Correlates of Structural and Functional Brain Connectomics in Neuropsychiatric Lupus
Systemic lupus erythematosus (SLE) is the prototype systemic autoimmune disease. Neuropsychiatric SLE (NPSLE) is a major cause of morbidity.
- Trial name
- INLES (NCT05880121)
- Testing
- MRI
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- IRCCS San Raffaele
Renal Aneurysm, Aneurysm Thoracic
Registry of Patients Treated by Preloaded Fenestrated Stent-graft Designs for Complex Endovascular Aortic Procedures
The aim of the study is to evaluate the outcomes of the preloaded stent-graft design (PLD) in the routine treatment of para-renal and thoraco-abdominal aneurysms.
- Conditions
- Renal Aneurysm, Aneurysm Thoracic, Aneurysm Abdominal
- Trial name
- NCT05141123
- Testing
- Complex Endovascular Aortic Procedures treated by Preloaded Fenestrated Stent-graft Designs for
- Where
- 19 sites in United States, Denmark and 6 more
- Volunteers
- 741 people
- Sponsor
- IRCCS San Raffaele
COVID-19 Testing, CNS Disease
Determination of COVID-19 Related Virus in Central Nervous System
Coronavirus disease 2019 (COVID-19) is a highly infectious pandemic disease caused by SARS-CoV-2 virus. Central Nervous System (CNS) complications associated with COVID-19 might be secondary sequelae due to exuberant systemic…
- Conditions
- COVID-19 Testing, CNS Disease, CNS Infection
- Trial name
- NCT04775784
- Testing
- Determination of SARS-CoV2 presence in CNS
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- IRCCS San Raffaele
Prostate Cancer
PET/MR for Prostate Cancer Restaging: a Phase II Prospective Monocentric Study
The overall goal is to provide an innovative approach to restage patients with biochemical recurrence of prostate cancer by using hybrid PET/MR with innovative radiotracers (68Ga-PSMA and 68Ga-RM2)
- Trial name
- NCT05806853
- Testing
- 68Ga-PSMA, 68Ga-RM2
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- IRCCS San Raffaele
Bipolar Disorder, Unipolar Depression
Development of a Software Tool, Using Artificial Intelligence, That Integrates Clinical, Biological, Genetic and Imaging Data to Predict Diagnosis and Outcome of Depressed Patients in Order to Enhance Prognosis and Limiting Healthcare Costs.
Based on robust evidence from literature, the investigators hypothesize the presence of disease-specific neurobiological underpinnings for bipolar and unipolar disorder, which may serve as biomarkers for differential diagnosis.
- Trial name
- NCT05801562
- Where
- Italy
- Volunteers
- 730 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Depression, Postpartum
Immune/Inflammatory Biomarkers in Postpartum Depression
This will be a very straightforward study assessing changes of immune/inflammatory peripheral biomarkers before/after delivery with postpartum mood and the psychopathological features of postpartum depression (PPD), and with MRI…
- Trial name
- PPDINFLAME (NCT05784116)
- Where
- Italy
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Cardiac Complication, COVID-19 Pneumonia
STUDIO DELLE MANIFESTAZIONI CARDIOVASCOLARI A LUNGO TERMINE MEDIANTE TECNICHE DI IMAGING
The aim of the project is to identify the prevalence and characteristics of long-term cardiovascular changes in Covid-19 infection.
- Trial name
- LONG-COVID (NCT05770336)
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- IRCCS San Raffaele
Hip Arthrosis
Capsulectomy vs Capsulotomy in Total Hip Arthroplasty. Clinical Outcomes and Proprioception Evaluation
The purpose of our study is to evaluate the differences in functional activities and proprioception after surgery in subjects who underwent hip prosthesis implant with capsulotomy or capsulectomy.
- Trial name
- NCT02749058
- Testing
- Capsulectomy in Direct Anterior Total Hip Arthroplasty, Capsulotomy in Direct Anterior Total Hip Arthroplasty
- Where
- Italy
- Volunteers
- 94 people
- Sponsor
- IRCCS San Raffaele
Non Functioning Pancreatic Endocrine Tumor
Diagnostic Accuracy of Preoperative Diagnostic Procedure in the Assessment of Lymph Node Metastases by NF-PanNENs
Pancreatic Neuroendocrine Neoplasms (PanNEN) are a heterogeneous group of neoplasms that arise from the endocrine cells of the pancreatic gland.
- Trial name
- NCT03918759
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS San Raffaele
Ulcerative Colitis Chronic Moderate, Ulcerative Colitis Chronic Severe
Comparison Between Bowel Ultrasound-based Treat to Target Versus Routine Treat to Target Strategies in Ulcerative Colitis
UC (UC) is a chronic, relapsing and destructive inflammatory disorder of the colon which can lead to organ damage and impair quality of life.
- Trial name
- NCT05735665
- Testing
- bowel ultrasound, colonoscopy
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- IRCCS San Raffaele
Ulcerative Colitis
Retrospective Observational Comparison Study Between Ustekinumab and Tofacitinib as Third Line Therapy in a Multicenter Cohort of Patients With Refractory Ulcerative Colitis.
Ulcerative colitis (UC) is a chronic remitting and relapsing inflammatory bowel disease. The pathogenesis is multifactorial, involving genetic predisposition, epithelial barrier defects, dysregulated immune responses, and…
- Trial name
- NCT05728008
- Testing
- Ustekinumab, Tofacitinib
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS San Raffaele
Crohn Disease, Perianal Fistula
Comparative Accuracy of Transperineal Ultrasound (TPUS) Versus Magnetic Resonance Imaging (MRI) for the Assessment of Perianal Fistulae in Patients With Crohn's Disease (CD): a Prospective Observational Longitudinal Cohort Study
Crohn's disease (CD) is a life-long chronic inflammatory bowel disease (IBD) that may affect any site of the gastrointestinal tract, most frequently the ileum and colon.
- Trial name
- TPUS-MRI (NCT05721794)
- Testing
- A multicentric prospective observational longitudinal cohort study.
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- IRCCS San Raffaele
Inflammatory Bowel Diseases
Quantitative Assessment of Intestinal Motility on Bowel Ultrasound in Patients With Inflammatory Bowel Disease: a Feasibility, Observational, Cross-sectional, Monocentric Study
Inflammatory bowel diseases (IBD), such as ulcerative colitis (UC) and Crohn's disease (CD), are chronic, relapsing and destructive inflammatory disorder of the intestinal wall.
- Trial name
- MOTUS (NCT05719402)
- Testing
- non-interventional prospective cross-sectional observational study
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS San Raffaele
Inflammatory Bowel Diseases, Rheumatologic Disease
EFFICACY AND SAFETY OF S.C. INFLIXIMAB IN PATIENTS SWITCHED FROM I.V. FORMULATION OF INFLIXIMAB
Phase-IV, national, multicentric, non-randomized, observational real-life study. The goal of this stud is to investigate the patient's benefits in terms of quality of life and work ability resulting from the switch from…
- Trial name
- NCT05719389
- Testing
- CT-P13
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- IRCCS San Raffaele
Inflammatory Bowel Diseases, Rheumatic Disorder
Impact of Adalimumab Withdrawal or Continuation on Severity of COVID-19 and Risk of IMID Relapse
This study is a retrospective pharmacological study, of a historical cohort. Collection of Retrospective data from February 2020 to 30 September 2021 The index date is the date of COVID-19 positive PCR test.
- Trial name
- COV-ADA (NCT05706038)
- Testing
- Adalimumab
- Where
- Italy
- Volunteers
- 49 people
- Sponsor
- IRCCS San Raffaele
Infertility
pArtiaL zonA pelluciDa Removal by assisteD hatchINg of Blastocysts
The aim of study is to assess the possible impact of assisted hatching on delivery rate after transfer of vitrified-warmed human blastocysts.
- Trial name
- NCT03623659
- Testing
- Laser assisted hatching
- Where
- 2 sites in Italy
- Volunteers
- 700 people
- Sponsor
- IRCCS San Raffaele